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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12198 scientific papers returned from the database with the search filters currently being used below.

Hematopoietic stem cell division is governed by distinct RUNX1 binding partners

Authors:
Robertson AL, Yue L, Choudhuri A, Kubaczka C, Wattrus SJ, Mandelbaum J, Avagyan S, Yang S, Freeman RJ, Chan V, Blair MC, Daley GQ, Zon LI
Citation:
bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.596542. doi: 10.1101/2024.06.07.596542. PMID: 38895208; PMCID: PMC11185638
Epub:
Not Epub
Abstract:
A defined number of hematopoietic stem cell (HSC) clones are born during development and expand to form the pool of adult stem...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Robertson AL, Yue L, Choudhuri A, Kubaczka C, Wattrus SJ, Mandelbaum J, Avagyan S, Yang S, Freeman RJ, Chan V, Blair MC, Daley GQ, Zon LI. Hematopoietic stem cell division is governed by distinct RUNX1 binding partners. bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.596542. doi: 10.1101/2024.06.07.596542. PMID: 38895208; PMCID: PMC11185638.

Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay

Authors:
Rahmati M, Chebli J, Kumar Banote R, Roselli S, Agholme L, Zetterberg H, Abramsson A
Citation:
eNeuro. 2024 Jun 10;11(6):ENEURO.0034-24.2024. doi: 10.1523/ENEURO.0034-24.2024. PMID: 38789273; PMCID: PMC11164851
Epub:
Not Epub
Abstract:
Studies on genetic robustness recently revealed transcriptional adaptation (TA) as a mechanism by which an organism can...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rahmati M, Chebli J, Kumar Banote R, Roselli S, Agholme L, Zetterberg H, Abramsson A. Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay. eNeuro. 2024 Jun 10;11(6):ENEURO.0034-24.2024. doi: 10.1523/ENEURO.0034-24.2024. PMID: 38789273; PMCID: PMC11164851.

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

Authors:
Abe K, Ino H, Niwa T, Semmy D, Takaochi A, Nishimura T, Mogi C, Uenaka M, Ishii M, Tanaka K, Ohkawa Y, Ishitani T
Citation:
Sci Adv. 2024 Jun 14;10(24):eadi1621. doi: 10.1126/sciadv.adi1621. Epub 2024 Jun 12. PMID: 38865462; PMCID: PMC11168456.
Epub:
Not Epub
Abstract:
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in...
Delivery Method:
microinjection
Organism or Cell Type:
Nothobranchius furzeri
Citation Extract:
Abe K, Ino H, Niwa T, Semmy D, Takaochi A, Nishimura T, Mogi C, Uenaka M, Ishii M, Tanaka K, Ohkawa Y, Ishitani T. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Sci Adv. 2024 Jun 14;10(24):eadi1621. doi: 10.1126/sciadv.adi1621. Epub 2024 Jun 12. PMID: 38865462; PMCID: PMC11168456..

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Authors:
McCluskey KE, Stovell KM, Law K, Kostyanovskaya E, Schmidt J, Exner CRT, Dea J, Brimble E, State MW, Willsey J, Willsey HR
Citation:
bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642
Epub:
Not Epub
Abstract:
The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
McCluskey KE, Stovell KM, Law K, Kostyanovskaya E, Schmidt J, Exner CRT, Dea J, Brimble E, State MW, Willsey J, Willsey HR. Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility. bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642.

Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector

Authors:
Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ
Citation:
Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249
Epub:
Not Epub
Abstract:
We previously reported high CD46 expression in prostate cancer and developed an antibody-drug conjugate and immunoPET agent...
Delivery Method:
antibody-conjugate; in vivo: intravenous
Organism or Cell Type:
LS174T cells; Swiss NIH nude mice explant
Citation Extract:
Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249.

Nkd1 functions downstream of Axin2 to attenuate Wnt signaling

Authors:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ
Citation:
Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801
Epub:
Not Epub
Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem-cell maintenance in adults and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801.

Comparing cell penetration of biotherapeutics across human cell lines

Authors:
Batistatou N and Kritzer J
Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257
Epub:
Not Epub
Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS, MIA PaCa-2, HEK293-T, BxPC-3, HepG2
Citation Extract:
Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257.

Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice

Authors:
Trundle J, Lu-Nguyen N, Malerba A, Popplewell L
Citation:
International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113
Epub:
Not Epub
Abstract:
Periostin, a multifunctional 90 kDa protein, plays a pivotal role in the pathogenesis of fibrosis across various tissues,...
Delivery Method:
intraperitoneal Vivo-Morpholino in vivo, Endo-Porter in culture
Organism or Cell Type:
mouse skeletal muscle fibroblast cells; D2-mdx and Dba-2J mice
Citation Extract:
Trundle J, Lu-Nguyen N, Malerba A, Popplewell L. Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice. International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113.

Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint

Authors:
Li W, McCurdy S, Lopez-Ramirez MA, Lee HS
Citation:
bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554
Epub:
Not Epub
Abstract:
Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li W, McCurdy S, Lopez-Ramirez MA, Lee HS. Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint. bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554.

Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide

Authors:
Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F
Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)...
Delivery Method:
BBB-penetrating peptide-linked
Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice
Citation Extract:
Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176.

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