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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

RNA m6A methyltransferase Mettl3 regulates spatial neural patterning in Xenopus

Authors:
Kim H, Jang S
Citation:
Mol Cell Biol. 2021 May 10:MCB.00104-21. doi: 10.1128/MCB.00104-21. Online ahead of print
Epub:
Yes
Abstract:
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, and has a widespread impact on mRNA stability and...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim H, Jang S. RNA m6A methyltransferase Mettl3 regulates spatial neural patterning in Xenopus. Mol Cell Biol. 2021 May 10:MCB.00104-21. doi: 10.1128/MCB.00104-21. Online ahead of print.

Cardioluminescence in transgenic zebrafish embryos: a Ca2+ imaging tool to study drug effects and pathological modeling

Authors:
Vicente M, Salgado-Almario J, Collins MM, Martínez-Sielva A, Minoshima M, Kikuchi K, Domingo B, Llopis J
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.06.442917
Epub:
Not Epub
Abstract:
The zebrafish embryo has emerged as an excellent model in cardiovascular research. The existing techniques to monitor Ca2+ in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vicente M, Salgado-Almario J, Collins MM, Martínez-Sielva A, Minoshima M, Kikuchi K, Domingo B, Llopis J. Cardioluminescence in transgenic zebrafish embryos: a Ca2+ imaging tool to study drug effects and pathological modeling. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.06.442917.

Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia

Authors:
Wiessner M, Maroofian R, Ni M-Y, Pedroni A, Müller JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM, Alfares AA, Zhu C, Uhrova MA, Alehabib E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH, Peterson JT, Strom TM, De JP, Deconinck T, De Ridder W, De Winter J, Pasquariello R, Ricca I,Alfadhel M, van de Warrenburg BP, Portier R, Bergmann C, Ghasemi FS,Jin SC, Bilguvar K, Hamed S, Abdelhameed M, Haridy NA, Maqbool S, Rahman F, Anwar N, Carmichael J, Pagnamenta A, Wood NW, Tran Mau-Them F, Haack T, Genomics England Research Consortium PREPARE network, Di Rocco M, <authors deleted - database limit> Shamseldin H, Al Tala S, Rezazadeh VJ, Najafi M, Deschner S, Gläser D, Hüttel W, Kruer MC, Kamsteeg E-J, Takiyama Y, Züchner S, Baets J, Synofzik M, Schüle R, Horvath R, Houlden H, Bartesaghi L, Lee H-J, Ampatzis K, Pierson TM, Senderek J
Citation:
Brain. 2021;[Epub] doi:10.1093/brain/awab041
Epub:
Not Epub
Abstract:
Human 4-hydroxyphenylpyruvate dioxygenase-like (HPDL) is a putative iron-containing non-heme oxygenase of unknown specificity...
Organism or Cell Type:
zebrafish
Citation Extract:
Wiessner M, Maroofian R, Ni M-Y, Pedroni A, Müller JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM, Alfares AA, Zhu C, Uhrova MA, Alehabib E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH, Peterson JT, Strom TM, De JP, Deconinck T, De Ridder W, De Winter J, Pasquariello R, Ricca I,Alfadhel M, van de Warrenburg BP, Portier R, Bergmann C, Ghasemi FS,Jin SC, Bilguvar K, Hamed S, Abdelhameed M, Haridy NA, Maqbool S, Rahman F, Anwar N, Carmichael J, Pagnamenta A, Wood NW, Tran Mau-Them F, Haack T, Genomics England Research Consortium PREPARE network, Di Rocco M, <authors deleted - database limit> Shamseldin H, Al Tala S, Rezazadeh VJ, Najafi M, Deschner S, Gläser D, Hüttel W, Kruer MC, Kamsteeg E-J, Takiyama Y, Züchner S, Baets J, Synofzik M, Schüle R, Horvath R, Houlden H, Bartesaghi L, Lee H-J, Ampatzis K, Pierson TM, Senderek J. Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia. Brain. 2021;[Epub] doi:10.1093/brain/awab041.

RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2

Authors:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.07.443200
Epub:
Not Epub
Abstract:
BACKGROUND: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin-2...
Citation Extract:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD. RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.07.443200 .

Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo

Authors:
Molina MD, Lepage T
Citation:
Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22
Epub:
Not Epub
Abstract:
Specification of the main axes of polarity of the embryo is an essential process during embryonic development. In many species...
Organism or Cell Type:
sea urchin
Citation Extract:
Molina MD, Lepage T. Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo. Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22.

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate

Authors:
Chuykin I, Kim K, Sokol S
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.02.442356
Epub:
Not Epub
Abstract:
The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chuykin I, Kim K, Sokol S. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.02.442356.

A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells

Authors:
Galton R, Fejes-Toth K, Bronner ME
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.30.442165
Epub:
Not Epub
Abstract:
In the metazoan germline, Piwi proteins play an essential regulatory role in maintenance of stemness and self-renewal by piRNA-...
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Galton R, Fejes-Toth K, Bronner ME. A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.30.442165 .

Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish

Authors:
Hung J-C, Wu J-L, Hong J-R
Citation:
Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832
Epub:
Not Epub
Abstract:
The BH3-only molecule Bad regulates cell death via its differential protein phosphorylation, but very few studies address its...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung J-C, Wu J-L, Hong J-R. Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832.

Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22

Authors:
Sheng J, Gong J, Shi Y, Wang X, Liu D
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.29.441918
Epub:
Not Epub
Abstract:
A precise neuro-vascular communication is crucial to orchestrate directional migration and patterning of the complex vascular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sheng J, Gong J, Shi Y, Wang X, Liu D. Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.29.441918 .

Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception

Authors:
Boutillon A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.26.441407
Epub:
Not Epub
Abstract:
Morphogenesis, wound healing and some cancer metastases depend upon migration of cell collectives that need to be guided to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boutillon A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB. Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.26.441407.

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