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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer

Authors:
Piatek MJ, Henderson V, Fearn A, Chaudhry B, Werner A
Citation:
PLoS ONE. 2017;12(5):e0178219. doi:10.1371/journal.pone.0178219
Epub:
Not Epub
Abstract:
Natural antisense transcripts (NATs) are complementary to protein coding genes and potentially regulate their expression....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Piatek MJ, Henderson V, Fearn A, Chaudhry B, Werner A. Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer. PLoS ONE. 2017;12(5):e0178219. doi:10.1371/journal.pone.0178219.

Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation

Authors:
Krens SFG, Veldhuis JH, Barone V, Čapek D, Maître J-L, Brodland GW, Heisenberg C-P
Citation:
Development. 2017;144:1798-806. doi:10.1242/dev.144964
Epub:
Not Epub
Abstract:
The segregation of different cell types into distinct tissues is a fundamental process in metazoan development. Differences in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Krens SFG, Veldhuis JH, Barone V, Čapek D, Maître J-L, Brodland GW, Heisenberg C-P. Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation. Development. 2017;144:1798-806. doi:10.1242/dev.144964.

Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd

Authors:
Tokuhiro S-i, Tokuoka M, Kobayashi K, Kubo A, Oda-Ishii I, Satou Y
Citation:
PLoS Genet. 2017:13(5):e1006741. https://doi.org/10.1371/journal.pgen.1006741
Epub:
Not Epub
Abstract:
In many animal embryos, a specific gene expression pattern is established along the animal-vegetal axis soon after zygotic...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Tokuhiro S-i, Tokuoka M, Kobayashi K, Kubo A, Oda-Ishii I, Satou Y. Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd. PLoS Genet. 2017:13(5):e1006741. https://doi.org/10.1371/journal.pgen.1006741.

Despic V, Dejung M, Gu M, Krishnan J, Zhang J, Herzel L, Straube K, Gerstein MB, Butter F, Neugebauer KM

Authors:
Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition
Citation:
Genome Res. 2017 Apr 5. pii: gr.215954.116. doi: 10.1101/gr.215954.116. [Epub ahead of print]
Epub:
Yes
Abstract:
During the maternal-to-zygotic transition (MZT), transcriptionally silent embryos rely on post-transcriptional regulation of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, Dejung M, Gu M, Krishnan J, Zhang J, Herzel L, Straube K, Gerstein MB, Butter F, Neugebauer KM. Genome Res. 2017 Apr 5. pii: gr.215954.116. doi: 10.1101/gr.215954.116. [Epub ahead of print].

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

Authors:
van Lessen M, Shibata-Germanos S, van Impel A, Hawkins TA, Rihel J, Schulte-Merker S
Citation:
Elife. 2017 May 12;6. pii: e25932. doi: 10.7554/eLife.25932. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van Lessen M, Shibata-Germanos S, van Impel A, Hawkins TA, Rihel J, Schulte-Merker S. Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. Elife. 2017 May 12;6. pii: e25932. doi: 10.7554/eLife.25932. [Epub ahead of print].

Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation

Authors:
Kumar V, Soni UK, Maurya VK, Singh K, Jha RK
Citation:
Sci Rep. 2017;7:1885. doi:10.1038/s41598-017-01764-7
Epub:
Not Epub
Abstract:
Integrin beta8 (ITGB8) is involved in the endometrial receptivity. The blastocyst first interacts with the luminal endometrial...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Kumar V, Soni UK, Maurya VK, Singh K, Jha RK. Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation. Sci Rep. 2017;7:1885. doi:10.1038/s41598-017-01764-7.

Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice

Authors:
Wang MX, Wu B, Lu P, Shah SN, Tucker JD, Bollinger LE, Lu Q
Citation:
Polymers. 2017;9(5):177. doi:10.3390/polym9050177
Epub:
Not Epub
Abstract:
A series of amphiphilic peptides modified PMO (Pt-PMO) were prepared, and their antisense effect and toxicity were evaluated...
Delivery Method:
peptide linked, Endo-Porter
Organism or Cell Type:
mice mdx, cell culture C2C12E23
Citation Extract:
Wang MX, Wu B, Lu P, Shah SN, Tucker JD, Bollinger LE, Lu Q. Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice. Polymers. 2017;9(5):177. doi:10.3390/polym9050177.

Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the cue-induced reinstatement of cocaine-seeking and normalize AMPA receptor subunit expression

Authors:
Lacrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA
Citation:
J Neurosci. 2017;[Epub ahead of print] doi:10.1523/JNEUROSCI.3717-16.2017
Epub:
Yes
Abstract:
Chronic treatment with ceftriaxone attenuates reinstatement of cocaine-seeking while increasing the function of the glutamate...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
rat, adult male Sprague Dawley
Citation Extract:
Lacrosse AL, O'Donovan SM, Sepulveda-Orengo MT, McCullumsmith RE, Reissner KJ, Schwendt M, Knackstedt LA. Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the cue-induced reinstatement of cocaine-seeking and normalize AMPA receptor subunit expression. J Neurosci. 2017;[Epub ahead of print] doi:10.1523/JNEUROSCI.3717-16.2017.

Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition

Authors:
Wagner G, Singhal N, Nicetto D, Straub T, Kremmer E, Rupp RAW
Citation:
PLoS Genet. 2017;13(5):e1006757. doi:10.1371/journal.pgen.1006757
Epub:
Not Epub
Abstract:
Zygotic gene expression programs control cell differentiation in vertebrate development. In Xenopus, these programs are...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis and Xenopus tropicalis
Citation Extract:
Wagner G, Singhal N, Nicetto D, Straub T, Kremmer E, Rupp RAW. Brg1 chromatin remodeling ATPase balances germ layer patterning by amplifying the transcriptional burst at midblastula transition. PLoS Genet. 2017;13(5):e1006757. doi:10.1371/journal.pgen.1006757.

Neurotrophin Receptor Ntrk2b Function In The Maintenance Of Dopamine And Serotonin Neurons In Zebrafish

Authors:
Sahu MP, Pajanoja C, Rozov S, Panula P, Castren E
Citation:
bioRxiv. 2017. doi:10.1101/136416
Epub:
Not Epub
Abstract:
Brain-derived neurotrophic factor (BDNF), together with its cognate receptor tyrosine kinase B (TrkB), plays an essential role...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sahu MP, Pajanoja C, Rozov S, Panula P, Castren E. Neurotrophin Receptor Ntrk2b Function In The Maintenance Of Dopamine And Serotonin Neurons In Zebrafish. bioRxiv. 2017. doi:10.1101/136416.

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