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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding

Authors:
Carney SM, Gomathinayagam S, Leuba SH, Trakselis MA
Citation:
J Biol Chem. 2017 Sep 22. pii: jbc.M117.814178. doi: 10.1074/jbc.M117.814178. [Epub ahead of print]
Epub:
Yes
Abstract:
Replicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE), where one DNA strand is encircled by...
Link:
http://www.jbc.org/content/early/2017/09/22/jbc.M117.814178.long
Citation Extract:
Carney SM, Gomathinayagam S, Leuba SH, Trakselis MA. Bacterial DnaB helicase interacts with the excluded strand to regulate unwinding. J Biol Chem. 2017 Sep 22. pii: jbc.M117.814178. doi: 10.1074/jbc.M117.814178. [Epub ahead of print].

Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis

Authors:
Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B
Citation:
Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397. doi: 10.1093/nar/gkx563
Epub:
Not Epub
Abstract:
Sister chromatid cohesion, mediated by cohesin complex and established by the acetyltransferases Esco1 and Esco2, is essential...
Link:
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkx563
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B. Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis. Nucleic Acids Res. 2017 Sep 19;45(16):9388-9397. doi: 10.1093/nar/gkx563.

Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation

Authors:
Beigel JH, Voell J, Muñoz P, Kumar P, Brooks KM, Zhang J, Iversen P, Heald A, Wong M, Davey RT
Citation:
Br J Clin Pharmacol. 2017 Sep 20. doi: 10.1111/bcp.13405. [Epub ahead of print]
Epub:
Yes
Abstract:
AIMS: The aims of the present study were to assess the safety, tolerability and pharmacokinetics of radavirsen following single...
Link:
http://onlinelibrary.wiley.com/doi/10.1111/bcp.13405/abstract
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Beigel JH, Voell J, Muñoz P, Kumar P, Brooks KM, Zhang J, Iversen P, Heald A, Wong M, Davey RT. Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation. Br J Clin Pharmacol. 2017 Sep 20. doi: 10.1111/bcp.13405. [Epub ahead of print].

The role of jab1, a putative downstream effector of the neurotrophic cytokine macrophage migration inhibitory factor (MIF) in zebrafish inner ear hair cell development

Authors:
Weber LJ, Marcy HK, Shen YC, Tomkovich SE, Brooks KM, Hilk KE, Barald KF
Citation:
Exp Neurol. 2017 Sep 16. pii: S0014-4886(17)30239-X. doi: 10.1016/j.expneurol.2017.09.009. [Epub ahead of print] Review
Epub:
Yes
Abstract:
Macrophage migration inhibitory factor (MIF) is a neurotrophic cytokine essential for inner ear hair cell (HC) development and...
Link:
http://www.sciencedirect.com/science/article/pii/S001448861730239X?via%3Dihub
Delivery Method:
electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Weber LJ, Marcy HK, Shen YC, Tomkovich SE, Brooks KM, Hilk KE, Barald KF. The role of jab1, a putative downstream effector of the neurotrophic cytokine macrophage migration inhibitory factor (MIF) in zebrafish inner ear hair cell development. Exp Neurol. 2017 Sep 16. pii: S0014-4886(17)30239-X. doi: 10.1016/j.expneurol.2017.09.009. [Epub ahead of print] Review.

Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin

Authors:
Giger FA, David NB
Citation:
Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201708116. doi: 10.1073/pnas.1708116114. [Epub ahead of print]
Epub:
Yes
Abstract:
Germ-layer formation during gastrulation is both a fundamental step of development and a paradigm for tissue formation and...
Link:
http://www.pnas.org/content/114/38/10143.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Giger FA, David NB. Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin. Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201708116. doi: 10.1073/pnas.1708116114. [Epub ahead of print].

Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly

Authors:
Sun Q, Liu X, Gong B, Wu D, Meng A, Jia S
Citation:
Int J Biol Sci. 2017 Sep 2;13(8):1051-1066. doi: 10.7150/ijbs.19203. eCollection 2017
Epub:
Not Epub
Abstract:
During embryonic gastrulation, coordinated cell movements occur to bring cells to their correct position. Among them, epiboly...
Link:
http://www.ijbs.com/v13p1051.htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun Q, Liu X, Gong B, Wu D, Meng A, Jia S. Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. Int J Biol Sci. 2017 Sep 2;13(8):1051-1066. doi: 10.7150/ijbs.19203. eCollection 2017.

Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing

Authors:
Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang H
Citation:
Proc Natl Acad Sci U S A. 2017 Aug 30. pii: 201711158. doi: 10.1073/pnas.1711158114. [Epub ahead of print]
Epub:
Yes
Abstract:
Posttranslational histone modifications play important roles in regulating chromatin-based nuclear processes. Histone H2AK119...
Link:
http://www.pnas.org/content/114/38/E7949.abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang H. Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 30. pii: 201711158. doi: 10.1073/pnas.1711158114. [Epub ahead of print].

Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis

Authors:
Boopathy GTK, Kulkarni M, Ho SY, Boey A, Chua EWM, Barathi VA, Carney TJ, Wang X, Hong W
Citation:
J Biol Chem. 2017 Sep 14. pii: jbc.M117.794743. doi: 10.1074/jbc.M117.794743. [Epub ahead of print]
Epub:
Yes
Abstract:
Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is...
Link:
http://www.jbc.org/content/early/2017/09/14/jbc.M117.794743.abstract
Organism or Cell Type:
zebrafish
Citation Extract:
Boopathy GTK, Kulkarni M, Ho SY, Boey A, Chua EWM, Barathi VA, Carney TJ, Wang X, Hong W. Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis. J Biol Chem. 2017 Sep 14. pii: jbc.M117.794743. doi: 10.1074/jbc.M117.794743. [Epub ahead of print].

Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death

Authors:
Cao S, Smith LL, Padilla-Lopez SR, Guida BS, Blume E, Shi J, Morton SU, Brownstein CA, Beggs AH, Kruer MC, Agrawal PB
Citation:
Hum Mol Genet. 2017 Sep 15;26(18):3545-3552. doi: 10.1093/hmg/ddx239
Epub:
Not Epub
Abstract:
Eukaryotic elongation factor 1A (EEF1A), is encoded by two distinct isoforms, EEF1A1 and EEF1A2; whereas EEF1A1 is expressed...
Link:
https://academic.oup.com/hmg/article-abstract/26/18/3545/3892407/Homozygous-EEF1A2-mutation-causes-dilated
Organism or Cell Type:
zebrafish
Citation Extract:
Cao S, Smith LL, Padilla-Lopez SR, Guida BS, Blume E, Shi J, Morton SU, Brownstein CA, Beggs AH, Kruer MC, Agrawal PB. Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death. Hum Mol Genet. 2017 Sep 15;26(18):3545-3552. doi: 10.1093/hmg/ddx239.

Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin

Authors:
Bonnet A, Lambert G, Ernest S, Dutrieux FX, Coulpier F, Lemoine S, Lobbardi R, Rosa FM
Citation:
Dev Cell. 2017 Aug 28. pii: S1534-5807(17)30632-9. doi: 10.1016/j.devcel.2017.08.004. [Epub ahead of print]
Epub:
Yes
Abstract:
Skeletal muscle contraction is mediated by myofibrils, complex multi-molecular scaffolds structured into repeated units, the...
Link:
http://www.sciencedirect.com/science/article/pii/S1534580717306329
Organism or Cell Type:
zebrafish
Citation Extract:
Bonnet A, Lambert G, Ernest S, Dutrieux FX, Coulpier F, Lemoine S, Lobbardi R, Rosa FM. Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin. Dev Cell. 2017 Aug 28. pii: S1534-5807(17)30632-9. doi: 10.1016/j.devcel.2017.08.004. [Epub ahead of print].

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