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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish
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Citation:
PLoS Genet. 2021;17(9):e1009823. doi:10.1371/journal.pgen.1009823 Epub:
Not Epub Abstract:
Epithelia such as epidermis cover large surfaces and are crucial for survival. Maintenance of tissue homeostasis by balancing... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Phatak M, Kulkarni S, Miles LB, Anjum N, Dworkin S, Sonawane M. Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish. PLoS Genet. 2021;17(9):e1009823. doi:10.1371/journal.pgen.1009823. |
Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy
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Citation:
J Neuromuscul Dis. 2021 Sep 23. doi: 10.3233/JND-210696. Online ahead of print Epub:
Not Epub Abstract:
Recently, the Food and Drug Administration granted accelerated approvals for four exon skipping therapies -Eteplirsen,... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice Citation Extract: Novak JS, Spathis R, Dang UJ, Fiorillo AA, Hindupur R, Tully CB, Mázala DAG, Canessa E, Brown KJ, Partridge TA, Hathout Y, Nagaraju K. Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy. J Neuromuscul Dis. 2021 Sep 23. doi: 10.3233/JND-210696. Online ahead of print. |
Effects of Chronic, Maximal Phosphorodiamidate Morpholino Oligomer (PMO) Dosing on Muscle Function and Dystrophin Restoration in a Mouse Model of Duchenne Muscular Dystrophy
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Citation:
J Neuromuscul Dis. 2021 Sep 18. doi: 10.3233/JND-210701. Online ahead of print Epub:
Not Epub Abstract:
Background: Phosphorodiamidate morpholino oligomer (PMO)-mediated exon skipping is currently used in clinical development to... Delivery Method:
injection Organism or Cell Type:
mice Citation Extract: Benny Klimek ME, Vila MC, Edwards K, Boehler J, Novak J, Zhang A, Van der Mulen JH, Tatum K, Quinn J, Fiorillo A, Burki U, Straub V, Lu QL, Hathout Y, van Den Anker J, Partridge TA, Morales M, Hoffman E, Nagaraju K. Effects of Chronic, Maximal Phosphorodiamidate Morpholino Oligomer (PMO) Dosing on Muscle Function and Dystrophin Restoration in a Mouse Model of Duchenne Muscular Dystrophy. J Neuromuscul Dis. 2021 Sep 18. doi: 10.3233/JND-210701. Online ahead of print. |
The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity
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Citation:
Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-911428/v1 Epub:
Not Epub Abstract:
Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Paradis M, Kucharowski N, Edwards G, Palacios SM, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow M. The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-911428/v1. |
The cohesin stabilizer Sororin drives G2-M transition and spindle assembly in mammalian oocytes
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Citation:
Sci Adv. 2021;7(39):eabg9335 doi:10.1126/sciadv.abg9335 Epub:
Not Epub Abstract:
During the S phase of mitosis, Sororin is recruited by acetylated Smc3 and stabilizes sister chromatid cohesion by... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Zhou C, Zhang X, Miao Y, Zhang Y, Li Y, Xiong B. The cohesin stabilizer Sororin drives G2-M transition and spindle assembly in mammalian oocytes. Sci Adv. 2021;7(39):eabg9335 doi:10.1126/sciadv.abg9335. |
Dopamine-neurotransmission and nociception in zebrafish: An anti-nociceptive role of dopamine receptor drd2a
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Citation:
Eur J Pharmacol. 2021 Sep 20:174517. doi: 10.1016/j.ejphar.2021.174517. Online ahead of print Epub:
Yes Abstract:
Dopamine (DA) is an important modulator in nociception and analgesia. Spinal DA receptors are involved in descending modulation... Organism or Cell Type:
zebrafish Citation Extract: van Reij RRI, Salmans MMA, Eijkenboom I, van den Hoogen NJ, Joosten EAJ, Vanoevelen JM. Dopamine-neurotransmission and nociception in zebrafish: An anti-nociceptive role of dopamine receptor drd2a. Eur J Pharmacol. 2021 Sep 20:174517. doi: 10.1016/j.ejphar.2021.174517. Online ahead of print. |
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy
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Citation:
Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2 Epub:
Yes Abstract:
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and... Delivery Method:
intranasal peptide-linked Organism or Cell Type:
mice Citation Extract: Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy. Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2. |
Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues
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Citation:
Org Biomol Chem. 2021;[Epub] doi:10.1039/D1OB01174J Epub:
Yes Abstract:
The polyanionic phosphodiester backbone of nucleic acids contributes to high nuclease sensitivity and low cellular uptake and... Citation Extract: Debreczeni N, Bege M, Herczeg M, Bereczki I, Batta G, Herczegh P, Borbás A. Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues. Org Biomol Chem. 2021;[Epub] doi:10.1039/D1OB01174J. |
Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling
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Citation:
Biomedicines. 2021;9(10):1294. doi:10.3390/biomedicines9101294 Epub:
Not Epub Abstract:
Zebrafish embryos and larvae have emerged as an excellent model in cardiovascular research and are amenable to live imaging... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Vicente M, Salgado-Almario J, Collins MM, Martínez-Sielva A, Minoshima M, Kikuchi K, Domingo B, Llopis J. Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling. Biomedicines. 2021;9(10):1294. doi:10.3390/biomedicines9101294. |
A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
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Citation:
Elife. 2021 Sep 22;10:e69795. doi: 10.7554/eLife.69795 Epub:
Not Epub Abstract:
Parkinson's disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 Sep 22;10:e69795. doi: 10.7554/eLife.69795. |