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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis

Authors:
García-Castillo J, Alcaraz-Pérez F, Martínez-Balsalobre E, García-Moreno D, Rossmann MP, Fernández-Lajarín M, Bernabé-García M, Pérez-Oliva AB, Rodríguez-Cortez VC, Clara Bueno C, Adatto I, Agarwal S, Menéndez P, Zon LI, Mulero V, Cayuela ML
Citation:
Proc Nat Acad Sci. 2021;118(32):e2015528118. doi:10.1073/pnas.2015528118
Epub:
Not Epub
Abstract:
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in...
Link:
https://www.pnas.org/content/118/32/e2015528118
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
García-Castillo J, Alcaraz-Pérez F, Martínez-Balsalobre E, García-Moreno D, Rossmann MP, Fernández-Lajarín M, Bernabé-García M, Pérez-Oliva AB, Rodríguez-Cortez VC, Clara Bueno C, Adatto I, Agarwal S, Menéndez P, Zon LI, Mulero V, Cayuela ML. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proc Nat Acad Sci. 2021;118(32):e2015528118. doi:10.1073/pnas.2015528118.

Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly

Authors:
Park JE, Kim E, Lee D-W, Park TK, Kim MS, Jang SY, Ahn J, Park KB, Kim K-H, Park H-C, Ki C-S, Kim D-K
Citation:
Sci Rep. 2021;11(1):15931. doi:0.1038/s41598-021-95133-0
Epub:
Not Epub
Abstract:
Rubinstein-Taybi syndrome (RSTS) is a human genetic disorder characterized by distinctive craniofacial features, broad thumbs...
Link:
https://www.nature.com/articles/s41598-021-95133-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Park JE, Kim E, Lee D-W, Park TK, Kim MS, Jang SY, Ahn J, Park KB, Kim K-H, Park H-C, Ki C-S, Kim D-K. Identification of de novo EP300 and PLAU variants in a patient with Rubinstein-Taybi syndrome-related arterial vasculopathy and skeletal anomaly. Sci Rep. 2021;11(1):15931. doi:0.1038/s41598-021-95133-0.

Effect of lgals3a on embryo development of zebrafish

Authors:
Chen K, Fan Y, Gu J, Han Z, Wang Y, Gao L, Zeng H, Mao C, Wang C
Citation:
Transgenic Res. 2021 Aug 4. doi: 10.1007/s11248-021-00276-5. Online ahead of print
Epub:
Yes
Abstract:
Our study was aimed to investigate the effects of lgals3a (Gal-3 encoding gene) on the development of zebrafish embryo and its...
Link:
https://link.springer.com/article/10.1007%2Fs11248-021-00276-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen K, Fan Y, Gu J, Han Z, Wang Y, Gao L, Zeng H, Mao C, Wang C. Effect of lgals3a on embryo development of zebrafish. Transgenic Res. 2021 Aug 4. doi: 10.1007/s11248-021-00276-5. Online ahead of print.

Human Spinal Cord-like Organoids to Model C9orf72 Amyotrophic Lateral Sclerosis and Test New Therapies In Vitro

Authors:
Costamagna G, Galli N, Rizzuti M, Frizzi B, Biella F, Taiana M, Ghezzi S, Comi GP, Faravelli I, Nizzardo M, Corti S
Citation:
EMJ Neurol. 2021;9(1):39-41. Abstract Review No. AR3
Epub:
Not Epub
Abstract:
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. Underlying genetic pathomechanisms include the...
Link:
https://www.emjreviews.com/neurology/abstract/human-spinal-cord-like-organoids-to-model-c9orf72-amyotrophic-lateral-sclerosis-and-test-new-therapies-in-vitro/
Organism or Cell Type:
cell culture: human spinal cord-like organoids
Citation Extract:
Costamagna G, Galli N, Rizzuti M, Frizzi B, Biella F, Taiana M, Ghezzi S, Comi GP, Faravelli I, Nizzardo M, Corti S. Human Spinal Cord-like Organoids to Model C9orf72 Amyotrophic Lateral Sclerosis and Test New Therapies In Vitro. EMJ Neurol. 2021;9(1):39-41. Abstract Review No. AR3.

