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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12519 scientific papers returned from the database with the search filters currently being used below.

ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish

Authors:
Xian C, Luo Q, Li W, Zou L, Liu J
Citation:
J Transl Med. 2025 Oct 6;23(1):1054. doi: 10.1186/s12967-025-07032-x. PMID: 41053757; PMCID: PMC12502130
Epub:
Not Epub
Abstract:
Background: The ATP synthase F1 subunit α (ATP5F1A) gene encodes a critical structural subunit of mitochondrial complex V....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12502130/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xian C, Luo Q, Li W, Zou L, Liu J. ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish. J Transl Med. 2025 Oct 6;23(1):1054. doi: 10.1186/s12967-025-07032-x. PMID: 41053757; PMCID: PMC12502130.

Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA

Authors:
Francis C, Frida JP, Thanh-Huong B
Citation:
Molecular Therapy - Nucleic Acids (1 Oct 2025)
Epub:
Not Epub
Abstract:
Synthetic messenger RNA (mRNA) therapeutics require precise control over their translation to minimize off-target effects. We...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S2162253125002835
Delivery Method:
Synthetic mRNA and PMOs conjugated to cholesterol or cleavable octoguanidine dendrimers
Organism or Cell Type:
HEK293T cells
Citation Extract:
Francis C, Frida JP, Thanh-Huong B . Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA. Molecular Therapy - Nucleic Acids (1 Oct 2025).

Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border

Authors:
Montequin A & LaBonne C
Citation:
bioRxiv [preprint] 2025.10.03.680132; doi: https://doi.org/10.1101/2025.10.03.680132
Epub:
Not Epub
Abstract:
The neural crest is a vertebrate stem cell population with broad developmental potential whose emergence requires precise...
Link:
https://www.biorxiv.org/content/10.1101/2025.10.03.680132v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Montequin A & LaBonne C. Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border. bioRxiv [preprint] 2025.10.03.680132; doi: https://doi.org/10.1101/2025.10.03.680132.

Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program

Authors:
Li X, Li D, Lou S, Lin J, Gao Y, Vona B, Mi C, Wang L, Ma L, Du M, Pan Y
Citation:
Cell Rep. 2025 Sep 30;44(10):116377. doi: 10.1016/j.celrep.2025.116377. Epub ahead of print. PMID: 41032419
Epub:
Not Epub
Abstract:
Genome-wide association studies have identified numerous loci associated with nonsyndromic cleft lip with/without cleft palate...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01148-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Li D, Lou S, Lin J, Gao Y, Vona B, Mi C, Wang L, Ma L, Du M, Pan Y. Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program. Cell Rep. 2025 Sep 30;44(10):116377. doi: 10.1016/j.celrep.2025.116377. Epub ahead of print. PMID: 41032419.

Identification of novel NDUFA3 variants in a patient with mitochondrial disorders

Authors:
Sun Y, Wei X, Xiao B, Luo Y, Wang Y, Liu R, Zhan Y, Ye X, Cai X, Xu S, Lyu J, Fang H, Yu Y
Citation:
Pediatr Res. 2025 Oct 2. doi: 10.1038/s41390-025-04403-4. Epub ahead of print. PMID: 41038977
Epub:
Not Epub
Abstract:
Background: Mitochondrial respiratory chain (RC) dysfunction constitutes the biochemical defect underlining a group of...
Link:
https://www.nature.com/articles/s41390-025-04403-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun Y, Wei X, Xiao B, Luo Y, Wang Y, Liu R, Zhan Y, Ye X, Cai X, Xu S, Lyu J, Fang H, Yu Y. Identification of novel NDUFA3 variants in a patient with mitochondrial disorders. Pediatr Res. 2025 Oct 2. doi: 10.1038/s41390-025-04403-4. Epub ahead of print. PMID: 41038977.

