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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility
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Citation:
bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642 Epub:
Not Epub Abstract:
The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: McCluskey KE, Stovell KM, Law K, Kostyanovskaya E, Schmidt J, Exner CRT, Dea J, Brimble E, State MW, Willsey J, Willsey HR. Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility. bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642. |
Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector
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Citation:
Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249 Epub:
Not Epub Abstract:
We previously reported high CD46 expression in prostate cancer and developed an antibody-drug conjugate and immunoPET agent... Delivery Method:
antibody-conjugate; in vivo: intravenous Organism or Cell Type:
LS174T cells; Swiss NIH nude mice explant Citation Extract: Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249. |
Nkd1 functions downstream of Axin2 to attenuate Wnt signaling
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Citation:
Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801 Epub:
Not Epub Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem-cell maintenance in adults and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801. |
Comparing cell penetration of biotherapeutics across human cell lines
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Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257 Epub:
Not Epub Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS, MIA PaCa-2, HEK293-T, BxPC-3, HepG2 Citation Extract: Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257. |
Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice
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Citation:
International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113 Epub:
Not Epub Abstract:
Periostin, a multifunctional 90 kDa protein, plays a pivotal role in the pathogenesis of fibrosis across various tissues,... Delivery Method:
intraperitoneal Vivo-Morpholino in vivo, Endo-Porter in culture Organism or Cell Type:
mouse skeletal muscle fibroblast cells; D2-mdx and Dba-2J mice Citation Extract: Trundle J, Lu-Nguyen N, Malerba A, Popplewell L. Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice. International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113. |
Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint
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Citation:
bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554 Epub:
Not Epub Abstract:
Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li W, McCurdy S, Lopez-Ramirez MA, Lee HS. Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint. bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554. |
Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide
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Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176 Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)... Delivery Method:
BBB-penetrating peptide-linked Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice Citation Extract: Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176. |
N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation
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Citation:
bioRxiv preprint; 2024.05.20.594965; doi.org/10.1101/2024.05.20.594965 Epub:
Not Epub Abstract:
During the development of the sensory nervous system, various cell types converge to form different tissues. The trigeminal... Delivery Method:
electroporation Organism or Cell Type:
chick embryo Citation Extract: Halmi C, McIntosh A, Leonard CE, Taneyhill LA. N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation. bioRxiv preprint; 2024.05.20.594965; doi.org/10.1101/2024.05.20.594965. |
Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells
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Citation:
eLife 12:RP91429. Epub:
Not Epub Abstract:
Hematopoietic stem cells emerge in the embryo from an aortic-derived tissue called the hemogenic endothelium (HE). The HE... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Torcq L, Majello S, Vivier C, Schmidt AA. Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells. eLife 12:RP91429.. |
Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors
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Citation:
Drug Deliv Transl Res. 2024 May 27. doi: 10.1007/s13346-024-01629-3. Online ahead of print. Epub:
Not Epub Abstract:
This study explores the efficacy of human serum albumin (HSA)-based Drug-Free Macromolecular Therapeutics (DFMT) in treating... Delivery Method:
Fab-linked Organism or Cell Type:
Human non-Hodgkin's lymphoma xenograft mice Citation Extract: Li J, Gambles MT, Jones B, Williams JA, Camp NJ, Shami PJ, Yang J, Kopeček J. Human serum albumin-based drug-free macromolecular therapeutics induce apoptosis in chronic lymphocytic leukemia patient cells by crosslinking of CD20 and/or CD38 receptors. Drug Deliv Transl Res. 2024 May 27. doi: 10.1007/s13346-024-01629-3. Online ahead of print.. |