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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.

Authors:
Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB , Li H, Pratelli M, Borchardt J, Czajkowski C, Borodinsky LN, Sweeney L, Cline HT, Spitzer NC.
Citation:
PNAS. 2024 April 3. 121 (15) e2318041121. doi:10.1073/pnas.2318041121
Epub:
Not Epub
Abstract:
Stable matching of neurotransmitters with their receptors is fundamental to synapse function and reliable...
Link:
https://www.pnas.org/doi/10.1073/pnas.2318041121
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Godavarthi SK, Hiramoto M, Ignatyev Y, Levin JB , Li H, Pratelli M, Borchardt J, Czajkowski C, Borodinsky LN, Sweeney L, Cline HT, Spitzer NC.. Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges.. PNAS. 2024 April 3. 121 (15) e2318041121. doi:10.1073/pnas.2318041121.

Notch is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth.

Authors:
Guerin DJ, Gutierrez B, Zhang B, Ai-Sun Tseng KAS.
Citation:
bioRxiv 2024.01.31.577915; [preprint] doi.org/10.1101/2024.01.31.577915
Epub:
Not Epub
Abstract:
The ability of an organism to regrow tissues is regulated by various signaling pathways. One such pathway that has been studied...
Link:
https://www.biorxiv.org/content/10.1101/2024.01.31.577915v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Guerin DJ, Gutierrez B, Zhang B, Ai-Sun Tseng KAS.. Notch is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth.. bioRxiv 2024.01.31.577915; [preprint] doi.org/10.1101/2024.01.31.577915.

Cdx1 and Gsc distinctly regulate the transcription of BMP4 target gene ventx3.2 by directly binding to the proximal promoter region in Xenopus gastrulae.

Authors:
Shankar Goutam R, Kumar V, Lee U, Kim J.
Citation:
Molecules and Cells. Volume 47, Issue 4, 2024. doi.org/10.1016/j.mocell.2024.100058.
Epub:
Not Epub
Abstract:
A comprehensive regulatory network of transcription factors controls the dorsoventral patterning of the body axis in developing...
Link:
https://www.sciencedirect.com/science/article/pii/S1016847824000827
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shankar Goutam R, Kumar V, Lee U, Kim J.. Cdx1 and Gsc distinctly regulate the transcription of BMP4 target gene ventx3.2 by directly binding to the proximal promoter region in Xenopus gastrulae.. Molecules and Cells. Volume 47, Issue 4, 2024. doi.org/10.1016/j.mocell.2024.100058..

Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo

Authors:
Furukawa F, Aoyagi A, Sano K, Sameshima K, Goto M, Tseng Y, Ikeda D, Lin C, Uchida K, Okumura S, Yasumoto K, Jimbo M, Hwang P.
Citation:
PNAS Nexus, Volume 3, Issue 4, April 2024, pgae125, doi.org/10.1093/pnasnexus/pgae125
Epub:
Not Epub
Abstract:
Yolk-consuming (lecithotrophic) embryos of oviparous animals, such as those of fish, need to make do with the maternally...
Link:
https://academic.oup.com/pnasnexus/article/3/4/pgae125/7632797
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Furukawa F, Aoyagi A, Sano K, Sameshima K, Goto M, Tseng Y, Ikeda D, Lin C, Uchida K, Okumura S, Yasumoto K, Jimbo M, Hwang P.. Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo. PNAS Nexus, Volume 3, Issue 4, April 2024, pgae125, doi.org/10.1093/pnasnexus/pgae125.

Mycobacterium Tuberculosis Hijacks Host Macrophages-Derived Interleukin 16 to Block Phagolysosome Maturation for Enhancing Intracellular Growth.

