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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12343 scientific papers returned from the database with the search filters currently being used below.

Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function

Authors:
Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG
Citation:
J Biol Chem. 2025 Jan 18:108209. doi: 10.1016/j.jbc.2025.108209. Epub ahead of print. PMID: 39832654
Epub:
Not Epub
Abstract:
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S0021925825000560
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG. Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function. J Biol Chem. 2025 Jan 18:108209. doi: 10.1016/j.jbc.2025.108209. Epub ahead of print. PMID: 39832654.

A Lateral Line Specific Mucin Involved in Cupula Growth and Vibration Detection in Zebrafish

Authors:
Ma Z, Tian Y, Wang Y, Wang C, Wang J, Fan C
Citation:
Int J Mol Sci. 2025 Jan 15;26(2):708. doi: 10.3390/ijms26020708. PMID: 39859421; PMCID: PMC11765562
Epub:
Not Epub
Abstract:
The lateral line system in fish is crucial for detecting water flow, which facilitates various behaviors such as prey detection...
Link:
https://www.mdpi.com/1422-0067/26/2/708
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma Z, Tian Y, Wang Y, Wang C, Wang J, Fan C. A Lateral Line Specific Mucin Involved in Cupula Growth and Vibration Detection in Zebrafish. Int J Mol Sci. 2025 Jan 15;26(2):708. doi: 10.3390/ijms26020708. PMID: 39859421; PMCID: PMC11765562.

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T-tubule pH regulation

Authors:
Neitzel LR, Silver M, Wasserman AH, Rea S, Hong CC, Williams CH
Citation:
Dev Dyn. 2025 Jan 22. doi: 10.1002/dvdy.770. Epub ahead of print. PMID: 39840753
Epub:
Not Epub
Abstract:
Disruption of extracellular pH and proton-sensing can profoundly impact cellular and protein functions, leading to...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.770
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Neitzel LR, Silver M, Wasserman AH, Rea S, Hong CC, Williams CH. A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T-tubule pH regulation. Dev Dyn. 2025 Jan 22. doi: 10.1002/dvdy.770. Epub ahead of print. PMID: 39840753.

Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance

Authors:
Widziolek M, Mieszkowska A, Marcinkowska M, Salamaga B, Folkert J, Rakus K, Chadzinska M, Potempa J, Stafford GP, Prajsnar TK, Murdoch C
Citation:
PLoS Pathog. 2025 Jan 21;21(1):e1012821. doi: 10.1371/journal.ppat.1012821. Epub ahead of print. PMID: 39836688
Epub:
Not Epub
Abstract:
Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, a highly prevalent disease manifested by chronic...
Link:
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012821
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Widziolek M, Mieszkowska A, Marcinkowska M, Salamaga B, Folkert J, Rakus K, Chadzinska M, Potempa J, Stafford GP, Prajsnar TK, Murdoch C. Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. PLoS Pathog. 2025 Jan 21;21(1):e1012821. doi: 10.1371/journal.ppat.1012821. Epub ahead of print. PMID: 39836688.

Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner

Authors:
Ide AD, Carpenter KA, Elaswad M, Opria K, Marcellin K, Gilliland C, Grainger S
Citation:
bioRxiv 2025.01.10.632371; doi: https://doi.org/10.1101/2025.01.10.632371
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise only during embryonic development, and their identity specification,...
Link:
https://www.biorxiv.org/content/10.1101/2025.01.10.632371v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ide AD, Carpenter KA, Elaswad M, Opria K, Marcellin K, Gilliland C, Grainger S. Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner. bioRxiv 2025.01.10.632371; doi: https://doi.org/10.1101/2025.01.10.632371.

Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma

Authors:
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA
Citation:
Sci Rep. 2025 Jan 13;15(1):1878. doi: 10.1038/s41598-024-84037-4. PMID: 39805917
Epub:
Not Epub
Abstract:
Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been...
Link:
https://www.nature.com/articles/s41598-024-84037-4
Delivery Method:
Vivo-Morpholino; intraperitoneal (i.p.) injection for mice
Organism or Cell Type:
cells: Dkk-1 expressing MOSJ cells, OEhMSCs and MG63 3D co-cultures; mice: DAR human PDX-OS xenograft NSG mouse model
Citation Extract:
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA. Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma. Sci Rep. 2025 Jan 13;15(1):1878. doi: 10.1038/s41598-024-84037-4. PMID: 39805917.

