You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders

Authors:
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN
Citation:
J Clin Invest. 2021 Feb 15;131(4):138634. doi: 10.1172/JCI138634
Epub:
Not Epub
Abstract:
Patients with neuromuscular disorders suffer from a lack of treatment options for skeletal muscle weakness and disease...
Link:
https://www.jci.org/articles/view/138634
Delivery Method:
injection
Organism or Cell Type:
mice (mdx)
Citation Extract:
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. J Clin Invest. 2021 Feb 15;131(4):138634. doi: 10.1172/JCI138634.

Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

Authors:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH
Citation:
Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30408-X
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: iPSC
Citation Extract:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5.

Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset

Authors:
Mournetas V, Massouridès E, Dupont JB, Kornobis E, Polvèche H, Jarrige M, Dorval ARL, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C
Citation:
J Cachexia Sarcopenia Muscle. 2021 Feb 14. doi: 10.1002/jcsm.12665. Online ahead of print
Epub:
Yes
Abstract:
Background: Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of...
Link:
https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12665
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: hiPSC, DMD Delta52 hESC‐derived
Citation Extract:
Mournetas V, Massouridès E, Dupont JB, Kornobis E, Polvèche H, Jarrige M, Dorval ARL, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C. Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset. J Cachexia Sarcopenia Muscle. 2021 Feb 14. doi: 10.1002/jcsm.12665. Online ahead of print.

Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development

Authors:
Dong Z, Chen X, Li Y, Zhuo R, Lai X, Liu M
Citation:
Front Cell Dev Biol. 2021 Jan 18;8:593234. doi: 10.3389/fcell.2020.593234. eCollection 2020
Epub:
Not Epub
Abstract:
Previously, fidgetin (fign) and its family members fidgetin-like 1 (fignl1) and fidgetin-like 2 (fignl2) were found to be...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.593234/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dong Z, Chen X, Li Y, Zhuo R, Lai X, Liu M. Microtubule Severing Protein Fignl2 Contributes to Endothelial and Neuronal Branching in Zebrafish Development. Front Cell Dev Biol. 2021 Jan 18;8:593234. doi: 10.3389/fcell.2020.593234. eCollection 2020.

Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish

Authors:
Li X, Ji G, Zhou J, Du J, Li X, Shi W, Hu Y, Zhou W, Hao A
Citation:
Front Cell Dev Biol. 2021 Jan 26;8:581636. doi: 10.3389/fcell.2020.581636. eCollection 2020
Epub:
Not Epub
Abstract:
The neural induction constitutes the initial step in the generation of the neural tube. Pcgf1, as one of six Pcgf paralogs, is...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2020.581636/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Ji G, Zhou J, Du J, Li X, Shi W, Hu Y, Zhou W, Hao A. Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish. Front Cell Dev Biol. 2021 Jan 26;8:581636. doi: 10.3389/fcell.2020.581636. eCollection 2020.

Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?

Authors:
Hughes MC, Perry SF
Citation:
J Comp Physiol B. 2021 Feb 12. doi: 10.1007/s00360-020-01331-z. Online ahead of print
Epub:
Yes
Abstract:
Oxygen uptake (ṀO2) in larval zebrafish prior to maturation of the gill relies on cutaneous O2 transfer. Under normoxic...
Link:
https://link.springer.com/article/10.1007%2Fs00360-020-01331-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hughes MC, Perry SF. Does blood flow limit acute hypoxia performance in larval zebrafish (Danio rerio)?. J Comp Physiol B. 2021 Feb 12. doi: 10.1007/s00360-020-01331-z. Online ahead of print.

Methods of In Vivo Gene-Specific Knockdown Using Morpholino and Vivo-Morpholino Oligonucleotides

Authors:
Ivanova AS, Korotkova DD, Martynova NY, Averyanova OV, Zaraisky AG, Tereshina MB
Citation:
Russ J Bioorg Chem. 2018;44:358–361. doi:10.1134/S106816201803007X
Epub:
Not Epub
Abstract:
The functioning of the small GTPase gene, Ras-dva1, has been studied during regeneration processes of the tadpole tails of the...
Link:
https://link.springer.com/article/10.1134/S106816201803007X
Delivery Method:
microinjection, Vivo-Morpholino injection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ivanova AS, Korotkova DD, Martynova NY, Averyanova OV, Zaraisky AG, Tereshina MB. Methods of In Vivo Gene-Specific Knockdown Using Morpholino and Vivo-Morpholino Oligonucleotides. Russ J Bioorg Chem. 2018;44:358–361. doi:10.1134/S106816201803007X.

LIM Homeobox 9 Knockdown by Morpholino does not Affect Zebrafish Retinal Development

Authors:
Guo R, Li F, Lu M, Ge K, Gan L, Sheng D
Citation:
Bio Open. 2021:bio.056382 doi:10.1242/bio.056382
Epub:
Not Epub
Abstract:
LIM homeobox 9 (Lhx9) is a member of the LIM homeodomain transcription factor family, which expresses and functions in various...
Link:
https://bio.biologists.org/content/early/2021/02/04/bio.056382
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guo R, Li F, Lu M, Ge K, Gan L, Sheng D. LIM Homeobox 9 Knockdown by Morpholino does not Affect Zebrafish Retinal Development. Bio Open. 2021:bio.056382 doi:10.1242/bio.056382.

Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis

Authors:
López-Cuevas P, Deane L, Yang Y, Hammond CL, Kague E
Citation:
Dis Model Mech. 2021;dmm.047001 doi:10.1242/dmm.047001
Epub:
Yes
Abstract:
Notochordal cells play a pivotal role in vertebral column patterning, contributing to the formation of the inner architecture...
Link:
https://dmm.biologists.org/content/early/2021/02/11/dmm.047001
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
López-Cuevas P, Deane L, Yang Y, Hammond CL, Kague E. Transformed notochordal cells trigger chronic wounds destabilizing the vertebral column and bone homeostasis. Dis Model Mech. 2021;dmm.047001 doi:10.1242/dmm.047001.

Chemokine-biased robust self-organizing polarization of migrating cells in vivo

Authors:
Olguin-Olguin A, Aalto A, Maugis B, Boquet-Pujadas A, Hoffmann D, Ermlich L, Betz T, Gov NS, Reichman-Fried M, Raz E
Citation:
Proc Natl Acad Sci USA. 2021;118(7);e2018480118 doi:10.1073/pnas.2018480118
Epub:
Not Epub
Abstract:
To study the mechanisms controlling front-rear polarity in migrating cells, we used zebrafish primordial germ cells (PGCs) as...
Link:
https://www.pnas.org/content/118/7/e2018480118
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Olguin-Olguin A, Aalto A, Maugis B, Boquet-Pujadas A, Hoffmann D, Ermlich L, Betz T, Gov NS, Reichman-Fried M, Raz E. Chemokine-biased robust self-organizing polarization of migrating cells in vivo. Proc Natl Acad Sci USA. 2021;118(7);e2018480118 doi:10.1073/pnas.2018480118.

Pages