You are here
Jon's Blog
Post date | ||
---|---|---|
Review of neurodegenerative disease and splice modulation |
Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies. https://translationalneurodegeneration.biomedcentral.com/articles/10.118... |
Monday, May 24, 2021 - 13:32 |
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease (Review) |
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease. |
Monday, May 17, 2021 - 11:33 |
SARS-CoV-2 RNA targets for steric blocking |
Potantial targets for steric blocking on the SARS-CoV-2 genome and transcripts. The SARS-CoV-2 RNA interactome. https://www.sciencedirect.com/science/article/pii/S1097276521003270 |
Monday, May 17, 2021 - 10:23 |
Positive control, human and mouse splice modification |
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552 |
Friday, May 14, 2021 - 11:52 |
MO knockdown of ectopic GFP in axlotl |
There are few papers reporting using a Morpholino to directly target GFP in vivo; here is one example. |
Friday, April 23, 2021 - 11:21 |
Oligo types, therapeutic Morpholinos, upregulation with Morpholinos |
Here are some types of oligos sorted by their mechanisms. RNase-H dependent
RNase-independent (steric blocking oligos)
Argonaute dependent
About the Morpholino drugs |
Thursday, April 15, 2021 - 09:24 |
Review of oligo delivery for therapeutics |
Hammond SH et al. Delivery of oligonucleotide-based therapeutics: challenges and opportunities. Embo Mol Med. 2021:e13243. doi: 10.15252/emmm.202013243 |
Wednesday, April 7, 2021 - 09:48 |
Review of mutant-morphant discrepency & genetic compensation |
Salanga CM, Salanga MC. Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants. Int J Mol Sci. 2021;22(7),3472. doi:10.3390/ijms22073472 |
Monday, March 29, 2021 - 13:39 |
Papers describing Morpholinos used in DMD studies |
Papers describing Morpholinos used in DMD studies NON-CLINICAL PAPERS |
Thursday, March 4, 2021 - 15:01 |
A description of using Morpholinos to block splice-regulatory protein binding sites |
Biayna J, Mazuelas H, Gel B, Terribas E, Dumbovic G, Rosas I, Fernández-Rodriguez J, Blanco I, Castellanos E, Carrió M, Lazaro C, Serra E. Using antisense oligonucleotides for the physiological modulation of the alternative splicing of NF1 exon 23a during PC12 neuronal differentiation. Sci Rep. 2021;11(1):3661. doi:10.1038/s41598-021-83152-w |
Thursday, February 11, 2021 - 10:44 |