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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12067 scientific papers returned from the database with the search filters currently being used below.
There are 12067 scientific papers returned from the database with the search filters currently being used below.
Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy
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Citation:
MDA Conference Abstracts. 2024;Poster 85 Epub:
Not Epub Abstract:
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that is the leading genetic cause of infantile death,... Citation Extract: Oconnor S, Hansen H, Osman E, Kaifer KD, Morcos P, Kacher M, Beatty D, Lorson C. Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy. MDA Conference Abstracts. 2024;Poster 85. |
Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration
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Citation:
Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5 Epub:
Not Epub Abstract:
Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
zebrafish Citation Extract: Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J. Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5. |
Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve
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Citation:
Circulation. 2023;148(Supp 1):A14239 Epub:
Not Epub Abstract:
Background: Extracellular matrix (ECM) is involved in aortic valve development and aortic valve anomaly. ADAMTS gene mediated... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lin Y, Yang Q, Lin X, Liu X, Kong X, Zhu L, Zhou B, Wang Y, Peng J, Zhu W, Wang J. Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve. Circulation. 2023;148(Supp 1):A14239 . |
Kif21a deficiency leads to impaired glomerular filtration barrier function
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Citation:
Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1 Epub:
Not Epub Abstract:
The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Riedmann H, Kayser S, Helmstädter M, Epting D, Bergmann C. Kif21a deficiency leads to impaired glomerular filtration barrier function. Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1. |
Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina
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Citation:
PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print Epub:
Not Epub Abstract:
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs,... Delivery Method:
injection then electroporation Organism or Cell Type:
zebrafish Citation Extract: Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR. Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print. |
The zebrafish paralog six2b is required for early proximal pronephros morphogenesis
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Citation:
Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3 Epub:
Not Epub Abstract:
The transcription factor Six2 plays a crucial role in maintaining self-renewing nephron progenitor cap mesenchyme (CM) during... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Belcher B, Vestal J, Lane S, Kell M, Smith L, Camarata T. The zebrafish paralog six2b is required for early proximal pronephros morphogenesis. Sci Rep. 2023 Nov 11;13(1):19699. doi: 10.1038/s41598-023-47046-3. |
Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773 Epub:
Not Epub Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem cell maintenance in adults and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Loss of Nkd1 is dominant over loss of Axin2 in regulating Wnt signaling. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.30.563773. |
Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia
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Citation:
Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3 Epub:
Not Epub Abstract:
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and... Delivery Method:
nanoparticle intraperitoneal (i.p.) Organism or Cell Type:
mice Citation Extract: Zhang Q, Lee CL, Yang T, Li J, Zeng Q, Liu X, Liu Z, Ruan D, Li Z, Kan ASY, Cheung KW, Mak ASL, Ng VWY, Zhao H, Fan X, Duan YG, Zhong L, Chen M, Du M, Li RHW, Liu P, Ng EHY, Yeung WSB, Gao Y, Yao Y, Chiu PCN. Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia. Sci Adv. 2023 Nov 3;9(44):eadi4777. doi: 10.1126/sciadv.adi4777. Epub 2023 Nov 3. |
Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243 Epub:
Not Epub Abstract:
Embryonic development is orchestrated by the action of morphogens, which spread out from a local source and activate, in a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gupta M, Kurth T, Heinemann F, Schwille P, Keil S, Knopf F, Brand M. Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565243. |
Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128 Epub:
Not Epub Abstract:
Candida spp. cause 750,000 cases per annum of invasive disease worldwide, with up to a 50% mortality rate. Poor efficacy of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Ayscough KR, Johnston SA, Condliffe AM, Elks PM. Candida albicans suppression of neutrophil reactive nitrogen species is rescued by host Hif-1α in vivo. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.02.565128. |