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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12343 scientific papers returned from the database with the search filters currently being used below.
There are 12343 scientific papers returned from the database with the search filters currently being used below.
SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish
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Citation:
J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623 Epub:
Not Epub Abstract:
Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Oh CK, Kim MS, Shin U, Kang JW, Kim YH, Ko HS, Ra JS, Ahn S, Choi EY, Yu S, Nam U, Choi T, Myung K, Lee Y. SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish. J Cell Physiol. 2025 Mar;240(3):e70023. doi: 10.1002/jcp.70023. PMID: 40134128; PMCID: PMC11937623. |
Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway
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Citation:
Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684 Epub:
Not Epub Abstract:
TAR DNA-binding protein 43 (TDP43) is a multifunctional RNA/DNA binding protein that serves as a hallmark of neurodegeneration... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yu T, Li M, Li M, Zhang Q, Zhang H, Jiang Z, Wang S, Mao H, Li D, Fan L, Hu C, Xu X. Zebrafish TDP43 positively regulates p65-mediated apoptotic pathway. Int J Biol Macromol. 2025 Mar 27:142599. doi: 10.1016/j.ijbiomac.2025.142599. Epub ahead of print. PMID: 40157684. |
OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction
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Citation:
Commun Biol 8, 529 (2025). https://doi.org/10.1038/s42003-025-07958-4 Epub:
Not Epub Abstract:
Many rhodopsin-like G-protein-coupled receptors (Rh-GPCRs) are known to either promote or inhibit angiogenesis. Among these,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Luo H, Zhang W, Zeng W, Wang Y, Feng J, Lan Y, Dong X, Liu T, Sun Y, Lu H
. OPN3-mediated positive regulation of angiogenesis in HUVECs through VEGFR2 interaction. Commun Biol 8, 529 (2025). https://doi.org/10.1038/s42003-025-07958-4. |
Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome
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Citation:
Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305 Epub:
Not Epub Abstract:
Biogenesis of lysosome-related organelle complex-3 (BLOC-3) is pivotal in vesicle trafficking and has been linked to Hermansky-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yong X, Jia G, Yang Q, Zhou C, Zhang S, Deng H, Billadeau DD, Su Z, Jia D. Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome. Nat Commun. 2025 Mar 26;16(1):2967. doi: 10.1038/s41467-025-58235-1. PMID: 40140412; PMCID: PMC11947305. |
Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model
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Citation:
2025. RSC Chemical Biology. 10.1039/D4CB00312H Epub:
Not Epub Abstract:
Splice-switching oligonucleotides (SSOs) have been developed as a treatment for various disorders, including Duchenne muscular... Delivery Method:
Pip6a peptide-linked; intravenous (i.v.) injection Organism or Cell Type:
cell culture: 2OS luciferase reporter cell line containing a mutated BTK intron 4, primary B cells with mutant BTK transcript; mice: BAC transgenic mice with full-length mutated human BTK pre-mRNA Citation Extract: Bestas B, Estupiñán HY, Wang Q, Kharazi S, He C, K. Mohammad D, Gupta D, Wiklander OPB, Lehto T, Lundin KE, Berglöf A, Karlsson MCI, Abendroth F, El Andaloussi S, Gait MJ, Wood MJA, Leumann CJ, Stetsenko DA, Månsson R, Wengel J, Zain R, Smith CIE. Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model. 2025. RSC Chemical Biology. 10.1039/D4CB00312H. |
Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish
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Citation:
Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113 Epub:
Not Epub Abstract:
During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F. Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113. |
Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome
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Citation:
bioRxiv [preprint] 2025.03.11.642683; doi: https://doi.org/10.1101/2025.03.11.642683 Epub:
Not Epub Abstract:
Timothy syndrome (TS) is a multisystem disorder with autistic-like features, seizures and arrhythmia as the main symptoms. Most... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Semenova SA, Sams AM, Nammi D, Menold M, Margolin G, Sinclair JL, Robertson KA, Larkin K, Kelly S, Golden A, Feldman B, Burgess HA. Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome. bioRxiv [preprint] 2025.03.11.642683; doi: https://doi.org/10.1101/2025.03.11.642683. |
A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA
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Citation:
Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302 Epub:
Not Epub Abstract:
Amino-modifiers are pivotal chemical modifications in nucleic acid scaffolds, serving applications ranging from (bio)... Delivery Method:
None Organism or Cell Type:
None Citation Extract: Saraya JS, Horton NG, Sammons SR, O'Flaherty DK. A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA. Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302. |
Catalytic activity of KMT5B promotes cilia tuft formation without affecting chromatin accessibility of ciliary genes
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Citation:
bioRxiv 2025.03.18.644017; doi: https://doi.org/10.1101/2025.03.18.644017 Epub:
Not Epub Abstract:
Multiciliated cells are a specialized cell type found in the brain, reproductive tract and respiratory tract of mammals.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Tait J, Marthen C, Hoelscher B, Straub T, Rupp R. Catalytic activity of KMT5B promotes cilia tuft formation without affecting chromatin accessibility of ciliary genes. bioRxiv 2025.03.18.644017; doi: https://doi.org/10.1101/2025.03.18.644017. |
Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation
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Citation:
J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015 Epub:
Not Epub Abstract:
Micro-dystrophin replacement gene therapy is currently under clinical trials in Duchenne muscular dystrophy (DMD) patients.... Delivery Method:
peptide-linked combined therapy with AAV-U7; retro-orbital & intravenous (i.v.) Organism or Cell Type:
mice: C57BL/6J, dystrophin−/−; utrophin−/− dKO, mdx (utrophin−/−) Citation Extract: Forand A, Moog S, Mougenot N, Lemaitre M, Sevoz-Couche C, Guesmia Z, Virtanen L, Giordani L, Muchir A, Pietri-Rouxel F. Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation. J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015. |