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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11661 scientific papers returned from the database with the search filters currently being used below.

Phosphorylation of adducin-1 by TPX2 promotes interpolar microtubule homeostasis and precise chromosome segregation in mouse oocytes

Authors:
Zhang Y, Fan B, Li X, Tang Y, Shao J, Liu L, Ren Y, Yang Y, Xu B
Citation:
Cell Biosci. 2022 Dec 20;12(1):205. doi: 10.1186/s13578-022-00943-y
Epub:
Not Epub
Abstract:
Background: ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang Y, Fan B, Li X, Tang Y, Shao J, Liu L, Ren Y, Yang Y, Xu B. Phosphorylation of adducin-1 by TPX2 promotes interpolar microtubule homeostasis and precise chromosome segregation in mouse oocytes. Cell Biosci. 2022 Dec 20;12(1):205. doi: 10.1186/s13578-022-00943-y.

Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development

Authors:
Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y, Gu HF
Citation:
Cells. 2022 Dec 7;11(24):3946. doi: 10.3390/cells11243946
Epub:
Not Epub
Abstract:
Folic acid (FA) is a synthetic and highly stable version of folate, while 6S-5-methyltetrahydrofolate is the predominant form...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lian Z, Wu Z, Gu R, Wang Y, Wu C, Cheng Z, He M, Wang Y, Cheng Y, Gu HF. Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development. Cells. 2022 Dec 7;11(24):3946. doi: 10.3390/cells11243946.

Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro

Authors:
Ghosh U, Gupta S, Sinha S
Citation:
Bioconjugate Chem. 2022;[Epub ahead of print] doi:10.1021/acs.bioconjchem.2c00587
Epub:
Yes
Abstract:
Thiol functionalized oligonucleotides are useful intermediates for a wide range of applications including DNA nanobiotechnology...
Delivery Method:
IGT-linked
Organism or Cell Type:
cell culture: MCF7
Citation Extract:
Ghosh U, Gupta S, Sinha S. Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro. Bioconjugate Chem. 2022;[Epub ahead of print] doi:10.1021/acs.bioconjchem.2c00587.

Evi5 is required for Xenopus limb and tail regeneration

Authors:
Yang L, Chen Y, Liu H, Liu Y, Yuan F, Li Q, Lin G
Citation:
Front Cell Dev Biol. 2022;10:1027666. doi:10.3389/fcell.2022.1027666
Epub:
Not Epub
Abstract:
Amphibians such as salamanders and the African clawed frog Xenopus are great models for regeneration studies because they can...
Delivery Method:
microinjection and electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Yang L, Chen Y, Liu H, Liu Y, Yuan F, Li Q, Lin G. Evi5 is required for Xenopus limb and tail regeneration. Front Cell Dev Biol. 2022;10:1027666. doi:10.3389/fcell.2022.1027666.

The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma

Authors:
Taylor W, Deschamps S, Reboutier D, Paillard L, Méreau A, Audic Y
Citation:
Cancer Research Comm. 2022;2(12):1669-83. doi:10.1158/2767-9764.CRC-22-0350
Epub:
Not Epub
Abstract:
The TP63 gene encodes the p63 transcription factor. It is frequently amplified or overexpressed in squamous cell carcinomas....
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Taylor W, Deschamps S, Reboutier D, Paillard L, Méreau A, Audic Y. The Splicing Factor PTBP1 Represses TP63 γ Isoform Production in Squamous Cell Carcinoma. Cancer Research Comm. 2022;2(12):1669-83. doi:10.1158/2767-9764.CRC-22-0350.

AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1--Dicer-1--mir-122 hierarchy

Authors:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M
Citation:
Front Cell Infect Microbiol. 2022;12:1011386. doi:10.3389/fcimb.2022.1011386
Epub:
Not Epub
Abstract:
Introduction and objective: Cholesterol homeostasis is a culmination of cellular synthesis, efflux, and catabolism to important...
Delivery Method:
GMO-PMO i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Das O, Kundu J, Ghosh A, Gautam A, Ghosh S, Chakraborty M, Masid A, Gauri SS, Mitra D, Dutta M, Mukherjee B, Sinha S, Bhaumik M. AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1--Dicer-1--mir-122 hierarchy. Front Cell Infect Microbiol. 2022;12:1011386. doi:10.3389/fcimb.2022.1011386.

Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions

Authors:
Templehof H, Moshe N, Avraham-Davidi I, Yaniv K
Citation:
JCI Insight. 2021 Jul 8;6(13):e130399. doi: 10.1172/jci.insight.130399
Epub:
Not Epub
Abstract:
Apolipoprotein B (ApoB) is the primary protein of chylomicrons, VLDLs, and LDLs and is essential for their production. Defects...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Templehof H, Moshe N, Avraham-Davidi I, Yaniv K. Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. JCI Insight. 2021 Jul 8;6(13):e130399. doi: 10.1172/jci.insight.130399.

Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis

Authors:
Fetsko AR, Sebo DJ, Taylor MR
Citation:
Dev Biol. 2022 Dec 8:S0012-1606(22)00218-4. doi: 10.1016/j.ydbio.2022.11.007. Online ahead of print
Epub:
Yes
Abstract:
During neurovascular development, brain endothelial cells (BECs) respond to secreted signals from the neuroectoderm that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fetsko AR, Sebo DJ, Taylor MR. Brain endothelial cells acquire blood-brain barrier properties in the absence of Vegf-dependent CNS angiogenesis. Dev Biol. 2022 Dec 8:S0012-1606(22)00218-4. doi: 10.1016/j.ydbio.2022.11.007. Online ahead of print.

Anp32a Promotes Neuronal Regeneration after Spinal Cord Injury of Zebrafish Embryos

Authors:
Lee H-C, Lai W-L, Lin C-Y, Zeng C-W, Sheu J-C, Chou T-B, Tsai H-J.
Citation:
Int J Mol Sci. 2022; 23(24):15921. doi:10.3390/ijms232415921
Epub:
Not Epub
Abstract:
After spinal cord injury (SCI) in mammals, neuronal regeneration is limited; in contrast, such regeneration occurs quickly in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee H-C, Lai W-L, Lin C-Y, Zeng C-W, Sheu J-C, Chou T-B, Tsai H-J.. Anp32a Promotes Neuronal Regeneration after Spinal Cord Injury of Zebrafish Embryos. Int J Mol Sci. 2022; 23(24):15921. doi:10.3390/ijms232415921.

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects

Authors:
Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK
Citation:
Nucleic Acids Res. 2022;gkac1108 doi:10.1093/nar/gkac1108
Epub:
Yes
Abstract:
Friedreich’s ataxia is an incurable disease caused by frataxin (FXN) protein deficiency, which is mostly induced by GAA repeat...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: 293T
Citation Extract:
Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Res. 2022;gkac1108 doi:10.1093/nar/gkac1108.

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