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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11761 scientific papers returned from the database with the search filters currently being used below.

Alternative splicing of its 5' untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Authors:
Ang Z, Hayer KE, Diz MT, Schmidt C, Zheng S, Xu F, Falkenstein CD, Loftus JP, Yang SY, Asnani M, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Schuster SJ, Thomas-Tikhonenko A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123
Epub:
Not Epub
Abstract:
CD20-directed immunotherapies, such as rituximab, are mainstays of clinical management of mature B-cell neoplasms, previously...
Link:
https://www.biorxiv.org/content/10.1101/2023.02.19.529123v1
Delivery Method:
electroporation of standard Morpholino; Vivo-Morpholino
Organism or Cell Type:
cell culture: OCI-Ly8, Raji and MEC-1
Citation Extract:
Ang Z, Hayer KE, Diz MT, Schmidt C, Zheng S, Xu F, Falkenstein CD, Loftus JP, Yang SY, Asnani M, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Schuster SJ, Thomas-Tikhonenko A. Alternative splicing of its 5' untranslated region controls CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123.

Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney

Authors:
Wesselman HM, Gatz AE, Pfaff MR, Arceri L, Wingert RA
Citation:
Cells. 2023 Feb 20;12(4):666. doi:10.3390/cells12040666
Epub:
Not Epub
Abstract:
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and...
Link:
https://www.mdpi.com/2073-4409/12/4/666
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wesselman HM, Gatz AE, Pfaff MR, Arceri L, Wingert RA. Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 2023 Feb 20;12(4):666. doi:10.3390/cells12040666.

USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling

Authors:
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E
Citation:
Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7
Epub:
Not Epub
Abstract:
The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt...
Link:
https://www.science.org/doi/10.1126/scisignal.abn8372
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E. USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7.

FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18

Authors:
Ulhaq ZS, Ogino Y, Tse WKF
Citation:
Biochem Biophys Res Commun. 2023 Feb 19;652:76-83. doi: 10.1016/j.bbrc.2023.02.046. Online ahead of print
Epub:
Not Epub
Abstract:
Variants in the gene encoding trafficking protein particle complex 11 (TRAPPC11) cause limb-girdle muscular dystrophy R18 (LGMD...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X23002206
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS, Ogino Y, Tse WKF. FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochem Biophys Res Commun. 2023 Feb 19;652:76-83. doi: 10.1016/j.bbrc.2023.02.046. Online ahead of print.

TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease

Authors:
Van Haute L, O'Connor E, Díaz-Maldonado H, Munro B, Polavarapu K, Hock DH, Arunachal G, Athanasiou-Fragkouli A, Bardhan M, Barth M, Bonneau D, Brunetti-Pierri N, Cappuccio G, Caruana NJ, Dominik N, Goel H, Helman G, Houlden H, Lenaers G, Mention K, Murphy D, Nandeesh B, Olimpio C, Powell CA, Preethish-Kumar V, Procaccio V, Rius R, Rebelo-Guiomar P, Simons C, Vengalil S, Zaki MS, Ziegler A, Thorburn DR, Stroud DA, Maroofian R, Christodoulou J, Gustafsson C, Nalini A, Lochmüller H, Minczuk M, Horvath R
Citation:
Nat Commun. 2023 Feb 23;14(1):1009. doi: 10.1038/s41467-023-36277-7
Epub:
Not Epub
Abstract:
Mutations in the mitochondrial or nuclear genomes are associated with a diverse group of human disorders characterized by...
Link:
https://www.nature.com/articles/s41467-023-36277-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Van Haute L, O'Connor E, Díaz-Maldonado H, Munro B, Polavarapu K, Hock DH, Arunachal G, Athanasiou-Fragkouli A, Bardhan M, Barth M, Bonneau D, Brunetti-Pierri N, Cappuccio G, Caruana NJ, Dominik N, Goel H, Helman G, Houlden H, Lenaers G, Mention K, Murphy D, Nandeesh B, Olimpio C, Powell CA, Preethish-Kumar V, Procaccio V, Rius R, Rebelo-Guiomar P, Simons C, Vengalil S, Zaki MS, Ziegler A, Thorburn DR, Stroud DA, Maroofian R, Christodoulou J, Gustafsson C, Nalini A, Lochmüller H, Minczuk M, Horvath R. TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nat Commun. 2023 Feb 23;14(1):1009. doi: 10.1038/s41467-023-36277-7.

