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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12236 scientific papers returned from the database with the search filters currently being used below.

Emx2 is an essential regulator of ciliated cell development across embryonic tissues

Authors:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA
Citation:
ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271
Epub:
Not Epub
Abstract:
Cilia are hair-like organelles with vital physiological roles, and ciliogenesis defects underlie a range of severe congenital...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004224024969
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA. Emx2 is an essential regulator of ciliated cell development across embryonic tissues. ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271.

Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension

Authors:
Zhao Z, Asai R, Mikawa T
Citation:
bioRxiv [preprint] 2024.10.25.620280; doi: https://doi.org/10.1101/2024.10.25.620280
Epub:
Not Epub
Abstract:
Background: Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline patterning in...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.25.620280v1.full
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Zhao Z, Asai R, Mikawa T. Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension. bioRxiv [preprint] 2024.10.25.620280; doi: https://doi.org/10.1101/2024.10.25.620280.

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

Authors:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q
Citation:
Eur J Cell Biol. 2024 Oct 24;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Online ahead of print. PMID: 39471724
Epub:
Not Epub
Abstract:
Mesoderm induction is a crucial step for vascular cell specification, vascular development and vasculogenesis. However, the...
Link:
https://www.sciencedirect.com/science/article/pii/S0171933524000827
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q. An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis. Eur J Cell Biol. 2024 Oct 24;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Online ahead of print. PMID: 39471724.

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

Authors:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W
Citation:
Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597
Epub:
Not Epub
Abstract:
Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/adbi.202400307
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocysts
Citation Extract:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W. PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597.

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

Authors:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A
Citation:
bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030
Epub:
Not Epub
Abstract:
Heterotaxy (HTX) is frequently caused by deleterious variants in the gene encoding Matrix metallopeptidase 21 (MMP21). However...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.13.618030v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A. MMP21 behaves as a fluid flow transported morphogen to impart laterality during development. bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030.

The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

Authors:
Emura N, Wavreil FDM, Fries A, Yajima M
Citation:
bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941
Epub:
Not Epub
Abstract:
The evolutionary introduction of asymmetric cell division (ACD) into the developmental program facilitates the formation of a...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11244941/
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin), Eucidaris tribuloides (sea urchin), Patiria miniata (sea star)
Citation Extract:
Emura N, Wavreil FDM, Fries A, Yajima M. The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo. bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941.

Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish

Authors:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N
Citation:
Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410
Epub:
Not Epub
Abstract:
Cells functioning at a specific zone by clustering according to gene expression are recognized as zonated cells. Here, we...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(24)00540-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N. Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish. Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410.

A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

Authors:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z
Citation:
Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788
Epub:
Not Epub
Abstract:
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly...
Link:
https://www.nature.com/articles/s41413-024-00364-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z. A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788.

Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model

Authors:
Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ
Citation:
Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859
Epub:
Not Epub
Abstract:
Primary familial brain calcification (PFBC) is a genetic neurological disease, yet no effective treatment is currently...
Link:
https://www.cell.com/neuron/fulltext/S0896-6273(24)00535-X
Delivery Method:
intracerebroventricular (i.c.v.) for mice; Endo-Porter for cells
Organism or Cell Type:
cell culture: Neuro-2A; mice: SLC20A2-KI
Citation Extract:
Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ. Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model. Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859.

An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics

Authors:
Li J, Chen F, Zhang D, Wang Y, Kozak D, Chen K
Citation:
Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205
Epub:
Not Epub
Abstract:
Chemically modified nucleic acid molecules have been developed as oligonucleotide therapeutics, and its assay is critical in...
Link:
https://pubs.acs.org/doi/10.1021/acs.analchem.4c03693
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Li J, Chen F, Zhang D, Wang Y, Kozak D, Chen K. An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics. Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205.

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