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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12236 scientific papers returned from the database with the search filters currently being used below.
There are 12236 scientific papers returned from the database with the search filters currently being used below.
ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis
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Citation:
PLoS Pathog. 2024 Sep 30;20(9):e1012593 Epub:
Not Epub Abstract:
The Apicomplexa phylum encompasses numerous obligate intracellular parasites, some associated with severe implications for... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Plasmodium falciparum Citation Extract: Shrivastava D, Abboud E, Ramchandra JP, Jha A, Marq JB, Chaurasia A, Mitra K, Sadik M, Siddiqi MI, Soldati-Favre D, Kloehn J, Habib S. ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis. PLoS Pathog. 2024 Sep 30;20(9):e1012593. |
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation
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Citation:
J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824 Epub:
Not Epub Abstract:
Background: Hereditary spastic paraplegia (HSP) is a rare genetically heterogeneous neurodegenerative disorder. The most common... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Luo M, Wang Y, Liang J, Wan X. Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation. J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824. |
RRAGD variants cause cardiac dysfunction in a zebrafish model
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Citation:
Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021 Epub:
Not Epub Abstract:
The Ras-related GTP-binding protein D (RRAGD) gene plays a crucial role in cellular processes. Recently, RRAGD variants found... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF. RRAGD variants cause cardiac dysfunction in a zebrafish model. Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021. |
Safety and efficacy of viltolarsen in ambulatory and nonambulatory males with Duchenne muscular dystrophy
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Citation:
Sci Rep. 2024 Oct 8;14(1):23488. doi: 10.1038/s41598-024-70783-y. PMID: 39379403 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by mutations in the dystrophin gene, causing... Delivery Method:
intravenous (i.v.) infusion Organism or Cell Type:
human Citation Extract: Harper AD, Topaloglu H, Mercuri E, Suslov V, Wu L, Ayanoglu CY, Tansey M, Previtera ML, Crozier RA, Magnus L, Clemens PR. Safety and efficacy of viltolarsen in ambulatory and nonambulatory males with Duchenne muscular dystrophy. Sci Rep. 2024 Oct 8;14(1):23488. doi: 10.1038/s41598-024-70783-y. PMID: 39379403. |
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
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Citation:
Nucleic Acids Res. 2024 Oct 7:gkae862. doi: 10.1093/nar/gkae862. Epub ahead of print. PMID: 39373517 Epub:
Not Epub Abstract:
Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species.... Delivery Method:
Endo-Porter Organism or Cell Type:
P22 or P35 mouse testes-derived Sertoli cells Citation Extract: Wang Y, Chembazhi UV, Yee D, Chen S, Ji J, Wang Y, Nguyen KL, Lin P, Ratti A, Hess RA, Qiao H, Ko C, Yang J, Kalsotra A, Mei W. PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators. Nucleic Acids Res. 2024 Oct 7:gkae862. doi: 10.1093/nar/gkae862. Epub ahead of print. PMID: 39373517. |
Haploidy-linked cell proliferation defects limit larval growth in zebrafish
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Citation:
Open Biol. 2024 Oct;14(10):240126. doi: 10.1098/rsob.240126. Epub 2024 Oct 9. PMID: 39378986 Epub:
Not Epub Abstract:
Haploid larvae in non-mammalian vertebrates are lethal, with characteristic organ growth retardation collectively called '... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yaguchi K, Saito D, Menon T, Matsura A, Hosono M, Mizutani T, Kotani T, Nair S, Uehara R. Haploidy-linked cell proliferation defects limit larval growth in zebrafish. Open Biol. 2024 Oct;14(10):240126. doi: 10.1098/rsob.240126. Epub 2024 Oct 9. PMID: 39378986. |
NPC1 links cholesterol trafficking to microglial morphology via the gastrosome
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Citation:
Nat Commun. 2024 Oct 5;15(1):8638. doi: 10.1038/s41467-024-52874-6. PMID: 39366931; PMCID: PMC11452621. Epub:
Not Epub Abstract:
Microglia play important roles in brain development and homeostasis by removing dying neurons through efferocytosis.... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zareba J, Cattaneo EF, Villani A, Othman A, Streb S, Peri F
. NPC1 links cholesterol trafficking to microglial morphology via the gastrosome. Nat Commun. 2024 Oct 5;15(1):8638. doi: 10.1038/s41467-024-52874-6. PMID: 39366931; PMCID: PMC11452621.. |
Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development
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Citation:
Dev Dyn. 2024 Oct 9. doi: 10.1002/dvdy.749. Epub ahead of print. PMID: 39381860 Epub:
Not Epub Abstract:
Background
The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are... Delivery Method:
electroporation Organism or Cell Type:
chick trigeminal placode cells Citation Extract: Hines MA, Taneyhill LA. Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development. Dev Dyn. 2024 Oct 9. doi: 10.1002/dvdy.749. Epub ahead of print. PMID: 39381860. |
An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway
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Citation:
Cells. 2024; 13(19):1625. https://doi.org/10.3390/cells13191625 Epub:
Not Epub Abstract:
Mdmx (Mdm4) is established as an oncogene mainly through repression of the p53 tumour suppressor. On the other hand, anti-... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Bou Malhab LJ, Schmidt S, Fagotto-Kaufmann C, Pion E, Gadea G, Roux P, Fagotto F, Debant A, Xirodimas DP. An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway. Cells. 2024; 13(19):1625. https://doi.org/10.3390/cells13191625. |
Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides
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Citation:
Angew Chem Int Ed Engl. 2024 Sep 26:e202415272. doi: 10.1002/anie.202415272. Epub ahead of print. PMID: 39325927 Epub:
Not Epub Abstract:
Antibody-oligonucleotide conjugate (AOC) affords preferential cell targeting and enhanced cellular uptake of antisense... Delivery Method:
antibody-linked; mice: intravenous (i.v.) Organism or Cell Type:
cell culture: C2C12; mice: TfR1-humanized C57BL/6 Citation Extract: Pan L, Zhou L, Bi J, Chang S, Bai Z, Yu J, Wang R, Li Z, Zhang X, Chou JJ. Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides. Angew Chem Int Ed Engl. 2024 Sep 26:e202415272. doi: 10.1002/anie.202415272. Epub ahead of print. PMID: 39325927. |