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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12248 scientific papers returned from the database with the search filters currently being used below.

Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation

Authors:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH
Citation:
Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517
Epub:
Not Epub
Abstract:
Sex determination of mammalian gonads hinges upon sex-specific differentiation of gonadal supporting cells: Sertoli cells in...
Link:
https://www.science.org/doi/10.1126/sciadv.aea7403
Delivery Method:
Vivo-Morpholino culture
Organism or Cell Type:
C57BL/6J mouse gonads
Citation Extract:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH. Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation. Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517.

Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy

Authors:
Stenler S, Huang J, van Westering TLE, Coenen-Stass AML, Krjutškov K, Andaloussi SEL, Wood MJA, Roberts TC
Citation:
bioRxiv [preprint] 2025.12.23.696144; doi: https://doi.org/10.64898/2025.12.23.696144
Epub:
Not Epub
Abstract:
Exon skipping is a leading therapeutic approach for Duchenne muscular dystrophy (DMD), a progressive muscle wasting disorder...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.23.696144v1.full
Delivery Method:
Pip6a peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Stenler S, Huang J, van Westering TLE, Coenen-Stass AML, Krjutškov K, Andaloussi SEL, Wood MJA, Roberts TC. Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy. bioRxiv [preprint] 2025.12.23.696144; doi: https://doi.org/10.64898/2025.12.23.696144.

Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis

Authors:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P
Citation:
Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212
Epub:
Not Epub
Abstract:
Giardia duodenalis is an intestinal protozoan parasite responsible for giardiasis, a disease primarily characterized by...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12758212/
Delivery Method:
electroporation
Organism or Cell Type:
Giardia duodenalis
Citation Extract:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P. Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis. Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212.

Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development

Authors:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF
Citation:
Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269
Epub:
Not Epub
Abstract:
Deficiency in the retinoschisin protein (RS1) causes X-linked juvenile retinoschisis (XLRS), a retinal degenerative disease...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12578269/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF. Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development. Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269.

Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish

Authors:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C
Citation:
J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267
Epub:
Not Epub
Abstract:
Background: Probiotic nutrition has the potential to improve health and prevents diseases, and probiotics such as Bacillus spp...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0022316625008028
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C. Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish. J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267.

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection

Authors:
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T
Citation:
Nat Commun. 2025 Dec 22;16(1):10853. doi: 10.1038/s41467-025-66765-x. PMID: 41429785; PMCID: PMC12722745
Epub:
Not Epub
Abstract:
Intrathecal injection of steric-block antisense oligonucleotides (ASOs) provides therapeutic opportunities for targeting the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12722745/
Delivery Method:
cholesterol-conjugated PMO/RNA heteroduplex; intracerebroventricular (i.c.v.) and intrathecal (i.t.) injection
Organism or Cell Type:
mdx and human SOD1 mice; Sprague–Dawley wild-type rats
Citation Extract:
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T. Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. Nat Commun. 2025 Dec 22;16(1):10853. doi: 10.1038/s41467-025-66765-x. PMID: 41429785; PMCID: PMC12722745.

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance

Authors:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V
Citation:
bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667
Epub:
Not Epub
Abstract:
Beyond serving as cohesive barriers, epithelial tissues are involved in tissue surveillance and actively clear apoptotic cells...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V. De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance. bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667.

Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms

Authors:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S
Citation:
Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395
Epub:
Not Epub
Abstract:
The proliferation of early erythrocyte and the subsequent maturation are critical events during erythropoiesis, while how these...
Link:
https://www.nature.com/articles/s41420-025-02846-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S. Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms. Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395.

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

Authors:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR
Citation:
Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088
Epub:
Not Epub
Abstract:
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD) whose genetic basis remains elusive,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12698088/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR. Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome. Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088.

Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion

Authors:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA
Citation:
Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366
Epub:
Not Epub
Abstract:
Tuberculous meningitis is unique among bacterial meningitides because it occurs in two temporally separated steps: mycobacteria...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01433-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA. Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion. Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366.

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