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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12543 scientific papers returned from the database with the search filters currently being used below.

Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border

Authors:
Hamrud E, Leese J, Thiery AP, Buzzi AL, Vigilante A, Briscoe J, Streit A
Citation:
Development. 2025 Nov 14:dev.204943. doi: 10.1242/dev.204943. Epub ahead of print. PMID: 41235466
Epub:
Not Epub
Abstract:
During development, dynamic changes in gene expression and chromatin architecture drive the transition from progenitors to...
Link:
https://journals.biologists.com/dev/article-abstract/doi/10.1242/dev.204943/369834/Dynamic-changes-in-chromatin-accessibility-during
Delivery Method:
electroporation
Organism or Cell Type:
chick epiblast
Citation Extract:
Hamrud E, Leese J, Thiery AP, Buzzi AL, Vigilante A, Briscoe J, Streit A. Dynamic changes in chromatin accessibility during cell fate specification at the neural plate border. Development. 2025 Nov 14:dev.204943. doi: 10.1242/dev.204943. Epub ahead of print. PMID: 41235466.

Astacin Metalloproteinase PpMC5 of Mesenchyme Cells Regulates Epithelial Cell Proliferation and Survival to Promote Starfish Larval Development

Authors:
Okura Y, Sawada K, Gojobori J, Kadota J, Hase S, Kaneko H
Citation:
Dev Growth Differ. 2025 Nov 12. doi: 10.1111/dgd.70030. Epub ahead of print. PMID: 41220323
Epub:
Not Epub
Abstract:
The simple, triploblastic, epithelial body structure of the Patiria pectinifera starfish larva contains one mesenchyme cell...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/dgd.70030
Delivery Method:
microinjection
Organism or Cell Type:
Patiria pectinifera (starfish)
Citation Extract:
Okura Y, Sawada K, Gojobori J, Kadota J, Hase S, Kaneko H. Astacin Metalloproteinase PpMC5 of Mesenchyme Cells Regulates Epithelial Cell Proliferation and Survival to Promote Starfish Larval Development. Dev Growth Differ. 2025 Nov 12. doi: 10.1111/dgd.70030. Epub ahead of print. PMID: 41220323.

Physical and functional interaction of Lrrc56 and Odad3 is required for deployment of axonemal dyneins in vertebrate multiciliated cells

Authors:
Reyes-Nava NG, Lee C, Papoulas O, Hong J, Marcotte EM, Wallingford JB
Citation:
Dis Model Mech. 2025 Nov 13:dmm.052523. doi: 10.1242/dmm.052523. Epub ahead of print. PMID: 41229303
Epub:
Not Epub
Abstract:
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous motile ciliopathy characterized by chronic respiratory disease...
Link:
https://journals.biologists.com/dmm/article/doi/10.1242/dmm.052523/369813/Physical-and-functional-interaction-of-Lrrc56-and
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Reyes-Nava NG, Lee C, Papoulas O, Hong J, Marcotte EM, Wallingford JB. Physical and functional interaction of Lrrc56 and Odad3 is required for deployment of axonemal dyneins in vertebrate multiciliated cells. Dis Model Mech. 2025 Nov 13:dmm.052523. doi: 10.1242/dmm.052523. Epub ahead of print. PMID: 41229303.

Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction

Authors:
Bolanos-Palmieri P, Schenk H, Bähre H, Schroder P, Staggs L, Haller H, Schiffer M
Citation:
FASEB J. 2025 Nov 30;39(22):e71228. doi: 10.1096/fj.202502175R. PMID: 41222982; PMCID: PMC12611232
Epub:
Not Epub
Abstract:
Managing tryptophan (TRP) availability is important for cell homeostasis, and a dynamic balance between dietary intake and its...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12611232/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bolanos-Palmieri P, Schenk H, Bähre H, Schroder P, Staggs L, Haller H, Schiffer M. Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction. FASEB J. 2025 Nov 30;39(22):e71228. doi: 10.1096/fj.202502175R. PMID: 41222982; PMCID: PMC12611232.

Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes

Authors:
Vélez EJ, Véron V, Gouis J, Reji S, Dias K, Herpin A, Beaumatin F, Seiliez I
Citation:
Sci Rep 15, 39347 (2025). https://doi.org/10.1038/s41598-025-23022-x
Epub:
Not Epub
Abstract:
Endosomal microautophagy (eMI) is a recently discovered autophagic process where cytosolic proteins are selectively captured in...
Link:
https://www.nature.com/articles/s41598-025-23022-x
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: Stably transfected RTH-149 cells expressing mutated KFERQ motifs or KFERQ-PA-mCherry1
Citation Extract:
Vélez EJ, Véron V, Gouis J, Reji S, Dias K, Herpin A, Beaumatin F, Seiliez I. Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes. Sci Rep 15, 39347 (2025). https://doi.org/10.1038/s41598-025-23022-x.

Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus

Authors:
Hendrickson CL, Blitz IL, Hussein A, Paraiso KD, Cho JS, Klymkowsky MW, Kofron MJ, Cho KWY
Citation:
PLoS Biol. 2025 Nov 4;23(11):e3003476. doi: 10.1371/journal.pbio.3003476. Epub ahead of print. PMID: 41187170
Epub:
Not Epub
Abstract:
Germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003476
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Hendrickson CL, Blitz IL, Hussein A, Paraiso KD, Cho JS, Klymkowsky MW, Kofron MJ, Cho KWY. Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus. PLoS Biol. 2025 Nov 4;23(11):e3003476. doi: 10.1371/journal.pbio.3003476. Epub ahead of print. PMID: 41187170.

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

Authors:
Klein R, Onyuru J, Centa JL, Viera EM, Putnam CD, Hoffman HM, Hastings ML
Citation:
Nucleic Acids Res. 2025 Oct 28;53(20):gkaf1116. doi: 10.1093/nar/gkaf1116. PMID: 41206040; PMCID: PMC12596483
Epub:
Not Epub
Abstract:
Inflammation has an essential role in healing. However, over-active inflammation disrupts normal cellular functions and can be...
Link:
https://academic.oup.com/nar/article/53/20/gkaf1116/8316289
Delivery Method:
Endo-Porter for cells; intraperitoneal (i.p.) & subcutaneous (s.c.) injection for mice
Organism or Cell Type:
cell culture: THP-1 & immortalized murine bone marrow-derived macrophages (iBMDMs); mice: C57BL/6 & Nlrp3D301N/+ LysMCre+
Citation Extract:
Klein R, Onyuru J, Centa JL, Viera EM, Putnam CD, Hoffman HM, Hastings ML. Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation. Nucleic Acids Res. 2025 Oct 28;53(20):gkaf1116. doi: 10.1093/nar/gkaf1116. PMID: 41206040; PMCID: PMC12596483.

Epigenetic regulation of cilia stability and kidney development by the chromatin remodeling SWI/SNF complex in zebrafish

Authors:
Cheng X, Zhu Q, Ma S, Peng X, Huang G, Liu G, Zhang W, Zhang Y, Jiang C, Qiu A, Cao Y
Citation:
Journal of Genetics and Genomiccs. 2025. ISSN 1673-8527, https://doi.org/10.1016/j.jgg.2025.11.001
Epub:
Not Epub
Abstract:
Cilia are vital subcellular organelles whose assembly is regulated by master transcription factors, such as Foxj1 and Rfx....
Link:
https://www.sciencedirect.com/science/article/pii/S1673852725002905
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng X, Zhu Q, Ma S, Peng X, Huang G, Liu G, Zhang W, Zhang Y, Jiang C, Qiu A, Cao Y. Epigenetic regulation of cilia stability and kidney development by the chromatin remodeling SWI/SNF complex in zebrafish. Journal of Genetics and Genomiccs. 2025. ISSN 1673-8527, https://doi.org/10.1016/j.jgg.2025.11.001.

Multi-scale discovery of herbacetin as a macrophage-targeted SGK1-STAT1 signaling inhibitor alleviating lung inflammation and barrier dysfunction

Authors:
Ge X, Yu S, Wu S, Zhang S, Zhao R, Zhao L
Citation:
Phytomedicine, Volume 148, 2025, 157489, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2025.157489
Epub:
Not Epub
Abstract:
Introduction: Acute lung injury (ALI) is characterized by dysregulated macrophage-epithelial interactions, leading to barrier...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0944711325011262
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ge X, Yu S, Wu S, Zhang S, Zhao R, Zhao L. Multi-scale discovery of herbacetin as a macrophage-targeted SGK1-STAT1 signaling inhibitor alleviating lung inflammation and barrier dysfunction. Phytomedicine, Volume 148, 2025, 157489, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2025.157489.

Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth

Authors:
Liu X, Lin B, Li P, Cai Z, Cao W, Yang W, Zeng J, Li L, Zhou Y, Huang D, Stainier DYR, Ran P, Yin W
Citation:
Nat Commun. 2025 Oct 30;16(1):9610. doi: 10.1038/s41467-025-64597-3. PMID: 41168230; PMCID: PMC12575704
Epub:
Not Epub
Abstract:
The mechanisms regulating organ size remain poorly understood. Here, we show that FREM2 is a critical modulator of lung size....
Link:
https://www.nature.com/articles/s41467-025-64597-3
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Isolated tracheas and lungs from C57BL/6J mouse embryos
Citation Extract:
Liu X, Lin B, Li P, Cai Z, Cao W, Yang W, Zeng J, Li L, Zhou Y, Huang D, Stainier DYR, Ran P, Yin W. Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth. Nat Commun. 2025 Oct 30;16(1):9610. doi: 10.1038/s41467-025-64597-3. PMID: 41168230; PMCID: PMC12575704.

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