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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12299 scientific papers returned from the database with the search filters currently being used below.
There are 12299 scientific papers returned from the database with the search filters currently being used below.
A Novel De Novo Missense Variant in Netrin-1 (NTN1) Associated With Chorioretinal Coloboma, Sensorineural Hearing Loss and Polydactyly
Citation:
Clin Genet. 2024 Dec 8. doi: 10.1111/cge.14651. Epub ahead of print. PMID: 39648562 Epub:
Not Epub Abstract:
Microphthalmia, anophthalmia and coloboma (MAC) comprise a highly heterogeneous spectrum of congenital ocular malformations... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Toms M, Heppell C, Owen N, Malka S, Moosajee M; Genomics England Research Consortium. A Novel De Novo Missense Variant in Netrin-1 (NTN1) Associated With Chorioretinal Coloboma, Sensorineural Hearing Loss and Polydactyly. Clin Genet. 2024 Dec 8. doi: 10.1111/cge.14651. Epub ahead of print. PMID: 39648562. |
Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish
Citation:
Adipocyte. 2024 Dec;13(1):2435862. doi: 10.1080/21623945.2024.2435862. Epub 2024 Dec 7. PMID: 39644214; PMCID: PMC11633180 Epub:
Not Epub Abstract:
Obesity is a highly prevalent disorder with complex aetiology. Therefore, studying its associated cellular and molecular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Guggeri L, Sosa-Redaelli I, Cárdenas-Rodríguez M, Alonso M, González G, Naya H, Prieto-Echagüe V, Lepanto P, Badano JL. Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish. Adipocyte. 2024 Dec;13(1):2435862. doi: 10.1080/21623945.2024.2435862. Epub 2024 Dec 7. PMID: 39644214; PMCID: PMC11633180. |
Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma
Citation:
PLoS Genet. 2024 Dec 5;20(12):e1011502. doi: 10.1371/journal.pgen.1011502. PMID: 39637236; PMCID: PMC11651621 Epub:
Not Epub Abstract:
Primary angle closure glaucoma (PACG) affects more than 20 million people worldwide, with an increased prevalence in south-east... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chakraborty S, Sarma J, Roy SS, Mitra S, Bagchi S, Das S, Saha S, Mahapatra S, Bhattacharjee S, Maulik M, Acharya M. Functional investigation suggests CNTNAP5 involvement in glaucomatous neurodegeneration obtained from a GWAS in primary angle closure glaucoma. PLoS Genet. 2024 Dec 5;20(12):e1011502. doi: 10.1371/journal.pgen.1011502. PMID: 39637236; PMCID: PMC11651621. |
Development of a riboflavin-responsive model of riboflavin transporter deficiency in zebrafish
Citation:
Hum Mol Genet. 2025 Feb 1;34(3):265-276. doi: 10.1093/hmg/ddae171. PMID: 39656631 Epub:
Not Epub Abstract:
Riboflavin transporter deficiency (RTD) is a rare and progressive neurodegenerative disease resulting from the disruption of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Choueiri CM, Lau J, O'Connor E, DiBattista A, Wong BY, Spendiff S, Horvath R, Pena I, MacKenzie A, Lochmüller H. Development of a riboflavin-responsive model of riboflavin transporter deficiency in zebrafish. Hum Mol Genet. 2025 Feb 1;34(3):265-276. doi: 10.1093/hmg/ddae171. PMID: 39656631. |
Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation
Citation:
Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337 Epub:
Not Epub Abstract:
Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bowley G, Irving S, Hoefer I, Wilkinson R, Pasterkamp G, Darwish HMS, White S, Francis SE, Chico T, Noel E, Serbanovic-Canic J, Evans PC. Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Sci Rep. 2024 Dec 3;14(1):30130. doi: 10.1038/s41598-024-77370-1. PMID: 39627337. |
Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes
Citation:
EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968 Epub:
Not Epub Abstract:
The microtubule cytoskeleton is a major driving force of neuronal circuit development. Fine-tuned remodelling of this network... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ten Martin D, Jardin N, Vougny J, Giudicelli F, Gasmi L, Berbée N, Henriot V, Lebrun L, Haumaître C, Kneussel M, Nicol X, Janke C, Magiera MM, Hazan J, Fassier C. Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes. EMBO J. 2024 Nov 29. doi: 10.1038/s44318-024-00307-x. Epub ahead of print. PMID: 39613968. |
Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications
Citation:
NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155 Epub:
Not Epub Abstract:
We have subjected several analogs of DNA that have been widely used as antisense oligonucleotide (ASO) inhibitors of gene... Delivery Method:
None Organism or Cell Type:
None Citation Extract: Galindo-Murillo R, Cohen JS, Akabayov B. Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications. NAR Genomics and Bioinformatics. Volume 6, Issue 4. December 2024. lqae155. https://doi.org/10.1093/nargab/lqae155. |
Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos
Citation:
(2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230 Epub:
Not Epub Abstract:
Introduction: Due to the impact of antibody-dependent enhancement and viral variation, effective vaccines or antiviral... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: Vero, HepG2 and A549 Citation Extract: Niu M, Yi W, Dong Z, Li X, Dong X, Yu L, Han Y, Zhang O, Sheng Z, An J, Li H and Sun Y
. Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos. (2024) Front. Immunol. 15:1491230. doi: 10.3389/fimmu.2024.1491230. |
Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients
Citation:
bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028 Epub:
Not Epub Abstract:
Background: VLA-4 is a disease progression biomarker in patients with Duchenne Muscular Dystrophy (DMD) including those treated... Delivery Method:
intravenous (i.v.) Organism or Cell Type:
mdx mice Citation Extract: Padhye AS, Kiriaev L, Tiong C, Gearing LJ, Wilson T, Houweling PJ, Tachas G. Mdx mice dosed with antisense to CD49d and dystrophin exon skip morpholino; reduced force loss and affected gene expression pathways support ATL1102 combination therapy in DMD patients. bioRxiv [preprint] 2024.11.23.625028; doi: https://doi.org/10.1101/2024.11.23.625028. |
Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
Citation:
Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139 Epub:
Not Epub Abstract:
The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of... Delivery Method:
(RXR)4 peptide-linked Organism or Cell Type:
cell culture: Calu-3 Citation Extract: Schwerdtner M, Schmacke LC, Nave J, Limburg H, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells. Viruses. 2024 Nov 20;16(11):1798. doi: 10.3390/v16111798. PMID: 39599912; PMCID: PMC11599139. |