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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides

Authors:
Abes S, Moulton H, Turner J, Clair P, Richard JP, Iversen P, Gait MJ, Lebleu B
Citation:
Biochem Soc Trans. 2007 Feb;35(Pt 1):53-5
Epub:
Not Epub
Abstract:
CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Abes S, Moulton H, Turner J, Clair P, Richard JP, Iversen P, Gait MJ, Lebleu B. Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides. Biochem Soc Trans. 2007 Feb;35(Pt 1):53-5.

Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers

Authors:
Amantana A, Iversen PL
Citation:
Curr Opin Pharmacol. 2005 Oct;5(5):550-5.
Epub:
Not Epub
Abstract:
The concept of using antisense oligonucleotides to interfere with gene expression offers a new therapeutic strategy for the...
Delivery Method:
not applicable
Organism or Cell Type:
not applicable
Citation Extract:
Amantana A, Iversen PL. Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers. Curr Opin Pharmacol. 2005 Oct;5(5):550-5..

Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide-Morpholino Oligomer Conjugate

Authors:
Amantana A, Moulton HM, Cate ML, Reddy MT, Whitehead T, Hassinger JN, Youngblood DS, Iversen PL
Citation:
Bioconjug Chem. 2007 Jul-Aug;18(4):1325-31. Epub 2007 Jun 21
Epub:
Not Epub
Abstract:
Objective: Conjugation of arginine-rich cell-penetrating peptide (CPP) to phosphorodiamidate morpholino oligomers (PMO) has...
Link:
https://pubs.acs.org/doi/10.1021/bc070060v
Delivery Method:
i.v. injection, peptide conjugates vs. bare Morpholino
Organism or Cell Type:
Rat
Citation Extract:
Amantana A, Moulton HM, Cate ML, Reddy MT, Whitehead T, Hassinger JN, Youngblood DS, Iversen PL. Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide-Morpholino Oligomer Conjugate. Bioconjug Chem. 2007 Jul-Aug;18(4):1325-31. Epub 2007 Jun 21.

Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis

Authors:
Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelrod JD
Citation:
PLoS One. 2010 Feb 2;5(2):e8999
Epub:
Not Epub
Abstract:
Left-right asymmetry in vertebrates is initiated in an early embryonic structure called the ventral node in human and mouse,...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelrod JD. Planar Cell Polarity Enables Posterior Localization of Nodal Cilia and Left-Right Axis Determination during Mouse and Xenopus Embryogenesis. PLoS One. 2010 Feb 2;5(2):e8999.

Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β-catenin signaling

Authors:
Aldiri I, Moore KB, Hutcheson DA, Zhang J, Vetter ML
Citation:
Development. 2013 Jun 5. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The histone methyltransferase complex PRC2 controls key steps in developmental transitions and cell fate choices; however, its...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Aldiri I, Moore KB, Hutcheson DA, Zhang J, Vetter ML. Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β-catenin signaling. Development. 2013 Jun 5. [Epub ahead of print].

Premature aging in telomerase-deficient zebrafish

Authors:
Anchelin M, Alcaraz-Pérez F, Martínez CM, Bernabé-García M, Mulero V, Cayuela ML
Citation:
Dis Model Mech. 2013 Jul 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The study of telomere biology is crucial to the understanding of aging and cancer. In the pursuit of greater knowledge in the...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Anchelin M, Alcaraz-Pérez F, Martínez CM, Bernabé-García M, Mulero V, Cayuela ML. Premature aging in telomerase-deficient zebrafish. Dis Model Mech. 2013 Jul 18. [Epub ahead of print].

Rapid adaptation to food availability by a dopamine-mediated morphogenetic response

Authors:
Adams DK, Sewell MA, Angerer RC, Angerer LM
Citation:
Nat Commun. 2011 Dec 20;2:592. doi: 10.1038/ncomms1603
Epub:
Not Epub
Abstract:
Food can act as a powerful stimulus, eliciting metabolic, behavioural and developmental responses. These phenotypic changes can...
Delivery Method:
Microinjection
Organism or Cell Type:
sea urchin
Citation Extract:
Adams DK, Sewell MA, Angerer RC, Angerer LM. Rapid adaptation to food availability by a dopamine-mediated morphogenetic response. Nat Commun. 2011 Dec 20;2:592. doi: 10.1038/ncomms1603.

Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm

Authors:
Aerne B, Ish-Horowicz D
Citation:
Development. 2004 Jul;131(14):3391-3399
Epub:
Not Epub
Abstract:
Segmentation in vertebrate embryos is controlled by a biochemical oscillator ('segmentation clock') intrinsic to the...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Aerne B, Ish-Horowicz D. Receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm. Development. 2004 Jul;131(14):3391-3399.

Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart

Authors:
Allen BG, Allen-Brady K, Weeks DL
Citation:
Mech Dev. 2006 Oct;123(10):719-29. Epub 2006 Jul 26
Epub:
Not Epub
Abstract:
Normal vertebrate heart development depends upon the expression of homeodomain containing proteins related to the Drosophila...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Allen BG, Allen-Brady K, Weeks DL. Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic heart. Mech Dev. 2006 Oct;123(10):719-29. Epub 2006 Jul 26.

Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus

Authors:
Armisen R, Fuentes R, Olguin P, Cabrejos ME, Kukuljan M
Citation:
J Neurosci. 2002 Oct 1;22(19):8347-51
Epub:
Not Epub
Abstract:
The ability of neurons to fire rapid action potential relies on the expression of voltage-gated sodium channels; the onset of...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Armisen R, Fuentes R, Olguin P, Cabrejos ME, Kukuljan M. Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus. J Neurosci. 2002 Oct 1;22(19):8347-51.

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