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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12159 scientific papers returned from the database with the search filters currently being used below.

Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish

Authors:
Mendoza A, Nassar KM, Marston M, Gil A, Hasan S
Citation:
Mol Biol Rep. 2025 Sep 25;52(1):947. doi: 10.1007/s11033-025-11023-y. PMID: 40996562
Epub:
Not Epub
Abstract:
Prior studies on non-canonical Wnt signaling have established Dishevelled Associated Activator of Morphogenesis 1 (Daam1) as a...
Link:
https://link.springer.com/article/10.1007/s11033-025-11023-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mendoza A, Nassar KM, Marston M, Gil A, Hasan S. Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish. Mol Biol Rep. 2025 Sep 25;52(1):947. doi: 10.1007/s11033-025-11023-y. PMID: 40996562.

WDR5 and Myc cooperate to regulate formation of neural crest stem cells

Authors:
Compton K, Barter E, La Bonne C
Citation:
Development. 2025 Dec 29:dev.205204. doi: 10.1242/dev.205204. Epub ahead of print. PMID: 41459783
Epub:
Not Epub
Abstract:
WDR5, a multifunctional scaffolding protein, has established roles in chromatin regulation and pluripotency, but its functions...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.205204/370244/WDR5-and-Myc-cooperate-to-regulate-formation-of
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Compton K, Barter E, La Bonne C. WDR5 and Myc cooperate to regulate formation of neural crest stem cells. Development. 2025 Dec 29:dev.205204. doi: 10.1242/dev.205204. Epub ahead of print. PMID: 41459783.

Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice

Authors:
Feliz-Mosquea YR, Wilson AS, Cruz-Diaz N, Payne VS, Cook KL, Soto-Pantoja DR
Citation:
Physiol Rep. 2025 Sep;13(18):e70400. doi: 10.14814/phy2.70400. PMID: 40976979; PMCID: PMC12451018
Epub:
Not Epub
Abstract:
Triple-negative breast cancer (TNBC) predominantly affects young and minority women, with cytotoxic chemotherapy regimens...
Link:
https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70400
Delivery Method:
intraperitoneal (i.p.)
Organism or Cell Type:
BALB/c mice with 4T1 tumor explants
Citation Extract:
Feliz-Mosquea YR, Wilson AS, Cruz-Diaz N, Payne VS, Cook KL, Soto-Pantoja DR. Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice. Physiol Rep. 2025 Sep;13(18):e70400. doi: 10.14814/phy2.70400. PMID: 40976979; PMCID: PMC12451018.

Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm

Authors:
Mendez AR, Pybus C, Greenberg DE
Citation:
Frontiers in Microbiology. Volume 16 - 2025, 2025. doi: 10.3389/fmicb.2025.1660799
Epub:
Not Epub
Abstract:
Background: Members of the Burkholderia cepacia complex (Bcc) are known to cause severe pulmonary infections in...
Link:
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1660799
Delivery Method:
peptide-linked
Organism or Cell Type:
Burkholderia cepacia
Citation Extract:
Mendez AR, Pybus C, Greenberg DE. Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm. Frontiers in Microbiology. Volume 16 - 2025, 2025. doi: 10.3389/fmicb.2025.1660799.

Reactive oxygen species counteract zebrafish wound contraction and promote wound healing

Authors:
Ding C, Li L, Wang Y, Nguyen HA, Chan DD, Umulis DM, Buganza AT, Deng Q
Citation:
Biophys J. 2025 Nov 4;124(21):3717-3732. doi: 10.1016/j.bpj.2025.09.027. Epub 2025 Sep 19. PMID: 40975783
Epub:
Not Epub
Abstract:
Reactive oxygen species (ROS) are second messengers that drive wound closure. However, the mechanism by which ROS regulate...
Link:
https://www.cell.com/biophysj/fulltext/S0006-3495(25)00607-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding C, Li L, Wang Y, Nguyen HA, Chan DD, Umulis DM, Buganza AT, Deng Q. Reactive oxygen species counteract zebrafish wound contraction and promote wound healing. Biophys J. 2025 Nov 4;124(21):3717-3732. doi: 10.1016/j.bpj.2025.09.027. Epub 2025 Sep 19. PMID: 40975783.

