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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12236 scientific papers returned from the database with the search filters currently being used below.

The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae

Authors:
Yu T, Chen M, Wen J, Liu J, Li K, Jin L, Yue J, Yang Z, Xi J
Citation:
Bone. 2024 Sep 18;189:117261. doi: 10.1016/j.bone.2024.117261. Online ahead of print. PMID: 39303930
Epub:
Not Epub
Abstract:
Glucocorticoids (GCs) are extensively used as anti-inflammatory and immunosuppressive medications in the long-term treatment of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S8756328224002503
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Chen M, Wen J, Liu J, Li K, Jin L, Yue J, Yang Z, Xi J. The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 2024 Sep 18;189:117261. doi: 10.1016/j.bone.2024.117261. Online ahead of print. PMID: 39303930.

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

Authors:
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K
Citation:
Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577
Epub:
Not Epub
Abstract:
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome...
Link:
https://www.cell.com/cell/fulltext/S0092-8674(24)00911-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K. TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival. Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577.

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Authors:
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B
Citation:
Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906
Epub:
Not Epub
Abstract:
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390906/
Delivery Method:
Vivo-Morpholino; intraperitoneal
Organism or Cell Type:
C57BL/6 mice
Citation Extract:
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906.

TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio)

Authors:
Li K, Qi Z, Xie Z, Li W, Yang X, Zhai Y, Zhou X, Xie X, Song W
Citation:
J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633
Epub:
Not Epub
Abstract:
Tris (2,6-dimethylphenyl) phosphate (TDMPP), a novel organic phosphorus flame retardant (OPFR), has been found to have...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0304389424019587
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li K, Qi Z, Xie Z, Li W, Yang X, Zhai Y, Zhou X, Xie X, Song W. TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio). J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633.

Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy

Authors:
Wells JR, Padua MB, Haaning AM, Smith AM, Morris SA, Tariq M, Ware SM
Citation:
HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249
Epub:
Not Epub
Abstract:
Heterotaxy is a disorder characterized by severe congenital heart defects (CHDs) and abnormal left-right patterning in other...
Link:
https://www.cell.com/hgg-advances/pdf/S2666-2477(24)00093-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wells JR, Padua MB, Haaning AM, Smith AM, Morris SA, Tariq M, Ware SM. Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy. HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249.

p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

Authors:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R
Citation:
Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711
Epub:
Not Epub
Abstract:
Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal...
Link:
https://www.nature.com/articles/s41467-024-51922-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R. p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711.

Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response

Authors:
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L
Citation:
Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062
Epub:
Not Epub
Abstract:
Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01070-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L. Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response. Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062.

Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage

Authors:
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M
Citation:
Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572
Epub:
Not Epub
Abstract:
The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired...
Link:
https://www.nature.com/articles/s41419-024-07042-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M. Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572.

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

Authors:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T
Citation:
bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312
Epub:
Not Epub
Abstract:
Body axis specification is a crucial event in animal embryogenesis and was an essential evolutionary innovation for founding...
Link:
https://www.biorxiv.org/content/10.1101/2024.09.05.609312v1
Delivery Method:
microinjection
Organism or Cell Type:
Clytia hemisphaerica
Citation Extract:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T. Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution. bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312.

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

Authors:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331
Epub:
Not Epub
Abstract:
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00218-X
Delivery Method:
peptide-linked; intranasal and intratracheal
Organism or Cell Type:
cell culture: Hela-ACE2; mice: K18-hACE2
Citation Extract:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA. Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331.

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