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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development
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Citation:
PLoS Genet. 2021;17(8):e1009698. doi:10.1371/journal.pgen.1009698 Epub:
Not Epub Abstract:
Hirschsprung disease (HSCR) is a complex genetic disease characterized by absence of ganglia in the intestine. HSCR etiology... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kuil LE, MacKenzie KC, Tang CS, Windster JD, Le TL, Karim A, de Graaf BM, van der Helm R, van Bever Y, Sloots CEJ, Meeussen C, Tibboel D, de Klein A, Wijnen RMH, Amiel J, Lyonnet S, Garcia-Barcelo M-M, Tam PKH, Alves MM, Brooks AS, Hofstra RMW, Brosens E. Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genet. 2021;17(8):e1009698. doi:10.1371/journal.pgen.1009698. |
Deep learning to design nuclear-targeting abiotic miniproteins
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Citation:
Nat Chem. 2021;[Epub ahead of print] doi:10.1038/s41557-021-00766-3 Epub:
Not Epub Abstract:
There are more amino acid permutations within a 40-residue sequence than atoms on Earth. This vast chemical search space... Delivery Method:
protein-linked Organism or Cell Type:
cell culture Citation Extract: Schissel CK, Mohapatra S, Wolfe JM, Fadzen CM, Bellovoda K, Wu C-L, Wood JA, Malmberg AB, Loas A, Gómez-Bombarelli R, Pentelute BL. Deep learning to design nuclear-targeting abiotic miniproteins. Nat Chem. 2021;[Epub ahead of print] doi:10.1038/s41557-021-00766-3. |
Disc and Actin-Associated Protein 1 Influence Host Attachment in the Intestinal Parasite Giardia lamblia
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.06.455446 Epub:
Not Epub Abstract:
The deep-branching eukaryote Giardia lamblia is an extracellular parasite that attaches to the host intestine via a microtubule... Delivery Method:
electroporation Organism or Cell Type:
Giardia lamblia Citation Extract: Steele-Ogus MC, Obenaus AM, Sniadecki NJ, Paredez AR. Disc and Actin-Associated Protein 1 Influence Host Attachment in the Intestinal Parasite Giardia lamblia. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.06.455446. |
Neuron Navigator 3 (NAV3) is Required for Heart Development
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Citation:
Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-734749/v1 Epub:
Not Epub Abstract:
Background: As a tightly controlled biological process, cardiogenesis requires the specification and migration of a suite of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lv F, Yuan F, Lu X, Ge X, Shi L, Wang X, Liu D, Chen C. Neuron Navigator 3 (NAV3) is Required for Heart Development. Research Square. 2021;[preprint] doi:10.21203/rs.3.rs-734749/v1. |
Adequate expression of neuropeptide Y is essential for the recovery of zebrafish motor function following spinal cord injury
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Citation:
Exp Neurol. 2021 Aug 4:113831. doi: 10.1016/j.expneurol.2021.113831. Online ahead of print Epub:
Yes Abstract:
In strong contrast to limited repair within the mammalian central nervous system, the spinal cord of adult zebrafish is capable... Organism or Cell Type:
zebrafish Citation Extract: Cui C, Wang LF, Huang SB, Zhao P, Chen YQ, Wu YB, Qiao CM, Zhao WJ, Shen YQ. Adequate expression of neuropeptide Y is essential for the recovery of zebrafish motor function following spinal cord injury. Exp Neurol. 2021 Aug 4:113831. doi: 10.1016/j.expneurol.2021.113831. Online ahead of print. |
Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.03.454978 Epub:
Not Epub Abstract:
Vessel growth integrates diverse extrinsic signals with intrinsic signaling cascades to coordinate cell migration and sprouting... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Watterston C, Halabi R, McFarlane S, Childs SJ. Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.03.454978. |
Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish
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Citation:
PLoS Genet. 2021;17(8):e1009693. doi:10.1371/journal.pgen.1009693 Epub:
Not Epub Abstract:
The ubiquitin-proteasome system plays important roles in various biological processes as it degrades the majority of cellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gao S, Wang Z, Wang L, Wang H, Yuan H, Liu X, Chen S, Chen Z, de Thé H, Zhang W, Zhang Y, Zhu J, Zhou J. Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish. PLoS Genet. 2021;17(8):e1009693. doi:10.1371/journal.pgen.1009693. |
Open-Label Evaluation of Eteplirsen in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping: PROMOVI Trial
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Citation:
J Neuromuscul Dis. 2021 Jun 8;[Epub ahead of print]. doi:10.3233/JND-210643 Epub:
Yes Abstract:
Background: Eteplirsen received accelerated FDA approval for treatment of Duchenne muscular dystrophy (DMD) with mutations... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: McDonald CM, Shieh PB, Abdel-Hamid HZ, Connolly AM, Ciafaloni E, Wagner KR, Goemans N, Mercuri E, Khan N, Koenig E, Malhotra J, Zhang W, Han B, Mendell JR, the Italian DMD Telethon Registry Study Group, Leuven NMRC Registry Investigators, CINRG Duchenne Natural History Investigators, and PROMOVI Trial Clinical Investigators. Open-Label Evaluation of Eteplirsen in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping: PROMOVI Trial. J Neuromuscul Dis. 2021 Jun 8;[Epub ahead of print]. doi:10.3233/JND-210643. |
The role of Musashi-1 in CEP290 c.2991+1655A>G cryptic exon splicing in Leber Congenital Amaurosis
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Citation:
bioRXiv. 2021;[preprint] doi:10.1101/2021.08.04.454918 Epub:
Not Epub Abstract:
Human photoreceptors maximise alternative exon splicing to generate a unique set of gene isoforms. Conversely, the inclusion of... Organism or Cell Type:
cell culture: human retinal organoids Citation Extract: Ottaviani D, Lane A, Jovanovic K, Gardner JC, Sladen PE, Hau KL, Panes AB, Guarascio R, Hardcastle AJ, Cheetham ME. The role of Musashi-1 in CEP290 c.2991+1655A>G cryptic exon splicing in Leber Congenital Amaurosis. bioRXiv. 2021;[preprint] doi:10.1101/2021.08.04.454918. |
An efficient miRNA knockout approach using CRISPR-Cas9 in Xenopus
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.05.454468 Epub:
Not Epub Abstract:
In recent years CRISPR-Cas9 knockouts (KO) have become increasingly ultilised to study gene function. MicroRNAs (miRNAs) are... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Godden AM, Ward NJ, van der Lee M, Abu-Daya A, Guille M, Wheeler GN. An efficient miRNA knockout approach using CRISPR-Cas9 in Xenopus. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.05.454468 . |