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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12263 scientific papers returned from the database with the search filters currently being used below.
There are 12263 scientific papers returned from the database with the search filters currently being used below.
Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells in systemic lupus erythematosus and averts glomerular pathology
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Citation:
Exp Mol Med. 2026 Nov 2 Epub:
Not Epub Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation in multiple organ systems.... Delivery Method:
human PBMCs from patients with Systemic lupus erythematosus; SLE-prone MRL-lpr mice Organism or Cell Type:
Vivo-Morpholino; Alzet minipumps for mice Citation Extract: Rodrigues Lima-Junior J, Hu Z, Hamane K, Kumar A, Taghi Khani A, Sanchez Ortiz A, Guo X, Jung DH, Qin H, Tao S, Sanz I, Meffre E, Marzan K, Koff JL, Lorenson MY, Gu Z, Wu X, Walker AM, Swaminathan S. Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells in systemic lupus erythematosus and averts glomerular pathology. Exp Mol Med. 2026 Nov 2. |
ADA2 controls autophagy-dependent mitochondrial fitness to restrain type I interferon activation
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Citation:
Cell Death Differ. 2026 Oct 31 Epub:
Not Epub Abstract:
Adenosine deaminase 2 (ADA2) is a secreted enzyme recently shown to localize to lysosomes and bind DNA, yet its cellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bulté D, Romano A, Ottorini A, Rigamonti C, Pacini G, Brix A, Rocco A, Barzaghi F, Pettinato E, Carbone S, Rudilosso L, Visconti C, Scala S, Insalaco A, de Benedetti F, Caorsi R, Gattorno M, Cesana D, Pistocchi A, Maltecca F, Aiuti A, Mortellaro A. ADA2 controls autophagy-dependent mitochondrial fitness to restrain type I interferon activation. Cell Death Differ. 2026 Oct 31. |
Inhibitors for a conserved filarial catechol-O-methyltransferase with potent efficacy against all life-stages of Brugia malayi infection in gerbils
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Citation:
Scientific Reports. 2026 Oct 25 Epub:
Not Epub Abstract:
Filarial nematodes of genus Brugia cause lymphatic filariasis, with over 36 million chronically debilitated people and 885... Delivery Method:
Endo-Porter Organism or Cell Type:
B. malayi worms (microfilariae & adults) Citation Extract: Mia MM, Sk MF, Paudel BR, Azam AR, Allaie IM, Zhang X, Tajkhorshid E, Witola WH. Inhibitors for a conserved filarial catechol-O-methyltransferase with potent efficacy against all life-stages of Brugia malayi infection in gerbils. Scientific Reports. 2026 Oct 25. |
Morpholino-mediated splice switching of NELFE suppresses hepatocellular carcinoma cell phenotypes in vitro and in vivo
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Citation:
Mol Ther Nucleic Acids. 2026 Oct 1;37(4):103124 Epub:
Not Epub Abstract:
Hepatocellular carcinoma (HCC) is among the deadliest cancers worldwide, with rising incidence and few targeted therapies,... Delivery Method:
Vivo-MOs, Vivo-MOs loaded onto Definity microbubbles, ultrasound-targeted microbubble destruction (UTMD) of Vivo-MOs loaded onto Definity microbubbles, electroporation for Huh1 and Huh7 cells, intraperitoneal (i.p.) and retroorbital injection for mice Organism or Cell Type:
Huh1 spheroids and cells, Huh7 cells, MHCC97H xenografts in NOD/SCID mice Citation Extract: Reynolds LM, Lamm R, Zhang K, Barry-Wolbers AE, Lucci A, Ruiz BN, Wessner CE, Nguyen T, Hammond KM, Eckert C, Liu JB, Choochuen P, Hong KY, Jiang W, Forgues M, Palazzo GM, Lin D, Bodzin AS, Shah AP, Wang XW, Martin SP, Fawzi NL, Gaida MM, Eisenbrey JR, Dang H. Morpholino-mediated splice switching of NELFE suppresses hepatocellular carcinoma cell phenotypes in vitro and in vivo. Mol Ther Nucleic Acids. 2026 Oct 1;37(4):103124. |
The small eyes of good effort zebrafish mutant result from a splicing defect in chromosome assembly factor 1, subunit b and persists upon Tp53 disruption
