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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2

Authors:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.07.443200
Epub:
Not Epub
Abstract:
BACKGROUND: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin-2...
Link:
https://www.biorxiv.org/content/10.1101/2021.05.07.443200v1
Citation Extract:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD. RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.07.443200 .

Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo

Authors:
Molina MD, Lepage T
Citation:
Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22
Epub:
Not Epub
Abstract:
Specification of the main axes of polarity of the embryo is an essential process during embryonic development. In many species...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0070215319300821
Organism or Cell Type:
sea urchin
Citation Extract:
Molina MD, Lepage T. Maternal factors regulating symmetry breaking and dorsal-ventral axis formation in the sea urchin embryo. Curr Top Dev Biol. 2020;140:283-316. doi: 10.1016/bs.ctdb.2019.10.007. Epub 2019 Nov 22.

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate

Authors:
Chuykin I, Kim K, Sokol S
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.02.442356
Epub:
Not Epub
Abstract:
The orientation of epithelial cells in the plane of the tissue, known as planar cell polarity (PCP), is regulated by...
Link:
https://www.biorxiv.org/content/10.1101/2021.05.02.442356v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chuykin I, Kim K, Sokol S. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.02.442356.

A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells

Authors:
Galton R, Fejes-Toth K, Bronner ME
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.30.442165
Epub:
Not Epub
Abstract:
In the metazoan germline, Piwi proteins play an essential regulatory role in maintenance of stemness and self-renewal by piRNA-...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.30.442165v1.full
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Galton R, Fejes-Toth K, Bronner ME. A somatic piRNA pathway regulates epithelial-to-mesenchymal transition of chick neural crest cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.30.442165 .

Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish

Authors:
Hung J-C, Wu J-L, Hong J-R
Citation:
Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832
Epub:
Not Epub
Abstract:
The BH3-only molecule Bad regulates cell death via its differential protein phosphorylation, but very few studies address its...
Link:
https://www.mdpi.com/1422-0067/22/9/4832
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung J-C, Wu J-L, Hong J-R. Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. Int J Mol Sci. 2021;22:4832. doi:10.3390/ijms22094832.

Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22

Authors:
Sheng J, Gong J, Shi Y, Wang X, Liu D
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.29.441918
Epub:
Not Epub
Abstract:
A precise neuro-vascular communication is crucial to orchestrate directional migration and patterning of the complex vascular...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.29.441918v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sheng J, Gong J, Shi Y, Wang X, Liu D. Blood vessels regulate primary motor neuronal pathfinding in zebrafish via exosome contained microRNA-22. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.29.441918 .

Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception

Authors:
Boutillon A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.26.441407
Epub:
Not Epub
Abstract:
Morphogenesis, wound healing and some cancer metastases depend upon migration of cell collectives that need to be guided to...
Link:
https://www.biorxiv.org/content/10.1101/2021.04.26.441407v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boutillon A, Jahn D, González-Tirado S, Starruß J, Brusch L, David NB. Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.26.441407.

Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway

Authors:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H
Citation:
Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print
Epub:
Yes
Abstract:
The focal adhesion protein Kindlin2 is essential for integrin activation, a process that is fundamental to cell-extracellular...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.199441/261719/Kindlin2-regulates-neural-crest-specification-via
Organism or Cell Type:
Xenopus
Citation Extract:
Wang H, Wang C, Long Q, Zhang Y, Wang M, Liu J, Qi X, Cai D, Lu G, Sun J, Yao YG, Chan WY, Chan WY, Deng Y, Zhao H. Kindlin2 regulates neural crest specification via integrin-independent regulation of the FGF signaling pathway. Development. 2021 Apr 28:dev.199441. doi: 10.1242/dev.199441. Online ahead of print.

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis

Authors:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP
Citation:
J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print
Epub:
Yes
Abstract:
Context: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic...
Link:
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab283/6257595
Organism or Cell Type:
zebrafish
Citation Extract:
Martín M, Modenutti CP, Gil Rosas ML, Peyret V, Geysels RC, Bernal Barquero CE, Sobrero G, Muñoz L, Signorino M, Testa G, Miras MB, Masini-Repiso AM, Calcaterra NB, Coux G, Carrasco N, Martí MA, Nicola JP. A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis. J Clin Endocrinol Metab. 2021 Apr 29:dgab283. doi: 10.1210/clinem/dgab283. Online ahead of print.

The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin

Authors:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L
Citation:
Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5
Epub:
Not Epub
Abstract:
Dystrophin proteomic regulation in muscular dystrophies (MDs) remains unclear. We report that a long noncoding RNA (lncRNA),...
Link:
https://www.nature.com/articles/s41556-020-00595-5
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 Nov;22(11):1332-1345. doi: 10.1038/s41556-020-00595-5.

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