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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12299 scientific papers returned from the database with the search filters currently being used below.

Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects

Authors:
de Calbiac H, Renault S, Haouy G, Jung V, Roger K, Zhou Q, Campanari ML, Chentout L, Demy DL, Marian A, Goudin N, Edbauer D, Guerrera C, Ciura S, Kabashi E
Citation:
Autophagy. 2024 Oct;20(10):2164-2185. doi: 10.1080/15548627.2024.2358736. Epub 2024 Sep 24. PMID: 39316747; PMCID: PMC11423671
Epub:
Not Epub
Abstract:
degeneration. C9orf72 HRE is associated with lowered levels of C9orf72 expression and its translation results in the production...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Renault S, Haouy G, Jung V, Roger K, Zhou Q, Campanari ML, Chentout L, Demy DL, Marian A, Goudin N, Edbauer D, Guerrera C, Ciura S, Kabashi E. Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects. Autophagy. 2024 Oct;20(10):2164-2185. doi: 10.1080/15548627.2024.2358736. Epub 2024 Sep 24. PMID: 39316747; PMCID: PMC11423671.

Tau accumulation is cleared by the induced expression of VCP via autophagy

Authors:
Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS
Citation:
Acta Neuropathol. 2024 Sep 24;148(1):46. doi: 10.1007/s00401-024-02804-z. PMID: 39316141; PMCID: PMC11422276
Epub:
Not Epub
Abstract:
Tauopathy, including frontotemporal lobar dementia and Alzheimer's disease, describes a class of neurodegenerative...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24;148(1):46. doi: 10.1007/s00401-024-02804-z. PMID: 39316141; PMCID: PMC11422276.

Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool

Authors:
Meader E, Walcheck MT, Leder MR, Jing R, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim S-E, Daley GQ, Goessling W, North TE
Citation:
bioRxiv [preprint] 2024.09.23.614531; doi: https://doi.org/10.1101/2024.09.23.614531
Epub:
Not Epub
Abstract:
Embryonic hematopoietic stem and progenitor cells (HSPCs) have the unique ability to undergo rapid proliferation while...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Meader E, Walcheck MT, Leder MR, Jing R, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim S-E, Daley GQ, Goessling W, North TE. Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool. bioRxiv [preprint] 2024.09.23.614531; doi: https://doi.org/10.1101/2024.09.23.614531.

Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model

Authors:
Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Sasaki A, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata K, Sakaue F, Yokota T
Citation:
Nat Commun. 2024 Sep 26;15(1):7530. doi: 10.1038/s41467-024-48204-5. PMID: 39327422; PMCID: PMC11427662
Epub:
Not Epub
Abstract:
The approval of splice-switching oligonucleotides with phosphorodiamidate morpholino oligomers (PMOs) for treating Duchenne...
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Sasaki A, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata K, Sakaue F, Yokota T. Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nat Commun. 2024 Sep 26;15(1):7530. doi: 10.1038/s41467-024-48204-5. PMID: 39327422; PMCID: PMC11427662.

The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae

Authors:
Yu T, Chen M, Wen J, Liu J, Li K, Jin L, Yue J, Yang Z, Xi J
Citation:
Bone. 2024 Dec;189:117261. doi: 10.1016/j.bone.2024.117261. Epub 2024 Sep 18. PMID: 39303930
Epub:
Not Epub
Abstract:
Glucocorticoids (GCs) are extensively used as anti-inflammatory and immunosuppressive medications in the long-term treatment of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu T, Chen M, Wen J, Liu J, Li K, Jin L, Yue J, Yang Z, Xi J. The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 2024 Dec;189:117261. doi: 10.1016/j.bone.2024.117261. Epub 2024 Sep 18. PMID: 39303930.

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

Authors:
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K
Citation:
Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577
Epub:
Not Epub
Abstract:
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K. TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival. Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577.

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Authors:
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B
Citation:
Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906
Epub:
Not Epub
Abstract:
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as...
Delivery Method:
Vivo-Morpholino; intraperitoneal
Organism or Cell Type:
C57BL/6 mice
Citation Extract:
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906.

TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio)

Authors:
Li K, Qi Z, Xie Z, Li W, Yang X, Zhai Y, Zhou X, Xie X, Song W
Citation:
J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633
Epub:
Not Epub
Abstract:
Tris (2,6-dimethylphenyl) phosphate (TDMPP), a novel organic phosphorus flame retardant (OPFR), has been found to have...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li K, Qi Z, Xie Z, Li W, Yang X, Zhai Y, Zhou X, Xie X, Song W. TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio). J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633.

Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy

Authors:
Wells JR, Padua MB, Haaning AM, Smith AM, Morris SA, Tariq M, Ware SM
Citation:
HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249
Epub:
Not Epub
Abstract:
Heterotaxy is a disorder characterized by severe congenital heart defects (CHDs) and abnormal left-right patterning in other...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wells JR, Padua MB, Haaning AM, Smith AM, Morris SA, Tariq M, Ware SM. Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy. HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249.

p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

Authors:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R
Citation:
Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711
Epub:
Not Epub
Abstract:
Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R. p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711.

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