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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12244 scientific papers returned from the database with the search filters currently being used below.
There are 12244 scientific papers returned from the database with the search filters currently being used below.
NF2 lacking exon 11 induced by antisense gene therapy is able to partially recover merlin deficiency in NF2-SWN iPSC-derived spheroid model
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Citation:
Mol Ther Nucleic Acids. 2026 Aug 3;37(3):103046. doi: 10.1016/j.omtn.2026.103046. PMID: 42662719; PMCID: PMC13520096 Epub:
Not Epub Abstract:
NF2-related schwannomatosis (NF2-SWN) is an inherited autosomal dominant disorder resulting from loss-of-function mutations in... Delivery Method:
Endo-Porter, Vivo-Morpholino Organism or Cell Type:
NF2-SWN iPSC-derived spheroids Citation Extract: Casals-Sendra G, Jarne-Sanz I, Catasús N, Boluda-Luis I, Quer A, Amilibia E, Plotkin SR, Lázaro C, Serra E, Blanco I, Castellanos E. NF2 lacking exon 11 induced by antisense gene therapy is able to partially recover merlin deficiency in NF2-SWN iPSC-derived spheroid model. Mol Ther Nucleic Acids. 2026 Aug 3;37(3):103046. doi: 10.1016/j.omtn.2026.103046. PMID: 42662719; PMCID: PMC13520096. |
Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling
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Citation:
Mol Ther Nucleic Acids. 2026 Aug 12;37(3):103056. doi: 10.1016/j.omtn.2026.103056. PMID: 42668701; PMCID: PMC13524873 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a class of antisense oligonucleotides. While PMOs have enabled... Delivery Method:
none Organism or Cell Type:
none Citation Extract: Chou Y, Novikov I, Pierson D, Marx KA, Chanda A, Barsegov V. Kinetics, thermodynamics, and mechanisms of PMO interactions from computational molecular modeling. Mol Ther Nucleic Acids. 2026 Aug 12;37(3):103056. doi: 10.1016/j.omtn.2026.103056. PMID: 42668701; PMCID: PMC13524873. |
Timing matters: Exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy
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Citation:
Mol Ther Nucleic Acids. 2026 Jul 17;37(3):103017. doi: 10.1016/j.omtn.2026.103017. PMID: 42568847; PMCID: PMC13448210 Epub:
Not Epub Abstract:
Exon skipping is a leading therapeutic approach for Duchenne muscular dystrophy (DMD), whereby modulation of pre-mRNA splicing... Delivery Method:
peptide-linked; intravenous (i.v.) injection Organism or Cell Type:
mdx and C57BL/10 wild type mice Citation Extract: Stenler S, Huang J, van Westering TLE, Coenen-Stass AML, Jad Y, Krjutškov K, El Andaloussi S, Wood MJA, Roberts TC. Timing matters: Exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2026 Jul 17;37(3):103017. doi: 10.1016/j.omtn.2026.103017. PMID: 42568847; PMCID: PMC13448210. |
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance
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Citation:
Nat Commun. 2026 Aug 27;17(1):8900. doi: 10.1038/s41467-026-76710-1. PMID: 42660948; PMCID: PMC13522565 Epub:
Not Epub Abstract:
Beyond serving as cohesive barriers, epithelia clear apoptotic cells to regulate development, homeostasis and inflammation. How... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Häkkinen HM, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Ciampa L, Hoijman E, Vibe C, Wijma S, Ruprecht V. De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance. Nat Commun. 2026 Aug 27;17(1):8900. doi: 10.1038/s41467-026-76710-1. PMID: 42660948; PMCID: PMC13522565. |
Reduced expression of human metapneumovirus matrix protein impacts virus assembly and ribonucleoprotein localization
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Citation:
J Virol. 2026 Aug 31:e0106626. doi: 10.1128/jvi.01066-26. Epub ahead of print. PMID: 42671868 Epub:
Not Epub Abstract:
Human metapneumovirus (HMPV) causes severe respiratory tract infections in all cohorts, particularly in vulnerable groups such... Delivery Method:
