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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12515 scientific papers returned from the database with the search filters currently being used below.

Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model

Authors:
Chen YH, Chen WC, Liu PL, Chen HY
Citation:
Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924
Epub:
Not Epub
Abstract:
Introduction and hypothesis: Increased nerve growth factor (NGF) expression in the bladder is known to contribute to the...
Link:
https://link.springer.com/article/10.1007/s00192-025-06394-6
Delivery Method:
Vivo-Morpholino, intravesical instillation
Organism or Cell Type:
IC/PBS rat
Citation Extract:
Chen YH, Chen WC, Liu PL, Chen HY. Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model. Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924.

Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse

Authors:
Aghaeipour A, Mitsogiannis, Fergus C, Tetorou K, Gileadi TE, Stojek E, Talavera S, Singh S, Siddle M, Prendeville JA, Sokolowska E, Kelly VP, Morgan JE, Montanaro F, Muntoni F
Citation:
Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the DMD gene that disrupt the...
Link:
https://www.sciencedirect.com/science/article/pii/S216225312500304X
Delivery Method:
intracisternal magna (i.c.m.) injection
Organism or Cell Type:
mdx23 mice
Citation Extract:
Aghaeipour A, Mitsogiannis, Fergus C, Tetorou K, Gileadi TE, Stojek E, Talavera S, Singh S, Siddle M, Prendeville JA, Sokolowska E, Kelly VP, Morgan JE, Montanaro F, Muntoni F. Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse. Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750.

CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms

Authors:
Galloway A, Knop K, Gomez-Moreira C, Xavier V, Thomson S, Yoshikawa H, Suska O, Lukoszek R, Kaskar A, Lamond AI, MacVicar T, Cowling VH
Citation:
Cell Rep. 2025 Oct 13;44(10):116412. doi: 10.1016/j.celrep.2025.116412. Epub ahead of print. PMID: 41091598
Epub:
Not Epub
Abstract:
During T cell activation, mitochondrial biogenesis and cellular metabolism are altered to meet the elevated energy demands of...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01183-0
Delivery Method:
electroporation
Organism or Cell Type:
naive CD4+ T cells
Citation Extract:
Galloway A, Knop K, Gomez-Moreira C, Xavier V, Thomson S, Yoshikawa H, Suska O, Lukoszek R, Kaskar A, Lamond AI, MacVicar T, Cowling VH. CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms. Cell Rep. 2025 Oct 13;44(10):116412. doi: 10.1016/j.celrep.2025.116412. Epub ahead of print. PMID: 41091598.

polr2i is Required for Zebrafish Early Cardiac Development

Authors:
Chen Y, Zhang Q, Peng X, Wang X, Cao H, Chen Q, Huang S, Lei Y
Citation:
Front. Biosci. (Landmark Ed) 2025, 30(10), 44633. https://doi.org/10.31083/FBL44633
Epub:
Not Epub
Abstract:
Background: Congenital heart disease (CHD) is characterized by structural and functional anomalies of the heart and major...
Link:
https://www.imrpress.com/journal/FBL/30/10/10.31083/FBL44633
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen Y, Zhang Q, Peng X, Wang X, Cao H, Chen Q, Huang S, Lei Y. polr2i is Required for Zebrafish Early Cardiac Development. Front. Biosci. (Landmark Ed) 2025, 30(10), 44633. https://doi.org/10.31083/FBL44633 .

Activated protein C ameliorates diabetes-induced atherosclerosis by sustaining macrophage efferocytosis

Authors:
Ambreen S, Arif A, Shamkeeva S, Elwakiel A, Pal S, Jiang S, Farhan MA, Halloul Z, Griffin JH, Isermann B, Shahzad K
Citation:
Cardiovasc Diabetol. 2025 Oct 13;24(1):396. doi: 10.1186/s12933-025-02965-5. PMID: 41083981; PMCID: PMC12519743
Epub:
Not Epub
Abstract:
Macrophage efferocytosis, essential for the resolution of inflammation and plaque stability in atherosclerosis, is impaired in...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12519743/
Delivery Method:
Vivo-Morpholino; intraperitoneal (i.p.) injection
Organism or Cell Type:
ApoE−/− mice
Citation Extract:
Ambreen S, Arif A, Shamkeeva S, Elwakiel A, Pal S, Jiang S, Farhan MA, Halloul Z, Griffin JH, Isermann B, Shahzad K. Activated protein C ameliorates diabetes-induced atherosclerosis by sustaining macrophage efferocytosis. Cardiovasc Diabetol. 2025 Oct 13;24(1):396. doi: 10.1186/s12933-025-02965-5. PMID: 41083981; PMCID: PMC12519743.

