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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Slit2 is necessary for optic axon organization in the zebrafish ventral midline

Authors:
Davison C, Zolessi FR
Citation:
Cells Dev. 2021 Apr 10;166:203677. doi: 10.1016/j.cdev.2021.203677. Online ahead of print
Epub:
Not Epub
Abstract:
Slit-Robo signaling has been implicated in regulating several steps of retinal ganglion cell axon guidance, with a central role...
Organism or Cell Type:
zebrafish
Citation Extract:
Davison C, Zolessi FR. Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells Dev. 2021 Apr 10;166:203677. doi: 10.1016/j.cdev.2021.203677. Online ahead of print.

Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish

Authors:
Matharu NK, Yadav S, Kumar M, Mishra RK
Citation:
Cells Dev. 2021 Apr 24;166:203682. doi: 10.1016/j.cdev.2021.203682. Online ahead of print
Epub:
Not Epub
Abstract:
Homeotic genes and their genomic organization show remarkable conservation across bilaterians. Consequently, the regulatory...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Matharu NK, Yadav S, Kumar M, Mishra RK. Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish. Cells Dev. 2021 Apr 24;166:203682. doi: 10.1016/j.cdev.2021.203682. Online ahead of print.

Molluscan dorsal-ventral patterning relying on bmp2/4 and chordin provides insights into spiralian development and bilaterian evolution

Authors:
Tan S, Huan P, Liu B
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.11.245670
Epub:
Not Epub
Abstract:
Although a conserved mechanism relying on bmp2/4 and chordin is suggested in animal dorsal-ventral (DV) patterning, this...
Delivery Method:
microinjection
Organism or Cell Type:
Lottia goshimai (mollusk)
Citation Extract:
Tan S, Huan P, Liu B. Molluscan dorsal-ventral patterning relying on bmp2/4 and chordin provides insights into spiralian development and bilaterian evolution. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.11.245670 .

Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies

Authors:
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD
Citation:
Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552
Epub:
Not Epub
Abstract:
The literature surrounding the use of antisense oligonucleotides continues to grow, with new disease and mechanistic...
Delivery Method:
cell bathing, injection subcutaneous and intraperitoneal (s.c. & i.p.)
Organism or Cell Type:
cell culture: human fibroblasts, SH-SY5Y neuroblastoma, mdx myoblasts; mice
Citation Extract:
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552.

Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

Authors:
Tournière O, Busengdal H, Gahan JM, Rentzsch F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178
Epub:
Not Epub
Abstract:
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (cniderian)
Citation Extract:
Tournière O, Busengdal H, Gahan JM, Rentzsch F. Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178.

Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche

Authors:
Cacialli P, Mailhe M-P, Golub R, Bertrand JY
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809
Epub:
Not Epub
Abstract:
During embryonic development, very few hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium, that will...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Mailhe M-P, Golub R, Bertrand JY. Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809.

Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation

Authors:
Zhang F, Li X, Hao Y, Li Y, Ye D, He M, Wang H, Zhu Z, Sun Y
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715
Epub:
Not Epub
Abstract:
The surrogate reproduction technique provides a powerful tool for production of allogenic or xenogeneic gametes derived from...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, Hao Y, Li Y, Ye D, He M, Wang H, Zhu Z, Sun Y. Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715.

TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

Authors:
Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219
Epub:
Not Epub
Abstract:
The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219.

Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis

Authors:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D
Citation:
Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9
Epub:
Not Epub
Abstract:
GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D. Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9.

A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements

Authors:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H
Citation:
Science. 2021;372(6543): doi:10.1126/science.abc7531
Epub:
Not Epub
Abstract:
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain...
Delivery Method:
Endo-Porter
Organism or Cell Type:
Cell culture: HCC1806-LM2 , MDA-LM2
Citation Extract:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements. Science. 2021;372(6543): doi:10.1126/science.abc7531.

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