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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12152 scientific papers returned from the database with the search filters currently being used below.

A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2

Authors:
Chaytow H, Hassan IS, Akbar S, Popplewell L, Dickson G, Chen PE
Citation:
J Neurosci Methods. 2021;[Epub] doi:10.1016/j.jneumeth.2021.109357
Epub:
Not Epub
Abstract:
Background: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0165027021002922
Organism or Cell Type:
cell culture
Citation Extract:
Chaytow H, Hassan IS, Akbar S, Popplewell L, Dickson G, Chen PE. A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2. J Neurosci Methods. 2021;[Epub] doi:10.1016/j.jneumeth.2021.109357.

Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

Authors:
Maerker M, Getwan M, Dowdle ME, McSheene JC, Gonzalez V, Pelliccia JL, Hamilton DS, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Blum M, Schweickert A
Citation:
Nat Commun. 2021;12(1):5482. doi:10.1038/s41467-021-25464-z
Epub:
Not Epub
Abstract:
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at...
Link:
https://www.nature.com/articles/s41467-021-25464-z
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus, zebrafish
Citation Extract:
Maerker M, Getwan M, Dowdle ME, McSheene JC, Gonzalez V, Pelliccia JL, Hamilton DS, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Blum M, Schweickert A. Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nat Commun. 2021;12(1):5482. doi:10.1038/s41467-021-25464-z.

Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

Authors:
Suzzi S, Ahrendt R, Hans S, Semenova SA, Chekuru A, Wirsching P, Kroehne V, Bilican S, Sayed S, Winkler S, Spieß S, Machate A, Kaslin J, Panula P, Brand M
Citation:
PLoS Genet. 2021;17(9):e1009794. doi:10.1371/journal.pgen.1009794
Epub:
Not Epub
Abstract:
LRRK2 gain-of-function is considered a major cause of Parkinson’s disease (PD) in humans. However, pathogenicity of LRRK2 loss-...
Link:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009794
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Suzzi S, Ahrendt R, Hans S, Semenova SA, Chekuru A, Wirsching P, Kroehne V, Bilican S, Sayed S, Winkler S, Spieß S, Machate A, Kaslin J, Panula P, Brand M. Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain. PLoS Genet. 2021;17(9):e1009794. doi:10.1371/journal.pgen.1009794.

CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

Authors:
Franke M, De la Calle-Mustienes E, Neto A, Almuedo-Castillo M, Irastorza-Azcarate I, Acemel RD, Tena JJ, Santos-Pereira JM, Gómez-Skarmeta JL
Citation:
Nat Commun. 2021 Sep 13;12(1):5415. doi: 10.1038/s41467-021-25604-5
Epub:
Not Epub
Abstract:
Coordinated chromatin interactions between enhancers and promoters are critical for gene regulation. The architectural protein...
Link:
https://www.nature.com/articles/s41467-021-25604-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Franke M, De la Calle-Mustienes E, Neto A, Almuedo-Castillo M, Irastorza-Azcarate I, Acemel RD, Tena JJ, Santos-Pereira JM, Gómez-Skarmeta JL. CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression. Nat Commun. 2021 Sep 13;12(1):5415. doi: 10.1038/s41467-021-25604-5.

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa

Authors:
Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM
Citation:
Gene Ther. 2021 Sep 14. doi: 10.1038/s41434-021-00291-5. Online ahead of print
Epub:
Yes
Abstract:
By combining next generation whole exome sequencing and induced pluripotent stem cell (iPSC) technology we found that an Alu...
Link:
https://www.nature.com/articles/s41434-021-00291-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM. Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Gene Ther. 2021 Sep 14. doi: 10.1038/s41434-021-00291-5. Online ahead of print.

Myosin 1b regulates intestinal epithelial morphogenesis via interaction with UNC45A

Authors:
Revenu C, Lebreton C, Cannata Serio M, Rosello M, Duclaux-Loras R, Duroure K, Nicolle O, Eggeler F, Prospéri MT, Stoufflet J, Vougny J, Lépine P, Michaux G, Cerf-Bensussan N, Coudrier E, Perez F, Parlato M, Del Bene F
Citation:
Cell Rep. 2024 Dec 24;43(12):114941. doi: 10.1016/j.celrep.2024.114941. Epub 2024 Dec 4. PMID: 39636728
Epub:
Not Epub
Abstract:
Vesicle trafficking and the establishment of apicobasal polarity are essential processes in epithelial morphogenesis. UNC45A...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01292-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Revenu C, Lebreton C, Cannata Serio M, Rosello M, Duclaux-Loras R, Duroure K, Nicolle O, Eggeler F, Prospéri MT, Stoufflet J, Vougny J, Lépine P, Michaux G, Cerf-Bensussan N, Coudrier E, Perez F, Parlato M, Del Bene F. Myosin 1b regulates intestinal epithelial morphogenesis via interaction with UNC45A. Cell Rep. 2024 Dec 24;43(12):114941. doi: 10.1016/j.celrep.2024.114941. Epub 2024 Dec 4. PMID: 39636728.

The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress

Authors:
Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK
Citation:
J Biol Chem. 2021 Sep 9:101184. doi: 10.1016/j.jbc.2021.101184. Online ahead of print
Epub:
Not Epub
Abstract:
The deubiquitinating enzyme USP37 is known to contribute to timely onset of S-phase and progression of mitosis. However, it is...
Link:
https://www.jbc.org/article/S0021-9258(21)00986-8/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK. The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress. J Biol Chem. 2021 Sep 9:101184. doi: 10.1016/j.jbc.2021.101184. Online ahead of print.

Generation of a Triadin KnockOut Syndrome Zebrafish Model

Authors:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C
Citation:
Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720
Epub:
Not Epub
Abstract:
Different forms of sudden cardiac death have been described, including a recently identified form of genetic arrhythmogenic...
Link:
https://www.mdpi.com/1422-0067/22/18/9720
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C. Generation of a Triadin KnockOut Syndrome Zebrafish Model. Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720 .

Claudin-5a knockdown attenuates blood-neural barrier in zebrafish

Authors:
Ahn JC, Hwang SJ, Lee HJ, Kim KW
Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print
Epub:
Yes
Abstract:
Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1532045621002039
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahn JC, Hwang SJ, Lee HJ, Kim KW. Claudin-5a knockdown attenuates blood-neural barrier in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print.

Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development

Authors:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA
Citation:
Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6
Epub:
Not Epub
Abstract:
Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and craniofacial and/or renal defects. Variants...
Link:
https://journals.biologists.com/dev/article-abstract/148/17/dev199684/272053/Sobp-modulates-the-transcriptional-activation-of
Organism or Cell Type:
Xenopus
Citation Extract:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA. Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development. Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6.

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