Haploinsufficiency of SF3B2 causes craniofacial microsomia

Authors:
Timberlake AT, Griffin C, Heike Carrie L, Hing AV, Cunningham ML, Chitayat D, Davis MR, Doust SJ, Drake AF, Duenas-Roque MM, Goldblatt J, Gustafson JA, Hurtado-Villa P, Johns A, Karp N, Laing NG, Magee L, Mullegama SV, Pachajoa H, Porras-Hurtado GL, Schnur RE, Slee J, Singer SL, Staffenberg DA, Timms AE, Wise CA, Zarante I, Saint-Jeannet J-P, Luquetti DV
Citation:
Nat Commun. 2021;12(1):4680. doi:10.1038/s41467-021-24852-9
Epub:
Not Epub
Abstract:
Craniofacial microsomia (CFM) is the second most common congenital facial anomaly, yet its genetic etiology remains unknown. We...
Link:
https://www.nature.com/articles/s41467-021-24852-9
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Timberlake AT, Griffin C, Heike Carrie L, Hing AV, Cunningham ML, Chitayat D, Davis MR, Doust SJ, Drake AF, Duenas-Roque MM, Goldblatt J, Gustafson JA, Hurtado-Villa P, Johns A, Karp N, Laing NG, Magee L, Mullegama SV, Pachajoa H, Porras-Hurtado GL, Schnur RE, Slee J, Singer SL, Staffenberg DA, Timms AE, Wise CA, Zarante I, Saint-Jeannet J-P, Luquetti DV. Haploinsufficiency of SF3B2 causes craniofacial microsomia. Nat Commun. 2021;12(1):4680. doi:10.1038/s41467-021-24852-9.

Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells

Authors:
Gambles MT, Li J, Wang J, Sborov D, Yang J, Kopeček J
Citation:
Molecules. 2021;26(15):4658. doi:10.3390/molecules26154658
Epub:
Not Epub
Abstract:
Recently, we designed an inventive paradigm in nanomedicine -- drug-free macromolecular therapeutics (DFMT). The ability of...
Link:
https://www.mdpi.com/1420-3049/26/15/4658
Organism or Cell Type:
cell culture: Raji (Burkitt’s lymphoma), Daudi (Burkitt’s lymphoma), RPMI 8226 (multiple myeloma), and ANBL-6 (multiple myeloma)
Citation Extract:
Gambles MT, Li J, Wang J, Sborov D, Yang J, Kopeček J. Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells. Molecules. 2021;26(15):4658. doi:10.3390/molecules26154658.

Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis

Authors:
Matrone G, Xia B, Chen K, Denvir MA, Andrew H. Baker AH, Cooke JP
Citation:
Proc Nat Acad Sci USA. 2021;118(31):e2008559118
Epub:
Yes
Abstract:
A network of molecular factors drives the development, differentiation, and maintenance of endothelial cells. Friend leukemia...
Link:
https://www.pnas.org/content/118/31/e2008559118
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Matrone G, Xia B, Chen K, Denvir MA, Andrew H. Baker AH, Cooke JP. Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proc Nat Acad Sci USA. 2021;118(31):e2008559118.

m(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish

Authors:
Huang L, Liang H, Wang S, Chen S
Citation:
Biochem Biophys Res Commun. 2021 Aug 27;567:171-176. doi: 10.1016/j.bbrc.2021.06.043. Epub 2021 Jun 21
Epub:
Not Epub
Abstract:
N6-Methyladenosine (m6A) is the most prevalent internal modification in eukaryotic mRNAs that modulates mRNA metabolism and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X21009645
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Huang L, Liang H, Wang S, Chen S. m(6)A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish. Biochem Biophys Res Commun. 2021 Aug 27;567:171-176. doi: 10.1016/j.bbrc.2021.06.043. Epub 2021 Jun 21.

Nuclear-cytoplasmic compartmentalization promotes robust timing of mitotic events by cyclin B1-Cdk1

Authors:
Maryu G, Yang Q
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.28.454130
Epub:
Not Epub
Abstract:
Studies applying well-mixed cytosolic extracts found the mitotic network centered on cyclin-dependent kinase (Cdk1) performs...
Link:
https://www.biorxiv.org/content/10.1101/2021.07.28.454130v1
Organism or Cell Type:
Xenopus
Citation Extract:
Maryu G, Yang Q. Nuclear-cytoplasmic compartmentalization promotes robust timing of mitotic events by cyclin B1-Cdk1. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.28.454130 .

Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells

Authors:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E
Citation:
J Virol. 2021 Jul 28:JVI0090621. doi: 10.1128/JVI.00906-21. Online ahead of print
Epub:
Not Epub
Abstract:
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs...
Link:
https://journals.asm.org/doi/10.1128/JVI.00906-21
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human and mouse airway cells
Citation Extract:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E. Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells. J Virol. 2021 Jul 28:JVI0090621. doi: 10.1128/JVI.00906-21. Online ahead of print.

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