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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12152 scientific papers returned from the database with the search filters currently being used below.

Robust cytoplasmic partitioning by solving a cytoskeletal instability

Authors:
Rinaldin M, Kickuth A, Lamson A, Dalton B, Xu Y, Mejstřík P, Di Talia S, Brugués J
Citation:
Nature. 2026 Jan 28. doi: 10.1038/s41586-025-10023-z. Epub ahead of print. PMID: 41606324
Epub:
Not Epub
Abstract:
Early development across vertebrates and insects critically relies on robustly reorganizing the cytoplasm of fertilized eggs...
Link:
https://www.nature.com/articles/s41586-025-10023-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rinaldin M, Kickuth A, Lamson A, Dalton B, Xu Y, Mejstřík P, Di Talia S, Brugués J. Robust cytoplasmic partitioning by solving a cytoskeletal instability. Nature. 2026 Jan 28. doi: 10.1038/s41586-025-10023-z. Epub ahead of print. PMID: 41606324.

Estrogen produced in the retina by brain aromatase plays a significant role in zebrafish eye development

Authors:
Ulhaq ZS, Kishida M
Citation:
Biochim Biophys Acta Gene Regul Mech. 2025 Dec 15;1869(1):195133. doi: 10.1016/j.bbagrm.2025.195133. Epub ahead of print. PMID: 41407153
Epub:
Not Epub
Abstract:
Aromatase is a key enzyme in estrogen biosynthesis, expressed in multiple tissues including the brain and retina. In teleost...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1874939925000586
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS, Kishida M. Estrogen produced in the retina by brain aromatase plays a significant role in zebrafish eye development. Biochim Biophys Acta Gene Regul Mech. 2025 Dec 15;1869(1):195133. doi: 10.1016/j.bbagrm.2025.195133. Epub ahead of print. PMID: 41407153.

Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling

Authors:
Zhou K, Liu H, Zhu K, Yu L, Xu PF, Li Y
Citation:
Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2516989123. doi: 10.1073/pnas.2516989123. Epub 2026 Jan 23. PMID: 41576080; PMCID: PMC12846792
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs), which sustain lifelong blood cell production, emerge from hemogenic endothelium during...
Link:
https://www.pnas.org/doi/10.1073/pnas.2516989123
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou K, Liu H, Zhu K, Yu L, Xu PF, Li Y. Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling. Proc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2516989123. doi: 10.1073/pnas.2516989123. Epub 2026 Jan 23. PMID: 41576080; PMCID: PMC12846792.

Convergent evolution of scavenger cell development at brain borders

Authors:
Gaudi AU, Meier M, Baltaci OF, Chowdhary S, Tulenko FJ, Dudczig S, Stamatis S-A, Paterson S, Yu H, Galeano MCR, Mason E, Miles LB, Bryson-Richardson RJ, Pask AJ, Vukovic J, Lagendijk AK, Smith KA, Kaslin J, Harrison MRM, Currie PD, Bower NI, Hogan BM
Citation:
Nature (2026). https://doi.org/10.1038/s41586-025-10003-3
Epub:
Not Epub
Abstract:
The vertebrate central nervous system is protected by the blood–brain barrier and meningeal membranes, which ensure immune...
Link:
https://www.nature.com/articles/s41586-025-10003-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gaudi AU, Meier M, Baltaci OF, Chowdhary S, Tulenko FJ, Dudczig S, Stamatis S-A, Paterson S, Yu H, Galeano MCR, Mason E, Miles LB, Bryson-Richardson RJ, Pask AJ, Vukovic J, Lagendijk AK, Smith KA, Kaslin J, Harrison MRM, Currie PD, Bower NI, Hogan BM. Convergent evolution of scavenger cell development at brain borders. Nature (2026). https://doi.org/10.1038/s41586-025-10003-3.

mTOR signaling governs the formation of epithelial apical projections via S6K1-RhoA and aPKC-Lgl2 axes

Authors:
Sen S, Ghosh P, Mukherjee S, Prabhu S, Khurana G, Pinto CS, Gupta K, Venkatramani R, Sonawane M
Citation:
Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2501779123. doi: 10.1073/pnas.2501779123. Epub 2026 Jan 13. PMID: 41528872; PMCID: PMC12818559
Epub:
Not Epub
Abstract:
In metazoans, epithelia perform functions of absorption, diffusion, and secretion. The actin-based apical projections on the...
Link:
https://www.pnas.org/doi/10.1073/pnas.2501779123
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sen S, Ghosh P, Mukherjee S, Prabhu S, Khurana G, Pinto CS, Gupta K, Venkatramani R, Sonawane M. mTOR signaling governs the formation of epithelial apical projections via S6K1-RhoA and aPKC-Lgl2 axes. Proc Natl Acad Sci U S A. 2026 Jan 20;123(3):e2501779123. doi: 10.1073/pnas.2501779123. Epub 2026 Jan 13. PMID: 41528872; PMCID: PMC12818559.

CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

Authors:
Uruci S, Boer DEC, Chrystal PW, Lalonde M, Panagopoulos A, Yakoub G, Kirdök I, de Lint K, van der Woude M, Wendel TJ, Brussee SJ, Wondergem AP, van Overbeek NK, Schotman N, Lingeman J, Ljungman M, van Oudenaarden A, van Attikum H, Vertegaal ACO, Noordermeer SM, Wolthuis RMF, Altmeyer M, Hamperl S, Tropepe V, van den Berg J, van den Heuvel D, Luijsterburg MS
Citation:
Nature. 2026 Jan 14. doi: 10.1038/s41586-025-09943-7. Epub ahead of print. PMID: 41535461
Epub:
Not Epub
Abstract:
Fine-tuning DNA replication and transcription is crucial to prevent collisions between their machineries1. This is particularly...
Link:
https://www.nature.com/articles/s41586-025-09943-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Uruci S, Boer DEC, Chrystal PW, Lalonde M, Panagopoulos A, Yakoub G, Kirdök I, de Lint K, van der Woude M, Wendel TJ, Brussee SJ, Wondergem AP, van Overbeek NK, Schotman N, Lingeman J, Ljungman M, van Oudenaarden A, van Attikum H, Vertegaal ACO, Noordermeer SM, Wolthuis RMF, Altmeyer M, Hamperl S, Tropepe V, van den Berg J, van den Heuvel D, Luijsterburg MS. CFAP20 salvages arrested RNAPII from the path of co-directional replisomes. Nature. 2026 Jan 14. doi: 10.1038/s41586-025-09943-7. Epub ahead of print. PMID: 41535461.

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles

Authors:
Chrisman AN, Sugimoto C, Butler-Struben H, Minie VA, Eagle AL, Anderson D, Duque-Wilckens N, Ramos A, Lewis YI, Archdeacon SC, Robison AJ, Trainor BC
Citation:
Neuropsychopharmacology. 2026 Jan 17. doi: 10.1038/s41386-026-02352-y. Epub ahead of print. PMID: 41548026
Epub:
Not Epub
Abstract:
Oxytocin is a neuropeptide that can promote or inhibit affiliative social behaviors. Recent evidence suggests that these...
Link:
https://www.nature.com/articles/s41386-026-02352-y
Delivery Method:
hypothalamus paraventricular nucleus injection
Organism or Cell Type:
California mice (Peromyscus californicus)
Citation Extract:
Chrisman AN, Sugimoto C, Butler-Struben H, Minie VA, Eagle AL, Anderson D, Duque-Wilckens N, Ramos A, Lewis YI, Archdeacon SC, Robison AJ, Trainor BC. Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles. Neuropsychopharmacology. 2026 Jan 17. doi: 10.1038/s41386-026-02352-y. Epub ahead of print. PMID: 41548026.

PATJ deficiency leads to cystic kidney disease and related ciliopathies

Authors:
Epting D, Braun DA, Decker E, Ott E, Eisenberger T, Bachmann N, Nedvetsky P, Krahn MP, Hildebrandt F, Bergmann C
Citation:
HGG Adv. 2026 Jan 15;7(1):100514. doi: 10.1016/j.xhgg.2025.100514. Epub 2025 Sep 9. PMID: 40931526; PMCID: PMC12512994
Epub:
Not Epub
Abstract:
Cystic kidney disease and related ciliopathies are caused by pathogenic variants in genes that commonly result in ciliary...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12512994/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Epting D, Braun DA, Decker E, Ott E, Eisenberger T, Bachmann N, Nedvetsky P, Krahn MP, Hildebrandt F, Bergmann C. PATJ deficiency leads to cystic kidney disease and related ciliopathies. HGG Adv. 2026 Jan 15;7(1):100514. doi: 10.1016/j.xhgg.2025.100514. Epub 2025 Sep 9. PMID: 40931526; PMCID: PMC12512994.

Rtf1-dependent transcriptional pausing regulates cardiogenesis

Authors:
Langenbacher AD, Lu F, Tsang L, Huang ZYS, Keer B, Tian Z, Eide A, Pellegrini M, Nakano H, Nakano A, Chen JN
Citation:
Elife. 2026 Jan 15;13:RP94524. doi: 10.7554/eLife.94524. PMID: 41537425; PMCID: PMC12807453
Epub:
Not Epub
Abstract:
Transcriptional pause-release critically regulates cellular RNA biogenesis, yet how dysregulation of this process impacts...
Link:
https://elifesciences.org/articles/94524
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Langenbacher AD, Lu F, Tsang L, Huang ZYS, Keer B, Tian Z, Eide A, Pellegrini M, Nakano H, Nakano A, Chen JN. Rtf1-dependent transcriptional pausing regulates cardiogenesis. Elife. 2026 Jan 15;13:RP94524. doi: 10.7554/eLife.94524. PMID: 41537425; PMCID: PMC12807453.

The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision

Authors:
Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J; Genomics England Research Consortium; Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, Leroux MR
Citation:
Nat Commun. 2022 Nov 3;13(1):6595. doi: 10.1038/s41467-022-33820-w. PMID: 36329026; PMCID: PMC9633640
Epub:
Not Epub
Abstract:
Motile and non-motile cilia are associated with mutually-exclusive genetic disorders. Motile cilia propel sperm or...
Link:
https://www.nature.com/articles/s41467-022-33820-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chrystal PW, Lambacher NJ, Doucette LP, Bellingham J, Schiff ER, Noel NCL, Li C, Tsiropoulou S, Casey GA, Zhai Y, Nadolski NJ, Majumder MH, Tagoe J, D'Esposito F, Cordeiro MF, Downes S, Clayton-Smith J, Ellingford J; Genomics England Research Consortium; Mahroo OA, Hocking JC, Cheetham ME, Webster AR, Jansen G, Blacque OE, Allison WT, Au PYB, MacDonald IM, Arno G, Leroux MR. The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision. Nat Commun. 2022 Nov 3;13(1):6595. doi: 10.1038/s41467-022-33820-w. PMID: 36329026; PMCID: PMC9633640.

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