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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12198 scientific papers returned from the database with the search filters currently being used below.

Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina

Authors:
Lee MS, Jui J, Sahu A, Goldman D
Citation:
Development. 2024 Jul 10:dev.203062. doi: 10.1242/dev.203062. Epub ahead of print. PMID: 38984586
Epub:
Not Epub
Abstract:
In the injured zebrafish retina, Müller glial cells (MG) reprogram to adopt retinal stem cell properties and regenerate damaged...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.203062/359756/Mycb-and-Mych-stimulate-Muller-glial-cell
Delivery Method:
intravitreal injection and electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Lee MS, Jui J, Sahu A, Goldman D. Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina. Development. 2024 Jul 10:dev.203062. doi: 10.1242/dev.203062. Epub ahead of print. PMID: 38984586.

Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

Authors:
Chen S, Yin J, Liang J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P
Citation:
bioRxiv 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293
Epub:
Not Epub
Abstract:
Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to...
Link:
https://www.biorxiv.org/content/10.1101/2024.05.09.593293v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen S, Yin J, Liang J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P. Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation. bioRxiv 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293.

Mechanical forces remodel the cardiac extracellular matrix during zebrafish development

Authors:
Gentile A, Albu M, Xu Y, Mortazavi N, Ribeiro da Silva A, Stainier DYR, Gunawan F
Citation:
Development. 2024 Jul 1;151(13):dev202310. doi: 10.1242/dev.202310. Epub 2024 Jul 10. PMID: 38984541
Epub:
Not Epub
Abstract:
The cardiac extracellular matrix (cECM) is fundamental for organ morphogenesis and maturation, during which time it undergoes...
Link:
https://journals.biologists.com/dev/article/151/13/dev202310/359785/Mechanical-forces-remodel-the-cardiac
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gentile A, Albu M, Xu Y, Mortazavi N, Ribeiro da Silva A, Stainier DYR, Gunawan F. Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. Development. 2024 Jul 1;151(13):dev202310. doi: 10.1242/dev.202310. Epub 2024 Jul 10. PMID: 38984541.

Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development

Authors:
Hines MA & Taneyhill LA
Citation:
bioRxiv [preprint] 2024.07.12.603323; doi: https://doi.org/10.1101/2024.07.12.603323
Epub:
Not Epub
Abstract:
The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned...
Link:
https://www.biorxiv.org/content/10.1101/2024.07.12.603323v1
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Hines MA & Taneyhill LA. Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development. bioRxiv [preprint] 2024.07.12.603323; doi: https://doi.org/10.1101/2024.07.12.603323.

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing

Authors:
Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE
Citation:
Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928.
Epub:
Not Epub
Abstract:
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and...
Link:
https://www.nature.com/articles/s41556-024-01460-5
Delivery Method:
Pre-treat cells then cerebellum injection into NOD-SCID mice
Organism or Cell Type:
HDMB03 and MB3W1 cell line-derived tumourspheres
Citation Extract:
Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE. A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928..

The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients

Authors:
Imai S, Watanabe N, Tone Y, Mitamura R, Mori J, Kameyama T, Yamada T, Kusano K
Citation:
Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781
Epub:
Not Epub
Abstract:
Currently four kinds of phosphorodiamidate morpholino oligomers (PMOs) such as viltolarsen have been approved for the treatment...
Link:
https://dmd.aspetjournals.org/content/52/9/1029.long
Delivery Method:
i.v. bolus injection (mice), i.v. infusion and bolus injection (monkey)
Organism or Cell Type:
mice (mdx): C57BL/10ScSn-DmdmdxJ, Cynomolgus monkeys
Citation Extract:
Imai S, Watanabe N, Tone Y, Mitamura R, Mori J, Kameyama T, Yamada T, Kusano K. The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients. Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781.

Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy

Authors:
Nicastro M, Vermeer Alexa MC, Postema PG,Tadros R, Bowling FZ, Aegisdottir, HM, et al.
Citation:
medRxiv [preprint] 2024.07.04.24309755
Epub:
Not Epub
Abstract:
POPDC2 encodes for the Popeye domain-containing protein 2 which has an important role in cardiac pacemaking and conduction, due...
Link:
https://www.medrxiv.org/content/10.1101/2024.07.04.24309755v1.full-text
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nicastro M, Vermeer Alexa MC, Postema PG,Tadros R, Bowling FZ, Aegisdottir, HM, et al.. Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy. medRxiv [preprint] 2024.07.04.24309755.

Molecular analysis of a self-organizing signaling pathway for Xenopus axial patterning from egg to tailbud

Authors:
Azbazdar Y, De Robertis EM
Citation:
Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2408346121. doi: 10.1073/pnas.2408346121. Epub 2024 Jul 5. PMID: 38968117
Epub:
Not Epub
Abstract:
Xenopus embryos provide a favorable material to dissect the sequential steps that lead to dorsal-ventral (D-V) and anterior-...
Link:
https://www.pnas.org/doi/10.1073/pnas.2408346121
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Azbazdar Y, De Robertis EM. Molecular analysis of a self-organizing signaling pathway for Xenopus axial patterning from egg to tailbud. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2408346121. doi: 10.1073/pnas.2408346121. Epub 2024 Jul 5. PMID: 38968117.

Evolution and host-specific adaptation of Pseudomonas aeruginosa

Authors:
Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA
Citation:
Science. 2024 Jul 5;385(6704):eadi0908. doi: 10.1126/science.adi0908. Epub 2024 Jul 5. PMID: 38963857
Epub:
Not Epub
Abstract:
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying...
Link:
https://www.science.org/doi/10.1126/science.adi0908
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA. Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science. 2024 Jul 5;385(6704):eadi0908. doi: 10.1126/science.adi0908. Epub 2024 Jul 5. PMID: 38963857.

Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System

Authors:
Chen H, Zou Y, Kang X, Yang G, Yang X, Yao Y, Magnuson JT, Cao X, Qiu W, Xu EG, Zheng C
Citation:
Environ Sci Technol. 2024 Jul 8
Epub:
Not Epub
Abstract:
Perfluorooctane sulfonamide (PFOSA) is an immediate perfluorooctanesulfonate (PFOS) precursor (PreFOS). Previous studies have...
Link:
https://pubs.acs.org/doi/10.1021/acs.est.4c01153
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen H, Zou Y, Kang X, Yang G, Yang X, Yao Y, Magnuson JT, Cao X, Qiu W, Xu EG, Zheng C. Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System. Environ Sci Technol. 2024 Jul 8.

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