You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration

Authors:
Shlomi C, Kovari DT, Wei W, Keate R, Curtis JE, Nie S
Citation:
J Mol Cell Biol. 2017 Oct 6. doi: 10.1093/jmcb/mjx044. [Epub ahead of print]
Epub:
Yes
Abstract:
The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep...
Link:
https://academic.oup.com/jmcb/article-abstract/doi/10.1093/jmcb/mjx044/4356862/Cdc42-regulates-the-cellular-localization-of
Citation Extract:
Shlomi C, Kovari DT, Wei W, Keate R, Curtis JE, Nie S. Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration. J Mol Cell Biol. 2017 Oct 6. doi: 10.1093/jmcb/mjx044. [Epub ahead of print].

Guidelines for morpholino use in zebrafish

Authors:
Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB
Citation:
PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct
Epub:
Not Epub
Abstract:
No abstract available.
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007000
Organism or Cell Type:
zebrafish
Citation Extract:
Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. Guidelines for morpholino use in zebrafish. PLoS Genet. 2017 Oct 19;13(10):e1007000. doi: 10.1371/journal.pgen.1007000. eCollection 2017 Oct.

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8

Authors:
Kim HT, Lee MS, Jeong YM, Ro H, Kim DI, Shin YH, Kim JE, Hwang KS, Choi JH, Bahn M, Lee JJ, Lee SH, Bae YK, Lee JS, Choi JK, Kim NS, Yeo CY, Kim CH
Citation:
Sci Rep. 2017 Oct 16;7(1):13278. doi: 10.1038/s41598-017-13429-6
Epub:
Not Epub
Abstract:
Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of...
Link:
https://www.nature.com/articles/s41598-017-13429-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim HT, Lee MS, Jeong YM, Ro H, Kim DI, Shin YH, Kim JE, Hwang KS, Choi JH, Bahn M, Lee JJ, Lee SH, Bae YK, Lee JS, Choi JK, Kim NS, Yeo CY, Kim CH. Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017 Oct 16;7(1):13278. doi: 10.1038/s41598-017-13429-6.

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle

Authors:
Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA
Citation:
Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7
Epub:
Not Epub
Abstract:
Exon skipping is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), employing morpholino antisense...
Link:
https://www.nature.com/articles/s41467-017-00924-7
Delivery Method:
injection, retro-orbital
Organism or Cell Type:
Mice, C57Bl/10ScSn-mdx/J or C57Bl/10ScSnJ (Bl10 or wild-type)
Citation Extract:
Novak JS, Hogarth MW, Boehler JF, Nearing M, Vila MC, Heredia R, Fiorillo AA, Zhang A, Hathout Y, Hoffman EP, Jaiswal JK, Nagaraju K, Cirak S, Partridge TA. Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun. 2017 Oct 16;8(1):941. doi: 10.1038/s41467-017-00924-7.

Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration

Authors:
Baek KI, Packard RR, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK
Citation:
Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print]
Epub:
Yes
Abstract:
AIMS: Redox active ultrafine particles (UFP, d < 0.2 µm) promote vascular oxidative stress and atherosclerosis. Notch...
Link:
http://online.liebertpub.com/doi/abs/10.1089/ars.2017.7166
Organism or Cell Type:
zebrafish
Citation Extract:
Baek KI, Packard RR, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particles Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2017 Oct 17. doi: 10.1089/ars.2017.7166. [Epub ahead of print].

hace1 influences zebrafish cardiac development via ROS-dependent mechanisms

Authors:
Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, Chacko S, Lewis S, Scott IC, Sorensen PHB, Berman JN
Citation:
Dev Dyn. 2017 Oct 11. doi: 10.1002/dvdy.24600. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: In this study we reveal a previously undescribed role of the HACE1 (HECT domain and Ankyrin repeat Containing E3...
Link:
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24600/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, Chacko S, Lewis S, Scott IC, Sorensen PHB, Berman JN. hace1 influences zebrafish cardiac development via ROS-dependent mechanisms. Dev Dyn. 2017 Oct 11. doi: 10.1002/dvdy.24600. [Epub ahead of print].

An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes

Authors:
Jain HV, Boehler JF, Verthelyi D, Nagaraju K, Beaucage SL
Citation:
RSC Adv. 2017;7:42519-42528. doi: 10.1039/C7RA04247G. Epub 2017 Sep 4
Epub:
Not Epub
Abstract:
An efficient method for the delivery of uncharged polyA-tailed phosphorodiamidate morpholino sequences (PMO) in mammalian cells...
Link:
http://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra04247g
Delivery Method:
complementary phosphorothioate oligo
Organism or Cell Type:
cell culture: HeLa pLuc705, mdx myotubes
Citation Extract:
Jain HV, Boehler JF, Verthelyi D, Nagaraju K, Beaucage SL. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes. RSC Adv. 2017;7:42519-42528. doi: 10.1039/C7RA04247G. Epub 2017 Sep 4.

Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation

Authors:
Sonavane PR, Wang C, Dzamba B, Weber GF, Periasamy A, DeSimone DW
Citation:
Development. 2017 Oct 5. pii: dev.155200. doi: 10.1242/dev.155200. [Epub ahead of print]
Epub:
Yes
Abstract:
Coordination of individual cell behaviors is a critical step in the assembly and morphogenesis of tissues. Xenopus mesendoderm...
Link:
http://dev.biologists.org/content/early/2017/10/05/dev.155200.long
Organism or Cell Type:
Xenopus
Citation Extract:
Sonavane PR, Wang C, Dzamba B, Weber GF, Periasamy A, DeSimone DW. Mechanical and signaling roles for keratin intermediate filaments in the assembly and morphogenesis of mesendoderm tissue at gastrulation. Development. 2017 Oct 5. pii: dev.155200. doi: 10.1242/dev.155200. [Epub ahead of print].

A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning

Authors:
Amiel AR, Johnston H, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E, Martindale MQ
Citation:
Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14
Epub:
Not Epub
Abstract:
Germ layer formation and axial patterning are biological processes that are tightly linked during embryonic development of most...
Link:
http://www.sciencedirect.com/science/article/pii/S0012160617302804
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Amiel AR, Johnston H, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E, Martindale MQ. A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning. Dev Biol. 2017 Oct 15;430(2):346-361. doi: 10.1016/j.ydbio.2017.08.015. Epub 2017 Aug 14.

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Authors:
Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F
Citation:
Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23
Epub:
Not Epub
Abstract:
BACKGROUND: We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658...
Link:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60756-3/fulltext
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet. 2011 Aug 13;378(9791):595-605. doi: 10.1016/S0140-6736(11)60756-3. Epub 2011 Jul 23.

Pages