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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11495 scientific papers returned from the database with the search filters currently being used below.

MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis

Authors:
Gan J, Liu S, Zhang Y, He L, Bai L, Liao R, Zhao J, Guo M, Jiang W, Li J, Li Q, Mu G, Wu Y, Wang X, Zhang X, Zhou D, Lv H, Wang Z, Zhang Y, Qian C, Feng M, Chen H, Meng Q, Huang X
Citation:
Exp Mol Med. 2022 Aug;54(8):1290-1305. doi: 10.1038/s12276-022-00837-6. Epub 2022 Aug 30
Epub:
Not Epub
Abstract:
The functional role of microRNA-375 (miR-375) in the development of prostate cancer (PCa) remains controversial. Previously, we...
Delivery Method:
exosomes
Organism or Cell Type:
mice BALB/c
Citation Extract:
Gan J, Liu S, Zhang Y, He L, Bai L, Liao R, Zhao J, Guo M, Jiang W, Li J, Li Q, Mu G, Wu Y, Wang X, Zhang X, Zhou D, Lv H, Wang Z, Zhang Y, Qian C, Feng M, Chen H, Meng Q, Huang X. MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis. Exp Mol Med. 2022 Aug;54(8):1290-1305. doi: 10.1038/s12276-022-00837-6. Epub 2022 Aug 30.

A lysosomal regulatory circuit essential for the development and function of microglia

Authors:
Iyer H, Shen K, Meireles AM, Talbot WS
Citation:
Sci Adv. 2022 Sep 2;8(35):eabp8321. doi: 10.1126/sciadv.abp8321. Epub 2022 Aug 31
Epub:
Not Epub
Abstract:
As the primary phagocytic cells of the central nervous system, microglia exquisitely regulate their lysosomal activity to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Iyer H, Shen K, Meireles AM, Talbot WS. A lysosomal regulatory circuit essential for the development and function of microglia. Sci Adv. 2022 Sep 2;8(35):eabp8321. doi: 10.1126/sciadv.abp8321. Epub 2022 Aug 31.

Optical Control of MicroRNA Function in Zebrafish Embryos

Authors:
Brown W, Bardhan A, Darrah K, Tsang M, Deiters A
Citation:
J Am Chem Soc. 2022 Sep 8. doi: 10.1021/jacs.2c04479. Online ahead of print
Epub:
Yes
Abstract:
MicroRNAs play crucial and dynamic roles in vertebrate development and diseases. Some, like miR-430, are highly expressed...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brown W, Bardhan A, Darrah K, Tsang M, Deiters A. Optical Control of MicroRNA Function in Zebrafish Embryos. J Am Chem Soc. 2022 Sep 8. doi: 10.1021/jacs.2c04479. Online ahead of print.

Hemifacial microsomia is linked a rare homozygous variant V162I in FRK and validated in zebrafish

Authors:
Xiong J, Wang X, Fan C, Yan J, Zhu J, Cai T
Citation:
Oral Dis. 2022 Sep 7. doi: 10.1111/odi.14372. Online ahead of print
Epub:
Yes
Abstract:
Objectives: Hemifacial microsomia (HFM) is a common birth defect involving the first and second branchial arch derivatives....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiong J, Wang X, Fan C, Yan J, Zhu J, Cai T . Hemifacial microsomia is linked a rare homozygous variant V162I in FRK and validated in zebrafish. Oral Dis. 2022 Sep 7. doi: 10.1111/odi.14372. Online ahead of print.

Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing

Authors:
Pattanayak S, Sarode BR, Deiters A, Chen JK
Citation:
Chembiochem. 2022 Sep 6. doi: 10.1002/cbic.202200374. Online ahead of print
Epub:
Not Epub
Abstract:
Caged morpholino oligonucleotides (cMOs) are synthetic tools that allow light-inducible gene silencing in live organisms....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pattanayak S, Sarode BR, Deiters A, Chen JK. Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing. Chembiochem. 2022 Sep 6. doi: 10.1002/cbic.202200374. Online ahead of print.

[Construction of zebrafish models for screening intracranial hemorrhage associated genes]

Authors:
Yan SY, Zhang XR, Zhang RJ, Ma L, Li H, He M, Wu C, Xiao AQ, You C, Liu Y, Wang YQ, Tian R
Citation:
Zhonghua Yi Xue Za Zhi. 2022 Sep 6;102(33):2619-2623. doi:10.3760/cma.j.cn112137-20211206-02713
Epub:
Not Epub
Abstract:
Objective: To construct zebrafish models for the screening of intracranial hemorrhage (ICH) associated genes. Methods: ICH...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan SY, Zhang XR, Zhang RJ, Ma L, Li H, He M, Wu C, Xiao AQ, You C, Liu Y, Wang YQ, Tian R. [Construction of zebrafish models for screening intracranial hemorrhage associated genes]. Zhonghua Yi Xue Za Zhi. 2022 Sep 6;102(33):2619-2623. doi:10.3760/cma.j.cn112137-20211206-02713.

Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly

Authors:
Cao Y, Zhu X, Zhen P, Tian Y, Ji D, Xue K, Yan W, Chai J, Liu H, Wang W
Citation:
Cell Prolif. 2022 Aug 19:e13322. doi: 10.1111/cpr.13322. Online ahead of print
Epub:
Yes
Abstract:
Objectives: Poor oocyte quality is detrimental to fertilization and embryo development, which causes infertility. Cystathionine...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Cao Y, Zhu X, Zhen P, Tian Y, Ji D, Xue K, Yan W, Chai J, Liu H, Wang W. Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly. Cell Prolif. 2022 Aug 19:e13322. doi: 10.1111/cpr.13322. Online ahead of print.

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Authors:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.08.25.505359
Epub:
Not Epub
Abstract:
Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through homeostatic mechanisms...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK. A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. bioRxiv. 2022;[preprint] doi:10.1101/2022.08.25.505359.

Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

Authors:
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B
Citation:
Nat Commun. 2022;13,5062. doi:10.1038/s41467-022-32477-9
Epub:
Not Epub
Abstract:
A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression. Nat Commun. 2022;13,5062. doi:10.1038/s41467-022-32477-9.

Pannexin 1 drives efficient epithelial repair after tissue injury

Authors:
Lucas CD, Medina CB, Bruton FA, Dorward DA, Raymond MH, Tufan T, Etchegaray JI, Barron B, Oremek MEM, Arandjelovic S, Farber E, Onngut-Gumuscu S, Ke E, Whyte MKB, Rossi AG, Ravichandran KS
Citation:
Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13
Epub:
Not Epub
Abstract:
Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lucas CD, Medina CB, Bruton FA, Dorward DA, Raymond MH, Tufan T, Etchegaray JI, Barron B, Oremek MEM, Arandjelovic S, Farber E, Onngut-Gumuscu S, Ke E, Whyte MKB, Rossi AG, Ravichandran KS. Pannexin 1 drives efficient epithelial repair after tissue injury. Sci Immunol. 2022 May 13;7(71):eabm4032. doi: 10.1126/sciimmunol.abm4032. Epub 2022 May 13.

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