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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12347 scientific papers returned from the database with the search filters currently being used below.

p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

Authors:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R
Citation:
Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711
Epub:
Not Epub
Abstract:
Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal...
Link:
https://www.nature.com/articles/s41467-024-51922-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R. p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711.

Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response

Authors:
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L
Citation:
Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062
Epub:
Not Epub
Abstract:
Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01070-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L. Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response. Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062.

Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage

Authors:
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M
Citation:
Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572
Epub:
Not Epub
Abstract:
The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired...
Link:
https://www.nature.com/articles/s41419-024-07042-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M. Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572.

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

Authors:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T
Citation:
bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312
Epub:
Not Epub
Abstract:
Body axis specification is a crucial event in animal embryogenesis and was an essential evolutionary innovation for founding...
Link:
https://www.biorxiv.org/content/10.1101/2024.09.05.609312v1
Delivery Method:
microinjection
Organism or Cell Type:
Clytia hemisphaerica
Citation Extract:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T. Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution. bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312.

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

Authors:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331
Epub:
Not Epub
Abstract:
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00218-X
Delivery Method:
peptide-linked; intranasal and intratracheal
Organism or Cell Type:
cell culture: Hela-ACE2; mice: K18-hACE2
Citation Extract:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA. Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331.

Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice

Authors:
Banerjee A & Chatterji U
Citation:
Chemosphere. 2024 Sep 6:143293. doi: 10.1016/j.chemosphere.2024.143293. Online ahead of print. PMID: 39245217
Epub:
Not Epub
Abstract:
Severe toxic effects of arsenic on human physiology have been of immense concern worldwide. Arsenic causes irrevocable...
Link:
https://www.sciencedirect.com/science/article/pii/S004565352402191X
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Banerjee A & Chatterji U. Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice. Chemosphere. 2024 Sep 6:143293. doi: 10.1016/j.chemosphere.2024.143293. Online ahead of print. PMID: 39245217.

Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

Authors:
Cheng T, Liu X, Dong Y, Tian Y-M, Xing Y-Y, Chen C-Y, Liu C, Li Y-F, Huang Y, Zhuo D-H, Xu X, Luan J-Y, Fu X-X, Jin Z-X, Mo J, Xu X, Liang H-Q, Xu P-F
Citation:
(2024) eLife [preprint] 13:RP100200
Epub:
Not Epub
Abstract:
During gastrulation, the mesendoderm is firstly specified by morphogens such as Nodal, and then segregates into endoderm and...
Link:
https://elifesciences.org/reviewed-preprints/100200
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng T, Liu X, Dong Y, Tian Y-M, Xing Y-Y, Chen C-Y, Liu C, Li Y-F, Huang Y, Zhuo D-H, Xu X, Luan J-Y, Fu X-X, Jin Z-X, Mo J, Xu X, Liang H-Q, Xu P-F. Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors. (2024) eLife [preprint] 13:RP100200.

A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos

Authors:
Oda I & Satou Y
Citation:
bioRxiv [preprint] 2024.08.27.610013; doi: https://doi.org/10.1101/2024.08.27.610013
Epub:
Not Epub
Abstract:
Ascidian larval muscle cells present a classic example of autonomous development. A regulatory mechanism for these cells has...
Link:
https://www.biorxiv.org/content/10.1101/2024.08.27.610013v1
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian)
Citation Extract:
Oda I & Satou Y. A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos. bioRxiv [preprint] 2024.08.27.610013; doi: https://doi.org/10.1101/2024.08.27.610013.

Phase I/II Trial of Brogidirsen: Dual-Targeting Antisense Oligonucleotides for Exon 44 Skipping in Duchenne Muscular Dystrophy

Authors:
Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y
Citation:
medRxiv [preprint] 2024.08.28.24312624; doi: https://doi.org/10.1101/2024.08.28.24312624
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle disorder caused by mutations in the DMD gene, resulting in dystrophin loss...
Link:
https://www.medrxiv.org/content/10.1101/2024.08.28.24312624v1
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y . Phase I/II Trial of Brogidirsen: Dual-Targeting Antisense Oligonucleotides for Exon 44 Skipping in Duchenne Muscular Dystrophy. medRxiv [preprint] 2024.08.28.24312624; doi: https://doi.org/10.1101/2024.08.28.24312624.

Slc4a7 Regulates Retina Development in Zebrafish

Authors:
Zhuang Y, Li D, Tang C, Zhao X, Wang R, Tao D, Huang X, Liu X
Citation:
International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613
Epub:
Not Epub
Abstract:
Inherited retinal degenerations (IRDs) are a group of genetic disorders characterized by the progressive degeneration of...
Link:
https://www.mdpi.com/1422-0067/25/17/9613
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhuang Y, Li D, Tang C, Zhao X, Wang R, Tao D, Huang X, Liu X. Slc4a7 Regulates Retina Development in Zebrafish. International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613.

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