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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11497 scientific papers returned from the database with the search filters currently being used below.

Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

Authors:
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B
Citation:
Nat Commun. 2022;13,5062. doi:10.1038/s41467-022-32477-9
Epub:
Not Epub
Abstract:
A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression. Nat Commun. 2022;13,5062. doi:10.1038/s41467-022-32477-9.

Pannexin 1 drives efficient epithelial repair after tissue injury

Authors:
Lucas CD, Medina CB, Bruton FA, Dorward DA, Raymond MH, Tufan T, Etchegaray JI, Barron B, Oremek MEM, Arandjelovic S, Farber E, Onngut-Gumuscu S, Ke E, Whyte MKB, Rossi AG, Ravichandran KS
Citation:
Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13
Epub:
Not Epub
Abstract:
Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lucas CD, Medina CB, Bruton FA, Dorward DA, Raymond MH, Tufan T, Etchegaray JI, Barron B, Oremek MEM, Arandjelovic S, Farber E, Onngut-Gumuscu S, Ke E, Whyte MKB, Rossi AG, Ravichandran KS. Pannexin 1 drives efficient epithelial repair after tissue injury. Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13.

Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury

Authors:
Zhuang M, Scholz A, Walz G, Yakulov TA
Citation:
Int J Mol Sci. 2022;23(17):9582. doi:10.3390/ijms23179582
Epub:
Not Epub
Abstract:
Acute kidney injury (AKI) is commonly associated with severe human diseases, and often worsens the outcome in hospitalized...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhuang M, Scholz A, Walz G, Yakulov TA. Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. Int J Mol Sci. 2022;23(17):9582. doi:10.3390/ijms23179582.

PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties

Authors:
Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC
Citation:
Molec Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.033
Epub:
Not Epub
Abstract:
Therapies that restore dystrophin expression are presumed to correct Duchenne muscular dystrophy (DMD), with antisense-mediated...
Delivery Method:
injection
Organism or Cell Type:
mice
Citation Extract:
Chwalenia K, Oieni J, Zemła J, Lekka M, Ahlskog N, Coenen-Stass AML, McClorey G, Wood MJA, Lomonosova Y, Roberts TC. PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties. Molec Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.033.

Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops

Authors:
Talbot CD, Walsh MD, Cutty SJ, Elsayed R, Vlachaki E, Bruce AEE, Wardle FC, Nelson AC
Citation:
Front Cell Dev Biol. 2022;10:982477 doi: 10.3389/fcell.2022.982477
Epub:
Not Epub
Abstract:
The T-box family transcription factor Eomesodermin (Eomes) is present in all vertebrates, with many key roles in the developing...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Talbot CD, Walsh MD, Cutty SJ, Elsayed R, Vlachaki E, Bruce AEE, Wardle FC, Nelson AC. Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Front Cell Dev Biol. 2022;10:982477 doi: 10.3389/fcell.2022.982477.

TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration

Authors:
Chen X, Liu F, Chen K, Wang Y, Yin A, Kang X, Yang S, Zhao H, Dong S, Li Y, Chen J, Wu Y
Citation:
CNS Neurosci Ther. 2022 Aug 19. doi:10.1111/cns.13943. Online ahead of print
Epub:
Yes
Abstract:
Aims: TFG-related axonal Charcot-Marie-Tooth (CMT) disease is a late-onset, autosomal dominant, hereditary motor, and sensory...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Liu F, Chen K, Wang Y, Yin A, Kang X, Yang S, Zhao H, Dong S, Li Y, Chen J, Wu Y. TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS Neurosci Ther. 2022 Aug 19. doi:10.1111/cns.13943. Online ahead of print.

A Cell-Penetrating Peptide Enhances Delivery and Efficacy of Phosphorodiamidate Morpholino Oligomers in mdx Mice

Authors:
Gan L, Wu LCL, Wood JA, Yao M, Treleaven CM, Estrella NL, Wentworth BM, Hanson GL, Passini MA
Citation:
Mol Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.019
Epub:
Yes
Abstract:
Antisense RNA technology is a strategy for the treatment of Duchenne muscular dystrophy (DMD), a progressive and universally...
Citation Extract:
Gan L, Wu LCL, Wood JA, Yao M, Treleaven CM, Estrella NL, Wentworth BM, Hanson GL, Passini MA. A Cell-Penetrating Peptide Enhances Delivery and Efficacy of Phosphorodiamidate Morpholino Oligomers in mdx Mice. Mol Ther Nucleic Acids. 2022;[Epub ahead of print] doi:10.1016/j.omtn.2022.08.019.

Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo

Authors:
Tommy Gambles M, Li J, Christopher Radford D, Sborov D, Shami P, Yang J, Kopeček J
Citation:
J Control Release. 2022 Aug 26:S0168-3659(22)00552-1. doi: 10.1016/j.jconrel.2022.08.045. Online ahead of print
Epub:
Yes
Abstract:
Drug-Free Macromolecular Therapeutics (DFMT) is a new paradigm in macromolecular therapeutics that induces apoptosis in target...
Organism or Cell Type:
cell culture: Raji (CD20+; CD38+) B cells; xenograft mouse
Citation Extract:
Tommy Gambles M, Li J, Christopher Radford D, Sborov D, Shami P, Yang J, Kopeček J. Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo. J Control Release. 2022 Aug 26:S0168-3659(22)00552-1. doi: 10.1016/j.jconrel.2022.08.045. Online ahead of print.

Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing

Authors:
Le BT, Paul S, Jastrzebska K, Langer H, Caruthers MH, Veedu RN
Citation:
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2207956119. doi: 10.1073/pnas.2207956119. Epub 2022 Aug 29
Epub:
Not Epub
Abstract:
Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense...
Delivery Method:
lipofectin
Organism or Cell Type:
cell culture: murine myotubes
Citation Extract:
Le BT, Paul S, Jastrzebska K, Langer H, Caruthers MH, Veedu RN. Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2207956119. doi: 10.1073/pnas.2207956119. Epub 2022 Aug 29.

Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development

Authors:
Zakaria ZZ, Eisa-Beygi S, Benslimane FM, Ramchandran R, Yalcin HC
Citation:
J Vis Exp. 2022 Aug 9;(186). doi: 10.3791/63324
Epub:
Not Epub
Abstract:
The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zakaria ZZ, Eisa-Beygi S, Benslimane FM, Ramchandran R, Yalcin HC. Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development. J Vis Exp. 2022 Aug 9;(186). doi: 10.3791/63324.

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