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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.19.452884 Epub:
Not Epub Abstract:
The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Naylor RWW, Lemarie E, Jackson-Crawford A, Davenport JB, Mironov A, Lowe M, Lennon R. A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.19.452884. |
Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
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Citation:
Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4 Epub:
Not Epub Abstract:
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine... Delivery Method:
cell bathing Organism or Cell Type:
cell culture: Vero-E6 & SARS-CoV-2 Citation Extract: Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4. |
Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations
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Citation:
Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281 Epub:
Not Epub Abstract:
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281. |
Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae
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Citation:
J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print Epub:
Not Epub Abstract:
Freshwater fish live in environments where pH levels fluctuate more than those in seawater. During acidic stress, the acid-base... Delivery Method:
microinjection Organism or Cell Type:
Oryzias latipes (medaka) Citation Extract: Lin CH, Hu HJ, Chuang HJ, Tsou YL, Hwang PP. Cortisol and glucocorticoid receptor 2 regulate acid secretion in medaka (Oryzias latipes) larvae. J Comp Physiol B. 2021 Jul 17. doi: 10.1007/s00360-021-01390-w. Online ahead of print. |
Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms
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Citation:
Res Sq. 2021;[preprint] doi:10.21203/rs.3.rs-677459/v1 Epub:
Not Epub Abstract:
Osteosarcoma (OS) is the most common primary bone malignancy. Chemotherapy plays an essential role in OS treatment, potentially... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: (RFP)-labeled MOSJ-Dkk1 murine osteochondral sarcoma line, xenograft in Foxn1-/Foxn1- mice Citation Extract: Pan S, Cesarek M, Godoy C, Co C, Schindler C, Padilla K, Poole R, Dabney A, Gregory C. Morpholino-driven transcriptional blockade of Dkk-1 in experimental osteosarcoma inhibits bone damage and tumor expansion by multiple mechanisms. Res Sq. 2021;[preprint] doi:10.21203/rs.3.rs-677459/v1. |
SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy
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Citation:
Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006 Epub:
Yes Abstract:
Alternative mRNA splicing is a fundamental process to increase the versatility of the genome. In humans, cardiac mRNA splicing... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Boeckel J-N, Möbius-Winkler M, Müller M, Rebs S, Eger N, Schoppe L, Tappu R, Kokot KE, Kneuer JM, Gaul S, Bordalo DM, Lai A, Haas J, Ghanbari M, Drewe-Boss P, Liss M, Katus HA, Ohler U, Gotthardt M, Laufs U, Streckfuss-Bömeke K, Meder B. SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Genomics Proteomics Bioinformatics. 2021;[Epub ahead of print] doi:10.1016/j.gpb.2021.01.006. |
Cell adhesions link subcellular actomyosin dynamics to tissue scale force production during vertebrate convergent extension
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.06.21.449290 Epub:
Not Epub Abstract:
Axis extension is a fundamental biological process that shapes multicellular organisms. The design of an animal’s body plan is... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Huebner RJ, Weng S, Lee C, Sarıkaya S, Papoulas O, Cox RM, Marcotte EM, Wallingford JB. Cell adhesions link subcellular actomyosin dynamics to tissue scale force production during vertebrate convergent extension. bioRxiv. 2021;[preprint] doi:10.1101/2021.06.21.449290 . |
The atypical RNA-binding protein TAF15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.06.14.041913 Epub:
Not Epub Abstract:
The FET family of atypical RNA-binding proteins includes Fused in sarcoma (Fus), Ewing’s sarcoma (EWS), and the TATA-binding... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: DeJong CS, Dichmann DS, Exner CRT, Xu Y, Harland RM. The atypical RNA-binding protein TAF15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis. bioRxiv. 2021;[preprint] doi:10.1101/2021.06.14.041913 . |
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
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Citation:
Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2 Epub:
Not Epub Abstract:
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase,... Delivery Method:
microinjection Organism or Cell Type:
mouse oocyte Citation Extract: Thomas C, Wetherall B, Levasseur D, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes. Nat Commun. 2021;12(1):4322. doi:10.1038/s41467-021-24554-2. |
Real time large scale in vivo observations by light-sheet microscopy reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord
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Citation:
arXiv. 2021;2107.05242v1 [preprint] Epub:
Not Epub Abstract:
Axonal growth and guidance at the ventral floor plate is here followed in vivo in real time at high resolution by light-sheet... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Andersen SSL. Real time large scale in vivo observations by light-sheet microscopy reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord. arXiv. 2021;2107.05242v1 [preprint]. |