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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation

Authors:
Li N, Zhou P, Yang M, Fang X, Krämer N, Mughal TA, Abbasi AA, Yang Y, Kaindl AM, Hu H
Citation:
Clin Genet. 2021 Apr 9. doi: 10.1111/cge.13965. Online ahead of print
Epub:
Yes
Abstract:
RAPGEF1 is a guanine nucleotide exchange factor responsible for transmitting extracellular signals to the Ras family of GTPase...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/cge.13965
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li N, Zhou P, Yang M, Fang X, Krämer N, Mughal TA, Abbasi AA, Yang Y, Kaindl AM, Hu H. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation. Clin Genet. 2021 Apr 9. doi: 10.1111/cge.13965. Online ahead of print.

Endothelial struts enable the generation of large lumenized blood vessels de novo

Authors:
Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D
Citation:
Nat Cell Biol. 2021;23(4):322-329. doi:10.1038/s41556-021-00664-3
Epub:
Not Epub
Abstract:
De novo blood vessel formation occurs through coalescence of endothelial cells (ECs) into a cord-like structure, followed by...
Link:
https://www.nature.com/articles/s41556-021-00664-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weijts B, Shaked I, Ginsberg M, Kleinfeld D, Robin C, Traver D. Endothelial struts enable the generation of large lumenized blood vessels de novo. Nat Cell Biol. 2021;23(4):322-329. doi:10.1038/s41556-021-00664-3.

BMP heterodimers signal via distinct type I receptor class functions

Authors:
Tajer B, Dutko JA, Little SC, Mullins MC
Citation:
Proc Nat Acad Sci USA. 2021;118(15):e2017952118. doi:10.1073/pnas.2017952118
Epub:
Not Epub
Abstract:
Heterodimeric TGF-β ligands outperform homodimers in a variety of developmental, cell culture, and therapeutic contexts;...
Link:
https://www.pnas.org/content/118/15/e2017952118.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tajer B, Dutko JA, Little SC, Mullins MC. BMP heterodimers signal via distinct type I receptor class functions. Proc Nat Acad Sci USA. 2021;118(15):e2017952118. doi:10.1073/pnas.2017952118.

Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

Authors:
Peruzzo R, Corrà S, Costa R, Brischigliaro M, Varanita T, Biasutto L, Rampazzo C, Ghezzi D, Leanza L, Zoratti M, Zeviani M, De Pittà C, Viscomi C, Costa R, Szabò I
Citation:
Nat Comm. 2021;12(1):2103. doi:10.1038/s41467-021-22062-x
Epub:
Not Epub
Abstract:
Mitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking....
Link:
https://www.nature.com/articles/s41467-021-22062-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Peruzzo R, Corrà S, Costa R, Brischigliaro M, Varanita T, Biasutto L, Rampazzo C, Ghezzi D, Leanza L, Zoratti M, Zeviani M, De Pittà C, Viscomi C, Costa R, Szabò I. Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction. Nat Comm. 2021;12(1):2103. doi:10.1038/s41467-021-22062-x.

Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos

Authors:
Kiyozumi D, Yaguchi S, Yaguchi J, Yamazaki A, Sekiguchi K
Citation:
Exp Anim. 2021 Apr 6. doi: 10.1538/expanim.21-0001. Online ahead of print
Epub:
Yes
Abstract:
Sea urchin embryos have been one of model organisms to investigate cellular behaviors because of their simple cell composition...
Link:
https://www.jstage.jst.go.jp/article/expanim/advpub/0/advpub_21-0001/_article
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Kiyozumi D, Yaguchi S, Yaguchi J, Yamazaki A, Sekiguchi K. Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos. Exp Anim. 2021 Apr 6. doi: 10.1538/expanim.21-0001. Online ahead of print.

Pluripotency factors determine gene expression repertoire at zygotic genome activation

Authors:
Gao M, Veil M, Rosenblatt M, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2020.02.16.949362
Epub:
Not Epub
Abstract:
Awakening of zygotic transcription in animal embryos relies on maternal pioneer transcription factors. The interplay of global...
Link:
https://www.biorxiv.org/content/10.1101/2020.02.16.949362v3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gao M, Veil M, Rosenblatt M, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D. Pluripotency factors determine gene expression repertoire at zygotic genome activation. bioRxiv. 2021;[preprint] doi:10.1101/2020.02.16.949362.

Sobp modulates Six1 transcriptional activation and is required during craniofacial development

Authors:
Tavares ALP, Jourdeuil K, Neilson K, Majumdar H, Moody SA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472
Epub:
Not Epub
Abstract:
Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, craniofacial and/or renal defects. Mutations in...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.05.438472v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Tavares ALP, Jourdeuil K, Neilson K, Majumdar H, Moody SA. Sobp modulates Six1 transcriptional activation and is required during craniofacial development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472.

Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos

Authors:
Jung J, Kim E, Rhee M
Citation:
Mol Cells. 2021 Apr 6. doi: 10.14348/molcells.2021.0005. Online ahead of print
Epub:
Yes
Abstract:
To define novel networks of Parkinson's disease (PD) pathogenesis, the substantia nigra pars compacta of A53T mice, where...
Link:
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2021.0005
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jung J, Kim E, Rhee M. Kapd Is Essential for Specification of the Dopaminergic Neurogenesis in Zebrafish Embryos. Mol Cells. 2021 Apr 6. doi: 10.14348/molcells.2021.0005. Online ahead of print.

Sea urchin larvae utilize light for regulating the pyloric opening

Authors:
Yaguchi J, Yaguchi S
Citation:
BMC Biol. 2021 Apr 6;19(1):64. doi: 10.1186/s12915-021-00999-1
Epub:
Not Epub
Abstract:
Background: Light is essential for various biological activities. In particular, visual information through eyes or eyespots is...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00999-1
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi J, Yaguchi S. Sea urchin larvae utilize light for regulating the pyloric opening. BMC Biol. 2021 Apr 6;19(1):64. doi: 10.1186/s12915-021-00999-1.

Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion

Authors:
Rho SS, Kobayashi I, Oguri-Nakamura E, Ando K, Fujiwara M, Kamimura N, Hirata H, Iida A, Iwai Y, Mochizuki N, Fukuhara S
Citation:
Dev Cell. 2019 Jun 3;49(5):681-696.e6. doi: 10.1016/j.devcel.2019.03.023. Epub 2019 Apr 18
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) emerge from hemogenic endothelium (HE) within the ventral portion of the dorsal aorta during...
Link:
https://www.sciencedirect.com/science/article/pii/S1534580719302345
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rho SS, Kobayashi I, Oguri-Nakamura E, Ando K, Fujiwara M, Kamimura N, Hirata H, Iida A, Iwai Y, Mochizuki N, Fukuhara S. Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Dev Cell. 2019 Jun 3;49(5):681-696.e6. doi: 10.1016/j.devcel.2019.03.023. Epub 2019 Apr 18.

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