You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12282 scientific papers returned from the database with the search filters currently being used below.

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

Authors:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W
Citation:
Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597
Epub:
Not Epub
Abstract:
Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/adbi.202400307
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocysts
Citation Extract:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W. PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597.

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

Authors:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A
Citation:
bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030
Epub:
Not Epub
Abstract:
Heterotaxy (HTX) is frequently caused by deleterious variants in the gene encoding Matrix metallopeptidase 21 (MMP21). However...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.13.618030v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A. MMP21 behaves as a fluid flow transported morphogen to impart laterality during development. bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030.

The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

Authors:
Emura N, Wavreil FDM, Fries A, Yajima M
Citation:
bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941
Epub:
Not Epub
Abstract:
The evolutionary introduction of asymmetric cell division (ACD) into the developmental program facilitates the formation of a...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11244941/
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin), Eucidaris tribuloides (sea urchin), Patiria miniata (sea star)
Citation Extract:
Emura N, Wavreil FDM, Fries A, Yajima M. The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo. bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941.

Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish

Authors:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N
Citation:
Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410
Epub:
Not Epub
Abstract:
Cells functioning at a specific zone by clustering according to gene expression are recognized as zonated cells. Here, we...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(24)00540-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N. Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish. Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410.

A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

Authors:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z
Citation:
Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788
Epub:
Not Epub
Abstract:
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly...
Link:
https://www.nature.com/articles/s41413-024-00364-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z. A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788.

Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model

Authors:
Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ
Citation:
Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859
Epub:
Not Epub
Abstract:
Primary familial brain calcification (PFBC) is a genetic neurological disease, yet no effective treatment is currently...
Link:
https://www.cell.com/neuron/fulltext/S0896-6273(24)00535-X
Delivery Method:
intracerebroventricular (i.c.v.) for mice; Endo-Porter for cells
Organism or Cell Type:
cell culture: Neuro-2A; mice: SLC20A2-KI
Citation Extract:
Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ. Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model. Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859.

An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics

Authors:
Li J, Chen F, Zhang D, Wang Y, Kozak D, Chen K
Citation:
Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205
Epub:
Not Epub
Abstract:
Chemically modified nucleic acid molecules have been developed as oligonucleotide therapeutics, and its assay is critical in...
Link:
https://pubs.acs.org/doi/10.1021/acs.analchem.4c03693
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Li J, Chen F, Zhang D, Wang Y, Kozak D, Chen K. An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics. Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205.

ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis

Authors:
Shrivastava D, Abboud E, Ramchandra JP, Jha A, Marq JB, Chaurasia A, Mitra K, Sadik M, Siddiqi MI, Soldati-Favre D, Kloehn J, Habib S
Citation:
PLoS Pathog. 2024 Sep 30;20(9):e1012593
Epub:
Not Epub
Abstract:
The Apicomplexa phylum encompasses numerous obligate intracellular parasites, some associated with severe implications for...
Link:
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012593
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Plasmodium falciparum
Citation Extract:
Shrivastava D, Abboud E, Ramchandra JP, Jha A, Marq JB, Chaurasia A, Mitra K, Sadik M, Siddiqi MI, Soldati-Favre D, Kloehn J, Habib S. ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis. PLoS Pathog. 2024 Sep 30;20(9):e1012593.

Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation

Authors:
Luo M, Wang Y, Liang J, Wan X
Citation:
J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824
Epub:
Not Epub
Abstract:
Background: Hereditary spastic paraplegia (HSP) is a rare genetically heterogeneous neurodegenerative disorder. The most common...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429824/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo M, Wang Y, Liang J, Wan X. Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation. J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824.

RRAGD variants cause cardiac dysfunction in a zebrafish model

Authors:
Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF
Citation:
Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021
Epub:
Not Epub
Abstract:
The Ras-related GTP-binding protein D (RRAGD) gene plays a crucial role in cellular processes. Recently, RRAGD variants found...
Link:
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00705.2023
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF. RRAGD variants cause cardiac dysfunction in a zebrafish model. Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021.

Pages