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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12343 scientific papers returned from the database with the search filters currently being used below.

Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis

Authors:
Coßmann J, Kos PI, Varamogianni-Mamatsi V, Assenheimer DS, Bischof TA, Kuhn T, Vomhof T, Papantonis A, Giorgetti L, Gebhardt JCM
Citation:
Nat Commun. 2025 Feb 21;16(1):1833. doi: 10.1038/s41467-025-56889-5. PMID: 39979259; PMCID: PMC11842872
Epub:
Not Epub
Abstract:
The three-dimensional folding of chromosomes is essential for nuclear functions such as DNA replication and gene regulation....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11842872/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Coßmann J, Kos PI, Varamogianni-Mamatsi V, Assenheimer DS, Bischof TA, Kuhn T, Vomhof T, Papantonis A, Giorgetti L, Gebhardt JCM. Increasingly efficient chromatin binding of cohesin and CTCF supports chromatin architecture formation during zebrafish embryogenesis. Nat Commun. 2025 Feb 21;16(1):1833. doi: 10.1038/s41467-025-56889-5. PMID: 39979259; PMCID: PMC11842872.

Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation

Authors:
Escot S, Hassanein Y, Elouin A, Torres-Paz J, Mellottee L, Ignace A, David NB
Citation:
Commun Biol. 2025 Feb 28;8(1):328. doi: 10.1038/s42003-025-07689-6. PMID: 40021913; PMCID: PMC11871229
Epub:
Not Epub
Abstract:
Cell migrations are crucial for embryonic development, wound healing, the immune response, as well as for cancer progression....
Link:
https://www.nature.com/articles/s42003-025-07689-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Escot S, Hassanein Y, Elouin A, Torres-Paz J, Mellottee L, Ignace A, David NB. Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation. Commun Biol. 2025 Feb 28;8(1):328. doi: 10.1038/s42003-025-07689-6. PMID: 40021913; PMCID: PMC11871229.

Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs

Authors:
Feng Q, Lin Z, Zhao D, Li M, Yang S, Xiang AP, Ye C, Yao C
Citation:
Cell Rep. 2025 Mar 25;44(3):115376. doi: 10.1016/j.celrep.2025.115376. Epub 2025 Feb 27. PMID: 40019833
Epub:
Not Epub
Abstract:
The catalytic role of U6 snRNP in pre-mRNA splicing has been well established. In this study, we utilize an antisense...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00147-0
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa, HEK-293, SW480, NIH3T3, Neuro-2a
Citation Extract:
Feng Q, Lin Z, Zhao D, Li M, Yang S, Xiang AP, Ye C, Yao C. Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs. Cell Rep. 2025 Mar 25;44(3):115376. doi: 10.1016/j.celrep.2025.115376. Epub 2025 Feb 27. PMID: 40019833.

The temporal control and activity of maternal zsquildlike-A/hnrnpaba during zebrafish embryogenesis indicate a role in early pattern formation

Authors:
Molnar N, Capik A, Ishak A, Maglakelidze N, Pasick LJ, Reneker B, Volino A, O'Connell ML
Citation:
Zygote. 2025 Feb 25:1-11. doi: 10.1017/S0967199425000024. Epub ahead of print. PMID: 39995299
Epub:
Not Epub
Abstract:
During embryogenesis in Danio rerio (zebrafish), the earliest morphological patterning events are dependent on the precise...
Link:
https://www.cambridge.org/core/journals/zygote/article/temporal-control-and-activity-of-maternal-zsquildlikeahnrnpaba-during-zebrafish-embryogenesis-indicate-a-role-in-early-pattern-formation/98A933EFB75A071E5D31123CAB6CBC3C
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Molnar N, Capik A, Ishak A, Maglakelidze N, Pasick LJ, Reneker B, Volino A, O'Connell ML. The temporal control and activity of maternal zsquildlike-A/hnrnpaba during zebrafish embryogenesis indicate a role in early pattern formation. Zygote. 2025 Feb 25:1-11. doi: 10.1017/S0967199425000024. Epub ahead of print. PMID: 39995299.

