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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway

Authors:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H
Citation:
Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print
Epub:
Yes
Abstract:
The focal adhesion protein Kindlin2 is essential for integrin activation, a process that is fundamental to cell-extracellular...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.199441/261719/Kindlin2-regulates-neural-crest-specification-via
Organism or Cell Type:
Xenopus
Citation Extract:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H. Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway. Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print.

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis

Authors:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP
Citation:
J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print
Epub:
Yes
Abstract:
Context: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic...
Link:
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab283/6257595
Organism or Cell Type:
zebrafish
Citation Extract:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print.

The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin

Authors:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L
Citation:
Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5
Epub:
Not Epub
Abstract:
Dystrophin proteomic regulation in muscular dystrophies (MDs) remains unclear. We report that a long noncoding RNA (lncRNA),...
Link:
https://www.nature.com/articles/s41556-020-00595-5
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5.

Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm

Authors:
Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D
Citation:
Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10
Epub:
Not Epub
Abstract:
Anterior to posterior growth of the vertebrate body is fueled by a posteriorly located population of bipotential neuro-...
Link:
https://journals.biologists.com/dev/article/142/14/2499/408/Wnt-signaling-and-tbx16-form-a-bistable-switch-to
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bouldin CM, Manning AJ, Peng YH, Farr GH 3rd, Hung KL, Dong A, Kimelman D. Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development. 2015 Jul 15;142(14):2499-507. doi: 10.1242/dev.124024. Epub 2015 Jun 10.

Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations

Authors:
Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten CD, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E
Citation:
Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print
Epub:
Not Epub
Abstract:
Mutations in USH2A are among the most common causes of syndromic and non-syndromic retinitis pigmentosa (RP). The two most...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(21)00212-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dulla K, Slijkerman R, van Diepen HC, Albert S, Dona M, Beumer W, Turunen JJ, Chan HL, Schulkens IA, Vorthoren L, Besten CD, Buil L, Schmidt I, Miao J, Venselaar H, Zang J, Neuhauss SCF, Peters T, Broekman S, Pennings R, Kremer H, Platenburg G, Adamson P, de Vrieze E, van Wijk E. Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Mol Ther. 2021;29(8)2441-55. doi: 10.1016/j.ymthe.2021.04.024. Online ahead of print.

Pinhead antagonizes Admp to promote notochord formation

Authors:
Itoh K, Ossipova O, Sokol S
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.21.440817
Epub:
Not Epub
Abstract:
Dorsoventral patterning of a vertebrate embryo critically depends on the activity of Smad1 that mediates signaling by several...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.21.440817v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Itoh K, Ossipova O, Sokol S. Pinhead antagonizes Admp to promote notochord formation. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.21.440817.

Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast

Authors:
Yuan X, Qin Y, Wang J, Fan C
Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053
Epub:
Yes
Abstract:
Ototoxicity of drugs is an important inducement for hearing loss. Anisomycin is a candidate drug for parasite, cancer,...
Link:
https://pubmed.ncbi.nlm.nih.gov/33887477/
Organism or Cell Type:
zebrafish
Citation Extract:
Yuan X, Qin Y, Wang J, Fan C. Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 19:109053. doi: 10.1016/j.cbpc.2021.109053.

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

Authors:
Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB
Citation:
Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3
Epub:
Not Epub
Abstract:
Current therapeutic options for treating colorectal cancer have little clinical efficacy and acquired resistance during...
Link:
https://www.nature.com/articles/s41467-021-22531-3
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: CMT93 cells; human organoids
Citation Extract:
Gudiño V, Pohl SÖ, Billard CV, Cammareri P, Bolado A, Aitken S, Stevenson D, Hall AE, Agostino M, Cassidy J, Nixon C, von Kriegsheim A, Freile P, Popplewell L, Dickson G, Murphy L, Wheeler A, Dunlop M, Din F, Strathdee D, Sansom OJ, Myant KB. RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nat Commun. 2021 Apr 20;12(1):2335. doi:10.1038/s41467-021-22531-3.

Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating

Authors:
Zhao L, Xie H, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C, Huang K
Citation:
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2015689118. doi: 10.1073/pnas.2015689118
Epub:
Not Epub
Abstract:
Coordinated beating is crucial for the function of multiple cilia. However, the molecular mechanism is poorly understood. Here...
Link:
https://www.pnas.org/content/118/17/e2015689118.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao L, Xie H, Kang Y, Lin Y, Liu G, Sakato-Antoku M, Patel-King RS, Wang B, Wan C, King SM, Zhao C, Huang K. Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2015689118. doi: 10.1073/pnas.2015689118.

Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5

Authors:
Jacinto R, Sampaio P, Roxo-Rosa M, Pestana S, Lopes SS
Citation:
Front Cell Dev Biol. 2021 Apr 1;9:624531. doi: 10.3389/fcell.2021.624531. eCollection 2021
Epub:
Not Epub
Abstract:
The left-right (LR) field recognizes the importance of the mechanism involving the calcium permeable channel Polycystin-2....
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2021.624531/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacinto R, Sampaio P, Roxo-Rosa M, Pestana S, Lopes SS. Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Front Cell Dev Biol. 2021 Apr 1;9:624531. doi: 10.3389/fcell.2021.624531. eCollection 2021.

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