Sex determination factor, a novel male-linked gene in the sea cucumber Apostichopus japonicus: Molecular characterization, expression patterns and effects of gene knockdown

Authors:
Meng W, Kong L, Abulizi A, Cong J, Sun Z, Chang Y
Citation:
Comp Biochem Physiol B Biochem Mol Biol. 2025 Jan 6;277:111071. doi: 10.1016/j.cbpb.2025.111071. Epub ahead of print. PMID: 39778676
Epub:
Not Epub
Abstract:
Apostichopus japonicus is a highly significant marine aquaculture species. Research findings have indicated that male sea...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1096495925000028
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Apostichopus japonicus (sea cucumber)
Citation Extract:
Meng W, Kong L, Abulizi A, Cong J, Sun Z, Chang Y. Sex determination factor, a novel male-linked gene in the sea cucumber Apostichopus japonicus: Molecular characterization, expression patterns and effects of gene knockdown. Comp Biochem Physiol B Biochem Mol Biol. 2025 Jan 6;277:111071. doi: 10.1016/j.cbpb.2025.111071. Epub ahead of print. PMID: 39778676.

Comprehensive analysis of the xbp1 gene in Pacific abalone Haliotis discus hannai: Structure, expression, and role in heat stress response

Authors:
Huang D, Li X, Pan M, Liu Y, Qin G, Chen Z, Yu X, Mai K, Zhang W
Citation:
Int J Biol Macromol. 2025 Jan 10:139771. doi: 10.1016/j.ijbiomac.2025.139771. Epub ahead of print. PMID: 39800022
Epub:
Not Epub
Abstract:
The present study explores the x-box binding protein 1 (xbp1) gene in Haliotis discus hannai (Pacific abalone), focusing on its...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0141813025003204
Delivery Method:
injection
Organism or Cell Type:
Haliotis discus hannai (Pacific abalone)
Citation Extract:
Huang D, Li X, Pan M, Liu Y, Qin G, Chen Z, Yu X, Mai K, Zhang W. Comprehensive analysis of the xbp1 gene in Pacific abalone Haliotis discus hannai: Structure, expression, and role in heat stress response. Int J Biol Macromol. 2025 Jan 10:139771. doi: 10.1016/j.ijbiomac.2025.139771. Epub ahead of print. PMID: 39800022.

Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development

Authors:
Chen S, Xu J, Xiao Y, Cai H, Zhou J, Cai W, Wang Y
Citation:
Clin Genet. 2025 Jan 6. doi: 10.1111/cge.14678. Epub ahead of print. PMID: 39763071
Epub:
Not Epub
Abstract:
Coxsackie and adenovirus receptor-like membrane protein (CLMP) mutation is identified as a genetic risk factor of congenital...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/cge.14678
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen S, Xu J, Xiao Y, Cai H, Zhou J, Cai W, Wang Y. Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development. Clin Genet. 2025 Jan 6. doi: 10.1111/cge.14678. Epub ahead of print. PMID: 39763071.

CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans

Authors:
Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, Xuan Goh W, Beckers A, Brady AF, Ewans LJ, Djaziri N, Almontashiri NAM, Alghamdi MA, Alharby E, Dasouki M, Romo L, Tan WH, Maddirevula S, Alkuraya FS, Giordano JL, Alkelai A, Wapner RJ, Stals K, Alfadhel M, Alswaid AF, Bogusch S, Schafer-Kosulya A, Vogel S, Vick P, Schweickert A, Wakeling M, Moreau de Bellaing A, Alshamsi AM, Sanlaville D, Mbarek H, Saad C, Ellard S, Eisenhaber F, Tripolszki K, Beetz C, Bauer P, Gossler A, Eisenhaber B, Blum M, Bouvagnet P, Bertoli-Avella A, Amiel J, Gordon CT, Reversade B
Citation:
Am J Hum Genet. 2024 Dec 27:S0002-9297(24)00448-8. doi: 10.1016/j.ajhg.2024.12.006. Epub ahead of print. PMID: 39753129
Epub:
Not Epub
Abstract:
Four genes-DAND5, PKD1L1, MMP21, and CIROP-form a genetic module that has specifically evolved in vertebrate species that...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0002929724004488
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, Xuan Goh W, Beckers A, Brady AF, Ewans LJ, Djaziri N, Almontashiri NAM, Alghamdi MA, Alharby E, Dasouki M, Romo L, Tan WH, Maddirevula S, Alkuraya FS, Giordano JL, Alkelai A, Wapner RJ, Stals K, Alfadhel M, Alswaid AF, Bogusch S, Schafer-Kosulya A, Vogel S, Vick P, Schweickert A, Wakeling M, Moreau de Bellaing A, Alshamsi AM, Sanlaville D, Mbarek H, Saad C, Ellard S, Eisenhaber F, Tripolszki K, Beetz C, Bauer P, Gossler A, Eisenhaber B, Blum M, Bouvagnet P, Bertoli-Avella A, Amiel J, Gordon CT, Reversade B. CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans. Am J Hum Genet. 2024 Dec 27:S0002-9297(24)00448-8. doi: 10.1016/j.ajhg.2024.12.006. Epub ahead of print. PMID: 39753129.

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