You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
|
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046 Epub:
Not Epub Abstract:
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046. |
Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice
|
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012 Epub:
Not Epub Abstract:
Oligonucleotide therapeutics are an established class of drugs for the treatment of genetic disorders. Their clinical... Delivery Method:
heteroduplex oligonucleotide (HDO) platform Organism or Cell Type:
cell culture: SMA Type II patient fibroblasts, hSMN2 mouse Citation Extract: Halloy F, Ahlskog N, Wood M. Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012. |
Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae
|
Citation:
Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001 Epub:
Not Epub Abstract:
Calcium binding proteins are essential for neural development and cellular activity. Calretinin, encoded by calb2a and calb2b,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H. Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae. Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001. |
An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo
|
Citation:
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print Epub:
Yes Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice Citation Extract: Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print. |
Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring
|
Citation:
Cells. 2024;13:214. doi:10.3390/cells13030214 Epub:
Not Epub Abstract:
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes Hyperhomocysteinemia (HHcy), a metabolic disorder... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chatterje B, Fatima F, Seth S, Sinha Roy S. Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 2024;13:214. doi:10.3390/cells13030214. |
TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish
|
Citation:
Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240 Epub:
Yes Abstract:
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L. TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish. Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240. |
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
|
Citation:
Cell Biol Toxicol. 2024 Jan 22;40(1):2. doi: 10.1007/s10565-024-09847-8 Epub:
Not Epub Abstract:
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jing Y, Luo Y, Li L, Liu M, Liu JX. Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell Biol Toxicol. 2024 Jan 22;40(1):2. doi: 10.1007/s10565-024-09847-8. |
The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio
|
Citation:
Mol Gen Microbiol Virol. 2024;38:143-9. doi:10.3103/S0891416823030059 Epub:
Not Epub Abstract:
The Annexin 2 protein (ANXA2) encoded by the ANXA2 gene performs a number of biological functions that are primarily related to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Partevian SA, Safina DR, Rudenok MM, Rybolovlev IN, Semenova EI, Shadrina MI, Slominsky PA, Kostrov SV, Alieva AKh. The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio. Mol Gen Microbiol Virol. 2024;38:143-9. doi:10.3103/S0891416823030059. |
Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling
|
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.15.575806 Epub:
Not Epub Abstract:
SLC13A5 encodes a citrate transporter highly expressed in the brain important for regulating intra- and extracellular citrate... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dogra D, Phan VA, Gavrilovici C, DiMarzo N, Ibhazehiebo K, Kurrasch DM. Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.15.575806. |
Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production
|
Citation:
Zool Res. 2024 Jan 18;45(1):176-188. doi: 10.24272/j.issn.2095-8137.2023.032 Epub:
Not Epub Abstract:
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (22:6n-3, DHA), play crucial roles in the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li Y, Li X, Ye D, Zhang R, Liu C, He M, Wang H, Hu W, Sun Y. Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zool Res. 2024 Jan 18;45(1):176-188. doi: 10.24272/j.issn.2095-8137.2023.032. |