You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12533 scientific papers returned from the database with the search filters currently being used below.
There are 12533 scientific papers returned from the database with the search filters currently being used below.
Silencing of mitochondrial gene expression using polymorpholino chimeras
|
Citation:
Nat Rev Mol Cell Biol. 2025 Nov 3. doi: 10.1038/s41580-025-00923-3. Epub ahead of print. PMID: 41184643 Epub:
Not Epub Abstract:
The human mitochondrial genome encodes 13 essential protein components of the oxidative phosphorylation complexes responsible... Citation Extract: Dahal D. Silencing of mitochondrial gene expression using polymorpholino chimeras. Nat Rev Mol Cell Biol. 2025 Nov 3. doi: 10.1038/s41580-025-00923-3. Epub ahead of print. PMID: 41184643. |
Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation
|
Citation:
J Cell Biol. 2025 Dec 1;224(12):e202501122. doi: 10.1083/jcb.202501122. Epub 2025 Oct 28. PMID: 41147954 Epub:
Not Epub Abstract:
One of the most basic principles in embryonic development is ensuring the proper size of tissues and organs to meet functional... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang X, Shi R, Xiang Y, Gao Y, Wan G, Sun S, Liu D. Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation. J Cell Biol. 2025 Dec 1;224(12):e202501122. doi: 10.1083/jcb.202501122. Epub 2025 Oct 28. PMID: 41147954. |
A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation
|
Citation:
Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626 Epub:
Not Epub Abstract:
Epithelial cells are inherently contractile and in homeostasis, tissue integrity is maintained by balancing the uneven... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Matsuzawa K, Suzuki M, Cho Y, Fujinaga R, Ikenouchi J. A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation. Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626. |
Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras
|
Citation:
bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180 Epub:
Not Epub Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein... Delivery Method:
cells: Endo-Porter PEG; mice: stereotaxic injection Organism or Cell Type:
HEK293T cells, primary cortical neurons from humanized SNCA PAC-Tg (SNCAWT) mice, human iPSC neurons; humanized SNCA mice Citation Extract: Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Li H, Gadhave K, Kumbhar R, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J. Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras. bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180. |
Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins
|
Citation:
EMBO Rep. 2025 Oct 21. doi: 10.1038/s44319-025-00602-6. Epub ahead of print. PMID: 41120592 Epub:
Not Epub Abstract:
Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical for organ... Delivery Method:
Vivo-Morpholino injection post-caudal fin amputation Organism or Cell Type:
zebrafish Citation Extract: Martínez-Balsalobre E, Anchelin M, Hernández-Silva D, Mione MC, Mulero V, Alcaraz-Pérez F, García-Castillo J, Cayuela ML. Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins. EMBO Rep. 2025 Oct 21. doi: 10.1038/s44319-025-00602-6. Epub ahead of print. PMID: 41120592. |
Maternal factor OTX2 regulates human embryonic genome activation and early development
|
Citation:
Nat Genet. 2025 Oct 27. doi: 10.1038/s41588-025-02350-8. Epub ahead of print. PMID: 41145868 Epub:
Not Epub Abstract:
Transcription factors (TFs) are instrumental in kickstarting embryonic genome activation (EGA) in many species, yet their... Delivery Method:
injection Organism or Cell Type:
human embryo Citation Extract: Wang Q, Zhang C, Dang Y, Sun J, Zou Z, Li C, Ma S, Li Z, Liu H, Ma X, Yang Z, Wang L, Wu K, Chen ZJ, Xie W, Zhao H. Maternal factor OTX2 regulates human embryonic genome activation and early development. Nat Genet. 2025 Oct 27. doi: 10.1038/s41588-025-02350-8. Epub ahead of print. PMID: 41145868. |
Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish
|
Citation:
Cells. 2025 Oct 9;14(19):1572. doi: 10.3390/cells14191572. PMID: 41090799; PMCID: PMC12523338 Epub:
Not Epub Abstract:
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang G, Li Q, Xu Y, Zhao H, Yang C, Liu D, Gong J . Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish. Cells. 2025 Oct 9;14(19):1572. doi: 10.3390/cells14191572. PMID: 41090799; PMCID: PMC12523338. |
Divergent late stage functionalisation of luminescent europium(III) complexes for targeting and imaging applications
|
Citation:
Chem Commun (Camb). 2025 Oct 9. doi: 10.1039/d5cc04784f. Epub ahead of print. PMID: 41065065 Epub:
Not Epub Abstract:
An efficient approach to six functionalised europium(III) complexes based on a common alkyne intermediate is exemplified by... Delivery Method:
none Organism or Cell Type:
cell culture: NIH-3T3 & A-549 Citation Extract: Cheung TL, Alexander C, Li H, Parker D. Divergent late stage functionalisation of luminescent europium(III) complexes for targeting and imaging applications. Chem Commun (Camb). 2025 Oct 9. doi: 10.1039/d5cc04784f. Epub ahead of print. PMID: 41065065. |
Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model
|
Citation:
Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924 Epub:
Not Epub Abstract:
Introduction and hypothesis: Increased nerve growth factor (NGF) expression in the bladder is known to contribute to the... Delivery Method:
Vivo-Morpholino, intravesical instillation Organism or Cell Type:
IC/PBS rat Citation Extract: Chen YH, Chen WC, Liu PL, Chen HY. Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model. Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924. |
Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse
|
Citation:
Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the DMD gene that disrupt the... Delivery Method:
intracisternal magna (i.c.m.) injection Organism or Cell Type:
mdx23 mice Citation Extract: Aghaeipour A, Mitsogiannis, Fergus C, Tetorou K, Gileadi TE, Stojek E, Talavera S, Singh S, Siddle M, Prendeville JA, Sokolowska E, Kelly VP, Morgan JE, Montanaro F, Muntoni F. Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse. Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750. |