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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Selenoprotein deficiency disorder predisposes to aortic aneurysm formation
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Citation:
Nat Commun. 2023 Dec 2;14(1):7994. doi: 10.1038/s41467-023-43851-6 Epub:
Not Epub Abstract:
Aortic aneurysms, which may dissect or rupture acutely and be lethal, can be a part of multisystem disorders that have a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Schoenmakers E, Marelli F, Jørgensen HF, Visser WE, Moran C, Groeneweg S, Avalos C, Jurgens SJ, Figg N, Finigan A, Wali N, Agostini M, Wardle-Jones H, Lyons G, Rusk R, Gopalan D, Twiss P, Visser JJ, Goddard M, Nashef SAM, Heijmen R, Clift P, Sinha S, Pirruccello JP, Ellinor PT, Busch-Nentwich EM, Ramirez-Solis R, Murphy MP, Persani L, Bennett M, Chatterjee K. Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nat Commun. 2023 Dec 2;14(1):7994. doi: 10.1038/s41467-023-43851-6. |
Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1
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Citation:
Mol Ther Nucleic Acids. 2023 Oct 19;34:102060. doi: 10.1016/j.omtn.2023.102060. eCollection 2023 Dec 12 Epub:
Not Epub Abstract:
Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: hiPSC-CMs Citation Extract: Shiba N, Yang X, Sato M, Kadota S, Suzuki Y, Agata M, Nagamine K, Izumi M, Honda Y, Koganehira T, Kobayashi H, Ichimura H, Chuma S, Nakai J, Tohyama S, Fukuda K, Miyazaki D, Nakamura A, Shiba Y. Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1. Mol Ther Nucleic Acids. 2023 Oct 19;34:102060. doi: 10.1016/j.omtn.2023.102060. eCollection 2023 Dec 12. |
A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?
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Citation:
Contact (Thousand Oaks). 2023 Nov 7;6:25152564231211409. doi: 10.1177/25152564231211409 Epub:
Not Epub Abstract:
We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca2+... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rice KL, Chan CM, Kelu JJ, Miller AL, Webb SE. A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?. Contact (Thousand Oaks). 2023 Nov 7;6:25152564231211409. doi: 10.1177/25152564231211409. |
Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation
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Citation:
Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458. Online ahead of print Epub:
Not Epub Abstract:
Background: A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV)... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lin Y, Yang Q, Lin X, Liu X, Qian Y, Xu D, Cao N, Han X, Zhu Y, Hu W, He X, Yu Z, Kong X, Zhu L, Zhong Z, Liu K, Zhou B, Wang Y, Peng J, Zhu W, Wang J. Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 2023 Nov 29. doi: 10.1161/CIRCULATIONAHA.123.065458. Online ahead of print. |
Biallelic COQ4 Variants in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization
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Citation:
Mov Disord. 2023 Nov 28. doi: 10.1002/mds.29664. Online ahead of print Epub:
Not Epub Abstract:
Background: Hereditary spastic paraplegias (HSP) are neurologic disorders characterized by progressive lower-extremity... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lin X, Jiang JY, Hong DJ, Lin KJ, Li JJ, Chen YJ, Qiu YS, Wang Z, Liao YC, Yang K, Shi Y, Wang MW, Hsu SL, Hong S, Zeng YH, Chen XC, Wang N, Lee YC, Chen WJ. Biallelic COQ4 Variants in Hereditary Spastic Paraplegia: Clinical and Molecular Characterization. Mov Disord. 2023 Nov 28. doi: 10.1002/mds.29664. Online ahead of print. |
ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae
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Citation:
Mol Genet Metab. 2023;108097:[Epub] doi:10.1016/j.ymgme.2023.108097 Epub:
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Citrullinemia type 1 (CTLN1) is a rare autosomal recessive urea cycle disorder caused by deficiency of the cytosolic enzyme... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Seidl MJ, Scharre S, Posset R, Druck A-C, Epp F, Okun JG, Dimitrov B, Hoffmann GF, Kölker S, Zielonka M. ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae. Mol Genet Metab. 2023;108097:[Epub] doi:10.1016/j.ymgme.2023.108097. |
Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2
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Citation:
Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24 Epub:
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The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Colozza G, Lee H, Merenda A, Wu SS, Català-Bordes A, Radaszkiewicz TW, Jordens I, Lee JH, Bamford AD, Farnhammer F, Low TY, Maurice MM, Bryja V, Kim J, Koo BK. Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Sci Adv. 2023 Nov 24;9(47):eadh9673. doi: 10.1126/sciadv.adh9673. Epub 2023 Nov 24. |
Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development
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Citation:
Sci Adv. 2023 Nov 24;9(47):eadg6532. doi: 10.1126/sciadv.adg6532. Epub 2023 Nov 24 Epub:
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Eggs accumulate thousands of translationally repressed mRNAs that are translated into proteins after fertilization to direct... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T. Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development. Sci Adv. 2023 Nov 24;9(47):eadg6532. doi: 10.1126/sciadv.adg6532. Epub 2023 Nov 24. |
Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry
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Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.23.568438 Epub:
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The body plan of vertebrates appears externally bilaterally symmetric. Nonetheless the positioning and morphology of internal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Eggeler F, Boulanger-Weill J, De Santis F, Belleri L, Duroure K, Auer TO, Albadri S, Del Bene F. Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.23.568438. |
Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases
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Citation:
Nat Commun. 2023 Nov 23;14(1):7668. doi: 10.1038/s41467-023-43349-1 Epub:
Not Epub Abstract:
Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cheng X, Barakat R, Pavani G, Usha MK, Calderon R, Snella E, Gorden A, Zhang Y, Gadue P, French DL, Dorman KS, Fidanza A, Campbell CA, Espin-Palazon R. Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases. Nat Commun. 2023 Nov 23;14(1):7668. doi: 10.1038/s41467-023-43349-1. |