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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 11902 scientific papers returned from the database with the search filters currently being used below.
There are 11902 scientific papers returned from the database with the search filters currently being used below.
mRNA location and translation rate determine protein targeting to dual destinations
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Citation:
Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print Epub:
Yes Abstract:
Numerous proteins are targeted to two or multiple subcellular destinations where they exert distinct functional consequences.... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: MDA-MB-231 Citation Extract: Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S. mRNA location and translation rate determine protein targeting to dual destinations. Mol Cell. 2023 Jul 20:S1097-2765(23)00514-2. doi: 10.1016/j.molcel.2023.06.036. Online ahead of print. |
Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping
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Citation:
Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808 Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO)-mediated exon skipping has become a valuable tool for investigating gene function and... Citation Extract: Zhu A, Chiba S, Shimizu Y, Kunitake K, Okuno Y, Aoki Y, Yokota T. Ensemble-Learning and Feature Selection Techniques for Enhanced Antisense Oligonucleotide Efficacy Prediction in Exon Skipping. Pharmaceutics. 2023 Jun 24;15(7):1808. doi: 10.3390/pharmaceutics15071808. |
BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides
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Citation:
Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705 Epub:
Not Epub Abstract:
Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site... Delivery Method:
electroporation Organism or Cell Type:
cell culture: HEK293 Citation Extract: Chakravarthy M, Veedu RN. BACE1 Inhibition Using 2'-OMePS Steric Blocking Antisense Oligonucleotides. Genes (Basel). 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705. |
HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53
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Citation:
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24 Epub:
Yes Abstract:
Cataract is a leading ocular disease causing global blindness. The mechanism of cataractogenesis has not been well defined.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fu JL, Zheng SY, Wang Y, Hu XB, Xiao Y, Wang JM, Zhang L, Wang L, Nie Q, Hou M, Bai YY, Gan YW, Liang XM, Xie LL, Li DW. HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2221522120. doi: 10.1073/pnas.2221522120. Epub 2023 Jul 24. |
Non-canonical function of folate/folate receptor 1 during neural tube formation
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Citation:
bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718 Epub:
Not Epub Abstract:
Folate supplementation reduces the occurrence of neural tube defects, one of the most common and serious birth defects,... Delivery Method:
Vivo-Morpholino, microinjection Organism or Cell Type:
human neural organoids from iPSCs, Xenopus laevis Citation Extract: Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. Non-canonical function of folate/folate receptor 1 during neural tube formation. bioRxiv. 2023 Jul 21:[preprint]. doi:10.1101/2023.07.19.549718. |
Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1
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Citation:
Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print Epub:
Not Epub Abstract:
Germ granules, condensates of phase-separated RNA and protein, are organelles that are essential for germline development in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Westerich KJ, Tarbashevich K, Schick J, Gupta A, Zhu M, Hull K, Romo D, Zeuschner D, Goudarzi M, Gross-Thebing T, Raz E. Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. Dev Cell. 2023 Jul 11:S1534-5807(23)00307-6. doi: 10.1016/j.devcel.2023.06.009. Online ahead of print. |
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
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Citation:
Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print Epub:
Yes Abstract:
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid and myeloid lineages. HSPCs are... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ghersi JJ, Baldissera G, Hintzen J, Luff SA, Cheng S, Xia IF, Sturgeon CM, Nicoli S. Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. Nat Cell Biol. 2023 Jul 17. doi: 10.1038/s41556-023-01187-9. Online ahead of print. |
Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523 Epub:
Not Epub Abstract:
Staphylococcus aureus is a bacterial pathogen that poses a major threat to human health. The ability of this bacterium to adapt... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM. Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.12.548523 . |
A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539 Epub:
Not Epub Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Salmonella enterica serovar Typhimurium strain SL1344 Citation Extract: Ghosh C, Popella L, Dhamodharan V, Jung J, Barquist L, Höbartner C, Vogel J. A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics. bioRxiv. 2023;[preprint] doi:10.1101/2023.07.11.548539. |
Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo
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Citation:
Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022 Epub:
Not Epub Abstract:
Hematopoietic stem cells (HSCs) guarantee the continuous supply of all blood lineages during life. In response to stress, HSCs... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cacialli P, Dogan S, Linnerz T, Pasche C, Bertrand JY. Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 2023 Jul 11;18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022. |