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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish

Authors:
Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T
Citation:
Commun Biol. 2024 Jan 5;7(1):31. doi: 10.1038/s42003-023-05692-3
Epub:
Not Epub
Abstract:
The stability of cellular phenotypes in developing organisms depends on error-free transmission of epigenetic and genetic...
Link:
https://www.nature.com/articles/s42003-023-05692-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lawir DF, Soza-Ried C, Iwanami N, Siamishi I, Bylund GO, O Meara C, Sikora K, Kanzler B, Johansson E, Schorpp M, Cauchy P, Boehm T. Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Commun Biol. 2024 Jan 5;7(1):31. doi: 10.1038/s42003-023-05692-3.

Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling

Authors:
Tanner CD, Rosowski EE
Citation:
Infect Immun. 2024 Jan 3:e0038023. doi: 10.1128/iai.00380-23. Online ahead of print
Epub:
Not Epub
Abstract:
Macrophages act as a first line of defense against pathogens. Against Aspergillus fumigatus, a fungus with pathogenic potential...
Link:
https://journals.asm.org/doi/10.1128/iai.00380-23
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanner CD, Rosowski EE. Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Infect Immun. 2024 Jan 3:e0038023. doi: 10.1128/iai.00380-23. Online ahead of print.

Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development

Authors:
Zi H, Peng X, Cao J, Xie T, Liu T, Li H, Bu J, Du J, Li J
Citation:
Cell Rep. 2024 Jan 3;43(1):113652. doi: 10.1016/j.celrep.2023.113652. Online ahead of print
Epub:
Not Epub
Abstract:
Blood flow is known to regulate cerebrovascular development through acting on vascular endothelial cells (ECs). As an...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01663-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zi H, Peng X, Cao J, Xie T, Liu T, Li H, Bu J, Du J, Li J. Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development. Cell Rep. 2024 Jan 3;43(1):113652. doi: 10.1016/j.celrep.2023.113652. Online ahead of print.

The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells

Authors:
Gossen S, Gerstner S, Borchers A
Citation:
Cells Dev. 2023 Dec 30;177:203899. doi: 10.1016/j.cdev.2023.203899. Online ahead of print
Epub:
Not Epub
Abstract:
Directed cell migration requires a local fine-tuning of Rho GTPase activity to control protrusion formation, cell-cell...
Link:
https://www.sciencedirect.com/science/article/pii/S266729012300075X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gossen S, Gerstner S, Borchers A. The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells. Cells Dev. 2023 Dec 30;177:203899. doi: 10.1016/j.cdev.2023.203899. Online ahead of print.

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Authors:
Merkuri F, Rothstein M, Simoes-Costa M
Citation:
Nat Commun. 2024 Jan 2;15(1):90. doi: 10.1038/s41467-023-44121-1
Epub:
Not Epub
Abstract:
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes...
Link:
https://www.nature.com/articles/s41467-023-44121-1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Merkuri F, Rothstein M, Simoes-Costa M. Histone lactylation couples cellular metabolism with developmental gene regulatory networks. Nat Commun. 2024 Jan 2;15(1):90. doi: 10.1038/s41467-023-44121-1.

Development of FKBP5 ASOs to mitigate tau pathology

Authors:
Gebru NT, Hill SE, Blair LJ
Citation:
Alzheimers Dement. 2023;[Epub] doi:10.1002/alz.082780
Epub:
Not Epub
Abstract:
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of abnormal...
Link:
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.082780
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human neuroglioma, mouse hippocampal neuron, mice
Citation Extract:
Gebru NT, Hill SE, Blair LJ. Development of FKBP5 ASOs to mitigate tau pathology. Alzheimers Dement. 2023;[Epub] doi:10.1002/alz.082780.

AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.

Authors:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G
Citation:
Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237
Epub:
Not Epub
Abstract:
AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic...
Link:
https://www.cureus.com/articles/215610-amondys-45-casimersen-a-novel-antisense-phosphorodiamidate-morpholino-oligomer-clinical-considerations-for-treatment-in-duchenne-muscular-dystrophy#!/
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Vasterling ME, Maitski RJ, Davis BA, Barnes JE, Kelkar RA, Klapper RJ, Patel H, Ahmadzadeh S, Shekoohi S, Kaye AD, Varrassi G. AMONDYS 45 (Casimersen), a Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations for Treatment in Duchenne Muscular Dystrophy.. Cureus. 2023;15(12):e51237. doi:10.7759/cureus.51237.

Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse

Authors:
Park E, Yun S-H, Jin H-S, Lee C-G, Lee S-H, Choi S-Y, Woo HG, Lim JE, Oh B, Jeong S-Y
Citation:
medRxiv. 2023;[preprint] doi:10.1101/2023.12.20.23300337
Epub:
Not Epub
Abstract:
BACKGROUNDS Osteopetrosis, a rare skeletal disease, is characterized by an increased bone mass resulting from impaired bone...
Link:
https://www.medrxiv.org/content/10.1101/2023.12.20.23300337v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Park E, Yun S-H, Jin H-S, Lee C-G, Lee S-H, Choi S-Y, Woo HG, Lim JE, Oh B, Jeong S-Y. Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse. medRxiv. 2023;[preprint] doi:10.1101/2023.12.20.23300337.

Cost-effective strategies to knock down genes of interest in the retinas of adult Zebrafish

Authors:
Shihabeddin E, Santhanam A, O'Brien J
Citation:
Front Cell Neurosci. 2023;(17):[Epub] doi:10.3389/fncel.2023.1321337
Epub:
Not Epub
Abstract:
High throughput sequencing has generated an enormous amount of information about the genes expressed in various cell types and...
Link:
https://www.frontiersin.org/articles/10.3389/fncel.2023.1321337/abstract
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Shihabeddin E, Santhanam A, O'Brien J. Cost-effective strategies to knock down genes of interest in the retinas of adult Zebrafish. Front Cell Neurosci. 2023;(17):[Epub] doi:10.3389/fncel.2023.1321337.

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning

Authors:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Citation:
bioRxiv. 2023:[preprint] doi:10.1101/2023.03.29.534583
Epub:
Not Epub
Abstract:
Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis (RM) episodes precipitated...
Link:
https://www.biorxiv.org/content/10.1101/2023.03.29.534583v3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P. TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. bioRxiv. 2023:[preprint] doi:10.1101/2023.03.29.534583.

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