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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors
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Citation:
(2024) eLife [preprint] 13:RP100200 Epub:
Not Epub Abstract:
During gastrulation, the mesendoderm is firstly specified by morphogens such as Nodal, and then segregates into endoderm and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cheng T, Liu X, Dong Y, Tian Y-M, Xing Y-Y, Chen C-Y, Liu C, Li Y-F, Huang Y, Zhuo D-H, Xu X, Luan J-Y, Fu X-X, Jin Z-X, Mo J, Xu X, Liang H-Q, Xu P-F. Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors. (2024) eLife [preprint] 13:RP100200. |
A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos
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Citation:
bioRxiv [preprint] 2024.08.27.610013; doi: https://doi.org/10.1101/2024.08.27.610013 Epub:
Not Epub Abstract:
Ascidian larval muscle cells present a classic example of autonomous development. A regulatory mechanism for these cells has... Delivery Method:
microinjection Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian) Citation Extract: Oda I & Satou Y. A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos. bioRxiv [preprint] 2024.08.27.610013; doi: https://doi.org/10.1101/2024.08.27.610013. |
Phase I/II Trial of Brogidirsen: Dual-Targeting Antisense Oligonucleotides for Exon 44 Skipping in Duchenne Muscular Dystrophy
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Citation:
medRxiv [preprint] 2024.08.28.24312624; doi: https://doi.org/10.1101/2024.08.28.24312624 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle disorder caused by mutations in the DMD gene, resulting in dystrophin loss... Delivery Method:
intravenous (i.v.) infusion Organism or Cell Type:
human Citation Extract: Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y . Phase I/II Trial of Brogidirsen: Dual-Targeting Antisense Oligonucleotides for Exon 44 Skipping in Duchenne Muscular Dystrophy. medRxiv [preprint] 2024.08.28.24312624; doi: https://doi.org/10.1101/2024.08.28.24312624. |
Slc4a7 Regulates Retina Development in Zebrafish
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Citation:
International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613 Epub:
Not Epub Abstract:
Inherited retinal degenerations (IRDs) are a group of genetic disorders characterized by the progressive degeneration of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhuang Y, Li D, Tang C, Zhao X, Wang R, Tao D, Huang X, Liu X. Slc4a7 Regulates Retina Development in Zebrafish. International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613. |
Second generation lethality in RNAseH2a knockout zebrafish
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Citation:
Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725 Epub:
Not Epub Abstract:
Removal of ribonucleotides from DNA by RNaseH2 is essential for genome stability, and its impacted function causes the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF, van Eeden FJ
. Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725. |
Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona
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Citation:
(2024) eLife [preprint] 13:RP99825 Epub:
Not Epub Abstract:
Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via its adhesive organ. The... Delivery Method:
microinjection Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian) Citation Extract: Hozumi A, Totsuka NM, Onodera A, Wang Y, Hamada M, Shiraishi A, Satake H, Horie T, Hotta K, Sasakura Y. Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona. (2024) eLife [preprint] 13:RP99825. |
Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons
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Citation:
bioRxiv [preprint] 2024.08.30.610519; doi: https://doi.org/10.1101/2024.08.30.610519 Epub:
Not Epub Abstract:
Deregulated proliferation of a plasma cell (PC) clone is accompanied by an excess production of a monoclonal immunoglobulin (mo... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: SK-MM-2 & RPMI 8226 Citation Extract: Lambert JM, Praité A, Contini M, Omar Ashi M, Marchalot A, Le Pennec S, Sirac C, Al Hayek A, Delpy L. Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons. bioRxiv [preprint] 2024.08.30.610519; doi: https://doi.org/10.1101/2024.08.30.610519. |
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming
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Citation:
Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079 Epub:
Not Epub Abstract:
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C. 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079. |
Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry
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Citation:
J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635 Epub:
Not Epub Abstract:
Sequencing of phosphorodiamidate morpholino oligomers (PMOs) by hydrophilic interaction chromatography (HILIC) coupled to... Citation Extract: Wang M, O'Day B, Michaels B, Jurayj J, Cai BZ, Wei T. Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635. |
Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development
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Citation:
J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837 Epub:
Not Epub Abstract:
Antibody–oligonucleotide conjugates (AOCs) are promising treatments for Duchenne muscular dystrophy (DMD). They work via... Delivery Method:
antibody-linked; intravenous (i.v.) Organism or Cell Type:
mice: ICR, C57BL/6, C57BL/10ScSn-Dmdmdx/J, C57BL/10ScSnJ Citation Extract: Cochran M, Marks I, Albin T, Arias D, Kovach P, Darimont B, Huang H, Etxaniz U, Kwon HW, Shi Y, Diaz M, Tyaglo O, Levin A, Doppalapudi VR. Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development. J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837. |