Bone morphogenetic protein-mediated Ventx3.2 regulates mesendoderm patterning and gut morphogenesis during Xenopus embryogenesis

Authors:
Goutam RS, Kumar V, Lee U, Kim J
Citation:
Biochem Biophys Res Commun. 2025 Sep 10;784:152623. doi: 10.1016/j.bbrc.2025.152623. Epub ahead of print. PMID: 40967030
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signaling plays a pivotal role in germ layer specification and organogenesis during vertebrate...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X25013397
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goutam RS, Kumar V, Lee U, Kim J. Bone morphogenetic protein-mediated Ventx3.2 regulates mesendoderm patterning and gut morphogenesis during Xenopus embryogenesis. Biochem Biophys Res Commun. 2025 Sep 10;784:152623. doi: 10.1016/j.bbrc.2025.152623. Epub ahead of print. PMID: 40967030.

Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease

Authors:
Chembazhi UV, Bangru S, Dutta RK, Das D, Peiffer B, Natua S, Toohill K, Leona A, Purwar I, Bhowmik A, Goyal Y, Sun Z, Diehl AM, Kalsotra A
Citation:
Nat Commun. 2025 Sep 10;16(1):8049. doi: 10.1038/s41467-025-63251-2. PMID: 40931030; PMCID: PMC12423296
Epub:
Not Epub
Abstract:
Individuals with progressive liver failure risk dying without liver transplantation. However, our understanding of why...
Link:
https://www.nature.com/articles/s41467-025-63251-2
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: AML12
Citation Extract:
Chembazhi UV, Bangru S, Dutta RK, Das D, Peiffer B, Natua S, Toohill K, Leona A, Purwar I, Bhowmik A, Goyal Y, Sun Z, Diehl AM, Kalsotra A. Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease. Nat Commun. 2025 Sep 10;16(1):8049. doi: 10.1038/s41467-025-63251-2. PMID: 40931030; PMCID: PMC12423296.

Tulp3 deficiency results in ciliopathy phenotypes during zebrafish embryogenesis

Authors:
Epting D, Devane J, Mertes R, Kayser S, Helmstädter M, Metzger P, Boerries M, Bergmann C, Ott E
Citation:
Sci Rep 15, 32435 (2025). https://doi.org/10.1038/s41598-025-16584-3
Epub:
Not Epub
Abstract:
Ciliopathies, caused by defective cilia biogenesis or function, comprise a genetically and clinically diverse group of...
Link:
https://www.nature.com/articles/s41598-025-16584-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Epting D, Devane J, Mertes R, Kayser S, Helmstädter M, Metzger P, Boerries M, Bergmann C, Ott E. Tulp3 deficiency results in ciliopathy phenotypes during zebrafish embryogenesis. Sci Rep 15, 32435 (2025). https://doi.org/10.1038/s41598-025-16584-3.

MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos

Authors:
Godden AM, Ward N, Sittewelle M, Antonaci M, Mir R, Kotov A, Monsoro-Burq AH, Wheeler GN
Citation:
Developmental Biology, 2025, ISSN 0012-1606, https://doi.org/10.1016/j.ydbio.2025.09.007
Epub:
Not Epub
Abstract:
Neural crest (NC) cells form a multipotent stem cell population specified during neurulation, which undergo an epithelial-to-...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160625002659
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Godden AM, Ward N, Sittewelle M, Antonaci M, Mir R, Kotov A, Monsoro-Burq AH, Wheeler GN. MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos. Developmental Biology, 2025, ISSN 0012-1606, https://doi.org/10.1016/j.ydbio.2025.09.007.

Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability

Authors:
Jastrzębska K, Szymańska A, Pawlak T, Dolot R
Citation:
Org Biomol Chem. 2025 Sep 10. doi: 10.1039/d5ob01223f. Epub ahead of print. PMID: 40928893
Epub:
Not Epub
Abstract:
We present the application of the oxathiaphospholane method for the synthesis of novel P-stereodefined phosphorothioate N-...
Link:
https://pubs.rsc.org/en/content/articlehtml/2025/ob/d5ob01223f
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Jastrzębska K, Szymańska A, Pawlak T, Dolot R. Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability. Org Biomol Chem. 2025 Sep 10. doi: 10.1039/d5ob01223f. Epub ahead of print. PMID: 40928893.

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