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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12223 scientific papers returned from the database with the search filters currently being used below.

Spermine oxidase promotes oxidative stress during islet inflammation

Authors:
Checkcinco C, Hammoud B, Saavedra XS, Puente AA, Shah H, Tersey SA, Anderson RM, Mirmira RG
Citation:
J Biol Chem. 2026 Aug 7:113412. doi: 10.1016/j.jbc.2026.113412. Epub ahead of print. PMID: 42567516
Epub:
Not Epub
Abstract:
Diabetes is characterized by impaired glucose homeostasis resulting from dysfunction and loss of insulin-producing islet β...
Link:
https://www.jbc.org/article/S0021-9258(26)02284-2/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Checkcinco C, Hammoud B, Saavedra XS, Puente AA, Shah H, Tersey SA, Anderson RM, Mirmira RG. Spermine oxidase promotes oxidative stress during islet inflammation. J Biol Chem. 2026 Aug 7:113412. doi: 10.1016/j.jbc.2026.113412. Epub ahead of print. PMID: 42567516.

Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates

Authors:
Hong J, Nair SR, Atayeter E, Jo EL, Gray RS, Young RL, Wallingford JB
Citation:
Cell Rep. 2026 Jul 31;45(8):117727. doi: 10.1016/j.celrep.2026.117727. Epub ahead of print. PMID: 42541726
Epub:
Not Epub
Abstract:
Motile cilia are evolutionarily conserved organelles performing essential roles in development and tissue homeostasis. Unlike...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00805-3
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hong J, Nair SR, Atayeter E, Jo EL, Gray RS, Young RL, Wallingford JB. Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates. Cell Rep. 2026 Jul 31;45(8):117727. doi: 10.1016/j.celrep.2026.117727. Epub ahead of print. PMID: 42541726.

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios

Authors:
Michael Cochran, Subbarao Nallagatla, Giuseppe Dello Iacono, Sami Abdulkadir, Danny Arias, Maryam Jordan, Hae Won Kwon, Arthur Levin, Michael Hood, Philip Kovach, Aidan Kim, Rob Burke, Barbora Malecova, Venkata Ramana Doppalapudi
Citation:
J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565
Epub:
Not Epub
Abstract:
Antibody–oligonucleotide conjugates (AOCs) enable targeted delivery of small interfering RNAs (siRNAs) by coupling them to...
Link:
https://pubs.acs.org/jmcmar/article/doi/10.1021/acs.jmedchem.6c00565/5251006/Neutral-Backbone-Modifications-Enhance-the
Delivery Method:
RNA/PMO heteroduplex; Lipofectamine RNAiMAX for cells, intravenous (i.v) injection for mice
Organism or Cell Type:
cell culture: SJCRH30; Hsd:ICR mice
Citation Extract:
Michael Cochran, Subbarao Nallagatla, Giuseppe Dello Iacono, Sami Abdulkadir, Danny Arias, Maryam Jordan, Hae Won Kwon, Arthur Levin, Michael Hood, Philip Kovach, Aidan Kim, Rob Burke, Barbora Malecova, Venkata Ramana Doppalapudi. Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios. J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565.

Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish

Authors:
Yang Q, Tian L, Wang J, Qi C, Qian Z, Liu Y, Zhou Y, Chen X, Tao J
Citation:
Chem Biol Interact. 2026 Aug 7:112290. doi: 10.1016/j.cbi.2026.112290. Epub ahead of print. PMID: 42567466
Epub:
Not Epub
Abstract:
2-phenylbenzimidazole-5-sulfonic acid (PBSA), a widely used organic UV filter, is frequently detected in aquatic environments,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0009279726003984
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Q, Tian L, Wang J, Qi C, Qian Z, Liu Y, Zhou Y, Chen X, Tao J. Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish. Chem Biol Interact. 2026 Aug 7:112290. doi: 10.1016/j.cbi.2026.112290. Epub ahead of print. PMID: 42567466.

Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy

Authors:
Qasim M, Naaz S, Pratihar S, Sharma SN, Sinha S
Citation:
Bioconjug Chem. 2026 Jul 21. doi: 10.1021/acs.bioconjchem.6c00176. Epub ahead of print. PMID: 42482424
Epub:
Not Epub
Abstract:
Although phosphorodiamidate morpholino oligomers (PMOs) are potent and stable antisense agents, their neutral backbone limits...
Link:
https://pubs.acs.org/bcches/article-abstract/doi/10.1021/acs.bioconjchem.6c00176/5226235/Structural-Optimization-of-Guanidinium-Linked?redirectedFrom=fulltext
Delivery Method:
guanidinium-linked morpholino oligomers with PMOs
Organism or Cell Type:
cell culture: MCF7 and HCT116
Citation Extract:
Qasim M, Naaz S, Pratihar S, Sharma SN, Sinha S. Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy. Bioconjug Chem. 2026 Jul 21. doi: 10.1021/acs.bioconjchem.6c00176. Epub ahead of print. PMID: 42482424.

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts

Authors:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y
Citation:
Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469
Epub:
Not Epub
Abstract:
Nonsyndromic cleft lip with or without palate (nCL/P) is a common congenital anomaly with a complex genetic basis. Previous...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70138
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y. A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469.

Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy

Authors:
Chung SK, Jung HB, Baek SJ, Park SM, Kim J, Lee SY, Min B, Kang YK
Citation:
Stem Cell Res Ther. 2026 Jul 13. doi: 10.1186/s13287-026-05176-1. Epub ahead of print
Epub:
Not Epub
Abstract:
TP53 missense mutations introduce single amino acid substitutions in the p53 protein, which can lead to diverse functional...
Link:
https://link.springer.com/article/10.1186/s13287-026-05176-1
Organism or Cell Type:
TP53 knock-in cell models
Citation Extract:
Chung SK, Jung HB, Baek SJ, Park SM, Kim J, Lee SY, Min B, Kang YK. Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy. Stem Cell Res Ther. 2026 Jul 13. doi: 10.1186/s13287-026-05176-1. Epub ahead of print.

Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras

Authors:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Liu B, Li H, Zhang X, Gadhave K, Kumbhar R, Jiang L, Liu Y, Luo M, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J
Citation:
Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123. doi: 10.1073/pnas.2526461123. Epub 2026 Jul 14
Epub:
Not Epub
Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein...
Link:
https://www.pnas.org/doi/10.1073/pnas.2526461123
Delivery Method:
PMO-based RNA-degrading chimeras; motor cortex infusion for mice
Organism or Cell Type:
cell culture: HEK293T cells, primary cortical neurons from humanized SNCA mice and human IPSC–derived cortical neurons; humanized SNCA mice
Citation Extract:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Liu B, Li H, Zhang X, Gadhave K, Kumbhar R, Jiang L, Liu Y, Luo M, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J . Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123. doi: 10.1073/pnas.2526461123. Epub 2026 Jul 14.

Oxidized PDI promotes thrombus formation in oxidative stress

Authors:
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R
Citation:
Blood. 2026 Jul 16;148(3):376-388. doi: 10.1182/blood.2025031756. PMID: 41785329; PMCID: PMC13098563
Epub:
Not Epub
Abstract:
Protein disulfide isomerase (PDI) functions in thrombus formation in vivo and represents a viable target for antithrombotic...
Link:
https://ashpublications.org/blood/article-abstract/148/3/376/566933/Oxidized-PDI-promotes-thrombus-formation-in
Delivery Method:
intravenous (i.v.) injection
Organism or Cell Type:
C57Bl/6J and R120D PDI mutant mice
Citation Extract:
Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R. Oxidized PDI promotes thrombus formation in oxidative stress. Blood. 2026 Jul 16;148(3):376-388. doi: 10.1182/blood.2025031756. PMID: 41785329; PMCID: PMC13098563.

SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation

Authors:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA
Citation:
Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293
Epub:
Not Epub
Abstract:
SIX1 variants underlying branchio-oto-renal syndrome occur in the SIX domain (SD) or homeodomain (HD). We tested whether...
Link:
https://journals.biologists.com/dev/article/153/13/dev205428/372167/SIX1-branchio-oto-renal-syndrome-variants-have
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA. SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation. Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293.

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