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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12390 scientific papers returned from the database with the search filters currently being used below.

Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression

Authors:
Deng K, Li M, Li Y, Xiang L, Wang Y, Shi H, Cheng J, Huang S, Lv Z
Citation:
Journal of Ginseng Research, 2025, ISSN 1226-8453, https://doi.org/10.1016/j.jgr.2025.05.007
Epub:
Not Epub
Abstract:
Background Hepatic fibrosis (HF) continues to be a significant global health concern, substantially contributing to morbidity...
Link:
https://www.sciencedirect.com/science/article/pii/S1226845325000685
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Deng K, Li M, Li Y, Xiang L, Wang Y, Shi H, Cheng J, Huang S, Lv Z. Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression. Journal of Ginseng Research, 2025, ISSN 1226-8453, https://doi.org/10.1016/j.jgr.2025.05.007.

Genetic compensation response contributes to Pleurodeles waltl limb regeneration

Authors:
Yin B, Yu C, Liu Y, Cai H, Wu W, Ye T, Wang L, Xiao L, Zhu Y, Guo H, Zhang K, Wang H
Citation:
NPJ Regen Med. 2025 May 31;10(1):25. doi: 10.1038/s41536-025-00417-y. PMID: 40450023; PMCID: PMC12126524
Epub:
Not Epub
Abstract:
Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly...
Link:
https://www.nature.com/articles/s41536-025-00417-y
Delivery Method:
injection by glass microcapillaries and PV830 PicoPump followed by electroporation
Organism or Cell Type:
Pleurodeles waltl (Iberian ribbed newt)
Citation Extract:
Yin B, Yu C, Liu Y, Cai H, Wu W, Ye T, Wang L, Xiao L, Zhu Y, Guo H, Zhang K, Wang H. Genetic compensation response contributes to Pleurodeles waltl limb regeneration. NPJ Regen Med. 2025 May 31;10(1):25. doi: 10.1038/s41536-025-00417-y. PMID: 40450023; PMCID: PMC12126524.

Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

Authors:
Stirling ER, Terabe M, Wilson AS, Kooshki M, Yamaleyeva LM, Alexander-Miller MA, Zhang W, Miller LD, Triozzi PL, Soto-Pantoja DR
Citation:
J Immunother Cancer. 2022 Nov;10(11):e004712. doi: 10.1136/jitc-2022-004712. PMID: 36418073; PMCID: PMC9685258
Epub:
Not Epub
Abstract:
Background: CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9685258/
Delivery Method:
Endo-Porter for cells, intraperitoneal (i.p.) for mice
Organism or Cell Type:
Pmel-1 CD8+ T cells; C57Bl/6 mice with B16 melanoma tumor explants
Citation Extract:
Stirling ER, Terabe M, Wilson AS, Kooshki M, Yamaleyeva LM, Alexander-Miller MA, Zhang W, Miller LD, Triozzi PL, Soto-Pantoja DR. Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response. J Immunother Cancer. 2022 Nov;10(11):e004712. doi: 10.1136/jitc-2022-004712. PMID: 36418073; PMCID: PMC9685258.

A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity

Authors:
Du LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ
Citation:
Sci Immunol. 2025 May 23;10(107):eadn3080. doi: 10.1126/sciimmunol.adn3080. Epub 2025 May 23. PMID: 40408429
Epub:
Not Epub
Abstract:
The immune response exhibits strong circadian rhythmicity, with enhanced bacterial clearance often synchronized with an...
Link:
https://www.science.org/doi/10.1126/sciimmunol.adn3080
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Du LY, Keerthisinghe P, Rolland L, Sung YJ, Darroch H, Linnerz T, Ashimbayeva E, Grant MJ, Kakadia PM, Ramachandran A, Tups A, Spaink HP, Bohlander SK, Cheeseman J, Crosier PS, Astin JW, Warman G, Hall CJ. A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity. Sci Immunol. 2025 May 23;10(107):eadn3080. doi: 10.1126/sciimmunol.adn3080. Epub 2025 May 23. PMID: 40408429.

