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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus

Authors:
Date P, Ackermann P, Furey C, Fink IB, Jonas S, Khokha MK, Kahle KT, Deniz E
Citation:
Sci Rep. 2019;9(1):6196. doi:10.1038/s41598-019-42549-4
Epub:
Not Epub
Abstract:
Cerebrospinal fluid (CSF) flow in the brain ventricles is critical for brain development. Altered CSF flow dynamics have been...
Link:
https://www.nature.com/articles/s41598-019-42549-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Date P, Ackermann P, Furey C, Fink IB, Jonas S, Khokha MK, Kahle KT, Deniz E. Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus. Sci Rep. 2019;9(1):6196. doi:10.1038/s41598-019-42549-4.

Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion

Authors:
Spataro R, Kousi M, Farhan SMK, Willer JR, Ross JP, Patrick A. Dion PA, Rouleau GA, Daly, Neale BM, La Bella V, Katsanis N
Citation:
Hum Genomics. 2019;13:19. doi:10.1186/s40246-019-0203-9
Epub:
Not Epub
Abstract:
Background: Amyotrophic lateral sclerosis [1] is a genetically heterogeneous neurodegenerative disorder, characterized by late-...
Link:
https://humgenomics.biomedcentral.com/articles/10.1186/s40246-019-0203-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Spataro R, Kousi M, Farhan SMK, Willer JR, Ross JP, Patrick A. Dion PA, Rouleau GA, Daly, Neale BM, La Bella V, Katsanis N. Mutations in ATP13A2 (PARK9) are associated with an amyotrophic lateral sclerosis-like phenotype, implicating this locus in further phenotypic expansion. Hum Genomics. 2019;13:19. doi:10.1186/s40246-019-0203-9.

Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite

Authors:
Abe K, Shimada A, Tayama S, Nishikawa H, Kaneko T, Tsuda S, Karaiwa A, Matsui T, Ishitani T, Takeda H
Citation:
Cell Rep. 2019;27(3):928-39.E4. doi:10.1016/j.celrep.2019.03.068
Epub:
Not Epub
Abstract:
Establishment of robust gene expression boundary is crucial for creating elaborate morphology during development. However,...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30398-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Abe K, Shimada A, Tayama S, Nishikawa H, Kaneko T, Tsuda S, Karaiwa A, Matsui T, Ishitani T, Takeda H. Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite. Cell Rep. 2019;27(3):928-39.E4. doi:10.1016/j.celrep.2019.03.068.

The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish

Authors:
Jiménez-Amilburu V, Stainier DYR
Citation:
Development. 2019;[Epub ahead of print] doi:10.1242/dev.171207
Epub:
Yes
Abstract:
Tissue morphogenesis requires changes in cell-cell adhesion as well as in cell shape and polarity. Cardiac trabeculation is a...
Link:
http://dev.biologists.org/content/early/2019/04/11/dev.171207
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiménez-Amilburu V, Stainier DYR. The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish. Development. 2019;[Epub ahead of print] doi:10.1242/dev.171207.

Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis

Authors:
Mills A, Bearce E, Cella R, Kim SW, Selig M, Lee S, Lowery LA
Citation:
Front Physiol. 2019;10:431 doi:10.3389/fphys.2019.00431
Epub:
Not Epub
Abstract:
Wolf-Hirschhorn Syndrome (WHS) is a human developmental disorder arising from a hemizygous perturbation, typically a...
Link:
https://www.frontiersin.org/articles/10.3389/fphys.2019.00431/full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mills A, Bearce E, Cella R, Kim SW, Selig M, Lee S, Lowery LA. Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis. Front Physiol. 2019;10:431 doi:10.3389/fphys.2019.00431.

Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development

Authors:
Hernandez JA, Castro VL, Reyes-Nava N, Montes LP, Quintana AM
Citation:
Blood Adv. 2019;3:1244-54. doi:10.1182/bloodadvances.2018024539
Epub:
Not Epub
Abstract:
Erythropoiesis is the process by which new red blood cells (RBCs) are formed and defects in this process can lead to anemia or...
Link:
http://www.bloodadvances.org/content/3/8/1244
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hernandez JA, Castro VL, Reyes-Nava N, Montes LP, Quintana AM. Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood Adv. 2019;3:1244-54. doi:10.1182/bloodadvances.2018024539.

Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation

Authors:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S
Citation:
Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8
Epub:
Yes
Abstract:
It is largely unknown how living organisms - especially vertebrates - survive and thrive in the coldness, darkness and high...
Link:
https://www.nature.com/articles/s41559-019-0864-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang K, Shen Y, Yang Y, Gan X, Liu G, Hu K, Li Y, Gao Z, Zhu L, Yan G, He L, Shan X, Yang L, Lu S, Zeng H, Pan X, Liu C, Yuan Y, Feng C, Xu W, Zhu C, Xiao W, Dong Y, Wang W, Qiu Q, He S. Morphology and genome of a snailfish from the Mariana Trench provide insights into deep-sea adaptation. Nature Ecol Evol. 2019;[Epub ahead of print] doi:10.1038/s41559-019-0864-8.

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

Authors:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J
Citation:
Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024
Epub:
Yes
Abstract:
During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes...
Link:
https://www.sciencedirect.com/science/article/pii/S0014483518307024
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vetrivel S, Tiso N, Kügler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Götz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Hölter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Rácz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Östereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, de Angelis MH, Graw J. Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019;[Epub ahead of print] doi:10.1016/j.exer.2019.03.024.

Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos

Authors:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J
Citation:
Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19
Epub:
Not Epub
Abstract:
During development from oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to...
Link:
http://dev.biologists.org/content/144/3/519
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19.

Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis

Authors:
Schwenty-Lara J, Nürnberger A, Borchers A
Citation:
Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print]
Epub:
Yes
Abstract:
BACKGROUND: Kabuki syndrome is a haploinsufficient congenital multi-organ malformation syndrome, which frequently includes...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.39
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schwenty-Lara J, Nürnberger A, Borchers A. Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print].

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