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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation
Citation:
Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337 Epub:
Not Epub Abstract:
Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E, Serbanovic-Canic J, Evans PC. Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337. |
Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes
Citation:
EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968 Epub:
Not Epub Abstract:
The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ten Martin D, Jardin N, Vougny J, Giudicelli F, Gasmi L, Berbée N, Henriot V, Lebrun L, Haumaître C, Kneussel M, Nicol X, Janke C, Magiera MM, Hazan J, Fassier C. Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes. EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968. |
Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications
Citation:
NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155 Epub:
Not Epub Abstract:
We have subjected several analogs of DNA that have been widely used as antisense oligonucleotide (ASO) inhibitors of gene... Delivery Method:
None Organism or Cell Type:
None Citation Extract: Galindo-Murillo R, Cohen JS, Akabayov B. Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications. NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155. |
Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos
Citation:
(2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230 Epub:
Not Epub Abstract:
Introduction: Due to the impact of antibody-dependent enhancement and viral variation, effective vaccines or antiviral... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: Vero, HepG2 and A549 Citation Extract: Niu M, Yi W, Dong Z, Li X, Dong X, Yu L, Han Y, Zhang O, Sheng Z, An J, Li H and Sun Y
. Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos. (2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230. |
Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients
Citation:
bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028 Epub:
Not Epub Abstract:
Background: VLA-4 is a disease progression biomarker in patients with Duchenne Muscular Dystrophy (DMD) including those treated... Delivery Method:
intravenous (i.v.) Organism or Cell Type:
mdx mice Citation Extract: Padhye AS, Kiriaev L, Tiong C, Gearing LJ, Wilson T, Houweling PJ, Tachas G. Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients. bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028. |
Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
Citation:
Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139 Epub:
Not Epub Abstract:
The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of... Delivery Method:
(RXR)4 peptide-linked Organism or Cell Type:
cell culture: Calu-3 Citation Extract: Schwerdtner M, Schmacke LC, Nave J, Limburg H, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells. Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139. |
An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients
Citation:
Dev Biol. 2024 Dec;516:59-70. doi: 10.1016/j.ydbio.2024.08.002. Epub 2024 Aug 3. PMID: 39098630; PMCID: PMC11425896 Epub:
Not Epub Abstract:
Dicer substrate interfering RNAs (DsiRNAs) destroy targeted transcripts using the RNA-Induced Silencing Complex (RISC) through... Delivery Method:
microinjection Organism or Cell Type:
Lytechinus variegatus (sea urchin) Citation Extract: Wilson K, Manner C, Miranda E, Berrio A, Wray GA, McClay DR. An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients. Dev Biol. 2024 Dec;516:59-70. doi: 10.1016/j.ydbio.2024.08.002. Epub 2024 Aug 3. PMID: 39098630; PMCID: PMC11425896. |
Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells
Citation:
Skelet Muscle. 2024 Nov 29;14(1):28. doi: 10.1186/s13395-024-00360-4. PMID: 39614336; PMCID: PMC11606086 Epub:
Not Epub Abstract:
Background: Antisense oligonucleotides (AON) represent a promising treatment for Duchenne muscular dystrophy (DMD) carrying out... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: DMD-patient-derived primary fibroblasts Citation Extract: Rossi R, Torelli S, Moore M, Ala P, Morgan J, Malhotra J, Muntoni F. Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells. Skelet Muscle. 2024 Nov 29;14(1):28. doi: 10.1186/s13395-024-00360-4. PMID: 39614336; PMCID: PMC11606086. |
Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications
Citation:
Org Lett. 2024 Nov 29;26(47):10061-10065. doi: 10.1021/acs.orglett.4c02903. Epub 2024 Nov 11. PMID: 39528231 Epub:
Not Epub Abstract:
To ensure specificity, loading of the sense strand of small interfering RNAs (siRNAs) into RISC must be inhibited. We show here... Delivery Method:
None Organism or Cell Type:
None Citation Extract: Datta D, Kumar P, Kundu J, Qin J, Gilbert JA, Schofield S, Donnelly DP, Liu J, Degaonkar R, Egli M, Manoharan M. Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications. Org Lett. 2024 Nov 29;26(47):10061-10065. doi: 10.1021/acs.orglett.4c02903. Epub 2024 Nov 11. PMID: 39528231. |
Zebrafish in-vivo study reveals deleterious activity of human TBC1D24 genetic variants linked with autosomal dominant hearing loss
Citation:
Biochim Biophys Acta Mol Basis Dis. 2024 Nov 23;1871(2):167598. doi: 10.1016/j.bbadis.2024.167598. Epub ahead of print. PMID: 39586506 Epub:
Not Epub Abstract:
Hearing loss is a common sensory impairment with a heterogeneous genetic etiology. Genetic variants in the TBC1D24 gene have... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sarosiak A, Jędrychowska J, Oziębło D, Gan NS, Bałdyga N, Leja ML, Węgierski T, Cruz IA, Raible DW, Skarżyński H, Tylzanowski P, Korzh V, Ołdak M. Zebrafish in-vivo study reveals deleterious activity of human TBC1D24 genetic variants linked with autosomal dominant hearing loss. Biochim Biophys Acta Mol Basis Dis. 2024 Nov 23;1871(2):167598. doi: 10.1016/j.bbadis.2024.167598. Epub ahead of print. PMID: 39586506. |