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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12236 scientific papers returned from the database with the search filters currently being used below.

The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP)

Authors:
Gil Rosas M, Centola C, Torres M, Mouguelar VS, David AP, Piga EJ, Gomez D, Calcaterra NB, Armas P, Coux G
Citation:
Sci Rep. 2024 Mar 29;14(1):7472. doi: 10.1038/s41598-024-58255-9
Epub:
Not Epub
Abstract:
Treacle ribosome biogenesis factor 1 (TCOF1) is responsible for about 80% of mandibular dysostosis (MD) cases. We have formerly...
Link:
https://www.nature.com/articles/s41598-024-58255-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gil Rosas M, Centola C, Torres M, Mouguelar VS, David AP, Piga EJ, Gomez D, Calcaterra NB, Armas P, Coux G. The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP). Sci Rep. 2024 Mar 29;14(1):7472. doi: 10.1038/s41598-024-58255-9.

Establishment of a zebrafish inbred strain, M-AB, capable of regular breeding and genetic manipulation

Authors:
Sadamitsu K, Velilla F, Shinya M, Kashima M, Imai Y, Kawasaki T, Watai K, Hosaka M, Hirata H, Sakai N
Citation:
Sci Rep. 2024 Mar 29;14(1):7455. doi: 10.1038/s41598-024-57699-3
Epub:
Not Epub
Abstract:
Inbred strains of organisms are genetically highly uniform and thus useful for life science research. We have previously...
Link:
https://www.nature.com/articles/s41598-024-57699-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sadamitsu K, Velilla F, Shinya M, Kashima M, Imai Y, Kawasaki T, Watai K, Hosaka M, Hirata H, Sakai N. Establishment of a zebrafish inbred strain, M-AB, capable of regular breeding and genetic manipulation. Sci Rep. 2024 Mar 29;14(1):7455. doi: 10.1038/s41598-024-57699-3.

MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis

Authors:
Bondue T, Khodaparast L, Khodaparast L, Cairoli S, Goffredo BM, Gijsbers R, van den Heuvel L, Levtchenko E
Citation:
Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F981-F987. doi: 10.1152/ajprenal.00014.2024. Epub 2024 Mar 28. PMID: 38545650
Epub:
Not Epub
Abstract:
In this study, we show that MFSD12 depletion with either CRISPR/Cas9-mediated gene editing or a translation-blocking morpholino...
Link:
https://journals.physiology.org/doi/abs/10.1152/ajprenal.00014.2024
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bondue T, Khodaparast L, Khodaparast L, Cairoli S, Goffredo BM, Gijsbers R, van den Heuvel L, Levtchenko E. MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis. Am J Physiol Renal Physiol. 2024 Jun 1;326(6):F981-F987. doi: 10.1152/ajprenal.00014.2024. Epub 2024 Mar 28. PMID: 38545650.

Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function

Authors:
Angom RS, Joshi A, Patowary A, Sivadas A, Ramasamy S, K V S, Kaushik K, Sabharwal A, Lalwani MK, K S, Singh N, Scaria V, Sivasubbu S
Citation:
Front Cell Dev Biol. 2024 Mar 8;12:1339292. doi: 10.3389/fcell.2024.1339292. eCollection 2024.
Epub:
Not Epub
Abstract:
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2024.1339292/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Angom RS, Joshi A, Patowary A, Sivadas A, Ramasamy S, K V S, Kaushik K, Sabharwal A, Lalwani MK, K S, Singh N, Scaria V, Sivasubbu S. Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Front Cell Dev Biol. 2024 Mar 8;12:1339292. doi: 10.3389/fcell.2024.1339292. eCollection 2024..

Pcgf5: An important regulatory factor in early embryonic neural induction

Authors:
Yang X, Zhou W, Zhou J, Li A, Zhang C, Fang Z, Wang C, Liu S, Hao A, Zhang M
Citation:
Heliyon. 2024 Mar 6;10(6):e27634. doi: 10.1016/j.heliyon.2024.e27634. eCollection 2024 Mar 30
Epub:
Not Epub
Abstract:
Polycomb group RING finger (PCGF) proteins, a crucial subunits of the Polycomb complex, plays an important role in regulating...
Link:
https://www.cell.com/heliyon/fulltext/S2405-8440(24)03665-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang X, Zhou W, Zhou J, Li A, Zhang C, Fang Z, Wang C, Liu S, Hao A, Zhang M. Pcgf5: An important regulatory factor in early embryonic neural induction. Heliyon. 2024 Mar 6;10(6):e27634. doi: 10.1016/j.heliyon.2024.e27634. eCollection 2024 Mar 30.

CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair

Authors:
Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick LM, Lam C, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD
Citation:
bioRxiv [Preprint]. 2024 Mar 6:2024.03.06.583756. doi: 10.1101/2024.03.06.583756
Epub:
Not Epub
Abstract:
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but the...
Link:
https://www.biorxiv.org/content/10.1101/2024.03.06.583756v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Mouse
Citation Extract:
Zondervan RL, Capobianco CA, Jenkins DC, Reicha JD, Fredrick LM, Lam C, Isenberg JS, Ahn J, Marcucio RS, Hankenson KD. CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair. bioRxiv [Preprint]. 2024 Mar 6:2024.03.06.583756. doi: 10.1101/2024.03.06.583756.

PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis

Authors:
Zhang J, Tian Y, Xu X, Wang B, Huang Z, Song K, Lou S, Kang J, Zhang N, Li J, Weng J, Liang Y, Ma W
Citation:
Autophagy. 2024 Jul;20(7):1616-1638. doi: 10.1080/15548627.2024.2333164. Epub 2024 Mar 27. PMID: 38513669; PMCID: PMC11210919
Epub:
Not Epub
Abstract:
PLD1 has been implicated in cytoskeletal reorganization and vesicle trafficking in somatic cells; however, its function...
Link:
https://www.tandfonline.com/doi/full/10.1080/15548627.2024.2333164
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang J, Tian Y, Xu X, Wang B, Huang Z, Song K, Lou S, Kang J, Zhang N, Li J, Weng J, Liang Y, Ma W. PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis. Autophagy. 2024 Jul;20(7):1616-1638. doi: 10.1080/15548627.2024.2333164. Epub 2024 Mar 27. PMID: 38513669; PMCID: PMC11210919.

Fbrsl1 is required for heart development in Xenopus laevis and de novo variants in FBRSL1 can cause human heart defects

Authors:
Berger H, Gerstner S, Horstmann MF, Pauli S, Borchers A
Citation:
Dis Model Mech. 2024 Jun 1;17(6):dmm050507. doi: 10.1242/dmm.050507. Epub 2024 May 14. PMID: 38501224; PMCID: PMC11128277.
Epub:
Not Epub
Abstract:
De novo truncating variants in fibrosin-like 1 (FBRSL1), a member of the AUTS2 gene family, cause a disability syndrome,...
Link:
https://journals.biologists.com/dmm/article/17/6/dmm050507/347305/
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Berger H, Gerstner S, Horstmann MF, Pauli S, Borchers A. Fbrsl1 is required for heart development in Xenopus laevis and de novo variants in FBRSL1 can cause human heart defects. Dis Model Mech. 2024 Jun 1;17(6):dmm050507. doi: 10.1242/dmm.050507. Epub 2024 May 14. PMID: 38501224; PMCID: PMC11128277..

An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo

Authors:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA
Citation:
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H860-H869. doi: 10.1152/ajpheart.00745.2023
Epub:
Not Epub
Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more...
Link:
https://journals.physiology.org/doi/full/10.1152/ajpheart.00745.2023
Delivery Method:
Vivo Morpholino
Organism or Cell Type:
Cell Culture
Citation Extract:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H860-H869. doi: 10.1152/ajpheart.00745.2023.

Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria

Authors:
Pals M, Wijnberg L, Yildiz C, Velema WA
Citation:
Angew Chem Int Ed Engl. 2024 Feb 26:e202402405. doi: 10.1002/anie.202402405. Online ahead of print
Epub:
Not Epub
Abstract:
Antibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/anie.202402405
Delivery Method:
siderophore conjugate
Organism or Cell Type:
Escherichia coli K12 MG1655 and Acinetobacter baumannii (ATCC19606)
Citation Extract:
Pals M, Wijnberg L, Yildiz C, Velema WA. Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria. Angew Chem Int Ed Engl. 2024 Feb 26:e202402405. doi: 10.1002/anie.202402405. Online ahead of print.

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