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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

MDB-06. Alternative Splicing Mediated By Otx2 Drives The Development Of Group 3 Medulloblastoma

Authors:
Saulnier, O, Zagozewski, J, Liang L, Hendrikse LD, Layug P, Gordon V., Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Palidwor G, Porter CJ, Richard S, Sharif T, Doble BW, Millen KJ, Taylor MD, Werbowetski-Ogilvie TE
Citation:
Neuro Oncol. 2024 Jun 18;26(Suppl 4):0
Epub:
Not Epub
Abstract:
OTX2 is a transcription factor and known molecular hallmark of Group 3 medulloblastoma (MB). While previous studies have...
Link:
https://academic.oup.com/neuro-oncology/article/26/Supplement_4/0/7694747
Organism or Cell Type:
cell culture; in vivo
Citation Extract:
Saulnier, O, Zagozewski, J, Liang L, Hendrikse LD, Layug P, Gordon V., Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Palidwor G, Porter CJ, Richard S, Sharif T, Doble BW, Millen KJ, Taylor MD, Werbowetski-Ogilvie TE. MDB-06. Alternative Splicing Mediated By Otx2 Drives The Development Of Group 3 Medulloblastoma. Neuro Oncol. 2024 Jun 18;26(Suppl 4):0.

Electroacupuncture facilitates vascular normalization by inhibiting Glyoxalase1 in endothelial cells to attenuate glycolysis and angiogenesis in triple-negative breast cancer

Authors:
Wan YX, Qi XW, Lian YY, Liu ZY, Wang H, Qiu YQ, Zhang CG, Li WN, Jiang HL, Yang DH, Zhao W, Chen ZS, Huang JC
Citation:
Cancer Lett. 2024 Jun 29;598:217094. doi: 10.1016/j.canlet.2024.217094. Epub ahead of print. PMID: 38945204
Epub:
Not Epub
Abstract:
Recent therapeutic strategies for the treatment of triple-negative breast cancer (TNBC) have shifted the focus from vascular...
Link:
https://doi.org/10.1016/j.canlet.2024.217094
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wan YX, Qi XW, Lian YY, Liu ZY, Wang H, Qiu YQ, Zhang CG, Li WN, Jiang HL, Yang DH, Zhao W, Chen ZS, Huang JC. Electroacupuncture facilitates vascular normalization by inhibiting Glyoxalase1 in endothelial cells to attenuate glycolysis and angiogenesis in triple-negative breast cancer. Cancer Lett. 2024 Jun 29;598:217094. doi: 10.1016/j.canlet.2024.217094. Epub ahead of print. PMID: 38945204.

Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

Authors:
Fu W, Lin Y, Bai M, Yao J, Huang C, Gao L, Mi N, Ma H, Tian L, Yue P, Zhang Y, Zhang J, Ren Y, Ding L, Dai L, Leung JW, Yuan J, Zhang W, Meng W
Citation:
Acta Pharmaceutica Sinica B. Available online 29 June 2024
Epub:
Not Epub
Abstract:
Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of...
Link:
https://www.sciencedirect.com/science/article/pii/S2211383524002582
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cholangiocarcinoma (CCA) cells; patient-derived organoids
Citation Extract:
Fu W, Lin Y, Bai M, Yao J, Huang C, Gao L, Mi N, Ma H, Tian L, Yue P, Zhang Y, Zhang J, Ren Y, Ding L, Dai L, Leung JW, Yuan J, Zhang W, Meng W. Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing. Acta Pharmaceutica Sinica B. Available online 29 June 2024.

Differential cellular stiffness across tissues that contribute to Xenopus neural tube closure

Authors:
Suzuki M, Yasue N, Ueno N
Citation:
Dev Growth Differ. 2024 Jun 26. doi: 10.1111/dgd.12936. Epub ahead of print. PMID: 38925637
Epub:
Not Epub
Abstract:
During the formation of the neural tube, the primordium of the vertebrate central nervous system, the actomyosin activity of...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/dgd.12936
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Suzuki M, Yasue N, Ueno N. Differential cellular stiffness across tissues that contribute to Xenopus neural tube closure. Dev Growth Differ. 2024 Jun 26. doi: 10.1111/dgd.12936. Epub ahead of print. PMID: 38925637.

