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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice

Authors:
Mourich DV, Oda SK, Schnell FJ, Crumley SL, Hauck LL, Moentenich CA, Marshall NB, Hinrichs DJ, Iversen PL
Citation:
Nucleic Acid Ther. 2014 Apr;24(2):114-26. doi: 10.1089/nat.2013.0449. Epub 2014 Feb 4
Epub:
Not Epub
Abstract:
Activated and regulatory T cells express the negative co-stimulatory molecule cytotoxic T-lymphocyte-associated antigen-4 (CTLA...
Link:
https://www.liebertpub.com/doi/abs/10.1089/nat.2013.0449
Organism or Cell Type:
non-obese diabetic (NOD) mice
Citation Extract:
Mourich DV, Oda SK, Schnell FJ, Crumley SL, Hauck LL, Moentenich CA, Marshall NB, Hinrichs DJ, Iversen PL. Alternative splice forms of CTLA-4 induced by antisense mediated splice-switching influences autoimmune diabetes susceptibility in NOD mice. Nucleic Acid Ther. 2014 Apr;24(2):114-26. doi: 10.1089/nat.2013.0449. Epub 2014 Feb 4.

The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish

Authors:
Stanic K, Reig G, Wichmann IA, Opazo JC, Owen GI, Corvalán AH, Concha ML, Amigo JD
Citation:
Sci Rep. 2019;9(1):7131. doi:10.1038/s41598-019-43436-8
Epub:
Not Epub
Abstract:
The Reprimo gene family comprises a group of single-exon genes for which their physiological function remains poorly understood...
Link:
https://www.nature.com/articles/s41598-019-43436-8
Citation Extract:
Stanic K, Reig G, Wichmann IA, Opazo JC, Owen GI, Corvalán AH, Concha ML, Amigo JD. The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Sci Rep. 2019;9(1):7131. doi:10.1038/s41598-019-43436-8.

Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis

Authors:
Heath CM, Wignall SM
Citation:
Mol Biol Cell. 2019 May 8:mbcE18100666. doi: 10.1091/mbc.E18-10-0666. [Epub ahead of print]
Epub:
Yes
Abstract:
Oocytes of many species lack centrioles, and therefore form acentriolar spindles. Despite the necessity of oocyte meiosis for...
Link:
https://www.molbiolcell.org/doi/abs/10.1091/mbc.E18-10-0666
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Heath CM, Wignall SM. Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis. Mol Biol Cell. 2019 May 8:mbcE18100666. doi: 10.1091/mbc.E18-10-0666. [Epub ahead of print].

Endoglin is a conserved regulator of vasculogenesis in zebrafish-Implications for hereditary haemorrhagic telangiectasia

Authors:
Zhang D, Zhou F, Zhao X, Liu B, Chen J, Yang J
Citation:
Biosci Rep. 2019 May 7. pii: BSR20182320. doi: 10.1042/BSR20182320. [Epub ahead of print]
Epub:
Yes
Abstract:
Hereditary haemorrhagic telangiectasia (HHT) is a progressive vascular disease with high mortality and prevalence. There is no...
Link:
http://www.bioscirep.org/content/early/2019/05/07/BSR20182320.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang D, Zhou F, Zhao X, Liu B, Chen J, Yang J. Endoglin is a conserved regulator of vasculogenesis in zebrafish-Implications for hereditary haemorrhagic telangiectasia. Biosci Rep. 2019 May 7. pii: BSR20182320. doi: 10.1042/BSR20182320. [Epub ahead of print].

Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish

Authors:
Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, Davis GE, Arnaout MA, Xiong JW
Citation:
FASEB J. 2015 Dec;29(12):4989-5005. doi: 10.1096/fj.15-273409. Epub 2015 Aug 26
Epub:
Not Epub
Abstract:
Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role...
Link:
www.fasebj.org/doi/full/10.1096/fj.15-273409
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, Davis GE, Arnaout MA, Xiong JW. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015 Dec;29(12):4989-5005. doi: 10.1096/fj.15-273409. Epub 2015 Aug 26.

GIPC proteins negatively modulate Plexind1 signaling during vascular development

Authors:
Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez-González J, Gay CM, Zygmunt T, Li X, Torres-Vázquez J
Citation:
Elife. 2019 May 3;8. pii: e30454. doi: 10.7554/eLife.30454
Epub:
Not Epub
Abstract:
Semaphorins (SEMAs) and their Plexin (PLXN) receptors are central regulators of metazoan cellular communication. SEMA-PLXND1...
Link:
https://elifesciences.org/articles/30454
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez-González J, Gay CM, Zygmunt T, Li X, Torres-Vázquez J. GIPC proteins negatively modulate Plexind1 signaling during vascular development. Elife. 2019 May 3;8. pii: e30454. doi: 10.7554/eLife.30454.

Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio)

Authors:
Tuttle M, Dalman MR, Liu Q, Londraville RL
Citation:
PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848
Epub:
Not Epub
Abstract:
We analyzed microarray expression data to highlight biological pathways that respond to embryonic zebrafish Leptin-a (lepa)...
Link:
https://peerj.com/articles/6848/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuttle M, Dalman MR, Liu Q, Londraville RL. Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio). PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848.

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice

Authors:
Wang M, Wu B, Shah SN, Lu P, Lu Q
Citation:
Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023
Epub:
Yes
Abstract:
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy with ongoing clinical...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30096-4
Delivery Method:
Endo-Porter, aminoglycoside
Organism or Cell Type:
cell culture, mice mdx
Citation Extract:
Wang M, Wu B, Shah SN, Lu P, Lu Q. Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice. Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023.

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress

Authors:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L
Citation:
Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18
Epub:
Not Epub
Abstract:
Several lines of evidence link the canonical oncogene BCL6 to stress response. Here we demonstrate that BCL6 evolved in...
Link:
http://cancerdiscovery.aacrjournals.org/content/9/5/662
Organism or Cell Type:
zebrafish
Citation Extract:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L. BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress. Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18.

Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation

Authors:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC
Citation:
Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print]
Epub:
Yes
Abstract:
A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on cell...
Link:
http://dev.biologists.org/content/early/2019/04/26/dev.173112
Citation Extract:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC. Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation. Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print].

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