You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12347 scientific papers returned from the database with the search filters currently being used below.
There are 12347 scientific papers returned from the database with the search filters currently being used below.
Second generation lethality in RNAseH2a knockout zebrafish
|
Citation:
Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725 Epub:
Not Epub Abstract:
Removal of ribonucleotides from DNA by RNaseH2 is essential for genome stability, and its impacted function causes the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF, van Eeden FJ
. Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725. |
Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona
|
Citation:
(2024) eLife [preprint] 13:RP99825 Epub:
Not Epub Abstract:
Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via its adhesive organ. The... Delivery Method:
microinjection Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian) Citation Extract: Hozumi A, Totsuka NM, Onodera A, Wang Y, Hamada M, Shiraishi A, Satake H, Horie T, Hotta K, Sasakura Y. Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona. (2024) eLife [preprint] 13:RP99825. |
Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons
|
Citation:
bioRxiv [preprint] 2024.08.30.610519; doi: https://doi.org/10.1101/2024.08.30.610519 Epub:
Not Epub Abstract:
Deregulated proliferation of a plasma cell (PC) clone is accompanied by an excess production of a monoclonal immunoglobulin (mo... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: SK-MM-2 & RPMI 8226 Citation Extract: Lambert JM, Praité A, Contini M, Omar Ashi M, Marchalot A, Le Pennec S, Sirac C, Al Hayek A, Delpy L. Selective killing of plasma cell clones using splice-switching oligonucleotides targeting immunoglobulin variable exons. bioRxiv [preprint] 2024.08.30.610519; doi: https://doi.org/10.1101/2024.08.30.610519. |
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming
|
Citation:
Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079 Epub:
Not Epub Abstract:
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C. 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079. |
Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry
|
Citation:
J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635 Epub:
Not Epub Abstract:
Sequencing of phosphorodiamidate morpholino oligomers (PMOs) by hydrophilic interaction chromatography (HILIC) coupled to... Citation Extract: Wang M, O'Day B, Michaels B, Jurayj J, Cai BZ, Wei T. Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635. |
Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development
|
Citation:
J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837 Epub:
Not Epub Abstract:
Antibody–oligonucleotide conjugates (AOCs) are promising treatments for Duchenne muscular dystrophy (DMD). They work via... Delivery Method:
antibody-linked; intravenous (i.v.) Organism or Cell Type:
mice: ICR, C57BL/6, C57BL/10ScSn-Dmdmdx/J, C57BL/10ScSnJ Citation Extract: Cochran M, Marks I, Albin T, Arias D, Kovach P, Darimont B, Huang H, Etxaniz U, Kwon HW, Shi Y, Diaz M, Tyaglo O, Levin A, Doppalapudi VR. Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development. J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837. |
Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response
|
Citation:
bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547 Epub:
Not Epub Abstract:
Oncogenic driver mutations are frequently found in normal tissues, suggesting that additional non-genetic factors are required... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Elliot AM, Ribeiro Bravo I, Astorga Johansson J, Hutton E, Cunningham R, Myllymaki H, Chang KY, Cholewa-Waclaw J, Zhao Y, Dobie R, Beltran M, Lewis A, Elks P, Hansen CG, Henderson N, Feng Y. Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response. bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547. |
Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model
|
Citation:
Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515 Epub:
Not Epub Abstract:
CHD2-related epilepsy is characterized by early-onset photosensitive myoclonic epilepsy with developmental delay and a high... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Melikishvili G, Striano P, Shojeinia E, Gachechiladze T, Kurua E, Tabatadze N, Melikishvili M, Koniashvili O, Khachiashvili G, Epitashvili N, Rimma G, Belyaev O, Tomenko T, Kharytonov V, Guliyeva U, Esguerra CV, Crawford AD, Dulac O. Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model. Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515. |
Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis
|
Citation:
Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038 Epub:
Not Epub Abstract:
Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Caetano da Silva C, Macias Trevino C, Mitchell J, Murali H, Tsimbal C, Dalessandro E, Carroll SH, Kochhar S, Curtis SW, Cheng CHE, Wang F, Kutschera E, Carstens RP, Xing Y, Wang K, Leslie EJ, Liao EC. Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038. |
mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish
|
Citation:
Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011 Epub:
Not Epub Abstract:
Mammalian target of rapamycin (mTOR) serves as the key sensor to control protein synthesis, cell growth, and survival. Despite... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Huang W, Yue Y, Hao W, Zhang Z, Cai P, Yang D. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011. |