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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12062 scientific papers returned from the database with the search filters currently being used below.

Elucidation of the genetic causes of bicuspid aortic valve disease

Authors:
Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CMH, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J
Citation:
Cardiovasc Res. 2023 May 2;119(3):857-866. doi: 10.1093/cvr/cvac099
Epub:
Not Epub
Abstract:
Aims: The present study aims to characterize the genetic risk architecture of bicuspid aortic valve (BAV) disease, the most...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CMH, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J. Elucidation of the genetic causes of bicuspid aortic valve disease. Cardiovasc Res. 2023 May 2;119(3):857-866. doi: 10.1093/cvr/cvac099.

Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo

Authors:
El Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.02.19.580938
Epub:
Not Epub
Abstract:
The temporal control of mitotic exit of individual Schwann cells (SCs) is essential for radial sorting and peripheral...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
El Hage O, Mikdache A, Boueid MJ, Degerny C, Tawk M. Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo. bioRxiv. 2024;[preprint] doi:10.1101/2024.02.19.580938.

Noncanonical function of folate through folate receptor 1 during neural tube formation

Authors:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN
Citation:
Nat Comm. 2024;15:1642. doi:10.1038/s41467-024-45775-1
Epub:
Not Epub
Abstract:
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: WTC-11 hiPSC
Citation Extract:
Balashova OA, Panoutsopoulos AA, Visina O, Selhub J, Knoepfler PS, Borodinsky LN. Noncanonical function of folate through folate receptor 1 during neural tube formation. Nat Comm. 2024;15:1642. doi:10.1038/s41467-024-45775-1.

Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression

Authors:
Story S, Bhaduri S, Ganguly S, Dakarapu R, Wicks SL, Bhadra J, Kwange S, Arya DP
Citation:
ACS Infect Dis. 2024 Feb 22. doi: 10.1021/acsinfecdis.3c00645. Online ahead of print
Epub:
Yes
Abstract:
Oligonucleotides offer a unique opportunity for sequence specific regulation of gene expression in bacteria. A fundamental...
Organism or Cell Type:
E. coli
Citation Extract:
Story S, Bhaduri S, Ganguly S, Dakarapu R, Wicks SL, Bhadra J, Kwange S, Arya DP. Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression. ACS Infect Dis. 2024 Feb 22. doi: 10.1021/acsinfecdis.3c00645. Online ahead of print.

Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells

Authors:
Dou Z, Lei H, Su W, Zhang T, Chen X, Yu B, Zhen X, Si J, Sun C, Zhang H, Di C
Citation:
Cell Death Dis. 2024;15:160. doi:10.1038/s41419-024-06507-x
Epub:
Not Epub
Abstract:
Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: A172, normal astrocyte cells (HA1800)
Citation Extract:
Dou Z, Lei H, Su W, Zhang T, Chen X, Yu B, Zhen X, Si J, Sun C, Zhang H, Di C. Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells. Cell Death Dis. 2024;15:160. doi:10.1038/s41419-024-06507-x.

Investigation of the pathogenesis of ADAR1 gene in dyschromatosis symmetrica hereditaria

Authors:
Zhang J, Jiang C, Wang Z, Fang B, He J, Li M
Citation:
Exp Dermatol. 2024 Feb;33(2):e15031. doi: 10.1111/exd.15031
Epub:
Not Epub
Abstract:
The pathogenesis of dyschromatosis symmetrica hereditaria (DSH) has not been well defined. In this study, we sought to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang J, Jiang C, Wang Z, Fang B, He J, Li M. Investigation of the pathogenesis of ADAR1 gene in dyschromatosis symmetrica hereditaria. Exp Dermatol. 2024 Feb;33(2):e15031. doi: 10.1111/exd.15031.

Protocol for tail vein injection in Xenopus tropicalis tadpoles

Authors:
Patel JH, Angell Swearer A, Kakebeen AD, Loh LR, Wills AE
Citation:
STAR Protoc. 2024 Feb 16;5(1):102895. doi: 10.1016/j.xpro.2024.102895. Online ahead of print
Epub:
Not Epub
Abstract:
Functional studies in post-embryonic Xenopus tadpoles are challenging because embryonic perturbations often lead to...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Patel JH, Angell Swearer A, Kakebeen AD, Loh LR, Wills AE. Protocol for tail vein injection in Xenopus tropicalis tadpoles. STAR Protoc. 2024 Feb 16;5(1):102895. doi: 10.1016/j.xpro.2024.102895. Online ahead of print.

Long-range chemical signalling in vivo is regulated by mechanical signals

Authors:
Pillai EK, Mukherjee S, Gampl N, McGinn RJ, Mooslehner KA, Thompson AJ, Franze K
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.02.15.580459
Epub:
Not Epub
Abstract:
Biological processes are regulated by chemical signals (e.g., morphogens, growth factors, and guidance cues) and mechanical...
Delivery Method:
microinjection, injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pillai EK, Mukherjee S, Gampl N, McGinn RJ, Mooslehner KA, Thompson AJ, Franze K. Long-range chemical signalling in vivo is regulated by mechanical signals. bioRxiv. 2024;[preprint] doi:10.1101/2024.02.15.580459 .

FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System

Authors:
Li B, Liu F, Chen X, Chen T, Zhang J, Liu Y, Yao Y, Hu W, Zhang M, Wang B, Liu L, Chen K, Wu Y
Citation:
Circulation. 2024 Feb 16. doi: 10.1161/CIRCULATIONAHA.123.064489. Online ahead of print
Epub:
Yes
Abstract:
Background: Hypertrophic cardiomyopathy (HCM) is a common heritable myocardiopathy. Although HCM has been reported to be...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li B, Liu F, Chen X, Chen T, Zhang J, Liu Y, Yao Y, Hu W, Zhang M, Wang B, Liu L, Chen K, Wu Y. FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System. Circulation. 2024 Feb 16. doi: 10.1161/CIRCULATIONAHA.123.064489. Online ahead of print.

Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications

Authors:
Geist Hauserman J, Laverty CG, Donkervoort S, Hu Y, Silverstein S, Neuhaus SB, Saade D, Vaughn G, Malicki D, Kaur R, Li Y, Luo Y, Liu P, Burr P, Foley AR, Mohassel P, Bönnemann CG
Citation:
HGG Adv. 2024 Feb 2;5(2):100274. doi: 10.1016/j.xhgg.2024.100274. Online ahead of print
Epub:
Not Epub
Abstract:
Pathogenic variants in the DES gene clinically manifest as progressive skeletal muscle weakness, cardiomyopathy with associated...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: P1
Citation Extract:
Geist Hauserman J, Laverty CG, Donkervoort S, Hu Y, Silverstein S, Neuhaus SB, Saade D, Vaughn G, Malicki D, Kaur R, Li Y, Luo Y, Liu P, Burr P, Foley AR, Mohassel P, Bönnemann CG. Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications. HGG Adv. 2024 Feb 2;5(2):100274. doi: 10.1016/j.xhgg.2024.100274. Online ahead of print.

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