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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11414 scientific papers returned from the database with the search filters currently being used below.

Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1

Authors:
Aljiboury A, Mujcic A, Curtis E, Cammerino T, Magny D, Lan Y, Bates M, Freshour J, Ahmed-Braimeh YH, Hehnly H.
Citation:
Mol Biol Cell. 2022 Aug 1;33(9):br14. doi: 10.1091/mbc.E22-01-0015. Epub 2022 May 24
Epub:
Not Epub
Abstract:
Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical properties of the centrosome'...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Aljiboury A, Mujcic A, Curtis E, Cammerino T, Magny D, Lan Y, Bates M, Freshour J, Ahmed-Braimeh YH, Hehnly H. . Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1. Mol Biol Cell. 2022 Aug 1;33(9):br14. doi: 10.1091/mbc.E22-01-0015. Epub 2022 May 24.

Reproductive sterility in aquaculture: A review of induction methods and an emerging approach with application to Pacific Northwest finfish species

Authors:
Xu L, Zhao M, Ryu JH, Hayman ES, Fairgrieve WT, Zohar Y, Luckenbach JA, Wong T-T
Citation:
Rev Aquac. 2022;[Epub]. doi:10.1111/raq.12712
Epub:
Yes
Abstract:
Aquaculture is the fastest-growing food-production sector and is striving to become a long-term sustainable approach to meet...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Oncorhynchus, Anoplopoma (Pacific Northwest finfish)
Citation Extract:
Xu L, Zhao M, Ryu JH, Hayman ES, Fairgrieve WT, Zohar Y, Luckenbach JA, Wong T-T. Reproductive sterility in aquaculture: A review of induction methods and an emerging approach with application to Pacific Northwest finfish species. Rev Aquac. 2022;[Epub]. doi:10.1111/raq.12712.

Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration

Authors:
Cadiz Diaz A, Schmidt NA, Yamazaki M, Hsieh CJ, Lisse TS, Rieger S
Citation:
Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2115009119. doi: 10.1073/pnas.2115009119. Epub 2022 Jul 19
Epub:
Not Epub
Abstract:
Tissue wounding induces cutaneous sensory axon regeneration via hydrogen peroxide (H2O2) that is produced by the epithelial...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cadiz Diaz A, Schmidt NA, Yamazaki M, Hsieh CJ, Lisse TS, Rieger S. Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2115009119. doi: 10.1073/pnas.2115009119. Epub 2022 Jul 19.

Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling

Authors:
Gessler S, Guthmann C, Schuler V, Lilienkamp M, Walz G, Yakulov TA
Citation:
Int J Mol Sci. 2022 Jul 17;23(14):7870. doi: 10.3390/ijms23147870
Epub:
Not Epub
Abstract:
Acute kidney injury (AKI) is a common complication of severe human diseases, resulting in increased morbidity and mortality as...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gessler S, Guthmann C, Schuler V, Lilienkamp M, Walz G, Yakulov TA. Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. Int J Mol Sci. 2022 Jul 17;23(14):7870. doi: 10.3390/ijms23147870.

Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio)

Authors:
Chen XK, Kwan JS, Wong GT, Yi ZN, Ma AC, Chang RC
Citation:
Exp Mol Med. 2022 Jul;54(7):973-987. doi: 10.1038/s12276-022-00801-4. Epub 2022 Jul 13
Epub:
Not Epub
Abstract:
Despite well-known systemic immune reactions in peripheral trauma, little is known about their roles in posttraumatic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen XK, Kwan JS, Wong GT, Yi ZN, Ma AC, Chang RC. Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Exp Mol Med. 2022 Jul;54(7):973-987. doi: 10.1038/s12276-022-00801-4. Epub 2022 Jul 13.

