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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11761 scientific papers returned from the database with the search filters currently being used below.

The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus

Authors:
Angerilli A, Tait J, Berges J, Shcherbakova I, Pokrovsky D, Schauer T, Smialowski P, Hsam O, Mentele E, Nicetto D, Rupp RA
Citation:
Life Sci Alliance. 2023 Apr 28;6(7):e202302023. doi: 10.26508/lsa.202302023. Print 2023 Jul
Epub:
Not Epub
Abstract:
H4 lysine 20 dimethylation (H4K20me2) is the most abundant histone modification in vertebrate chromatin. It arises from...
Link:
https://www.life-science-alliance.org/content/6/7/e202302023
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Angerilli A, Tait J, Berges J, Shcherbakova I, Pokrovsky D, Schauer T, Smialowski P, Hsam O, Mentele E, Nicetto D, Rupp RA. The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus. Life Sci Alliance. 2023 Apr 28;6(7):e202302023. doi: 10.26508/lsa.202302023. Print 2023 Jul.

Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction

Authors:
Fontana CM, Terrin F, Facchinello N, Meneghetti G, Dinarello A, Gambarotto L, Zuccarotto A, Caichiolo M, Brocca G, Verin R, Nazio F, Carnevali O, Cecconi F, Bonaldo P, Dalla Valle L
Citation:
Biol Res. 2023 Apr 28;56(1):19. doi: 10.1186/s40659-023-00430-9
Epub:
Not Epub
Abstract:
Background: AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein...
Link:
https://biolres.biomedcentral.com/articles/10.1186/s40659-023-00430-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fontana CM, Terrin F, Facchinello N, Meneghetti G, Dinarello A, Gambarotto L, Zuccarotto A, Caichiolo M, Brocca G, Verin R, Nazio F, Carnevali O, Cecconi F, Bonaldo P, Dalla Valle L. Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biol Res. 2023 Apr 28;56(1):19. doi: 10.1186/s40659-023-00430-9.

Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway

Authors:
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C
Citation:
Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15
Epub:
Not Epub
Abstract:
Background: Furin is a calcium-dependent serine protease found in almost all mammals. It plays an important role in...
Link:
https://www.discovmed.com/EN/10.24976/Discov.Med.202335175.15
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C. Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15.

Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish

Authors:
Dong Z, Chen X, Zhuo R, Li Y, Zhou Z, Sun Y, Liu Y, Liu M
Citation:
BMC Biol. 2023 Apr 24;21(1):95. doi: 10.1186/s12915-023-01599-x
Epub:
Not Epub
Abstract:
Background: Natronobacterium gregoryi Argonaute (NgAgo) was found to reduce mRNA without generating detectable DNA double-...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01599-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong Z, Chen X, Zhuo R, Li Y, Zhou Z, Sun Y, Liu Y, Liu M. Efficient manipulation of gene expression using Natronobacterium gregoryi Argonaute in zebrafish. BMC Biol. 2023 Apr 24;21(1):95. doi: 10.1186/s12915-023-01599-x.

Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

Authors:
Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J
Citation:
Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. Online ahead of print
Epub:
Not Epub
Abstract:
GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (...
Link:
https://elifesciences.org/articles/85902
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS. Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. Online ahead of print.

The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis

Authors:
He X, Ge C, Xia J, Xia Z, Zhao L, Huang S, Wang R, Pan J, Cheng T, Xu PF, Wang F, Min J
Citation:
Adv Sci (Weinh). 2023 Apr 17:e2205345. doi:10.1002/advs.202205345. Online ahead of print
Epub:
Yes
Abstract:
The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/advs.202205345
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
He X, Ge C, Xia J, Xia Z, Zhao L, Huang S, Wang R, Pan J, Cheng T, Xu PF, Wang F, Min J. The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis. Adv Sci (Weinh). 2023 Apr 17:e2205345. doi:10.1002/advs.202205345. Online ahead of print.

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

Authors:
Li Z, Lui KN, Lau ST, Lai FP, Li P, Chung PH, Wong KK, Tam PK, Garica-Barcelo MM, Hui CC, Sham PC, Ngan ES
Citation:
Nat Commun. 2023 Apr 15;14(1):2157. doi: 10.1038/s41467-023-37928-5
Epub:
Not Epub
Abstract:
Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells,...
Link:
https://www.nature.com/articles/s41467-023-37928-5
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: Hirschsprung disease enteric neural crest cells (HSCR-ENCC) from iPSCs
Citation Extract:
Li Z, Lui KN, Lau ST, Lai FP, Li P, Chung PH, Wong KK, Tam PK, Garica-Barcelo MM, Hui CC, Sham PC, Ngan ES. Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation. Nat Commun. 2023 Apr 15;14(1):2157. doi: 10.1038/s41467-023-37928-5.

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation

Authors:
Cervino AS, Collodel MG, Lopez IA, Hochbaum D, Hukriede NA, Cirio MC
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.04.15.537039
Epub:
Not Epub
Abstract:
The nephron, functional unit of the vertebrate kidney, is specialized in metabolic wastes excretion and body fluids...
Link:
https://www.biorxiv.org/content/10.1101/2023.04.15.537039v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cervino AS, Collodel MG, Lopez IA, Hochbaum D, Hukriede NA, Cirio MC. Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation. bioRxiv. 2023;[preprint] doi:10.1101/2023.04.15.537039.

Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides

Authors:
Tveiten H, Andersen Ø, Swain JK, Johnsen H, Mommens M, Slanchev K
Citation:
bioRxiv;[preprint] doi:10.1101/2023.04.14.536849
Epub:
Not Epub
Abstract:
Cultivation of sterile-only fish in aquaculture offers multiple benefits of environmental, economical, and social value. A...
Link:
https://www.biorxiv.org/content/10.1101/2023.04.14.536849v1
Delivery Method:
microinjection
Organism or Cell Type:
Salmo salar (Atlantic salmon)
Citation Extract:
Tveiten H, Andersen Ø, Swain JK, Johnsen H, Mommens M, Slanchev K. Production of sterile Atlantic salmon by germ cell ablation with antisense oligonucleotides. bioRxiv;[preprint] doi:10.1101/2023.04.14.536849.

Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial

Authors:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y
Citation:
Neuropsychopharmacol Rep. 2023;[Epub] doi:10.1002/npr2.12335
Epub:
Yes
Abstract:
Aim: The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer NS-089/NCNP-02...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/npr2.12335
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
human
Citation Extract:
Ishizuka T, Komaki H, Asahina Y, Nakamura H, Motohashi N, Takeshita E, Motohashi Y, Ishiyama A, Yonee C, Maruyama S, Hida E, Aoki Y. Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial. Neuropsychopharmacol Rep. 2023;[Epub] doi:10.1002/npr2.12335.

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