Authors:
Su H, Weng S, Luo L, Sun Q, Lin T, Ma H, He Y, Wu J, Wang H, Zhang W, Xu Y.
Citation:
Emerging Microbes & Infections 13, no. 1 (2024). doi:10.1080/22221751.2024.2322663.
Epub:
Not Epub
Abstract:
The discovery of promising cytokines and clarification of their immunological mechanisms in controlling the intracellular fate...
Link:
https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2322663
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Su H, Weng S, Luo L, Sun Q, Lin T, Ma H, He Y, Wu J, Wang H, Zhang W, Xu Y.. Mycobacterium Tuberculosis Hijacks Host Macrophages-Derived Interleukin 16 to Block Phagolysosome Maturation for Enhancing Intracellular Growth.. Emerging Microbes & Infections 13, no. 1 (2024). doi:10.1080/22221751.2024.2322663..

A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.

Authors:
Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D.
Citation:
The EMBO Journal 0(0): 1-25. doi.org/10.1038/s44318-024-00082-9
Epub:
Not Epub
Abstract:
Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m6A)...
Link:
Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m6A) methyltransferase, has hampered characterization of the essential role of METTL16-mediated RNA m6A modification in early embryonic development
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D.. A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.. The EMBO Journal 0(0): 1-25. doi.org/10.1038/s44318-024-00082-9.

Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome.

Authors:
Brenet A, Somkhit J, Csaba Z, Ciura S, Kabashi E, Yanicostas C, Soussi-Yanicostas N.
Citation:
Cells. 2024; 13(8):684. doi.org/10.3390/cells13080684
Epub:
Not Epub
Abstract:
It has been known for a long time that epileptic seizures provoke brain neuroinflammation involving the activation of...
Link:
https://www.mdpi.com/2073-4409/13/8/684
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brenet A, Somkhit J, Csaba Z, Ciura S, Kabashi E, Yanicostas C, Soussi-Yanicostas N.. Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome.. Cells. 2024; 13(8):684. doi.org/10.3390/cells13080684.

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.

Authors:
Han G, Zhang Y, Zhong L, Wang B, Qiu S, Song J, Lin C, Zou F, Wu J, Yu H, Liang C, Wen K, Seow Y, Yin H.
Citation:
EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00049-7. Online ahead of print.
Epub:
Not Epub
Abstract:
Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and...
Link:
https://www.embopress.org/doi/full/10.1038/s44321-024-00049-7
Delivery Method:
PMO loaded on exosomes
Organism or Cell Type:
Mouse
Citation Extract:
Han G, Zhang Y, Zhong L, Wang B, Qiu S, Song J, Lin C, Zou F, Wu J, Yu H, Liang C, Wen K, Seow Y, Yin H.. Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.. EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00049-7. Online ahead of print..

Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.

Authors:
Banerjee A, Das A, Ghosh A, Gupta A, Sinha S.
Citation:
J Org Chem. 2024 Mar 1;89(5):2895-2903. doi: 10.1021/acs.joc.3c02242. Epub 2024 Feb 12.
Epub:
Not Epub
Abstract:
The synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) incorporating single or double triazole rings in the...
Link:
https://pubs.acs.org/doi/10.1021/acs.joc.3c02242
Delivery Method:
triazole-incorporated PMOs
Citation Extract:
Banerjee A, Das A, Ghosh A, Gupta A, Sinha S.. Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.. J Org Chem. 2024 Mar 1;89(5):2895-2903. doi: 10.1021/acs.joc.3c02242. Epub 2024 Feb 12..

Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27

Authors:
Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin A, Sharma A, Oatley M, Yu T, Quigley K, Vest S, Cook JG, Bautch VL.
Citation:
Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1265-1282. doi: 10.1161/ATVBAHA.124.320671. Epub 2024 Apr 11. PMID: 38602102.
Epub:
Not Epub
Abstract:
Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow-...
Link:
https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.320671
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin A, Sharma A, Oatley M, Yu T, Quigley K, Vest S, Cook JG, Bautch VL.. Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1265-1282. doi: 10.1161/ATVBAHA.124.320671. Epub 2024 Apr 11. PMID: 38602102..

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