A collagenous extracellular matrix regulates germline gene expression in the sea star embryo

Authors:
Reyes G, Oulhen N, Wessel G
Citation:
Sci Rep. 2025 Oct 21;15(1):36693. doi: 10.1038/s41598-025-20746-8. PMID: 41120523; PMCID: PMC12541058
Epub:
Not Epub
Abstract:
The sea star Patiria miniata uses cell-cell signaling mechanisms in the inductive process of germline formation and here we...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12541058/
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata (sea star)
Citation Extract:
Reyes G, Oulhen N, Wessel G. A collagenous extracellular matrix regulates germline gene expression in the sea star embryo. Sci Rep. 2025 Oct 21;15(1):36693. doi: 10.1038/s41598-025-20746-8. PMID: 41120523; PMCID: PMC12541058.

ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish

Authors:
Xian C, Luo Q, Li W, Zou L, Liu J
Citation:
J Transl Med. 2025 Oct 6;23(1):1054. doi: 10.1186/s12967-025-07032-x. PMID: 41053757; PMCID: PMC12502130
Epub:
Not Epub
Abstract:
Background: The ATP synthase F1 subunit α (ATP5F1A) gene encodes a critical structural subunit of mitochondrial complex V....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12502130/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xian C, Luo Q, Li W, Zou L, Liu J. ATP5F1A deficiency causes developmental delay and motor dysfunction in humans and zebrafish. J Transl Med. 2025 Oct 6;23(1):1054. doi: 10.1186/s12967-025-07032-x. PMID: 41053757; PMCID: PMC12502130.

Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA

Authors:
Francis C, Frida JP, Thanh-Huong B
Citation:
Molecular Therapy - Nucleic Acids (1 Oct 2025)
Epub:
Not Epub
Abstract:
Synthetic messenger RNA (mRNA) therapeutics require precise control over their translation to minimize off-target effects. We...
Link:
https://linkinghub.elsevier.com/retrieve/pii/S2162253125002835
Delivery Method:
Synthetic mRNA and PMOs conjugated to cholesterol or cleavable octoguanidine dendrimers
Organism or Cell Type:
HEK293T cells
Citation Extract:
Francis C, Frida JP, Thanh-Huong B . Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA. Molecular Therapy - Nucleic Acids (1 Oct 2025).

Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border

Authors:
Montequin A & LaBonne C
Citation:
bioRxiv [preprint] 2025.10.03.680132; doi: https://doi.org/10.1101/2025.10.03.680132
Epub:
Not Epub
Abstract:
The neural crest is a vertebrate stem cell population with broad developmental potential whose emergence requires precise...
Link:
https://www.biorxiv.org/content/10.1101/2025.10.03.680132v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Montequin A & LaBonne C. Dynamic and non-uniform expression of key transcription factors provides novel insights into the emergence of neural crest cells at the neural plate border. bioRxiv [preprint] 2025.10.03.680132; doi: https://doi.org/10.1101/2025.10.03.680132.

Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program

Authors:
Li X, Li D, Lou S, Lin J, Gao Y, Vona B, Mi C, Wang L, Ma L, Du M, Pan Y
Citation:
Cell Rep. 2025 Sep 30;44(10):116377. doi: 10.1016/j.celrep.2025.116377. Epub ahead of print. PMID: 41032419
Epub:
Not Epub
Abstract:
Genome-wide association studies have identified numerous loci associated with nonsyndromic cleft lip with/without cleft palate...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01148-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Li D, Lou S, Lin J, Gao Y, Vona B, Mi C, Wang L, Ma L, Du M, Pan Y. Genetic regulation of ARID3B confers cleft lip with/without cleft palate susceptibility through LLPS-mediated transcriptional program. Cell Rep. 2025 Sep 30;44(10):116377. doi: 10.1016/j.celrep.2025.116377. Epub ahead of print. PMID: 41032419.

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