(RXR)4XB peptide-linked Organism or Cell Type:
A549 cells Citation Extract: Heim CJ, Stein DA, Moulton HM, Galperin E, Dutch RE. Reduced expression of human metapneumovirus matrix protein impacts virus assembly and ribonucleoprotein localization. J Virol. 2026 Aug 31:e0106626. doi: 10.1128/jvi.01066-26. Epub ahead of print. PMID: 42671868. |
Ptprz1b phosphatase binds Prickle2 to promote its membrane localization
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Citation:
iScience. 2026 Jul 13;29(8):116707 Epub:
Not Epub Abstract:
The Wnt/planar cell polarity (PCP) pathway plays a critical role in the development and homeostasis of multicellular organisms... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Le Y, Novotna S, Maia LA, Tolwinski NS, Winkler C, Harnos J. Ptprz1b phosphatase binds Prickle2 to promote its membrane localization. iScience. 2026 Jul 13;29(8):116707. |
Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene
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Citation:
Dis Model Mech. 2026 Aug 21:dmm.052875 Epub:
Not Epub Abstract:
Mutation specific therapeutic approaches, like exon skipping or gene-editing, hold promise for the treatment of Duchenne... Delivery Method:
Vivo-Morpholino, intramuscular (i.m.) injection Organism or Cell Type:
humanized DMD mouse models with either a deletion of exon 44, 45, 51 or 53 Citation Extract: van Putten M, Linssen M, de Winter CT, Brouwers CM, Claassens JWC, Verwey N, Walsh M, Stan TL, Aartsma-Rus A, Hohenstein P. Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene. Dis Model Mech. 2026 Aug 21:dmm.052875. |
Protocol for manipulating mRNA splicing via vivo-morpholino in early-activating muscle stem cells
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Citation:
STAR Protoc. 2026 Aug 20;7(3):104796 Epub:
Not Epub Abstract:
Muscle stem cells (MuSCs), also called satellite cells (SCs), are essential for skeletal muscle regeneration. SCs undergo rapid... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Tg:Pax7nGFP mice; muscle stem cells (MuSCs) also called satellite cells (SCs) Citation Extract: Lin K, Yin Y, Cheung TH. Protocol for manipulating mRNA splicing via vivo-morpholino in early-activating muscle stem cells. STAR Protoc. 2026 Aug 20;7(3):104796. |
Peptide-phosphorodiamidate morpholino oligomer therapy for dysferlinopathy induces pseudoexon skipping and restoration of functional protein
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Citation:
JCI Insight. 2026 Jul 14;11(16):e204742 Epub:
Not Epub Abstract:
The dysferlinopathies are a spectrum of autosomal recessive muscle diseases caused by mutations in the dysferlin gene (DYSF).... Delivery Method:
Endo-Porter for myotubes, Pip9b2 peptide-linked for mice, DNA-RNA hybrids with cholesterol conjugated to a nucleic acid strand that is complementary to PMO for mice; intravenous (i.v.) for mice Organism or Cell Type:
patient-derived myotubes; PE44.1 mice Citation Extract: Gooding JE, Park G, Wagh A, Watts JK, Dominov JA, Brown RH Jr. Peptide-phosphorodiamidate morpholino oligomer therapy for dysferlinopathy induces pseudoexon skipping and restoration of functional protein. JCI Insight. 2026 Jul 14;11(16):e204742. |
Sunitinib induces macrophage dysfunction and impaired tissue regeneration through suppression of PPARγ
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Citation:
Front. Immunol. (2026) 17:1900449. doi: 10.3389/fimmu.2026.1900449 Epub:
Not Epub Abstract:
Background: Sunitinib is a widely used multi-target tyrosine kinase inhibitor associated with side effects that may impair... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang Z, Qiao Q, Li J, Li Q, Yang Y, Zhou Y, Huang H, Chen D, Wang Y and Guo Y. Sunitinib induces macrophage dysfunction and impaired tissue regeneration through suppression of PPARγ. Front. Immunol. (2026) 17:1900449. doi: 10.3389/fimmu.2026.1900449. |