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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Comparing cell penetration of biotherapeutics across human cell lines
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Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257 Epub:
Not Epub Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS,MIA PcCa-2 HEK293-T, BxPC-3, HepG2 Citation Extract: Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257. |
Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice
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Citation:
International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113 Epub:
Not Epub Abstract:
Periostin, a multifunctional 90 kDa protein, plays a pivotal role in the pathogenesis of fibrosis across various tissues,... Delivery Method:
intraperitoneal Vivo-Morpholino in vivo, Endo-Porter in culture Organism or Cell Type:
mouse skeletal muscle fibroblast cells; D2-mdx and Dba-2J mice Citation Extract: Trundle J, Lu-Nguyen N, Malerba A, Popplewell L. Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice. International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113. |
Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint
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Citation:
bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554 Epub:
Not Epub Abstract:
Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li W, McCurdy S, Lopez-Ramirez MA, Lee HS. Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint. bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554. |
Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide
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Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176 Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)... Delivery Method:
BBB-penetrating peptide-linked Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice Citation Extract: Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176. |
N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation
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Citation:
bioRxiv preprint; 2024.05.20.594965; doi.org/10.1101/2024.05.20.594965 Epub:
Not Epub Abstract:
During the development of the sensory nervous system, various cell types converge to form different tissues. The trigeminal... Delivery Method:
electroporation Organism or Cell Type:
chick embryo Citation Extract: Halmi C, McIntosh A, Leonard CE, Taneyhill LA. N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation. bioRxiv preprint; 2024.05.20.594965; doi.org/10.1101/2024.05.20.594965. |
Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells
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Citation:
eLife 12:RP91429. Epub:
Not Epub Abstract:
Hematopoietic stem cells emerge in the embryo from an aortic-derived tissue called the hemogenic endothelium (HE). The HE... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Torcq L, Majello S, Vivier C, Schmidt AA. Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells. eLife 12:RP91429.. |
Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors
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Citation:
Drug Deliv Transl Res. 2024 May 27. doi: 10.1007/s13346-024-01629-3. Online ahead of print. Epub:
Not Epub Abstract:
This study explores the efficacy of human serum albumin (HSA)-based Drug-Free Macromolecular Therapeutics (DFMT) in treating... Delivery Method:
Fab-linked Organism or Cell Type:
Human non-Hodgkin's lymphoma xenograft mice Citation Extract: Li J, Gambles MT, Jones B, Williams JA, Camp NJ, Shami PJ, Yang J, Kopeček J. Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors. Drug Deliv Transl Res. 2024 May 27. doi: 10.1007/s13346-024-01629-3. Online ahead of print.. |
The interaction of Pu.1 and cMyb in zebrafish neutrophil development
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Citation:
Yi Chuan. 2024 Apr 20;46(4):319-332. doi: 10.16288/j.yczz.23-312 Epub:
Not Epub Abstract:
Granulopoiesis is a highly ordered and precisely regulated process in which hematopoietic-related transcription factors play... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jia-Xin H, Song'en X, Wen-Qing Z, Wei L. The interaction of Pu.1 and cMyb in zebrafish neutrophil development. Yi Chuan. 2024 Apr 20;46(4):319-332. doi: 10.16288/j.yczz.23-312. |
Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders
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Citation:
iScience. 2024 Feb 21. doi.org/10.1016/j.isci.2024.109293 Epub:
Not Epub Abstract:
The classic view of the lysosome as a static recycling center has been replaced with one of a dynamic and mobile hub of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lee JJ, Wang T, Wiggins K, Lu PN, Underwood C, Ochenkowska K, Samarut E, Pollard LM, Flanagan-Steet H, Steet R. Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 2024 Feb 21. doi.org/10.1016/j.isci.2024.109293. |
ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells
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Citation:
J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24 Epub:
Not Epub Abstract:
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses... Delivery Method:
(RXR)4 peptide-linked Organism or Cell Type:
cell culture: Calu-3 Citation Extract: Heindl MR, Rupp A-L, Schwerdtner M, Bestle D, Harbig A, De Rocher A, Schmacke LC, Staker B, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells . J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24. |