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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11971 scientific papers returned from the database with the search filters currently being used below.

Chaperone-mediated autophagy protects against hyperglycemic stress

Authors:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I
Citation:
Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415
Epub:
Yes
Abstract:
Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homeostasis and metabolism...
Link:
https://www.tandfonline.com/doi/figure/10.1080/15548627.2023.2267415
Organism or Cell Type:
Oncorhynchus mykiss (rainbow trout)
Citation Extract:
Vélez EJ, Schnebert S, Goguet M, Balbuena-Pecino S, Dias K, Beauclair L, Fontagné-Dicharry S, Véron V, Depincé A, Beaumatin F, Herpin A, Seiliez I. Chaperone-mediated autophagy protects against hyperglycemic stress. Autophagy. 2023 Oct 5:[Epub ahead of print]. doi:10.1080/15548627.2023.2267415.

Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification

Authors:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y
Citation:
Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2
Epub:
Not Epub
Abstract:
Hox genes orchestrate the segmental specification of the muscular circulatory system in invertebrates but it has not proven...
Link:
https://link.springer.com/article/10.1007/s00018-023-04933-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu P, Wang B, Jin D, Gu Y, He H, Meng X, Zhu W, Chiang DY, Li W, MacRae CA, Zu Y. Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. Cell Mol Life Sci. 2023;80:317. doi:10.1007/s00018-023-04933-2.

An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis

Authors:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099
Epub:
Not Epub
Abstract:
The study of neurogenesis is essential to understand fundamental developmental processes and for the development of cell...
Link:
https://www.biorxiv.org/content/10.1101/2023.10.05.561099v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A. An in vivo drug screen reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. bioRxiv. 2023;[preprint] doi:10.1101/2023.10.05.561099.

P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients

Authors:
Rossi R, Singh S, Torelli S, Catapano F, Chambers D, Morgan J, Malhotra J, Muntoni F
Citation:
Neuromuscul Disord. 2023;33(Supp 1):S104. doi:10.1016/j.nmd.2023.07.156
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked, rare, neuromuscular disease caused by mutations in the DMD gene affecting its...
Link:
https://www.nmd-journal.com/article/S0960-8966(23)00336-X/pdf
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Rossi R, Singh S, Torelli S, Catapano F, Chambers D, Morgan J, Malhotra J, Muntoni F. P29 DMD transcript imbalance and nuclear trafficking evaluation in muscle biopsies from baseline and golodirsen treated 4053-101 clinical trial patients. Neuromuscul Disord. 2023;33(Supp 1):S104. doi:10.1016/j.nmd.2023.07.156.

Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L

Authors:
P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model
Citation:
Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150
Epub:
Not Epub
Abstract:
There are promising treatment approaches emerging for Duchenne muscular dystrophy (DMD): exon skipping with peptide-conjugated...
Link:
https://www.nmd-journal.com/article/S0960-8966(23)00330-9/pdf
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model. Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L. Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150.

Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon

Authors:
Scholpp S, Lohs C, Brand M
Citation:
Development. 2003 Oct;130(20):4881-93. doi: 10.1242/dev.00683. Epub 2003 Aug 13
Epub:
Not Epub
Abstract:
Specification of the forebrain, midbrain and hindbrain primordia occurs during gastrulation in response to signals that pattern...
Link:
https://journals.biologists.com/dev/article/130/20/4881/52223/Engrailed-and-Fgf8-act-synergistically-to-maintain
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Scholpp S, Lohs C, Brand M. Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development. 2003 Oct;130(20):4881-93. doi: 10.1242/dev.00683. Epub 2003 Aug 13.

SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells

Authors:
Ermis E, Nargis T, Kulkarni A, May S, Tersey SA, Mirmira RG, Anderson RM
Citation:
J Endocrinol 2023;7(Supp1):bvad114.933. doi:10.1210/jendso/bvad114.933
Epub:
Not Epub
Abstract:
Type 1 diabetes (T1D) is an autoimmune disease, characterized in part by islet inflammation and macrophage infiltration leading...
Link:
https://academic.oup.com/jes/article/7/Supplement_1/bvad114.933/7290239
Organism or Cell Type:
zebrafish
Citation Extract:
Ermis E, Nargis T, Kulkarni A, May S, Tersey SA, Mirmira RG, Anderson RM. SAT066 Leukotriene B4 Receptor 2 Mediates Macrophage Migration To Injured β Cells. J Endocrinol 2023;7(Supp1):bvad114.933. doi:10.1210/jendso/bvad114.933.

The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling

Authors:
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E
Citation:
Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z
Epub:
Not Epub
Abstract:
The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in tissue homeostasis and human...
Link:
https://www.nature.com/articles/s41467-023-41836-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E. The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z.

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation

Authors:
Cervino AS, Collodel MG, Lopez IA, Roa C, Hochbaum D, Hukriede NA, Cirio MC
Citation:
Sci Rep. 2023 Oct 4;13(1):16671. doi: 10.1038/s41598-023-43662-1
Epub:
Not Epub
Abstract:
The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids...
Link:
https://www.nature.com/articles/s41598-023-43662-1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cervino AS, Collodel MG, Lopez IA, Roa C, Hochbaum D, Hukriede NA, Cirio MC. Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. Sci Rep. 2023 Oct 4;13(1):16671. doi: 10.1038/s41598-023-43662-1.

Purine Biosynthesis Pathways Are Required for Myogenesis in Xenopus laevis

Authors:
Duperray M, Hardet F, Henriet E, Saint-Marc C, Boué-Grabot E, Daignan-Fornier B, Massé K, Pinson B
Citation:
Cells. 2023;12:2379. doi:10.3390/cells12192379
Epub:
Not Epub
Abstract:
Purines are required for fundamental biological processes and alterations in their metabolism lead to severe genetic diseases...
Link:
https://www.mdpi.com/2073-4409/12/19/2379
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Duperray M, Hardet F, Henriet E, Saint-Marc C, Boué-Grabot E, Daignan-Fornier B, Massé K, Pinson B. Purine Biosynthesis Pathways Are Required for Myogenesis in Xenopus laevis. Cells. 2023;12:2379. doi:10.3390/cells12192379 .

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