You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12570 scientific papers returned from the database with the search filters currently being used below.

Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development

Authors:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF
Citation:
Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269
Epub:
Not Epub
Abstract:
Deficiency in the retinoschisin protein (RS1) causes X-linked juvenile retinoschisis (XLRS), a retinal degenerative disease...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12578269/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF. Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development. Dev Neurobiol. 2026 Jan;86(1):e23012. doi: 10.1002/dneu.23012. PMID: 41171855; PMCID: PMC12578269.

Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish

Authors:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C
Citation:
J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267
Epub:
Not Epub
Abstract:
Background: Probiotic nutrition has the potential to improve health and prevents diseases, and probiotics such as Bacillus spp...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0022316625008028
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou W, Liang H, Meng D, Xu S, Zhang Y, Zhu H, Wang Y, Yang Y, Zhang Z, Yao Y, Xu X, Ding Q, Li M, Zhou Z, Ran C. Diet-supplemented probiotic Bacillus velezensis protects against viral infection via the lipopeptide surfactin in zebrafish. J Nutr. 2025 Dec 27:101296. doi: 10.1016/j.tjnut.2025.101296. Epub ahead of print. PMID: 41461267.

Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection

Authors:
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T
Citation:
Nat Commun. 2025 Dec 22;16(1):10853. doi: 10.1038/s41467-025-66765-x. PMID: 41429785; PMCID: PMC12722745
Epub:
Not Epub
Abstract:
Intrathecal injection of steric-block antisense oligonucleotides (ASOs) provides therapeutic opportunities for targeting the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12722745/
Delivery Method:
cholesterol-conjugated PMO/RNA heteroduplex; intracerebroventricular (i.c.v.) and intrathecal (i.t.) injection
Organism or Cell Type:
mdx and human SOD1 mice; Sprague–Dawley wild-type rats
Citation Extract:
Yanagidaira M, Nagata T, Hasegawa J, Ishii T, Ebihara S, Nawa M, Yokota T. Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection. Nat Commun. 2025 Dec 22;16(1):10853. doi: 10.1038/s41467-025-66765-x. PMID: 41429785; PMCID: PMC12722745.

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance

Authors:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V
Citation:
bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667
Epub:
Not Epub
Abstract:
Beyond serving as cohesive barriers, epithelial tissues are involved in tissue surveillance and actively clear apoptotic cells...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V. De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance. bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667.

Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms

Authors:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S
Citation:
Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395
Epub:
Not Epub
Abstract:
The proliferation of early erythrocyte and the subsequent maturation are critical events during erythropoiesis, while how these...
Link:
https://www.nature.com/articles/s41420-025-02846-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S. Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms. Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395.

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

Authors:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR
Citation:
Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088
Epub:
Not Epub
Abstract:
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD) whose genetic basis remains elusive,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12698088/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR. Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome. Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088.

Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion

Authors:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA
Citation:
Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366
Epub:
Not Epub
Abstract:
Tuberculous meningitis is unique among bacterial meningitides because it occurs in two temporally separated steps: mycobacteria...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01433-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA. Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion. Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366.

Cohesin protein Smc3 influences kinocilial structure and function

Authors:
Mensching FM, Banoukh N, Iovine MK
Citation:
Biol Open. 2025 Dec 15;14(12):bio062029. doi: 10.1242/bio.062029. Epub 2025 Dec 11. PMID: 41263044
Epub:
Not Epub
Abstract:
Cohesinopathies and ciliopathies are congenital disorders affecting overlapping body systems. The extent to which these...
Link:
https://journals.biologists.com/bio/article/14/12/bio062029/370085/Cohesin-protein-Smc3-influences-kinocilial
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mensching FM, Banoukh N, Iovine MK. Cohesin protein Smc3 influences kinocilial structure and function. Biol Open. 2025 Dec 15;14(12):bio062029. doi: 10.1242/bio.062029. Epub 2025 Dec 11. PMID: 41263044.

Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis

Authors:
Le Friec J, Mourier H, Couly S, Cubedo N, Dubois K, Meunier J, Delprat B, De Zordo-Banliat A, Ayad T, Virieux D, Su TP, Lasbleiz C, Maurice T, Liévens JC
Citation:
Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938
Epub:
Not Epub
Abstract:
Background: Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of motor neurons, leading to muscle weakness...
Link:
https://link.springer.com/article/10.1186/s40035-025-00527-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Le Friec J, Mourier H, Couly S, Cubedo N, Dubois K, Meunier J, Delprat B, De Zordo-Banliat A, Ayad T, Virieux D, Su TP, Lasbleiz C, Maurice T, Liévens JC. Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis. Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938.

A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice

Authors:
Nolte T, Israel S, Drexler HCA, Fuellen G, Boiani M
Citation:
bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802
Epub:
Not Epub
Abstract:
The zona pellucida (ZP) is the quintessential extracellular structure of mammalian oocytes. Contrary to long-standing view that...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.12.692802v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse zygotes from B6C3F1 females mated to CD1 males
Citation Extract:
Nolte T, Israel S, Drexler HCA, Fuellen G, Boiani M. A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice. bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802.

Pages