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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 11761 scientific papers returned from the database with the search filters currently being used below.
There are 11761 scientific papers returned from the database with the search filters currently being used below.
Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish
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Citation:
Nat Commun. 2023;14,1543. doi:10.1038/s41467-023-37110-x Epub:
Not Epub Abstract:
Bicuspid aortic valve (BAV), the most common cardiovascular malformation occurs in 0.5-1.2% of the population. Although highly... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Odelin G, Faucherre A, Marchese D, Pinard A, Jaouadi H, Le Scouarnec S, Deleuze J-F, Génin E, Lindenbaum P, Redon R, Schott J-J, Chiarelli R, Achouri Y, Faure E, Herbane M, Théron A, Avierinos J-F, Jopling C, Collod-Béroud G, Rezsohazy R, Zaffran S. Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish. Nat Commun. 2023;14,1543. doi:10.1038/s41467-023-37110-x. |
CLN3 deficiency leads to neurological and metabolic perturbations during early development
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.03.17.533107 Epub:
Not Epub Abstract:
Juvenile Neuronal Ceroid Lipofuscinosis (or Batten disease) is an autosomal recessive, rare neurodegenerative disorder that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Heins-Marroquin U, Singh RR, Perathoner S, Gavotto F, Ruiz CM, Patraskaki M, Gomez-Giro G, Borgmann FK, Meyer M, Carpentier A, Warmoes MO, Jaeger C, Mittelbronn M, Schwamborn JC, Cordero-Maldonado ML, Crawford AD, Schymanski EL, Linster CL. CLN3 deficiency leads to neurological and metabolic perturbations during early development. bioRxiv. 2023;[preprint] doi:10.1101/2023.03.17.533107. |
Self-transfecting GMO-PMO antisense chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse
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Citation:
Mol Ther Nucleic Acids. 2023;32:203-228. doi:10.1016/j.omtn.2023.03.011 Epub:
Yes Abstract:
Phosphorodiamidate Morpholino Oligonucleotides (PMOs)-based antisense reagents cannot enter cells without help of any delivery... Delivery Method:
GMO-PMO Organism or Cell Type:
cell culture: MCF7; zebrafish; BALB/c mice Citation Extract: Das U, Kundu J, Shaw P, Bose C, Ghosh A, Gupta S, Sarkar S, Bhadra J, Sinha S. Self-transfecting GMO-PMO antisense chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse. Mol Ther Nucleic Acids. 2023;32:203-228. doi:10.1016/j.omtn.2023.03.011. |
Investigating the Impact of Delivery Routes for Exon Skipping Therapies in the CNS of DMD Mouse Models
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Citation:
Cells. 2023;12(6):908. doi:10.3390/cells12060908 Epub:
Not Epub Abstract:
Nucleic acid-based therapies have demonstrated great potential for the treatment of monogenetic diseases, including neurologic... Delivery Method:
intraperitoneal ip, intracerebroventricular icv, intra-cisterna magna icm, osmotic pump Organism or Cell Type:
mice Citation Extract: Saoudi A, Fergus C, Gileadi T, Montanaro F, Morgan JE, Kelly VP, Tensorer T, Garcia L, Vaillend C, Muntoni F, Goyenvalle A. Investigating the Impact of Delivery Routes for Exon Skipping Therapies in the CNS of DMD Mouse Models. Cells. 2023;12(6):908. doi:10.3390/cells12060908. |
Genetic mapping and molecular mechanism behind color variation in the Asian vine snake
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Citation:
Genome Biol. 2023 Mar 9;24(1):46. doi: 10.1186/s13059-023-02887-z Epub:
Not Epub Abstract:
Background: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Tang CY, Zhang X, Xu X, Sun S, Peng C, Song MH, Yan C, Sun H, Liu M, Xie L, Luo SJ, Li JT. Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. Genome Biol. 2023 Mar 9;24(1):46. doi: 10.1186/s13059-023-02887-z. |
Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway
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Citation:
Fish Shellfish Immunol. 2023 Mar 7:108672. doi: 10.1016/j.fsi.2023.108672. Online ahead of print Epub:
Yes Abstract:
Exposure to environmental contaminants frequently induces the occurrence of blood diseases, but the underlying molecular... Organism or Cell Type:
zebrafish Citation Extract: Jia K, Xiong H, Yuan W, Huang L, Xu J, Lu C, Hu Y, Huang K, Luo Q, Ma J, Lu H. Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway. Fish Shellfish Immunol. 2023 Mar 7:108672. doi: 10.1016/j.fsi.2023.108672. Online ahead of print. |
Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP
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Citation:
Hum Mol Genet. 2022 Aug 23;31(16):2796-2809. doi: 10.1093/hmg/ddac073 Epub:
Not Epub Abstract:
In order to report clinically actionable incidental findings in genetic testing, the American College of Medical Genetics and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Elfatih A, Da'as SI, Abdelrahman D, Mbarek H, Mohammed I, Hasan W, Fakhro KA; The Qatar Genome Program Research Consortium; Estivill X, Mifsud B. Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP. Hum Mol Genet. 2022 Aug 23;31(16):2796-2809. doi: 10.1093/hmg/ddac073. |
Gold nanoparticles conjugated DNA-tile nanomaterials for simultaneous delivery of morpholino antisense oligonucleotides and doxorubicin
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Citation:
J Drug Deliv Sci Technol. 2022;74:103546. doi:10.1016/j.jddst.2022.103546 Epub:
Not Epub Abstract:
Current therapies have limited treatment effect on cancer. Combinational delivery of multiple therapeutics has been commonly... Delivery Method:
nanoparticle Organism or Cell Type:
cell culture: breast cancer Citation Extract: Tunc CU, Culha M. Gold nanoparticles conjugated DNA-tile nanomaterials for simultaneous delivery of morpholino antisense oligonucleotides and doxorubicin. J Drug Deliv Sci Technol. 2022;74:103546. doi:10.1016/j.jddst.2022.103546. |
Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
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Citation:
Nature. 2023;[Epub ahead of orint]. doi:10.1038/s41586-023-05767-5 Epub:
Not Epub Abstract:
The nucleolus is the most prominent membraneless condensate in the nucleus. It comprises hundreds of proteins with distinct... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Shan L, Xu G, Yao R-W, Luan P-F, Huang Y, Zhang P-H, Pan Y-H, Zhang L, Gao X, Li Y, Cao S-M, Gao S-X, Yang Z-H, Li S, Yang L-Z, Wang Y, Wong CCL, Yu L, Li J, Yang L, Chen L-L. Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance. Nature. 2023;[Epub ahead of orint]. doi:10.1038/s41586-023-05767-5. |
Mucociliary Wnt signaling promotes cilia biogenesis and beating
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Citation:
Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2 Epub:
Not Epub Abstract:
It is widely thought that Wnt/Lrp6 signaling proceeds through the cytoplasm and that motile cilia are signaling-inert... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Seidl C, Da Silva F, Zhang K, Wohlgemuth K, Omran H, Niehrs C. Mucociliary Wnt signaling promotes cilia biogenesis and beating. Nat Commun. 2023 Mar 6;14(1):1259. doi: 10.1038/s41467-023-36743-2. |