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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12153 scientific papers returned from the database with the search filters currently being used below.

High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration

Authors:
Owens DA, Butler AM, Aguero TH, Newman KM, Van Booven D, King ML
Citation:
Development. 2017 Jan 15;144(2):292-304. doi: 10.1242/dev.139220
Epub:
Not Epub
Abstract:
During oogenesis, hundreds of maternal RNAs are selectively localized to the animal or vegetal pole, including determinants of...
Link:
https://dev.biologists.org/content/144/2/292.long
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Owens DA, Butler AM, Aguero TH, Newman KM, Van Booven D, King ML. High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration. Development. 2017 Jan 15;144(2):292-304. doi: 10.1242/dev.139220.

Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis

Authors:
Kim S, Chung A-H, Na JE, Lee SJ, Jeong SH, Kim E, Sun W, Rhyu IJ, Park H-C
Citation:
Glia. 2019;[Epub ahead of print] doi:10.1002/glia.23669
Epub:
Yes
Abstract:
Myelin is a specialized membrane that wraps around nerve fibers and is essential for normal axonal conduction in neurons. In...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.23669
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim S, Chung A-H, Na JE, Lee SJ, Jeong SH, Kim E, Sun W, Rhyu IJ, Park H-C. Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis. Glia. 2019;[Epub ahead of print] doi:10.1002/glia.23669.

Tfap2a is a novel gatekeeper of nephron differentiation during kidney development

Authors:
Chambers BE, Gerlach GF, Clark EG, Chen KH, Levesque AE, Leshchiner I, Goessling W, Wingert RA
Citation:
Development. 2019 Jun 3. pii: dev.172387. doi: 10.1242/dev.172387. [Epub ahead of print]
Epub:
Yes
Abstract:
Renal functional units known as nephrons undergo patterning events during development that create a segmental array of cellular...
Link:
https://dev.biologists.org/content/146/13/dev172387
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers BE, Gerlach GF, Clark EG, Chen KH, Levesque AE, Leshchiner I, Goessling W, Wingert RA. Tfap2a is a novel gatekeeper of nephron differentiation during kidney development. Development. 2019 Jun 3. pii: dev.172387. doi: 10.1242/dev.172387. [Epub ahead of print].

Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis

Authors:
Sharma P, Saraswathy VM, Xiang L, Fürthauer M
Citation:
Sci Rep. 2019;9(1):9958. doi:10.1038/s41598-019-46067-1
Epub:
Not Epub
Abstract:
The morphogenesis of the nervous system requires coordinating the specification and differentiation of neural precursor cells,...
Link:
https://www.nature.com/articles/s41598-019-46067-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Saraswathy VM, Xiang L, Fürthauer M. Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis. Sci Rep. 2019;9(1):9958. doi:10.1038/s41598-019-46067-1.

Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking

Authors:
Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW
Citation:
Biol Psychiatry. 2019 Jul 8. pii: S0006-3223(19)31508-2. doi: 10.1016/j.biopsych.2019.06.026. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Background: Opioid addiction is a critical medical and social problem characterized by vulnerability to relapse. Glutamatergic...
Link:
https://www.sciencedirect.com/science/article/pii/S0006322319315082
Delivery Method:
bilateral NAcore brain infusion Vivo-Morpholino
Organism or Cell Type:
Rats Sprague-Dawley male
Citation Extract:
Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW. Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking. Biol Psychiatry. 2019 Jul 8. pii: S0006-3223(19)31508-2. doi: 10.1016/j.biopsych.2019.06.026. [Epub ahead of print].

Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion

Authors:
Veloso A, Martin M, Bruyr J, O’Grady T, Deroanne C, Mottet D, Twizere J-C, Cherrier T, Dequiedt F
Citation:
Cell Death & Dis. 2019;10(7):512. doi:10.1038/s41419-019-1743-6
Epub:
Not Epub
Abstract:
Muscle formation is controlled by a number of key myogenic transcriptional regulators that govern stage-specific gene...
Link:
https://www.nature.com/articles/s41419-019-1743-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Veloso A, Martin M, Bruyr J, O’Grady T, Deroanne C, Mottet D, Twizere J-C, Cherrier T, Dequiedt F. Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion. Cell Death & Dis. 2019;10(7):512. doi:10.1038/s41419-019-1743-6.