Neurogenin 2 and Neuronal Differentiation 1 Control Proper Development of the Chick Trigeminal Ganglion and Its Nerve Branches

Authors:
Bina P, Hines MA, Sanyal J, Taneyhill LA
Citation:
J Dev Biol. 2023 Feb 19;11(1):8. doi: 10.3390/jdb11010008
Epub:
Not Epub
Abstract:
The trigeminal ganglion contains the cell bodies of sensory neurons comprising cranial nerve V, which relays information...
Link:
https://www.mdpi.com/2221-3759/11/1/8
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Bina P, Hines MA, Sanyal J, Taneyhill LA. Neurogenin 2 and Neuronal Differentiation 1 Control Proper Development of the Chick Trigeminal Ganglion and Its Nerve Branches. J Dev Biol. 2023 Feb 19;11(1):8. doi: 10.3390/jdb11010008.

Synthesis of Chlorophosphoramidate Monomer Morpholinos and PMOs

Authors:
Kundu J, Ghosh U, Ghosh A, Pattanayak S, Das A, Sinha S
Citation:
Curr Protoc. 2023 Feb;3(2):e686. doi: 10.1002/cpz1.686
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a successful class of antisense reagents that efficiently modulate...
Link:
https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.686
Citation Extract:
Kundu J, Ghosh U, Ghosh A, Pattanayak S, Das A, Sinha S. Synthesis of Chlorophosphoramidate Monomer Morpholinos and PMOs. Curr Protoc. 2023 Feb;3(2):e686. doi: 10.1002/cpz1.686.

p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling

Authors:
Kundu D, Kennedy L, Zhou T, Ekser B, Meadows V, Sybenga A, Kyritsi K, Chen L, Ceci L, Wu N, Wu C, Glaser S, Carpino G, Onori P, Gaudio E, Alpini G, Francis H
Citation:
Hepatology. 2023 Feb 20. doi: 10.1097/HEP.0000000000000307. Online ahead of print
Epub:
Yes
Abstract:
Backgroundand aim: Non-alcoholic fatty liver disease (NAFLD) is characterized by steatosis, hepatic inflammation, and fibrosis...
Link:
https://journals.lww.com/hep/Abstract/9900/p16_INK4A_drives_non_alcoholic_fatty_liver_disease.303.aspx
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kundu D, Kennedy L, Zhou T, Ekser B, Meadows V, Sybenga A, Kyritsi K, Chen L, Ceci L, Wu N, Wu C, Glaser S, Carpino G, Onori P, Gaudio E, Alpini G, Francis H. p16 INK4A drives non-alcoholic fatty liver disease phenotypes in high fat diet fed mice via biliary e2f1/foxo1/igf-1 signaling. Hepatology. 2023 Feb 20. doi: 10.1097/HEP.0000000000000307. Online ahead of print.

Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome

Authors:
Christiansen MK, Kjær-Sørensen K, Clavsen NC, Dittmann S, Jensen MF, Guldbrandsen HØ, Pedersen LN, Sørensen RH, Lildballe DL, Müller K, Müller P, Vogel K, Rudic B, Borggrefe M, Oxvig C, Aalkjær C, Schulze-Bahr E, Matchkov V, Bundgaard H, Jensen Henrik K
Citation:
Heart Rhythm. 2023;[Epub] doi:10.1016/j.hrthm.2023.02.010
Epub:
Yes
Abstract:
Background: A variant in the SLC4A3 anion exchanger has been identified as a novel cause of short QT syndrome (SQTS), but the...
Link:
https://www.heartrhythmjournal.com/article/S1547-5271(23)00148-0/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Christiansen MK, Kjær-Sørensen K, Clavsen NC, Dittmann S, Jensen MF, Guldbrandsen HØ, Pedersen LN, Sørensen RH, Lildballe DL, Müller K, Müller P, Vogel K, Rudic B, Borggrefe M, Oxvig C, Aalkjær C, Schulze-Bahr E, Matchkov V, Bundgaard H, Jensen Henrik K. Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome. Heart Rhythm. 2023;[Epub] doi:10.1016/j.hrthm.2023.02.010.

Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone

Authors:
Babonis LS, Enjolras C, Reft AJ, Foster BM, Hugosson F, Ryan JF, Daly M, Martindale MQ
Citation:
Nat Commun. 2023;14:885. doi:10.1038/s41467-023-36615-9
Epub:
Not Epub
Abstract:
Cnidocytes are the explosive stinging cells unique to cnidarians (corals, jellyfish, etc). Specialized for prey capture and...
Link:
https://www.nature.com/articles/s41467-023-36615-9
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Babonis LS, Enjolras C, Reft AJ, Foster BM, Hugosson F, Ryan JF, Daly M, Martindale MQ. Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone. Nat Commun. 2023;14:885. doi:10.1038/s41467-023-36615-9.

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