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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12282 scientific papers returned from the database with the search filters currently being used below.

Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner

Authors:
Ide AD, Carpenter KA, Elaswad M, Opria K, Marcellin K, Gilliland C, Grainger S
Citation:
bioRxiv 2025.01.10.632371; doi: https://doi.org/10.1101/2025.01.10.632371
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise only during embryonic development, and their identity specification,...
Link:
https://www.biorxiv.org/content/10.1101/2025.01.10.632371v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ide AD, Carpenter KA, Elaswad M, Opria K, Marcellin K, Gilliland C, Grainger S. Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner. bioRxiv 2025.01.10.632371; doi: https://doi.org/10.1101/2025.01.10.632371.

Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma

Authors:
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA
Citation:
Sci Rep. 2025 Jan 13;15(1):1878. doi: 10.1038/s41598-024-84037-4. PMID: 39805917
Epub:
Not Epub
Abstract:
Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been...
Link:
https://www.nature.com/articles/s41598-024-84037-4
Delivery Method:
Vivo-Morpholino; intraperitoneal (i.p.) injection for mice
Organism or Cell Type:
cells: Dkk-1 expressing MOSJ cells, OEhMSCs and MG63 3D co-cultures; mice: DAR human PDX-OS xenograft NSG mouse model
Citation Extract:
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA. Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma. Sci Rep. 2025 Jan 13;15(1):1878. doi: 10.1038/s41598-024-84037-4. PMID: 39805917.

Sex determination factor, a novel male-linked gene in the sea cucumber Apostichopus japonicus: Molecular characterization, expression patterns and effects of gene knockdown

Authors:
Meng W, Kong L, Abulizi A, Cong J, Sun Z, Chang Y
Citation:
Comp Biochem Physiol B Biochem Mol Biol. 2025 Jan 6;277:111071. doi: 10.1016/j.cbpb.2025.111071. Epub ahead of print. PMID: 39778676
Epub:
Not Epub
Abstract:
Apostichopus japonicus is a highly significant marine aquaculture species. Research findings have indicated that male sea...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1096495925000028
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Apostichopus japonicus (sea cucumber)
Citation Extract:
Meng W, Kong L, Abulizi A, Cong J, Sun Z, Chang Y. Sex determination factor, a novel male-linked gene in the sea cucumber Apostichopus japonicus: Molecular characterization, expression patterns and effects of gene knockdown. Comp Biochem Physiol B Biochem Mol Biol. 2025 Jan 6;277:111071. doi: 10.1016/j.cbpb.2025.111071. Epub ahead of print. PMID: 39778676.

Comprehensive analysis of the xbp1 gene in Pacific abalone Haliotis discus hannai: Structure, expression, and role in heat stress response

Authors:
Huang D, Li X, Pan M, Liu Y, Qin G, Chen Z, Yu X, Mai K, Zhang W
Citation:
Int J Biol Macromol. 2025 Jan 10:139771. doi: 10.1016/j.ijbiomac.2025.139771. Epub ahead of print. PMID: 39800022
Epub:
Not Epub
Abstract:
The present study explores the x-box binding protein 1 (xbp1) gene in Haliotis discus hannai (Pacific abalone), focusing on its...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0141813025003204
Delivery Method:
injection
Organism or Cell Type:
Haliotis discus hannai (Pacific abalone)
Citation Extract:
Huang D, Li X, Pan M, Liu Y, Qin G, Chen Z, Yu X, Mai K, Zhang W. Comprehensive analysis of the xbp1 gene in Pacific abalone Haliotis discus hannai: Structure, expression, and role in heat stress response. Int J Biol Macromol. 2025 Jan 10:139771. doi: 10.1016/j.ijbiomac.2025.139771. Epub ahead of print. PMID: 39800022.

Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development

Authors:
Chen S, Xu J, Xiao Y, Cai H, Zhou J, Cai W, Wang Y
Citation:
Clin Genet. 2025 Jan 6. doi: 10.1111/cge.14678. Epub ahead of print. PMID: 39763071
Epub:
Not Epub
Abstract:
Coxsackie and adenovirus receptor-like membrane protein (CLMP) mutation is identified as a genetic risk factor of congenital...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/cge.14678
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen S, Xu J, Xiao Y, Cai H, Zhou J, Cai W, Wang Y. Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development. Clin Genet. 2025 Jan 6. doi: 10.1111/cge.14678. Epub ahead of print. PMID: 39763071.

CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans

Authors:
Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, Xuan Goh W, Beckers A, Brady AF, Ewans LJ, Djaziri N, Almontashiri NAM, Alghamdi MA, Alharby E, Dasouki M, Romo L, Tan WH, Maddirevula S, Alkuraya FS, Giordano JL, Alkelai A, Wapner RJ, Stals K, Alfadhel M, Alswaid AF, Bogusch S, Schafer-Kosulya A, Vogel S, Vick P, Schweickert A, Wakeling M, Moreau de Bellaing A, Alshamsi AM, Sanlaville D, Mbarek H, Saad C, Ellard S, Eisenhaber F, Tripolszki K, Beetz C, Bauer P, Gossler A, Eisenhaber B, Blum M, Bouvagnet P, Bertoli-Avella A, Amiel J, Gordon CT, Reversade B
Citation:
Am J Hum Genet. 2024 Dec 27:S0002-9297(24)00448-8. doi: 10.1016/j.ajhg.2024.12.006. Epub ahead of print. PMID: 39753129
Epub:
Not Epub
Abstract:
Four genes-DAND5, PKD1L1, MMP21, and CIROP-form a genetic module that has specifically evolved in vertebrate species that...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0002929724004488
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, Xuan Goh W, Beckers A, Brady AF, Ewans LJ, Djaziri N, Almontashiri NAM, Alghamdi MA, Alharby E, Dasouki M, Romo L, Tan WH, Maddirevula S, Alkuraya FS, Giordano JL, Alkelai A, Wapner RJ, Stals K, Alfadhel M, Alswaid AF, Bogusch S, Schafer-Kosulya A, Vogel S, Vick P, Schweickert A, Wakeling M, Moreau de Bellaing A, Alshamsi AM, Sanlaville D, Mbarek H, Saad C, Ellard S, Eisenhaber F, Tripolszki K, Beetz C, Bauer P, Gossler A, Eisenhaber B, Blum M, Bouvagnet P, Bertoli-Avella A, Amiel J, Gordon CT, Reversade B. CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans. Am J Hum Genet. 2024 Dec 27:S0002-9297(24)00448-8. doi: 10.1016/j.ajhg.2024.12.006. Epub ahead of print. PMID: 39753129.

Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin

Authors:
Shen B, Wada S, Sugihara T, Nagata T, Nishioka H, Kawano-Yamashita E, Ozawa T, Koyanagi M, Terakita A
Citation:
iSCIENCE (2025)
Epub:
Not Epub
Abstract:
Inactivation of most light-sensitive GPCR opsins involves arrestin binding to terminate cell responses. In the zebrafish pineal...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(24)02933-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen B, Wada S, Sugihara T, Nagata T, Nishioka H, Kawano-Yamashita E, Ozawa T, Koyanagi M, Terakita A. Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin. iSCIENCE (2025).

Schwann cells have a limited window of time in which to initiate myelination signaling during early migration in vivo

Authors:
El-Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M
Citation:
Cells Dev. 2025 Jan 2:203993. doi: 10.1016/j.cdev.2024.203993. Epub ahead of print. PMID: 39755275
Epub:
Not Epub
Abstract:
The temporal control of mitotic exit of individual Schwann cells (SCs) is essential for radial sorting and peripheral...
Link:
https://www.sciencedirect.com/science/article/pii/S2667290124001037
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
El-Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M. Schwann cells have a limited window of time in which to initiate myelination signaling during early migration in vivo. Cells Dev. 2025 Jan 2:203993. doi: 10.1016/j.cdev.2024.203993. Epub ahead of print. PMID: 39755275.

Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis

Authors:
Du Y, Fu Y, Gao Y, Poojitha D, Kamala V, Li Q, Zhou X, Mohan C
Citation:
Front Immunol. 2024 Dec 19;15:1484525. doi: 10.3389/fimmu.2024.1484525. PMID: 39749339; PMCID: PMC11693704
Epub:
Not Epub
Abstract:
Background: Both intrinsic renal cells and immune cells contribute to driving renal inflammation and damage. However, the...
Link:
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1484525/full
Delivery Method:
Endo-Porter
Organism or Cell Type:
129x1/svJ bone marrow-derived macrophages
Citation Extract:
Du Y, Fu Y, Gao Y, Poojitha D, Kamala V, Li Q, Zhou X, Mohan C. Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis. Front Immunol. 2024 Dec 19;15:1484525. doi: 10.3389/fimmu.2024.1484525. PMID: 39749339; PMCID: PMC11693704.

Her9 controls the stemness properties of hindbrain boundary cells

Authors:
Engel-Pizcueta C, Hevia CF, Voltes A, Livet J, Pujades C
Citation:
Development. 2025 Jan 1;152(1):dev203164. doi: 10.1242/dev.203164. Epub 2025 Jan 2. PMID: 39628452
Epub:
Not Epub
Abstract:
The different spatiotemporal distribution of progenitor and neurogenic capacities permits that brain regions engage...
Link:
https://journals.biologists.com/dev/article/152/1/dev203164/364841/Her9-controls-the-stemness-properties-of-hindbrain
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Engel-Pizcueta C, Hevia CF, Voltes A, Livet J, Pujades C. Her9 controls the stemness properties of hindbrain boundary cells. Development. 2025 Jan 1;152(1):dev203164. doi: 10.1242/dev.203164. Epub 2025 Jan 2. PMID: 39628452.

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