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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation
Citation:
bioRxiv [preprint] 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293 Epub:
Not Epub Abstract:
Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen S, Liang J, Yin J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P. Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation. bioRxiv [preprint] 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293. |
Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers
Citation:
Cell Stem Cell. 2025 May 7:S1934-5909(25)00178-X. doi: 10.1016/j.stem.2025.04.011. Epub ahead of print. PMID: 40373768 Epub:
Not Epub Abstract:
Precise dorsal-ventral (D-V) patterning of the neural tube (NT) is essential for the development and function of the central... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Luo T, Liu C, Cheng T, Zhao GQ, Huang Y, Luan JY, Guo J, Liu X, Wang YF, Dong Y, Xiao Y, He E, Sun RZ, Chen X, Chen J, Ma J, Megason S, Ji J, Xu PF. Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers. Cell Stem Cell. 2025 May 7:S1934-5909(25)00178-X. doi: 10.1016/j.stem.2025.04.011. Epub ahead of print. PMID: 40373768. |
Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors
Citation:
Sci Adv. 2025 May 16;11(20):eadq3858. doi: 10.1126/sciadv.adq3858. Epub 2025 May 14. PMID: 40367180; PMCID: PMC12077515 Epub:
Not Epub Abstract:
During asymmetric cell division (ACD) of radial glia progenitors (RGPs), the cortical polarity regulator Par-3 is detected in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Garcia JQ, Mouilleau V, Ng H, Zhao X, Morgan DO, Guo S. Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors. Sci Adv. 2025 May 16;11(20):eadq3858. doi: 10.1126/sciadv.adq3858. Epub 2025 May 14. PMID: 40367180; PMCID: PMC12077515. |
A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations
Citation:
Blood. 2025 May 15;145(20):2317-2335. doi: 10.1182/blood.2023022576. PMID: 39642330 Epub:
Not Epub Abstract:
We have identified a new inherited bone marrow failure syndrome with severe congenital neutropenia (CN) caused by autosomal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Borbaran Bravo N, Deordieva E, Doll L, ElGamacy M, Dannenmann B, Azevedo J, Iannuzzo A, Delafontaine S, Lehners M, Kolodziej M, Hernandez Alvarez B, Hellmuth AS, Ritter M, Findik B, Zakharova V, Bräuning S, Kandabarau S, Lengerke C, Feil R, Meyts I, Delon J, Templin M, Sturm M, Rieß O, Zeidler C, Welte K, Shcherbina A, Klimiankou M, Skokowa J. A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations. Blood. 2025 May 15;145(20):2317-2335. doi: 10.1182/blood.2023022576. PMID: 39642330. |
DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function
Citation:
Nat Commun. 2025 May 14;16(1):4477. doi: 10.1038/s41467-025-59494-8. PMID: 40368879; PMCID: PMC12078682 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by DMD gene mutations, leading to the loss of... Delivery Method:
Endo-Porter for cells; DG9 peptide-linked for mice Organism or Cell Type:
cell culture: human myoblasts with exon 45 deletion, myotubes differentiated into cardiomyocytes; mice: hDMDdel52/mdx Citation Extract: Shah MNA, Wilton-Clark H, Haque F, Powell B, Sutanto LE, Maradiya R, Zhabyeyev P, Roshmi RR, Anwar S, Aslesh T, Lim KRQ, Maruyama R, Bigot A, Young CS, Bittner S, Spencer MJ, Moulton HM, Oudit GY, Yokota T. DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function. Nat Commun. 2025 May 14;16(1):4477. doi: 10.1038/s41467-025-59494-8. PMID: 40368879; PMCID: PMC12078682. |
Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model
Citation:
RSC Chem Biol. 2025 Mar 31;6(5):761-771. doi: 10.1039/d4cb00312h. PMID: 40171248; PMCID: PMC11955834 Epub:
Not Epub Abstract:
Splice-switching oligonucleotides (SSOs) have been developed as a treatment for various disorders, including Duchenne muscular... Delivery Method:
Pip6a peptide-linked; intravenous (i.v.) injection Organism or Cell Type:
primary B cells from BTK transgenic mice, BTK transgenic mice, BTK/Tec double-deficient mice Citation Extract: Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE. Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model. RSC Chem Biol. 2025 Mar 31;6(5):761-771. doi: 10.1039/d4cb00312h. PMID: 40171248; PMCID: PMC11955834. |
Protein-O-fucosylation of coreceptors may be required for Nodal signaling in Xenopus
Citation:
Mol Cells. 2025 May;48(5):100207. doi: 10.1016/j.mocell.2025.100207. Epub 2025 Mar 3. PMID: 40043779; PMCID: PMC11964751 Epub:
Not Epub Abstract:
Nodal-related ligands of TGF-β family play pivotal roles for mesoderm induction and body axis formation during vertebrate early... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kim YJ, Nho SJ, Lee SY, Yeo CY. Protein-O-fucosylation of coreceptors may be required for Nodal signaling in Xenopus. Mol Cells. 2025 May;48(5):100207. doi: 10.1016/j.mocell.2025.100207. Epub 2025 Mar 3. PMID: 40043779; PMCID: PMC11964751. |
An antisense oligomer conjugate with unpredicted bactericidal activity against Fusobacterium nucleatum
Citation:
mBio. 2025 Apr 29:e0052425. doi: 10.1128/mbio.00524-25. Epub ahead of print. PMID: 40298409 Epub:
Not Epub Abstract:
Fusobacteria are commensal members of the oral microbiome that can spread from their primary niche and colonize distal sites... Delivery Method:
(RXR)4XB peptide-linked Organism or Cell Type:
Fusobacterium nucleatum Citation Extract: Cosi V, Jung J, Popella L, Ponath F, Ghosh C, Barquist L, Vogel J. An antisense oligomer conjugate with unpredicted bactericidal activity against Fusobacterium nucleatum. mBio. 2025 Apr 29:e0052425. doi: 10.1128/mbio.00524-25. Epub ahead of print. PMID: 40298409. |
Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models
Citation:
Eur J Hum Genet. 2025 May;33(5):595-606. doi: 10.1038/s41431-024-01775-9. Epub 2024 Dec 19. PMID: 39702590; PMCID: PMC7617551 Epub:
Not Epub Abstract:
Orofacial clefting (OFC) is a frequent congenital anomaly and can occur either in the context of underlying syndromes or in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ishorst N, Hölzel S, Greve C, Yilmaz Ö, Lindenberg T, Lambertz J, Drichel D, Zametica B, Mingardo E, Kalanithy JC, Channab K, Kibris D, Henne S, Degenhardt F, Siewert A, Dixon M, Kruse T, Ongkosuwito E, Girisha KM, Pande S, Nowak S, Hagelueken G, Geyer M, Carels C, van Rooij IALM, Ludwig KU, Odermatt B, Mangold E. Role of ZFHX4 in orofacial clefting based on human genetic data and zebrafish models. Eur J Hum Genet. 2025 May;33(5):595-606. doi: 10.1038/s41431-024-01775-9. Epub 2024 Dec 19. PMID: 39702590; PMCID: PMC7617551. |
Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia
Citation:
Front Immunol. 2025 Feb 14;16:1539848. doi: 10.3389/fimmu.2025.1539848. PMID: 40028343; PMCID: PMC11868726 Epub:
Not Epub Abstract:
Introduction: Newborn screening for immunodeficiency has led to the identification of numerous cases for which the causal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sertori R, Truong B, Singh MK, Shinton S, Price R, Sharo A, Shultes P, Sunderam U, Rana S, Srinivasan R, Datta S, Font-Burgada J, Brenner SE, Puck JM, Wiest DL. Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Front Immunol. 2025 Feb 14;16:1539848. doi: 10.3389/fimmu.2025.1539848. PMID: 40028343; PMCID: PMC11868726. |