You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12255 scientific papers returned from the database with the search filters currently being used below.

Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation

Authors:
Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E, Serbanovic-Canic J, Evans PC
Citation:
Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337
Epub:
Not Epub
Abstract:
Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E, Serbanovic-Canic J, Evans PC. Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337.

Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes

Authors:
Ten Martin D, Jardin N, Vougny J, Giudicelli F, Gasmi L, Berbée N, Henriot V, Lebrun L, Haumaître C, Kneussel M, Nicol X, Janke C, Magiera MM, Hazan J, Fassier C
Citation:
EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968
Epub:
Not Epub
Abstract:
The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ten Martin D, Jardin N, Vougny J, Giudicelli F, Gasmi L, Berbée N, Henriot V, Lebrun L, Haumaître C, Kneussel M, Nicol X, Janke C, Magiera MM, Hazan J, Fassier C. Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes. EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968.

Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications

Authors:
Galindo-Murillo R, Cohen JS, Akabayov B
Citation:
NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155
Epub:
Not Epub
Abstract:
We have subjected several analogs of DNA that have been widely used as antisense oligonucleotide (ASO) inhibitors of gene...
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Galindo-Murillo R, Cohen JS, Akabayov B. Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications. NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155.

Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos

Authors:
Niu M, Yi W, Dong Z, Li X, Dong X, Yu L, Han Y, Zhang O, Sheng Z, An J, Li H and Sun Y
Citation:
(2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230
Epub:
Not Epub
Abstract:
Introduction: Due to the impact of antibody-dependent enhancement and viral variation, effective vaccines or antiviral...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: Vero, HepG2 and A549
Citation Extract:
Niu M, Yi W, Dong Z, Li X, Dong X, Yu L, Han Y, Zhang O, Sheng Z, An J, Li H and Sun Y . Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos. (2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230.

Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients

Authors:
Padhye AS, Kiriaev L, Tiong C, Gearing LJ, Wilson T, Houweling PJ, Tachas G
Citation:
bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028
Epub:
Not Epub
Abstract:
Background: VLA-4 is a disease progression biomarker in patients with Duchenne Muscular Dystrophy (DMD) including those treated...
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Padhye AS, Kiriaev L, Tiong C, Gearing LJ, Wilson T, Houweling PJ, Tachas G. Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients. bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028.

Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells

Authors:
Schwerdtner M, Schmacke LC, Nave J, Limburg H, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E
Citation:
Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139
Epub:
Not Epub
Abstract:
The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of...
Delivery Method:
(RXR)4 peptide-linked
Organism or Cell Type:
cell culture: Calu-3
Citation Extract:
Schwerdtner M, Schmacke LC, Nave J, Limburg H, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells. Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139.

An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients

Authors:
Wilson K, Manner C, Miranda E, Berrio A, Wray GA, McClay DR
Citation:
Dev Biol. 2024 Dec;516:59-70. doi: 10.1016/j.ydbio.2024.08.002. Epub 2024 Aug 3. PMID: 39098630; PMCID: PMC11425896
Epub:
Not Epub
Abstract:
Dicer substrate interfering RNAs (DsiRNAs) destroy targeted transcripts using the RNA-Induced Silencing Complex (RISC) through...
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Wilson K, Manner C, Miranda E, Berrio A, Wray GA, McClay DR. An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients. Dev Biol. 2024 Dec;516:59-70. doi: 10.1016/j.ydbio.2024.08.002. Epub 2024 Aug 3. PMID: 39098630; PMCID: PMC11425896.

Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells

Authors:
Rossi R, Torelli S, Moore M, Ala P, Morgan J, Malhotra J, Muntoni F
Citation:
Skelet Muscle. 2024 Nov 29;14(1):28. doi: 10.1186/s13395-024-00360-4. PMID: 39614336; PMCID: PMC11606086
Epub:
Not Epub
Abstract:
Background: Antisense oligonucleotides (AON) represent a promising treatment for Duchenne muscular dystrophy (DMD) carrying out...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: DMD-patient-derived primary fibroblasts
Citation Extract:
Rossi R, Torelli S, Moore M, Ala P, Morgan J, Malhotra J, Muntoni F. Golodirsen restores DMD transcript imbalance in Duchenne Muscular Dystrophy patient muscle cells. Skelet Muscle. 2024 Nov 29;14(1):28. doi: 10.1186/s13395-024-00360-4. PMID: 39614336; PMCID: PMC11606086.

Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications

Authors:
Datta D, Kumar P, Kundu J, Qin J, Gilbert JA, Schofield S, Donnelly DP, Liu J, Degaonkar R, Egli M, Manoharan M
Citation:
Org Lett. 2024 Nov 29;26(47):10061-10065. doi: 10.1021/acs.orglett.4c02903. Epub 2024 Nov 11. PMID: 39528231
Epub:
Not Epub
Abstract:
To ensure specificity, loading of the sense strand of small interfering RNAs (siRNAs) into RISC must be inhibited. We show here...
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Datta D, Kumar P, Kundu J, Qin J, Gilbert JA, Schofield S, Donnelly DP, Liu J, Degaonkar R, Egli M, Manoharan M. Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications. Org Lett. 2024 Nov 29;26(47):10061-10065. doi: 10.1021/acs.orglett.4c02903. Epub 2024 Nov 11. PMID: 39528231.

Zebrafish in-vivo study reveals deleterious activity of human TBC1D24 genetic variants linked with autosomal dominant hearing loss

Authors:
Sarosiak A, Jędrychowska J, Oziębło D, Gan NS, Bałdyga N, Leja ML, Węgierski T, Cruz IA, Raible DW, Skarżyński H, Tylzanowski P, Korzh V, Ołdak M
Citation:
Biochim Biophys Acta Mol Basis Dis. 2024 Nov 23;1871(2):167598. doi: 10.1016/j.bbadis.2024.167598. Epub ahead of print. PMID: 39586506
Epub:
Not Epub
Abstract:
Hearing loss is a common sensory impairment with a heterogeneous genetic etiology. Genetic variants in the TBC1D24 gene have...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sarosiak A, Jędrychowska J, Oziębło D, Gan NS, Bałdyga N, Leja ML, Węgierski T, Cruz IA, Raible DW, Skarżyński H, Tylzanowski P, Korzh V, Ołdak M. Zebrafish in-vivo study reveals deleterious activity of human TBC1D24 genetic variants linked with autosomal dominant hearing loss. Biochim Biophys Acta Mol Basis Dis. 2024 Nov 23;1871(2):167598. doi: 10.1016/j.bbadis.2024.167598. Epub ahead of print. PMID: 39586506.

Pages