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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture
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Citation:
Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006 Epub:
Not Epub Abstract:
Purpose
To understand the relationship between ciliogenesis and autophagy in the corneal epithelium.
Methods
siRNAs for... Organism or Cell Type:
Xenopus Citation Extract: Kaplan N, Wang S, Wang J, Yang W, Ventrella R, Majekodunmi A, Perez White BE, Getsios S, Mitchell BJ, Peng H, Lavker RM. Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture. Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006. |
Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression
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Citation:
J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740 Epub:
Yes Abstract:
Background
Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival... Delivery Method:
intracerebroventricular (icv) injection Organism or Cell Type:
mice Citation Extract: McCormack NM, Villalón E, Viollet C, Soltis AR, Dalgard CL, Lorson CL, Burnett BG. Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression. J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740. |
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division
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Citation:
Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244 Epub:
Not Epub Abstract:
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymmetry between... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244. |
Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung
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Citation:
Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print Epub:
Not Epub Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the... Delivery Method:
peptide-linked plus endosome escape reagent (OEC) Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse Citation Extract: Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print. |
Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial
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Citation:
Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print Epub:
Yes Abstract:
Introduction/aims: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting in the absence of... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Wagner KR, Kuntz NL, Koenig E, East L, Upadhyay S, Han B, Shieh PB. Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial. Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print. |
The gene regulatory system for specifying germ layers in early embryos of the simple chordate
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Citation:
Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210 Epub:
Not Epub Abstract:
In animal embryos, gene regulatory networks control the dynamics of gene expression in cells and coordinate such dynamics among... Delivery Method:
microinjection Organism or Cell Type:
Ciona intestinalis Citation Extract: Tokuoka M, Maeda K, Kobayashi K, Mochizuki A, Satou Y. The gene regulatory system for specifying germ layers in early embryos of the simple chordate. Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210. |
Integrin intra-heterodimer affinity inversely correlates with integrin activatability
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Citation:
Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230 Epub:
Not Epub Abstract:
Integrins are heterodimeric cell surface receptors composed of an α and β subunit that mediate cell adhesion to extracellular... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sun G, Guillon E, Holley SA. Integrin intra-heterodimer affinity inversely correlates with integrin activatability. Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230. |
eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping
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Citation:
Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442 Epub:
Yes Abstract:
Exon skipping using antisense oligonucleotides (ASOs) has recently proven to be a powerful tool for mRNA splicing modulation.... Organism or Cell Type:
cell culture: primary human myotubes Citation Extract: Chiba S, Lim KRQ, Sheri N, Anwar S, Erkut E, Shah MNA, Aslesh T, Woo S, Sheikh O, Maruyama R, Takano H, Kunitake K, Duddy W, Okuno Y, Aoki Y, Yokota T. eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping. Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442. |
Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β
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Citation:
J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print Epub:
Yes Abstract:
Neuro-immune interaction during development is strongly implicated in the pathogenesis of neurodevelopmental disorders, but the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Solek CM, Farooqi NAI, Brake N, Kesner P, Schohl A, Antel JP, Ruthazer ES. Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β. J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print. |
Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053 Epub:
Not Epub Abstract:
Zebrafish Müller glia (MG) respond to retinal injury by suppressing Notch signaling and producing progenitors for retinal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sahu A, Devi S, Jui J, Goldman D. Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053. |