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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies

Authors:
Holt RJ, Young RM, Crespo B, Ceroni F, Curry CJ, Bellacchio E, Bax DA, Ciolfi A, Simon M, Fagerberg CR, van Binsbergen E, De Luca A, Memo L, Dobyns WB, Mohammed AA, Clokie SJH, Seco CZ, Jiang Y-H, Sørensen KP, Andersen H, Sullivan J, Powis Z, Chassevent A, Smith-Hicks C, Petrovski S, Antoniadi T, Shashi V, Gelb BD, Wilson SW, Gerrelli D, Tartaglia M, Chassaing N, Calvas P, Ragge NK
Citation:
Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2019.07.005
Epub:
Yes
Abstract:
The identification of genetic variants implicated in human developmental disorders has been revolutionized by second-generation...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(19)30268-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Holt RJ, Young RM, Crespo B, Ceroni F, Curry CJ, Bellacchio E, Bax DA, Ciolfi A, Simon M, Fagerberg CR, van Binsbergen E, De Luca A, Memo L, Dobyns WB, Mohammed AA, Clokie SJH, Seco CZ, Jiang Y-H, Sørensen KP, Andersen H, Sullivan J, Powis Z, Chassevent A, Smith-Hicks C, Petrovski S, Antoniadi T, Shashi V, Gelb BD, Wilson SW, Gerrelli D, Tartaglia M, Chassaing N, Calvas P, Ragge NK. De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2019.07.005.

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

Authors:
Bonkhofer F, Rispoli R, Pinheiro P, Krecsmarik M, Schneider-Swales J, Tsang IHC, de Bruijn M, Monteiro R, Peterkin T, Patient R
Citation:
Nat Comm. 2019;10(1):3577. doi:10.1038/s41467-019-11423-2
Epub:
Not Epub
Abstract:
Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA)....
Link:
https://www.nature.com/articles/s41467-019-11423-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonkhofer F, Rispoli R, Pinheiro P, Krecsmarik M, Schneider-Swales J, Tsang IHC, de Bruijn M, Monteiro R, Peterkin T, Patient R. Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nat Comm. 2019;10(1):3577. doi:10.1038/s41467-019-11423-2.

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes

Authors:
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk H-D, Böttcher-Friebertshäuser E
Citation:
J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19
Epub:
Yes
Abstract:
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We...
Link:
https://jvi.asm.org/content/early/2019/08/05/JVI.00649-19
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: primary human bronchial epithelial cells (HBEC), primary type II alveolar epithelial cells (AECII) and Calu-3 cells
Citation Extract:
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk H-D, Böttcher-Friebertshäuser E. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19.

Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly

Authors:
Lepage SE, Tada M, Bruce AE
Citation:
Dev Biol. 2014 Jan 1;385(1):52-66. doi: 10.1016/j.ydbio.2013.10.015. Epub 2013 Oct 24
Epub:
Not Epub
Abstract:
Epiboly, the first morphogenetic cell movement that occurs in the zebrafish embryo, is the process by which the blastoderm...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160613005599
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lepage SE, Tada M, Bruce AE. Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly. Dev Biol. 2014 Jan 1;385(1):52-66. doi: 10.1016/j.ydbio.2013.10.015. Epub 2013 Oct 24.

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

Authors:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y
Citation:
bioRxiv. 2019:[preprint] doi:10.1101/693853
Epub:
Not Epub
Abstract:
The CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in...
Link:
https://www.biorxiv.org/content/10.1101/693853v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y. Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs. bioRxiv. 2019:[preprint] doi:10.1101/693853 .

Evolution of abbreviated development in Heliocidaris erythrogramma dramatically re-wired the highly conserved sea urchin developmental gene regulatory network to decouple signaling center function from ultimate fate

Authors:
Edgar A, Byrnev M, McClay DR, Wray GA
Citation:
bioRxiv. 2019:[preprint] doi:10.1101/712216
Epub:
Not Epub
Abstract:
Developmental gene regulatory networks (GRNs) describe the interactions among gene products that drive the differential...
Link:
https://www.biorxiv.org/content/10.1101/712216v1
Delivery Method:
microinjection
Organism or Cell Type:
Heliocidaris erythrogramma (sea urchin)
Citation Extract:
Edgar A, Byrnev M, McClay DR, Wray GA. Evolution of abbreviated development in Heliocidaris erythrogramma dramatically re-wired the highly conserved sea urchin developmental gene regulatory network to decouple signaling center function from ultimate fate. bioRxiv. 2019:[preprint] doi:10.1101/712216.

Gclc deletion in surface-ectoderm tissues induces microphthalmia

Authors:
Thompson B, Chen Y, Philippe J, Anderson D, Golla JP, Davidson E, Apostolopoulos N, Schey K, Katsanis N, Orlicky DJ, Thompson D, Vasiliou V
Citation:
bioRxiv. 2019:[preprint]. doi:10.1101/700591
Epub:
Not Epub
Abstract:
Glutamate cysteine ligase catalytic subunit (Gclc) is the catalytic subunit for the glutamate-cysteine ligase (Gcl) enzyme. Gcl...
Link:
https://www.biorxiv.org/content/10.1101/700591v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Thompson B, Chen Y, Philippe J, Anderson D, Golla JP, Davidson E, Apostolopoulos N, Schey K, Katsanis N, Orlicky DJ, Thompson D, Vasiliou V. Gclc deletion in surface-ectoderm tissues induces microphthalmia. bioRxiv. 2019:[preprint]. doi:10.1101/700591.

Planar Polarization of Cilia in the Zebrafish Floor Plate Involves Par3-Mediated Posterior Localization of Highly Motile Basal Bodies

Authors:
Donati A, Schneider-Maunoury S, Vesque C
Citation:
bioRxiv. 2019:[preprint] doi:10.1101/702282
Epub:
Not Epub
Abstract:
To produce a directional flow, ciliated epithelia display a uniform orientation of ciliary beating. Oriented beating requires...
Link:
https://www.biorxiv.org/content/10.1101/702282v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Donati A, Schneider-Maunoury S, Vesque C. Planar Polarization of Cilia in the Zebrafish Floor Plate Involves Par3-Mediated Posterior Localization of Highly Motile Basal Bodies. bioRxiv. 2019:[preprint] doi:10.1101/702282.

Greb1 is required for axial elongation and segmentation in vertebrate embryos

Authors:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D
Citation:
bioRxiv. 2019:[preprint] doi:10.1101/692095
Epub:
Not Epub
Abstract:
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that...
Link:
https://www.biorxiv.org/content/10.1101/692095v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D. Greb1 is required for axial elongation and segmentation in vertebrate embryos. bioRxiv. 2019:[preprint] doi:10.1101/692095.

Histone code dictates fate biasing of neural crest cells to melanocyte lineage

Authors:
Raja DA, Subramaniam Y, Gotherwal V, Tanwar J, Motiani R, Sivasubbu S, Gokhale RS, Natarajan VT
Citation:
bioRxiv. 2019;[preprint]. doi:10.1101/702332
Epub:
Not Epub
Abstract:
In the neural crest lineage, progressive fate-restriction and stem cell assignment are critical for both development and...
Link:
https://www.biorxiv.org/content/10.1101/702332v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Raja DA, Subramaniam Y, Gotherwal V, Tanwar J, Motiani R, Sivasubbu S, Gokhale RS, Natarajan VT. Histone code dictates fate biasing of neural crest cells to melanocyte lineage. bioRxiv. 2019;[preprint]. doi:10.1101/702332 .

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