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium

Authors:
Mukherjee A, Hilzendeger M, Rinvelt A, Fatma S, Schupp M, Dalle Nogare D, Chitnis AB
Citation:
bioRxiv [preprint] 2025.05.17.650326; doi: https://doi.org/10.1101/2025.05.17.650326
Epub:
Not Epub
Abstract:
A prepattern of Fgf signaling triggers formation of epithelial rosettes as protoneuromasts form periodically in the migrating...
Link:
https://www.biorxiv.org/content/10.1101/2025.05.17.650326v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mukherjee A, Hilzendeger M, Rinvelt A, Fatma S, Schupp M, Dalle Nogare D, Chitnis AB. Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium. bioRxiv [preprint] 2025.05.17.650326; doi: https://doi.org/10.1101/2025.05.17.650326.

FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis

Authors:
Wu P, Song N, Xiang Y, Tao Z, Mao B, Guo R, Wang X, Wu D, Zhang Z, Chen X, Ma D, Zhang T, Hao B, Ma J
Citation:
EMBO Mol Med. 2025 May 23. doi: 10.1038/s44321-025-00247-x. Epub ahead of print. PMID: 40410591
Epub:
Not Epub
Abstract:
Congenital ptosis, a genetic disorder involving levator palpebrae muscle dysfunction, is often associated with congenital...
Link:
https://www.embopress.org/doi/full/10.1038/s44321-025-00247-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu P, Song N, Xiang Y, Tao Z, Mao B, Guo R, Wang X, Wu D, Zhang Z, Chen X, Ma D, Zhang T, Hao B, Ma J. FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis. EMBO Mol Med. 2025 May 23. doi: 10.1038/s44321-025-00247-x. Epub ahead of print. PMID: 40410591.

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Authors:
Sanchez AC, Banoukh N, Mensching F, Skibbens RV, Iovine MK
Citation:
Dev Dyn. 2025 May 21. doi: 10.1002/dvdy.70037. Epub ahead of print. PMID: 40396618
Epub:
Not Epub
Abstract:
Background: Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS)....
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.70037
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez AC, Banoukh N, Mensching F, Skibbens RV, Iovine MK. Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos. Dev Dyn. 2025 May 21. doi: 10.1002/dvdy.70037. Epub ahead of print. PMID: 40396618.

Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation

Authors:
Gunne S, Sailer FK, Keutmann L, Schwerdtner M, Moulton HM, Böttcher-Friebertshäuser E, Schiffmann S
Citation:
Drugs and Drug Candidates. 2025; 4(2):25. https://doi.org/10.3390/ddc4020025
Epub:
Not Epub
Abstract:
Background: TMPRSS2 plays an important role in the viral entry mechanisms of influenza viruses and coronaviruses. Therefore,...
Link:
https://www.mdpi.com/2813-2998/4/2/25
Delivery Method:
peptide-linked
Organism or Cell Type:
Human regulatory T cells (Treg) and responder T cells
Citation Extract:
Gunne S, Sailer FK, Keutmann L, Schwerdtner M, Moulton HM, Böttcher-Friebertshäuser E, Schiffmann S. Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation. Drugs and Drug Candidates. 2025; 4(2):25. https://doi.org/10.3390/ddc4020025.

Conception and Synthesis of Sequence-Coded Morpholinos

Authors:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF
Citation:
Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184
Epub:
Not Epub
Abstract:
Solid-phase morpholino chemistry was explored as a new route to synthesize abiological sequence-defined oligomers. Two...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12099184/
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF. Conception and Synthesis of Sequence-Coded Morpholinos. Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184.

Silencing mitochondrial gene expression in living cells

Authors:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P
Citation:
Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134
Epub:
Not Epub
Abstract:
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key...
Link:
https://www.science.org/doi/10.1126/science.adr3498
Delivery Method:
peptide-linked (pCox41-25)
Organism or Cell Type:
HEK293T cells & isolated mitochondria
Citation Extract:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P. Silencing mitochondrial gene expression in living cells. Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134.

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