An RNA interference approach for functional studies in the sea urchin and its use in analysis of Nodal signaling gradients

Authors:
Wilson K, Manner C, Miranda E, Berrio A, Wray G, McClay DR
Citation:
bioRxiv [Preprint]. 2024.06.20.599930; doi: https://doi.org/10.1101/2024.06.20.599930
Epub:
Not Epub
Abstract:
We report the first RNAi-based gene knockdowns in a sea urchin. Dicer-Substrate interfering RNAs (DsiRNAs) successfully...
Link:
https://www.biorxiv.org/content/10.1101/2024.06.20.599930v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variagatus (sea urchin)
Citation Extract:
Wilson K, Manner C, Miranda E, Berrio A, Wray G, McClay DR. An RNA interference approach for functional studies in the sea urchin and its use in analysis of Nodal signaling gradients. bioRxiv [Preprint]. 2024.06.20.599930; doi: https://doi.org/10.1101/2024.06.20.599930.

U4 snRNP inhibits premature cleavage and polyadenylation of pre-mRNAs

Authors:
Feng Q, Zhao D, Lin Z, Li M, Xiang AP, Ye C, Yao C
Citation:
Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2406710121. doi: 10.1073/pnas.2406710121. Epub 2024 Jun 25. PMID: 38917004
Epub:
Not Epub
Abstract:
The essential role of U4 snRNP in pre-messenger RNA (mRNA) splicing has been well established. In this study, we utilized an...
Link:
https://www.pnas.org/doi/10.1073/pnas.2406710121
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Feng Q, Zhao D, Lin Z, Li M, Xiang AP, Ye C, Yao C. U4 snRNP inhibits premature cleavage and polyadenylation of pre-mRNAs. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2406710121. doi: 10.1073/pnas.2406710121. Epub 2024 Jun 25. PMID: 38917004.

Survival among patients receiving eteplirsen for up to 8 years for the treatment of Duchenne muscular dystrophy and contextualization with natural history controls

Authors:
Iff J, Done N, Tuttle E, Zhong Y, Wei F, Darras BT, McDonald CM, Mercuri E, Muntoni F
Citation:
Muscle Nerve. 2024 Jul;70(1):60-70. doi: 10.1002/mus.28075. Epub 2024 Mar 14. PMID: 38482981
Epub:
Not Epub
Abstract:
Eteplirsen, approved in the US for patients with Duchenne muscular dystrophy (DMD) with exon 51 skip-amenable variants, is...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mus.28075
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Iff J, Done N, Tuttle E, Zhong Y, Wei F, Darras BT, McDonald CM, Mercuri E, Muntoni F. Survival among patients receiving eteplirsen for up to 8 years for the treatment of Duchenne muscular dystrophy and contextualization with natural history controls. Muscle Nerve. 2024 Jul;70(1):60-70. doi: 10.1002/mus.28075. Epub 2024 Mar 14. PMID: 38482981.

Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells

Authors:
Flentke GR, Wilkie TE, Baulch J, Huang Y, Smith SM
Citation:
PLoS One. 2024 Jun 28;19(6):e0304557. doi: 10.1371/journal.pone.0304557. eCollection 2024. PMID: 38941348
Epub:
Not Epub
Abstract:
Prenatal alcohol exposure (PAE) causes cognitive impairment and a distinctive craniofacial dysmorphology, due in part to...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304557
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Flentke GR, Wilkie TE, Baulch J, Huang Y, Smith SM. Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 2024 Jun 28;19(6):e0304557. doi: 10.1371/journal.pone.0304557. eCollection 2024. PMID: 38941348.

Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation

Authors:
Lusk S, LaPotin S, Presnell JS, Kwan KM
Citation:
bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599642. doi: 10.1101/2024.06.18.599642. PMID: 38948711
Epub:
Not Epub
Abstract:
Uveal coloboma, a developmental eye defect, is caused by failed development of the optic fissure, a ventral structure in the...
Link:
https://www.biorxiv.org/content/10.1101/2024.06.18.599642v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lusk S, LaPotin S, Presnell JS, Kwan KM. Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation. bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599642. doi: 10.1101/2024.06.18.599642. PMID: 38948711.

3-Hydroxykynurenine targets kainate receptors to promote defense against infection

Authors:
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT
Citation:
Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z. Epub ahead of print. PMID: 38898166
Epub:
Not Epub
Abstract:
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely...
Link:
https://www.nature.com/articles/s41589-024-01635-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT. 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z. Epub ahead of print. PMID: 38898166.

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