DG9-Conjugated Morpholino-Based Exon 51-Skipping Therapy for Duchenne Muscular Dystrophy

Authors:
Shah MNA, Sutanto LE, Yokota T
Citation:
Methods Mol Biol. 2026;2963:1-14. doi: 10.1007/978-1-0716-4738-7_1. PMID: 41028673
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene that leads to the loss of...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4738-7_1
Delivery Method:
DG9 peptide-linked; retro-orbital
Organism or Cell Type:
mdx mice
Citation Extract:
Shah MNA, Sutanto LE, Yokota T. DG9-Conjugated Morpholino-Based Exon 51-Skipping Therapy for Duchenne Muscular Dystrophy. Methods Mol Biol. 2026;2963:1-14. doi: 10.1007/978-1-0716-4738-7_1. PMID: 41028673.

DG9-Conjugated Morpholino Rescues Phenotype in Spinal Muscular Atrophy Mice

Authors:
Haque US, Kohut M, Yokota T
Citation:
Methods Mol Biol. 2026;2963:15-40. doi: 10.1007/978-1-0716-4738-7_2. PMID: 41028674
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease characterized by decreased expression of the survival...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4738-7_2
Delivery Method:
DG9 peptide-linked, subcutaneous (s.c.)
Organism or Cell Type:
SMA mice
Citation Extract:
Haque US, Kohut M, Yokota T. DG9-Conjugated Morpholino Rescues Phenotype in Spinal Muscular Atrophy Mice. Methods Mol Biol. 2026;2963:15-40. doi: 10.1007/978-1-0716-4738-7_2. PMID: 41028674.

A Live-Cell NanoBRET Assay to Monitor RNA–Protein Interactions and Their Inhibition by Small Molecules

Authors:
Shan J, Taghavi A, Caine EA, Sekioka R, Rajchin V, Burke JM, Watkins JM, Childs-Disney JL, Disney MD
Citation:
ACS Cent. Sci. 2025 Sep 25. doi: 10.1021/acscentsci.5c00705
Epub:
Not Epub
Abstract:
RNA–protein interactions are critical for cellular processes, including translation, pre-mRNA splicing, post-transcriptional...
Link:
https://pubs.acs.org/doi/10.1021/acscentsci.5c00705
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
HeLa480 cells
Citation Extract:
Shan J, Taghavi A, Caine EA, Sekioka R, Rajchin V, Burke JM, Watkins JM, Childs-Disney JL, Disney MD. A Live-Cell NanoBRET Assay to Monitor RNA–Protein Interactions and Their Inhibition by Small Molecules. ACS Cent. Sci. 2025 Sep 25. doi: 10.1021/acscentsci.5c00705.

Transcriptome Analysis of Zyxin Cytoskeletal Protein Levels: Influence on Metabolism and Signaling Pathways in a Model of Xenopus laevis Embryos

Authors:
Parshina EA, Zaraisky A, Martynova N
Citation:
Russ J Bioorg Chem 51, 1990–1999 (2025). https://doi.org/10.1134/S1068162025601983
Epub:
Not Epub
Abstract:
Objective: Zyxin is a cytoskeletal protein that plays a crucial role in the assembly and restoration of actin filaments....
Link:
https://link.springer.com/article/10.1134/S1068162025601983
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parshina EA, Zaraisky A, Martynova N. Transcriptome Analysis of Zyxin Cytoskeletal Protein Levels: Influence on Metabolism and Signaling Pathways in a Model of Xenopus laevis Embryos. Russ J Bioorg Chem 51, 1990–1999 (2025). https://doi.org/10.1134/S1068162025601983.

Cytoskeletal Regulator Zyxin Stimulates Nuclear Translocation of YAP in Xenopus laevis Embryonic Cells

Authors:
Parshina EA, Orlov EE, Voronezhskaya EE, Martynova NY, Zaraisky AG
Citation:
Russ J Bioorg Chem 51, 1945–1953 (2025). https://doi.org/10.1134/S1068162025601727
Epub:
Not Epub
Abstract:
Objective: This study investigates the impact of zyxin on Yes-associated protein (YAP) signaling during embryonic development...
Link:
https://link.springer.com/article/10.1134/S1068162025601727
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parshina EA, Orlov EE, Voronezhskaya EE, Martynova NY, Zaraisky AG. Cytoskeletal Regulator Zyxin Stimulates Nuclear Translocation of YAP in Xenopus laevis Embryonic Cells. Russ J Bioorg Chem 51, 1945–1953 (2025). https://doi.org/10.1134/S1068162025601727.

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