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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy

Authors:
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R
Citation:
Brain. 2021 Apr 15:awab056. doi: 10.1093/brain/awab056. Online ahead of print
Epub:
Yes
Abstract:
Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG,...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab056/6224919
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R. Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. Brain. 2021 Apr 15:awab056. doi: 10.1093/brain/awab056. Online ahead of print.

Alternative splicing is a developmental switch for hTERT expression

Authors:
Penev A, Bazley A, Shen M, Boeke JD, Savage SA, Sfeir A
Citation:
Molec Cell. 2021;[Epub ahead of print]. doi:10.1016/j.molcel.2021.03.033
Epub:
Yes
Abstract:
Telomere length control is critical for cellular lifespan and tumor suppression. Telomerase is transiently activated in the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1097276521002288
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Penev A, Bazley A, Shen M, Boeke JD, Savage SA, Sfeir A. Alternative splicing is a developmental switch for hTERT expression. Molec Cell. 2021;[Epub ahead of print]. doi:10.1016/j.molcel.2021.03.033.

The connectome of neural crest enhancers reveals regulatory features of signaling systems

Authors:
Azambuja AP, Simoes-Costa M
Citation:
Dev Cell. 2021;56:1-15. doi:10.1016/j.devcel.2021.03.024
Epub:
Not Epub
Abstract:
Cell fate commitment is controlled by cis-regulatory elements often located in remote regions of the genome. To examine the...
Link:
https://www.cell.com/developmental-cell/pdfExtended/S1534-5807(21)00264-1
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Azambuja AP, Simoes-Costa M. The connectome of neural crest enhancers reveals regulatory features of signaling systems. Dev Cell. 2021;56:1-15. doi:10.1016/j.devcel.2021.03.024.

Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts

Authors:
Ambady P, Wu YJ, Kersch CN, Walker JM, Holland S, Muldoon LL, Neuwelt EA
Citation:
Cancer Gene Ther. 2021;[Epub]. doi:10.1038/s41417-021-00324-6
Epub:
Not Epub
Abstract:
Overexpression of O6-methylguanine DNA methyltransferase (MGMT) contributes to resistance to chemo-radiation therapy (CRT) in...
Link:
https://www.nature.com/articles/s41417-021-00324-6
Delivery Method:
radiation
Organism or Cell Type:
rats with brain tumor xenografts
Citation Extract:
Ambady P, Wu YJ, Kersch CN, Walker JM, Holland S, Muldoon LL, Neuwelt EA. Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts. Cancer Gene Ther. 2021;[Epub]. doi:10.1038/s41417-021-00324-6.

Rab35 regulates skeletogenesis and gastrulation by facilitating actin remodeling and vesicular trafficking

Authors:
Remsburg C, Testa M, Song JL
Citation:
Cells Dev. 2021 Mar;165:203660. doi:10.1016/j.cdev.2021.203660. Epub 2021 Feb 8
Epub:
Not Epub
Abstract:
Rab35 is a small GTPase that regulates plasma membrane to early endosome vesicular trafficking and mediates actin remodeling to...
Link:
https://www.sciencedirect.com/science/article/pii/S2667290121000073
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Remsburg C, Testa M, Song JL. Rab35 regulates skeletogenesis and gastrulation by facilitating actin remodeling and vesicular trafficking. Cells Dev. 2021 Mar;165:203660. doi:10.1016/j.cdev.2021.203660. Epub 2021 Feb 8.

Novel pre-clinical model for CDKL5 Deficiency Disorder

Authors:
Serrano RJ, Lee C, Bryson-Richardson RJ, Sztal TE
Citation:
bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.04.07.438335
Epub:
Not Epub
Abstract:
Cyclin-dependent kinase-like-5 (CDKL5) Deficiency Disorder (CDD) is a severe X-linked neurodegenerative disease characterized...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.07.438335v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Serrano RJ, Lee C, Bryson-Richardson RJ, Sztal TE. Novel pre-clinical model for CDKL5 Deficiency Disorder. bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.04.07.438335.

Exploring zebrafish larvae as a COVID-19 model: probable SARS-COV-2 replication in the swim bladder

Authors:
Laghi V, Rezelj V, Boucontet L, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.08.439059
Epub:
Not Epub
Abstract:
Animal models are essential to understand COVID-19 pathophysiology and for pre-clinical assessment of drugs and other...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.08.439059v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Laghi V, Rezelj V, Boucontet L, Boudinot P, Salinas I, Lutfalla G, Vignuzzi M, Levraud J-P. Exploring zebrafish larvae as a COVID-19 model: probable SARS-COV-2 replication in the swim bladder. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.08.439059.

Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration

Authors:
Geng F, Ma J, Li X, Hu Z, Zhang R
Citation:
Int J Mol Sci. 2021;22(8):3945. doi:10.3390/ijms22083945
Epub:
Not Epub
Abstract:
Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are...
Link:
https://www.mdpi.com/1422-0067/22/8/3945/htm
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geng F, Ma J, Li X, Hu Z, Zhang R. Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. Int J Mol Sci. 2021;22(8):3945. doi:10.3390/ijms22083945.

Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models

Authors:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439067
Epub:
Not Epub
Abstract:
The majority of kidney diseases arise from the loss of podocytes and from morphological changes of their highly complex foot...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.09.439067v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N. Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439067 .

Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis

Authors:
Adar-Levor S, Nachmias D, Gal-Oz ST, Jahn YM, Peyrieras N, Zaritsky A, Birnbaum RY, Elia N
Citation:
Proc Nat Acad Sci USA. 2021;118(15):e2021210118. doi:10.1073/pnas.2021210118
Epub:
Not Epub
Abstract:
Animal cytokinesis ends with the formation of a thin intercellular membrane bridge that connects the two newly formed sibling...
Link:
https://www.pnas.org/content/118/15/e2021210118
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adar-Levor S, Nachmias D, Gal-Oz ST, Jahn YM, Peyrieras N, Zaritsky A, Birnbaum RY, Elia N. Cytokinetic abscission is part of the midblastula transition in early zebrafish embryogenesis. Proc Nat Acad Sci USA. 2021;118(15):e2021210118. doi:10.1073/pnas.2021210118.

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