Targeting a Novel Site in Exon 51 with Antisense Oligonucleotides Induces Enhanced Exon Skipping in a Mouse Model of Duchenne Muscular Dystrophy

Authors:
Oppeneer T, Qi Y, Henshaw J, Larimore K, Melton A, Puoliväli J, Carter C, Fant P, Brennan S, Wetzel LA, Sigg MA, Crawford BE, Magat J, Froelich S, Woloszynek JC, O'Neill CA
Citation:
Nucleic Acid Ther. 2025 Feb 7. doi: 10.1089/nat.2024.0049. Epub ahead of print. PMID: 39916530
Epub:
Not Epub
Abstract:
Exon skipping with antisense oligonucleotides (ASOs) can correct disease-causing mutations of Duchenne muscular dystrophy (DMD...
Link:
https://www.liebertpub.com/doi/10.1089/nat.2024.0049
Delivery Method:
peptide-linked or bare oligo intravenous (i.v.) injection
Organism or Cell Type:
hDMDdel52/mdx mice
Citation Extract:
Oppeneer T, Qi Y, Henshaw J, Larimore K, Melton A, Puoliväli J, Carter C, Fant P, Brennan S, Wetzel LA, Sigg MA, Crawford BE, Magat J, Froelich S, Woloszynek JC, O'Neill CA. Targeting a Novel Site in Exon 51 with Antisense Oligonucleotides Induces Enhanced Exon Skipping in a Mouse Model of Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2025 Feb 7. doi: 10.1089/nat.2024.0049. Epub ahead of print. PMID: 39916530.

Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos

Authors:
Azbazdar Y, De Robertis EM
Citation:
Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351
Epub:
Not Epub
Abstract:
We recently reported that microinjection of Xenopus nodal-related (xnr) mRNAs into β-catenin-depleted Xenopus embryos rescued a...
Link:
https://www.pnas.org/doi/10.1073/pnas.2421772122
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Azbazdar Y, De Robertis EM. Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351.

Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia

Authors:
Welz R, Ramachandran D, Schröder-Heurich B, Richter K, Geffers R, von Kaisenberg CS, Dörk T, von Versen-Höynck F
Citation:
Physiol Genomics. 2025 Feb 10. doi: 10.1152/physiolgenomics.00006.2024. Epub ahead of print. PMID: 39928918
Epub:
Not Epub
Abstract:
Preeclampsia is a pregnancy specific hypertensive disorder and is associated with an increased postpartum risk of...
Link:
https://journals.physiology.org/doi/abs/10.1152/physiolgenomics.00006.2024
Delivery Method:
Lipofectamine 3000
Organism or Cell Type:
cell culture: cord blood endothelial colony forming cells (ECFCs)
Citation Extract:
Welz R, Ramachandran D, Schröder-Heurich B, Richter K, Geffers R, von Kaisenberg CS, Dörk T, von Versen-Höynck F. Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia. Physiol Genomics. 2025 Feb 10. doi: 10.1152/physiolgenomics.00006.2024. Epub ahead of print. PMID: 39928918.

CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos

Authors:
Descoteaux AE, Radulovic M, Alburi D, Bradham CA
Citation:
Dev Biol. 2025 Feb 11;521:85-95. doi: 10.1016/j.ydbio.2025.02.009. Epub ahead of print. PMID: 39947420
Epub:
Not Epub
Abstract:
MARVEL proteins, including those of the CMTM gene family, are multi-pass transmembrane proteins that play important roles in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160625000454
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Descoteaux AE, Radulovic M, Alburi D, Bradham CA. CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos. Dev Biol. 2025 Feb 11;521:85-95. doi: 10.1016/j.ydbio.2025.02.009. Epub ahead of print. PMID: 39947420.

CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos

Authors:
Kim M, Hutchins EJ
Citation:
Dev Biol. 2025 Mar;519:5-12. doi: 10.1016/j.ydbio.2024.11.013. Epub 2024 Nov 30. PMID: 39622311; PMCID: PMC11824683
Epub:
Not Epub
Abstract:
The chick embryo is a classical model system commonly used in developmental biology due to its amenability to gene perturbation...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160624002653
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Kim M, Hutchins EJ. CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos. Dev Biol. 2025 Mar;519:5-12. doi: 10.1016/j.ydbio.2024.11.013. Epub 2024 Nov 30. PMID: 39622311; PMCID: PMC11824683.

A peptide conjugate enables systemic injection of the morpholino inducer and more durable induction of T3H38 ribozyme-controlled AAV transgene in mice

Authors:
Tang X, Wang H, Yin Y, Zhong G
Citation:
Gene Ther. 2025 Feb 12. doi: 10.1038/s41434-025-00519-8. Epub ahead of print. PMID: 39939797
Epub:
Not Epub
Abstract:
Genetic switches that allow for precise control over transgene expression timing or levels may improve the safety and expand...
Link:
https://www.nature.com/articles/s41434-025-00519-8
Delivery Method:
peptide-linked, Vivo-Morpholino
Organism or Cell Type:
mouse
Citation Extract:
Tang X, Wang H, Yin Y, Zhong G. A peptide conjugate enables systemic injection of the morpholino inducer and more durable induction of T3H38 ribozyme-controlled AAV transgene in mice. Gene Ther. 2025 Feb 12. doi: 10.1038/s41434-025-00519-8. Epub ahead of print. PMID: 39939797.

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