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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12212 scientific papers returned from the database with the search filters currently being used below.

Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties

Authors:
Das A, Kuilya D, Sharma SN, Sinha S
Citation:
Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830
Epub:
Not Epub
Abstract:
The synthesis of morpholino dimer chlorophosphoramidates and phosphoramidites has been successfully achieved and the method has...
Link:
https://pubs.rsc.org/en/content/articlelanding/2026/cc/d6cc01842d
Delivery Method:
none
Organism or Cell Type:
PMO-DNA and PMO-RNA
Citation Extract:
Das A, Kuilya D, Sharma SN, Sinha S. Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties. Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830.

Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor

Authors:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K
Citation:
Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656
Epub:
Not Epub
Abstract:
Ribonucleic acid (RNA) biomarkers have emerged as vital molecular indicators in precision medicine, with accurate detection...
Link:
https://www.sciencedirect.com/science/article/pii/S1385894726021157
Delivery Method:
none
Organism or Cell Type:
SARS-CoV-2 viral RNA
Citation Extract:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K. Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor. Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656.

A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence

Authors:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W
Citation:
Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530
Epub:
Not Epub
Abstract:
Variants in the aminoacylase 1 (ACY1) gene are associated with diverse clinical phenotypes, but their roles in hearing loss...
Link:
https://link.springer.com/article/10.1007/s10528-026-11417-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W. A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence. Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530.

Kinetic and thermodynamic properties of phosphorothioate and phosphorodiamidate morpholino oligonucleotides binding to target RNA

Authors:
Hasegawa T, Sato K, Hara RI, Wada T, Sakamoto T
Citation:
J Biochem. 2026 Jun 19:mvag043. doi: 10.1093/jb/mvag043. Epub ahead of print. PMID: 42317169
Epub:
Not Epub
Abstract:
Recently, numerous nucleic acid therapeutics have been developed, and a substantial number of the approved agents are...
Link:
https://academic.oup.com/jb/advance-article-abstract/doi/10.1093/jb/mvag043/8711525
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Hasegawa T, Sato K, Hara RI, Wada T, Sakamoto T. Kinetic and thermodynamic properties of phosphorothioate and phosphorodiamidate morpholino oligonucleotides binding to target RNA. J Biochem. 2026 Jun 19:mvag043. doi: 10.1093/jb/mvag043. Epub ahead of print. PMID: 42317169.

The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway

Authors:
Lv J, Zeng T, Liao B, Liu L, Xiong L, Xie H, Zhu L, Jiang X, Zhong Z, Xie H
Citation:
Cells. 2026; 15(12):1046. https://doi.org/10.3390/cells15121046
Epub:
Not Epub
Abstract:
Ezrin, expressed by the EZR gene, is a member of the ERM protein family that connects the plasma membrane to the actin...
Link:
https://www.mdpi.com/2073-4409/15/12/1046
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv J, Zeng T, Liao B, Liu L, Xiong L, Xie H, Zhu L, Jiang X, Zhong Z, Xie H. The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway. Cells. 2026; 15(12):1046. https://doi.org/10.3390/cells15121046.

An aquaglyceroporin governs cellular water and CO2 conductance relevant for vesicular mineral formation in a marine calcifier

Authors:
Matt AS, Tetzlaff S, Jonusaite S, Quijada-Rodriguez A, Schewe M, Cordeiro S, Weihrauch D, Hu MY
Citation:
Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2524614123. doi: 10.1073/pnas.2524614123. Epub 2026 Jun 8. PMID: 42258730
Epub:
Not Epub
Abstract:
Many marine organisms generate biominerals by endocytotic uptake of seawater which is modified within calcifying cells to...
Link:
https://www.pnas.org/doi/10.1073/pnas.2524614123
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin larvae
Citation Extract:
Matt AS, Tetzlaff S, Jonusaite S, Quijada-Rodriguez A, Schewe M, Cordeiro S, Weihrauch D, Hu MY. An aquaglyceroporin governs cellular water and CO2 conductance relevant for vesicular mineral formation in a marine calcifier. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2524614123. doi: 10.1073/pnas.2524614123. Epub 2026 Jun 8. PMID: 42258730.

ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ1–42 Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer’s Disease-Associated psen1-Deficient Zebrafish Model

Authors:
Ricci S, Benuzzi M, Fazzina M, Cacialli P
Citation:
International Journal of Molecular Sciences. 2026; 27(11):4992. https://doi.org/10.3390/ijms27114992
Epub:
Not Epub
Abstract:
Familial Alzheimer’s disease (FAD) is a rare form of Alzheimer’s. FAD is mainly caused by one or multiple mutations in the...
Link:
https://www.mdpi.com/1422-0067/27/11/4992
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ricci S, Benuzzi M, Fazzina M, Cacialli P. ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ1–42 Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer’s Disease-Associated psen1-Deficient Zebrafish Model. International Journal of Molecular Sciences. 2026; 27(11):4992. https://doi.org/10.3390/ijms27114992.

A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy

Authors:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C
Citation:
Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075
Epub:
Not Epub
Abstract:
Introduction: Real-world data are needed to understand the treatment effect of eteplirsen, casimersen, and golodirsen (...
Link:
https://link.springer.com/article/10.1007/s12325-026-03609-0
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C. A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy. Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075.

A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy

Authors:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C
Citation:
Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075
Epub:
Not Epub
Abstract:
Introduction: Real-world data are needed to understand the treatment effect of eteplirsen, casimersen, and golodirsen (...
Link:
https://link.springer.com/article/10.1007/s12325-026-03609-0
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C. A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy. Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075.

A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy

Authors:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C
Citation:
Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075
Epub:
Not Epub
Abstract:
Introduction: Real-world data are needed to understand the treatment effect of eteplirsen, casimersen, and golodirsen (...
Link:
https://link.springer.com/article/10.1007/s12325-026-03609-0
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Dharmarajan S, Grabich S, Baxter R, Nadkar A, Schermer C. A Real-World Target Trial Emulation of Eteplirsen, Casimersen, and Golodirsen to Evaluate Survival Among Patients with Duchenne Muscular Dystrophy. Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03609-0. Epub ahead of print. PMID: 42250075.

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