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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Analysis of Chd-7 Defective Dauer Nematodes Implicates Collagen Misregulation in Charge Syndrome Features
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.26.437191 Epub:
Not Epub Abstract:
CHARGE syndrome is a complex developmental disorder caused by mutations in the chromodomain helicase DNA-binding protein7 (CHD7... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Jofré DM, Hoffman DK, Cervino AS, Grundy M, Yun S, Amrit FRG, Stolz DB, Salvatore E, Rossi FA, Ghazi A, Cirio MC, Yanowitz JL, Hochbaum D. Analysis of Chd-7 Defective Dauer Nematodes Implicates Collagen Misregulation in Charge Syndrome Features. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.26.437191. |
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
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Citation:
Nat Commun. 2021;12(1):1955. doi:10.1038/s41467-021-22252-7 Epub:
Not Epub Abstract:
p62/SQSTM1 is known to act as a key mediator in the selective autophagy of protein aggregates, or aggrephagy, by steering... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Yoon MJ, Choi B, Kim EJ, Ohk J, Yang C, Choi Y-G, Lee J, Kang C, Song HK, Kim YK, Woo J-S, Cho Y, Choi E-J, Jung H, Kim C. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy. Nat Commun. 2021;12(1):1955. doi:10.1038/s41467-021-22252-7. |
Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52
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Citation:
Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479 Epub:
Not Epub Abstract:
Marfan syndrome is one of the most common dominantly inherited connective tissue disorders, affecting 2–3 in 10,000 individuals... Delivery Method:
electroporation Organism or Cell Type:
cell culture: primary Marfan fibroblasts Citation Extract: Cale JM, Greer K, Fletcher S, Wilton SD. Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52. Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479. |
RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis
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Citation:
Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print Epub:
Not Epub Abstract:
Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN. RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis. Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print. |
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exon
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Citation:
Nat Comm. 2021;12(1):1918. doi:10.1038/s41467-021-22098-z Epub:
Not Epub Abstract:
The RNA-binding protein SFPQ plays an important role in neuronal development and has been associated with several... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gordon PM, Hamid F, Makeyev EV, Houart C. A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exon. Nat Comm. 2021;12(1):1918. doi:10.1038/s41467-021-22098-z. |
Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish
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Citation:
Front Immunol. 2021;12:956. doi:10.3389/fimmu.2021.636585 Epub:
Not Epub Abstract:
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Sipka T, Peroceschi R, Hassan-Abdi R, Groß M, Ellett F, Begon-Pescia C, Gonzalez C, Lutfalla G, Nguyen-Chi M. Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish. Front Immunol. 2021;12:956. doi:10.3389/fimmu.2021.636585. |
Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity
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Citation:
EMBO Rep. 2021 Mar 18;e51280. doi: 10.15252/embr.202051280 Epub:
Not Epub Abstract:
Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and can also be activated by some Group 9/10... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Babolmorad G, Latif A, Domingo IK, Pollock NM, Delyea C, Rieger AM, Allison WT, Bhavsar AP. Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity. EMBO Rep. 2021 Mar 18;e51280. doi: 10.15252/embr.202051280. |
The SCF/KIT pathway implements self-organised epithelial patterning by cell movement
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Citation:
Dev Cell. 2021;56(6):795-810. doi:10.1016/j.devcel.2021.02.026 Epub:
Not Epub Abstract:
How global patterns emerge from individual cell behaviors is poorly understood. In the Xenopus embryonic epidermis,... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Chuyen A, Rulquin C, Thome V, Clement R, Kodjabachian L, Pasini A. The SCF/KIT pathway implements self-organised epithelial patterning by cell movement. Dev Cell. 2021;56(6):795-810. doi:10.1016/j.devcel.2021.02.026. |
Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection
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Citation:
Nucleic Acids Res. 2021 Apr 19; 49(7): 3907–3918. doi:10.1093/nar/gkab152. Epub:
Yes Abstract:
Somatic expansion of the CAG repeat tract that causes Huntington's disease (HD) is thought to contribute to the rate of... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: human primary fibroblasts, mice Citation Extract: Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R. Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection. Nucleic Acids Res. 2021 Apr 19; 49(7): 3907–3918. doi:10.1093/nar/gkab152.. |
Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development
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Citation:
Theranostics. 2021 Feb 25;11(9):4316-4334. doi: 10.7150/thno.51745. eCollection 2021 Epub:
Not Epub Abstract:
Trio is a unique member of the Rho-GEF family that has three catalytic domains and is vital for various cellular processes in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Guo S, Meng L, Liu H, Yuan L, Zhao N, Ni J, Zhang Y, Ben J, Li YP, Ma J. Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development. Theranostics. 2021 Feb 25;11(9):4316-4334. doi: 10.7150/thno.51745. eCollection 2021. |