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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
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Citation:
Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print Epub:
Not Epub Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the... Delivery Method:
peptide-linked plus endosome escape reagent (OEC) Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse Citation Extract: Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print. |
Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial
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Citation:
Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print Epub:
Yes Abstract:
Introduction/aims: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting in the absence of... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Wagner KR, Kuntz NL, Koenig E, East L, Upadhyay S, Han B, Shieh PB. Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial. Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print. |
The gene regulatory system for specifying germ layers in early embryos of the simple chordate
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Citation:
Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210 Epub:
Not Epub Abstract:
In animal embryos, gene regulatory networks control the dynamics of gene expression in cells and coordinate such dynamics among... Delivery Method:
microinjection Organism or Cell Type:
Ciona intestinalis Citation Extract: Tokuoka M, Maeda K, Kobayashi K, Mochizuki A, Satou Y. The gene regulatory system for specifying germ layers in early embryos of the simple chordate. Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210. |
Integrin intra-heterodimer affinity inversely correlates with integrin activatability
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Citation:
Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230 Epub:
Not Epub Abstract:
Integrins are heterodimeric cell surface receptors composed of an α and β subunit that mediate cell adhesion to extracellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sun G, Guillon E, Holley SA. Integrin intra-heterodimer affinity inversely correlates with integrin activatability. Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230. |
eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping
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Citation:
Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442 Epub:
Yes Abstract:
Exon skipping using antisense oligonucleotides (ASOs) has recently proven to be a powerful tool for mRNA splicing modulation.... Organism or Cell Type:
cell culture: primary human myotubes Citation Extract: Chiba S, Lim KRQ, Sheri N, Anwar S, Erkut E, Shah MNA, Aslesh T, Woo S, Sheikh O, Maruyama R, Takano H, Kunitake K, Duddy W, Okuno Y, Aoki Y, Yokota T. eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping. Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442. |
Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β
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Citation:
J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print Epub:
Yes Abstract:
Neuro-immune interaction during development is strongly implicated in the pathogenesis of neurodevelopmental disorders, but the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Solek CM, Farooqi NAI, Brake N, Kesner P, Schohl A, Antel JP, Ruthazer ES. Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β. J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print. |
Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053 Epub:
Not Epub Abstract:
Zebrafish Müller glia (MG) respond to retinal injury by suppressing Notch signaling and producing progenitors for retinal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sahu A, Devi S, Jui J, Goldman D. Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053. |
A precise regulation of presenilin expression is required for the sea urchin early development
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Citation:
J Cell Sci. 2021;jcs.258382. doi:10.1242/jcs.258382 Epub:
Not Epub Abstract:
Presenilins or PSENs homologues are widely expressed across eukaryotes. Two PSEN are expressed in humans where they play a... Organism or Cell Type:
sea urchin Citation Extract: Bronchain O, Philippe-Caraty L, Anquetil V, Ciapa B. A precise regulation of presenilin expression is required for the sea urchin early development. J Cell Sci. 2021;jcs.258382. doi:10.1242/jcs.258382. |
Three-dimensional folding dynamics of the Xenopus tropicalis genome
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Citation:
Nat Genet. 2021;[Epub ahead of print] doi:10.1038/s41588-021-00878-z Epub:
Yes Abstract:
Animal interphase chromosomes are organized into topologically associating domains (TADs). How TADs are formed is not fully... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Niu L, Shen W, Shi Z, Tan Y, He N, Wan J, Sun J, Zhang Y, Huang Y, Wang W, Fang C, Li J, Zheng P, Cheung E, Chen Y, Li L, Hou C. Three-dimensional folding dynamics of the Xenopus tropicalis genome. Nat Genet. 2021;[Epub ahead of print] doi:10.1038/s41588-021-00878-z. |
Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.06.04.447039 Epub:
Not Epub Abstract:
Phosphorodiamidate Morpholino Oligonucleotides (PMOs)-based antisense reagents cannot enter inside cells by itself without the... Delivery Method:
guanidinium-morpholino and Morpholino chimeras Organism or Cell Type:
cell culture: Shh-Light 2, MCF7, PC-3, MDA MB-231, Shh-N; zebrafish Citation Extract: Kundu J, Das U, Bose C, Bhadra J, Sinha S. Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.06.04.447039. |