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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies
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Citation:
Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552 Epub:
Not Epub Abstract:
The literature surrounding the use of antisense oligonucleotides continues to grow, with new disease and mechanistic... Delivery Method:
cell bathing, injection subcutaneous and intraperitoneal (s.c. & i.p.) Organism or Cell Type:
cell culture: human fibroblasts, SH-SY5Y neuroblastoma, mdx myoblasts; mice Citation Extract: Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552. |
Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178 Epub:
Not Epub Abstract:
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other... Delivery Method:
microinjection Organism or Cell Type:
Nematostella vectensis (cniderian) Citation Extract: Tournière O, Busengdal H, Gahan JM, Rentzsch F. Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178. |
Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809 Epub:
Not Epub Abstract:
During embryonic development, very few hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium, that will... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cacialli P, Mailhe M-P, Golub R, Bertrand JY. Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809. |
Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715 Epub:
Not Epub Abstract:
The surrogate reproduction technique provides a powerful tool for production of allogenic or xenogeneic gametes derived from... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhang F, Li X, Hao Y, Li Y, Ye D, He M, Wang H, Zhu Z, Sun Y. Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715. |
TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219 Epub:
Not Epub Abstract:
The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis Citation Extract: Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219. |
Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis
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Citation:
Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9 Epub:
Not Epub Abstract:
GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D. Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9. |
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements
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Citation:
Science. 2021;372(6543): doi:10.1126/science.abc7531 Epub:
Not Epub Abstract:
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain... Delivery Method:
Endo-Porter Organism or Cell Type:
Cell culture: HCC1806-LM2 , MDA-LM2 Citation Extract: Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements. Science. 2021;372(6543): doi:10.1126/science.abc7531. |
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
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Citation:
Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740 Epub:
Not Epub Abstract:
Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740. |
Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.02.438148 Epub:
Not Epub Abstract:
RUNX1 is essential for the generation of hematopoietic stem cells (HSCs). Runx1 null mouse embryos lack definitive... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell’Orso S, Sartorelli V, Sood R, Liu P. Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.02.438148 . |
Maternal and zygotic factors sequentially shape the tissue regionalization of chromatin landscapes in early vertebrate embryos
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.14.439777 Epub:
Not Epub Abstract:
One of the first steps in cellular differentiation of vertebrate embryos is the formation of the three germ layers. Maternal... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Paraiso KD, Blitz IL, Cho KWY. Maternal and zygotic factors sequentially shape the tissue regionalization of chromatin landscapes in early vertebrate embryos. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.14.439777. |