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Jon's Blog
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Delivery of Morpholinos by irradiation |
Patent: |
Thursday, July 13, 2023 - 15:33 |
(Methods Cell Biol):Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish |
Cardenas-Rodriguez M, Drummond IA. The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish. Methods Cell Biol. 2023;176:1-25. doi: 10.1016/bs.mcb.2022.12.019. Epub 2023 Jan 27. |
Thursday, May 11, 2023 - 15:29 |
I have an article in Pharma's Almanac - Morpholino stories |
Morpholino article in Pharma's Almanac |
Friday, May 5, 2023 - 15:34 |
(Review) Recent Trends in Antisense Therapies for Duchenne Muscular Dystrophy |
Recent Trends in Antisense Therapies for Duchenne Muscular Dystrophy. |
Thursday, March 30, 2023 - 14:23 |
Morpholinos shorter than 25 bases |
A Morpholino user, accustomed to using 25-base Morpholinos in Xenopus laevis, was concerned about a design she received for a 20-base Morpholino. She wrote to ask if we had designed many short oligos and if they worked well. Here is my response. ------------------------------------- |
Wednesday, February 15, 2023 - 11:13 |
Molecular dynamics of aqueous Morpholino oligos |
Maksudov F, Kliuchnikov E, Pierson D, Ujwal ML, Marx KA, Chanda A, Barsegov V. Therapeutic Phosphorodiamidate Morpholino Oligonucleotides, an RNA mimic: Physical Properties, Solution Structures, and Folding Thermodynamics. Mol Ther Nucleic Acids. 2023;[Epub] doi:10.1016/j.omtn.2023.02.007 https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S21...(23)00027-6 |
Wednesday, February 15, 2023 - 10:15 |
Discussion of RNA change on adding translation blocking Morpholino |
From: **** Hello Jon, |
Wednesday, January 18, 2023 - 12:35 |
History: exon skipping |
Lim, K.R.Q., Yokota, T. (2018). Invention and Early History of Exon Skipping and Splice Modulation. In: Yokota, T., Maruyama, R. (eds) Exon Skipping and Inclusion Therapies. Methods in Molecular Biology, vol 1828. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8651-4_1 |
Tuesday, January 17, 2023 - 11:03 |
Master’s thesis based on microarray analysis of WT, Morphant and rescue fish |
Master’s thesis based on microarray analysis of WT, Morphant and rescue fish |
Monday, January 16, 2023 - 11:32 |
Vivo-Morpholino uptake by zebrafish larvae at 4dpf |
Liang H, Li Y, Li M, Zhou W, Chen J, Zhang Z, Yang Y, Ran C, Zhou Z. The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Front Immunol. 2022 Nov 3;13:1031962. doi: 10.3389/fimmu.2022.1031962. eCollection 2022. |
Monday, November 21, 2022 - 09:48 |