NIPBL: a new player in myeloid cell differentiation

Authors:
Mazzola M, Deflorian G, Pezzotta A, Ferrari L, Fazio G, Bresciani E, Saitta C, Ferrari L, Fumagalli M, Parma M, Marasca F, Bodega B, Riva P, Cotelli F, Biondi A, Marozzi A, Cazzaniga G, Pistocchi A
Citation:
Haematologica. 2019 Jul;104(7):1332-1341. doi: 10.3324/haematol.2018.200899. Epub 2019 Jan 10
Epub:
Not Epub
Abstract:
The nucleophosmin 1 gene (NPM1) is the most frequently mutated gene in acute myeloid leukemia. Notably, NPM1 mutations are...
Link:
http://www.haematologica.org/content/104/7/1332
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mazzola M, Deflorian G, Pezzotta A, Ferrari L, Fazio G, Bresciani E, Saitta C, Ferrari L, Fumagalli M, Parma M, Marasca F, Bodega B, Riva P, Cotelli F, Biondi A, Marozzi A, Cazzaniga G, Pistocchi A. NIPBL: a new player in myeloid cell differentiation. Haematologica. 2019 Jul;104(7):1332-1341. doi: 10.3324/haematol.2018.200899. Epub 2019 Jan 10.

DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract

Authors:
Blackburn ATM, Bekheirnia N, Uma VC, Corkins ME, Xu Y, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Krantz I, Rodriguez-Buritica D, Wheeler PG, Gazali LA, Mohamed Saeed Mohamed Al Shamsi A, Gomez-Ospina N, Chao HT, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Willsey HR, Braun MC, Lamb DJ, Miller RK, Bekheirnia MR
Citation:
Genet Med. 2019 Jul 2. doi: 10.1038/s41436-019-0576-0. [Epub ahead of print]
Epub:
Yes
Abstract:
PURPOSE: Haploinsufficiency of DYRK1A causes a recognizable clinical syndrome. The goal of this paper is to investigate...
Link:
https://www.nature.com/articles/s41436-019-0576-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Blackburn ATM, Bekheirnia N, Uma VC, Corkins ME, Xu Y, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Krantz I, Rodriguez-Buritica D, Wheeler PG, Gazali LA, Mohamed Saeed Mohamed Al Shamsi A, Gomez-Ospina N, Chao HT, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Willsey HR, Braun MC, Lamb DJ, Miller RK, Bekheirnia MR. DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract. Genet Med. 2019 Jul 2. doi: 10.1038/s41436-019-0576-0. [Epub ahead of print].

Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled

Authors:
Lee M, Hwang YS, Yoon J, Sun J, Harned A, Nagashima K, Daar IO
Citation:
J Cell Biol. 2019 Jul 3. pii: jcb.201811147. doi: 10.1083/jcb.201811147. [Epub ahead of print]
Epub:
Yes
Abstract:
Cilia are critical for proper embryonic development and maintaining homeostasis. Although extensively studied, there are still...
Link:
http://jcb.rupress.org/content/early/2019/07/02/jcb.201811147
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee M, Hwang YS, Yoon J, Sun J, Harned A, Nagashima K, Daar IO. Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled. J Cell Biol. 2019 Jul 3. pii: jcb.201811147. doi: 10.1083/jcb.201811147. [Epub ahead of print].

Long-term treatment with eteplirsen in nonambulatory patients with Duchenne muscular dystrophy

Authors:
Alfano LN, Charleston JS, Connolly AM, Cripe L, Donoghue C, Dracker R, Dworzak J, Eliopoulos H, Frank DE, Lewis S, Lucas K, Lynch J, Milici AJ, Flynt A, Naughton E, Rodino-Klapac LR, Sahenk Z, Schnell FJ, Young GD, Mendell JR, Lowes LP
Citation:
Medicine (Baltimore). 2019 Jun;98(26):e15858. doi: 10.1097/MD.0000000000015858
Epub:
Not Epub
Abstract:
This analysis aims to describe the outcomes of two nonambulatory patients with Duchenne muscular dystrophy (DMD) who...
Link:
https://journals.lww.com/md-journal/Fulltext/2019/06280/Long_term_treatment_with_eteplirsen_in.5.aspx
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Alfano LN, Charleston JS, Connolly AM, Cripe L, Donoghue C, Dracker R, Dworzak J, Eliopoulos H, Frank DE, Lewis S, Lucas K, Lynch J, Milici AJ, Flynt A, Naughton E, Rodino-Klapac LR, Sahenk Z, Schnell FJ, Young GD, Mendell JR, Lowes LP. Long-term treatment with eteplirsen in nonambulatory patients with Duchenne muscular dystrophy. Medicine (Baltimore). 2019 Jun;98(26):e15858. doi: 10.1097/MD.0000000000015858.

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