Leveraging gene therapy to achieve long-term continuous or controllable expression of biotherapeutics

Authors:
Cripe TP, Hutzen B, Currier MA, Chen CY, Glaspell AM, Sullivan GC, Hurley JM, Deighen MR, Venkataramany AS, Mo X, Stanek JR, Miller AR, Wijeratne S, Magrini V, Mardis ER, Mendell JR, Chandler DS, Wang PY
Citation:
Sci Adv. 2022 Jul 15;8(28):eabm1890. doi: 10.1126/sciadv.abm1890. Epub 2022 Jul 13
Epub:
Not Epub
Abstract:
T cells redirected to cancer cells either via a chimeric antigen receptor (CAR-T) or a bispecific molecule have been...
Delivery Method:
Endo-Porter, Vivo-Morpholino
Organism or Cell Type:
cell culture 293T, mice non-obese diabetic scid gamma NSG-SGM3
Citation Extract:
Cripe TP, Hutzen B, Currier MA, Chen CY, Glaspell AM, Sullivan GC, Hurley JM, Deighen MR, Venkataramany AS, Mo X, Stanek JR, Miller AR, Wijeratne S, Magrini V, Mardis ER, Mendell JR, Chandler DS, Wang PY. Leveraging gene therapy to achieve long-term continuous or controllable expression of biotherapeutics. Sci Adv. 2022 Jul 15;8(28):eabm1890. doi: 10.1126/sciadv.abm1890. Epub 2022 Jul 13.

Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice

Authors:
Desjardins CA, Yao M, Hall J, O'Donnell E, Venkatesan R, Spring S, Wen A, Hsia N, Shen P, Russo R, Lan B, Picariello T, Tang K, Weeden T, Zanotti S, Subramanian R, Ibraghimov-Beskrovnaya O
Citation:
Nucleic Acids Res. 2022 Aug 10:gkac641. doi: 10.1093/nar/gkac641. Online ahead of print
Epub:
Yes
Abstract:
Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon...
Delivery Method:
FORCE antigen-binding conjugate
Organism or Cell Type:
mice
Citation Extract:
Desjardins CA, Yao M, Hall J, O'Donnell E, Venkatesan R, Spring S, Wen A, Hsia N, Shen P, Russo R, Lan B, Picariello T, Tang K, Weeden T, Zanotti S, Subramanian R, Ibraghimov-Beskrovnaya O. Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice. Nucleic Acids Res. 2022 Aug 10:gkac641. doi: 10.1093/nar/gkac641. Online ahead of print.

AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy.

Authors:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.496022
Epub:
Not Epub
Abstract:
This discourse probes the mechanistic molecular details of butyrate action in maintaining host-cholesterol balance. Hepatic...
Delivery Method:
guanidinium-Morpholino GMO-PMO
Organism or Cell Type:
mice
Citation Extract:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M. AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy. . bioRxiv. 2022;[preprint] doi:10.1101/2022.06.13.496022 .

CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1

Authors:
Zhang MX, Wang JL, Mo CQ, Mao XP, Feng ZH, Li JY, Lin HS, Song HD, Xu QH, Wang YH, Lu J, Wei JH, Han H, Chen W, Mao HP, Luo JH, Chen ZH
Citation:
Oncogene. 2022 Jul 7. doi: 10.1038/s41388-022-02386-8. Online ahead of print
Epub:
Not Epub
Abstract:
Circular RNAs (circRNAs) play critical roles in clear cell renal cell carcinoma (ccRCC). However, their involvement in...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture
Citation Extract:
Zhang MX, Wang JL, Mo CQ, Mao XP, Feng ZH, Li JY, Lin HS, Song HD, Xu QH, Wang YH, Lu J, Wei JH, Han H, Chen W, Mao HP, Luo JH, Chen ZH. CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1. Oncogene. 2022 Jul 7. doi: 10.1038/s41388-022-02386-8. Online ahead of print.

Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit DUX4 Expression

Authors:
Lu-Nguyen N, Dickson G, Malerba A, Popplewell L
Citation:
Biomedicines. 2022 Jul 7;10(7):1623. doi: 10.3390/biomedicines10071623
Epub:
Not Epub
Abstract:
Silencing the expression of the double homeobox 4 (DUX4) gene offers great potential for the treatment of facioscapulohumeral...
Delivery Method:
Vivo-Morpholino i.p. injection
Organism or Cell Type:
mice
Citation Extract:
Lu-Nguyen N, Dickson G, Malerba A, Popplewell L. Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit DUX4 Expression. Biomedicines. 2022 Jul 7;10(7):1623. doi: 10.3390/biomedicines10071623.

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