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Citation:
Dev Biol. 2026 Oct 26;540:237-248 Epub:
Not Epub Abstract:
The differentiation of diverse retinal neurons, such as photoreceptors, is dependent on the complex interactions of cell cycle... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bailey TJ, Dressler L, Parks AC, Whittle J. The small eyes of good effort zebrafish mutant result from a splicing defect in chromosome assembly factor 1, subunit b and persists upon Tp53 disruption. Dev Biol. 2026 Oct 26;540:237-248. |
Proteomic and transcriptomic analysis reveals an intracellular role for zona pellucida protein 2 in mouse morula-blastocyst transition
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Citation:
BMC Genomics. 2026 Oct 22;27(1):885 Epub:
Not Epub Abstract:
Background: Since the first description in 1827, the zona pellucida (ZP) has been viewed as an extracellular structure... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nolte T, Israel S, Drexler HCA, Fuellen G, Wiese J, Boiani M. Proteomic and transcriptomic analysis reveals an intracellular role for zona pellucida protein 2 in mouse morula-blastocyst transition. BMC Genomics. 2026 Oct 22;27(1):885. |
Rhomboid protease Rhbdl2 influences macrophage recruitment and wound repair in zebrafish
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Citation:
J Cell Biol. 2026 Nov 2;225(11):e202602106. Epub 2026 Sep 11 Epub:
Not Epub Abstract:
Wound repair requires tight control of immune cell behavior, yet the mechanisms that restrain immune-driven wound repair... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gourkanti S, Ramakrishnan G, Cheung J, Schoen TJ, Munoz Y, Chavez RM, Dohnálek J, Martin K, Lovett-Barron M, Whisenant T, Strisovsky K, Neal SE. Rhomboid protease Rhbdl2 influences macrophage recruitment and wound repair in zebrafish. J Cell Biol. 2026 Nov 2;225(11):e202602106. Epub 2026 Sep 11. |
Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial
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Citation:
Lancet Neurol. 2026 Nov;25(11):983-996 Epub:
Not Epub Abstract:
Background
There are no approved exon skipping therapies to treat Duchenne muscular dystrophy due to DMD variants amenable to... Delivery Method:
intravenous (i.v.) infusion Organism or Cell Type:
human Citation Extract: Veerapandiyan A, Eskuri J, Laverty CG, McDonald CM, Phan H, Smith EC, Tesi Rocha C, Wong B, Morris M, Tami Y, Carmack T, Kovach P, Herzog JJ, Hughes SG, Zhu Y, Ackermann EJ, Flanigan KM, EXPLORE44 Study Investigators. Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial. Lancet Neurol. 2026 Nov;25(11):983-996. |
In vivo DNA damage protection during cell migration across confining embryonic tissue environments
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Citation:
Nat Cell Biol. 2026 Oct;28(10):2088-2105 Epub:
Not Epub Abstract:
Cells migrating through confined spaces can experience nuclear deformation, nuclear envelope damage and DNA lesions, but the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Häkkinen HM, Villaseca S, Alhashem Z, Hamidzadeh A, Chomiczewski S, Desevedavy M, Leleux S, Liu YH, Becker JM, Htun MR, Gallo F, El-Zohiry D, Petre V, Stefanowski K, Franze K, Renkawitz J, Scarpa E. In vivo DNA damage protection during cell migration across confining embryonic tissue environments. Nat Cell Biol. 2026 Oct;28(10):2088-2105. |
ENPP6 is a novel candidate gene for autosomal recessive CAKUT
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Citation:
Kidney International Reports. 2026 Oct 8:107135 Epub:
Not Epub Abstract:
Introduction: Congenital anomalies of the kidney and urinary tract (CAKUT) are a leading cause of childhood chronic kidney... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Mertens MN, Franken PG, Hardet PF, Kano PK, Lemberg MK, Hölzel S, Marchuk MD, Merz ML, El Desoky MS, Cingöz PS, Dicle MO. ENPP6 is a novel candidate gene for autosomal recessive CAKUT. Kidney International Reports. 2026 Oct 8:107135. |