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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

NQO2 inhibition relieves ROS effects on mouse oocyte meiotic maturation and embryo development

Authors:
Chen D, Li X, Xiaoyun Liu X, Liu X, Jiang X, Du J, Wang Q, Liang Y, Ma W
Citation:
Biol Reproduc. 2017;[Accepted manuscript] doi:10.1093/biolre/iox098
Epub:
Yes
Abstract:
NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron...
Link:
https://academic.oup.com/biolreprod/article-abstract/doi/10.1093/biolre/iox098/4103548/NQO2-inhibition-relieves-ROS-effects-on-mouse
Organism or Cell Type:
mouse oocyte
Citation Extract:
Chen D, Li X, Xiaoyun Liu X, Liu X, Jiang X, Du J, Wang Q, Liang Y, Ma W. NQO2 inhibition relieves ROS effects on mouse oocyte meiotic maturation and embryo development. Biol Reproduc. 2017;[Accepted manuscript] doi:10.1093/biolre/iox098.

A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants

Authors:
Ma Z, Zhu P, Pang M, Guo L, Chang N, Zheng J, Zhu X, Gao C, Huang H, Cui Z, Xiong JW, Peng J, Chen J
Citation:
Sci Rep. 2017 Sep 4;7(1):10381. doi: 10.1038/s41598-017-10968-w
Epub:
Not Epub
Abstract:
Conventional genetic screens for recessive mutants are inadequate for studying biological processes in the adult vertebrate due...
Link:
https://www.nature.com/articles/s41598-017-10968-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma Z, Zhu P, Pang M, Guo L, Chang N, Zheng J, Zhu X, Gao C, Huang H, Cui Z, Xiong JW, Peng J, Chen J. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Sci Rep. 2017 Sep 4;7(1):10381. doi: 10.1038/s41598-017-10968-w.

Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina

Authors:
Bessodes N, Parain K, Bronchain O, Bellefroid EJ, Perron M
Citation:
Neural Dev. 2017 Sep 1;12(1):16. doi: 10.1186/s13064-017-0093-2
Epub:
Not Epub
Abstract:
BACKGROUND: Amacrine interneurons that modulate synaptic plasticity between bipolar and ganglion cells constitute the most...
Link:
https://neuraldevelopment.biomedcentral.com/articles/10.1186/s13064-017-0093-2
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bessodes N, Parain K, Bronchain O, Bellefroid EJ, Perron M. Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina. Neural Dev. 2017 Sep 1;12(1):16. doi: 10.1186/s13064-017-0093-2.

Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts

Authors:
Tajik-Ahmadabad B, Polyzos A, Separovic F, Shabanpoor F
Citation:
Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116
Epub:
Yes
Abstract:
Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for...
Link:
http://www.sciencedirect.com/science/article/pii/S0378517317308384
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: patient-derived SMA fibroblasts
Citation Extract:
Tajik-Ahmadabad B, Polyzos A, Separovic F, Shabanpoor F. Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts. Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116.

Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference

Authors:
Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC
Citation:
Neuron. 2017;95:1-15. doi:j.neuron.2017.08.023
Epub:
Not Epub
Abstract:
Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the...
Link:
http://www.cell.com/action/showImagesData?pii=S0896-6273%2817%2930738-9
Delivery Method:
electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Dulcis D, Lippi G, Stark CJ, Do LH, Berg DK, Spitzer NC. Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron. 2017;95:1-15. doi:j.neuron.2017.08.023.

MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus

Authors:
Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A
Citation:
PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Deletions at chromosome 2p25.3 are associated with a syndrome consisting of intellectual disability and obesity. The smallest...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006957
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. [Epub ahead of print].

Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome

Authors:
Lee S-H, Nam T-S, Li W, Kim JH, Yoon W, Choi Y-D, Kim K-H, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim M-K, Choi S-Y
Citation:
Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z
Epub:
Not Epub
Abstract:
COACH syndrome is an autosomal recessive developmental disorder, a subtype of Joubert syndrome and related disorders,...
Link:
https://www.nature.com/articles/s41598-017-10652-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S-H, Nam T-S, Li W, Kim JH, Yoon W, Choi Y-D, Kim K-H, Cai H, Kim MJ, Kim C, Choy HE, Kim N, Chay KO, Kim M-K, Choi S-Y. Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome. Sci Rep. 2017;7:10222. doi:10.1038/s41598-017-10652-z.

RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo

Authors:
Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE
Citation:
Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3
Epub:
Not Epub
Abstract:
Nascent proteins can be positioned rapidly at precise subcellular locations by local protein synthesis (LPS) to facilitate...
Link:
http://www.cell.com/neuron/fulltext/S0896-6273(17)30638-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE. RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo. Neuron. 2017 Aug 16;95(4):852-868.e8. doi: 10.1016/j.neuron.2017.07.016. Epub 2017 Aug 3.

Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos

Authors:
Mellott DO, Thisdelle J, Burke RD
Citation:
Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print]
Epub:
Yes
Abstract:
We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation neural progenitors...
Link:
http://dev.biologists.org/content/early/2017/08/29/dev.151720
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Mellott DO, Thisdelle J, Burke RD. Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos. Development. 2017 Aug 29. pii: dev.151720. doi: 10.1242/dev.151720. [Epub ahead of print].

Dysfunction of the MDM2/p53 axis is linked to premature aging

Authors:
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C
Citation:
J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print]
Epub:
Yes
Abstract:
The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin...
Link:
https://www.jci.org/articles/view/92171
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G, Högel J, Thiele H, Nürnberg G, Nürnberg P, Hammerschmidt M, Zhu Y, Tong DR, Katz C, Martin GM, Oshima J, Prives C, Kubisch C. Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017 Aug 28. pii: 92171. doi: 10.1172/JCI92171. [Epub ahead of print].

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