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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis

Authors:
Yang R-M, Zhan M, Zhou Q-Y, Ye X-P, Wu F-Y, Dong M, Sun F, Fang Y, Zhang R-J, Zhang C-R, Yang L, Guo M-M, Zhang J-X, Liang J, Cheng F, Liu W, Han B, Zhou Y, Zhao S-X, Song H-D
Citation:
Genet Med. 2021;[Epub] doi:10.1038/s41436-021-01237-3
Epub:
Not Epub
Abstract:
Purpose: Congenital hypothyroidism (CH) is a common congenital endocrine disorder in humans. CH-related diseases such as...
Link:
https://www.nature.com/articles/s41436-021-01237-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang R-M, Zhan M, Zhou Q-Y, Ye X-P, Wu F-Y, Dong M, Sun F, Fang Y, Zhang R-J, Zhang C-R, Yang L, Guo M-M, Zhang J-X, Liang J, Cheng F, Liu W, Han B, Zhou Y, Zhao S-X, Song H-D. Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis. Genet Med. 2021;[Epub] doi:10.1038/s41436-021-01237-3.

LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy

Authors:
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V, Sivasubbu S
Citation:
EMBO J. 2021 Jun 28:e107134. doi:10.15252/embj.2020107134. Online ahead of print. https://www.embopress.org/doi/full/10.15252/embj.2020107134
Epub:
Not Epub
Abstract:
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a...
Link:
https://www.embopress.org/doi/full/10.15252/embj.2020107134
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V, Sivasubbu S. LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy. EMBO J. 2021 Jun 28:e107134. doi:10.15252/embj.2020107134. Online ahead of print. https://www.embopress.org/doi/full/10.15252/embj.2020107134.

Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning

Authors:
Lebedeva T, Aman AJ, Graf T, Niedermoser I, Zimmermann B, Kraus Y, Schatka M, Demilly A, Technau U, Genikhovich G
Citation:
Nat Commun. 2021;12(1):4032. doi:10.1038/s41467-021-24346-8
Epub:
Not Epub
Abstract:
In animals, body axis patterning is based on the concentration-dependent interpretation of graded morphogen signals, which...
Link:
https://www.nature.com/articles/s41467-021-24346-8
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Lebedeva T, Aman AJ, Graf T, Niedermoser I, Zimmermann B, Kraus Y, Schatka M, Demilly A, Technau U, Genikhovich G. Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning. Nat Commun. 2021;12(1):4032. doi:10.1038/s41467-021-24346-8.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

Authors:
Reis AH, Sokol SY
Citation:
Sci Rep. 2021;11:13433. doi:10.1038/s41598-021-92824-6
Epub:
Not Epub
Abstract:
The Wnt pathway activates target genes by controlling the β-catenin-T-cell factor (TCF) transcriptional complex during...
Link:
https://www.nature.com/articles/s41598-021-92824-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. Sci Rep. 2021;11:13433. doi:10.1038/s41598-021-92824-6.

Utilizing Zebrafish Embryos to Reveal Disruptions in Dorsoventral Patterning

Authors:
Dasgupta S, Cheng V, Volz DC
Citation:
Curr Protoc. 2021 Jun;1(6):e179. doi: 10.1002/cpz1.179
Epub:
Not Epub
Abstract:
Dorsoventral (DV) patterning is a key landmark of embryonic development that is primarily regulated by bone morphogenetic...
Link:
https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.179
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dasgupta S, Cheng V, Volz DC. Utilizing Zebrafish Embryos to Reveal Disruptions in Dorsoventral Patterning. Curr Protoc. 2021 Jun;1(6):e179. doi: 10.1002/cpz1.179.

Perturbation of astroglial Slc38 glutamine transporters by NH4+ contributes to neurophysiologic manifestations in acute liver failure

Authors:
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA
Citation:
FASEB J. 2021;35:e21588. doi:10.1096/fj.202001712RR
Epub:
Not Epub
Abstract:
Ammonia is considered the main pathogenic toxin in hepatic encephalopathy (HE). However, the molecular mechanisms involved have...
Link:
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001712RR
Delivery Method:
Vivo-Morpholino osmotic pump to frontal cortex
Organism or Cell Type:
C57Bl6 mice
Citation Extract:
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA. Perturbation of astroglial Slc38 glutamine transporters by NH4+ contributes to neurophysiologic manifestations in acute liver failure. FASEB J. 2021;35:e21588. doi:10.1096/fj.202001712RR.

Defects of cohesin loader lead to bone dysplasia associated with transcriptional disturbance

Authors:
Gu W, Wang, Gu R,Ouyang H, Bao B, Zheng L, Xu B
Citation:
J Cell Physiol. 2021;[Epub] doi:doi.org/10.1002/jcp.30491
Epub:
Not Epub
Abstract:
Cohesin loader nipped-B-like protein (Nipbl) is increasingly recognized for its important role in development and cancer....
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.30491
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gu W, Wang, Gu R,Ouyang H, Bao B, Zheng L, Xu B. Defects of cohesin loader lead to bone dysplasia associated with transcriptional disturbance. J Cell Physiol. 2021;[Epub] doi:doi.org/10.1002/jcp.30491.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

Authors:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G
Citation:
Nucl Acids Res. 2021;gkab533[Epub] doi:10.1093/nar/gkab533
Epub:
Yes
Abstract:
The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab533/6308501
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G. Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code. Nucl Acids Res. 2021;gkab533[Epub] doi:10.1093/nar/gkab533.

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

Authors:
Gentile A, Bensimon-Brito A, Priya R, Maischein HM, Piesker J, Guenther S, Gunawan F, Stainier DY
Citation:
Elife. 2021 Jun 21;10:e66143. doi: 10.7554/eLife.66143
Epub:
Not Epub
Abstract:
The transcription factor Snai1, a well-known regulator of epithelial-to-mesenchymal transition, has been implicated in early...
Link:
https://elifesciences.org/articles/66143
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gentile A, Bensimon-Brito A, Priya R, Maischein HM, Piesker J, Guenther S, Gunawan F, Stainier DY. The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. Elife. 2021 Jun 21;10:e66143. doi: 10.7554/eLife.66143.

Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases

Authors:
Cardenas-Rodriguez M, Austin-Tse C, Bergboer JGM, Molinari E, Sugano Y, Bachmann-Gagescu R, Sayer JA, Drummond IA
Citation:
J Cell Sci. 2021 Jun 22:jcs.258568. doi: 10.1242/jcs.258568. Online ahead of print
Epub:
Yes
Abstract:
Mutations in CEP290, a large multidomain coiled coil protein, are associated with multiple cilia-associated syndromes. Over 130...
Link:
https://journals.biologists.com/jcs/article/doi/10.1242/jcs.258568/269195/Genetic-compensation-for-cilia-defects-in-cep290
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cardenas-Rodriguez M, Austin-Tse C, Bergboer JGM, Molinari E, Sugano Y, Bachmann-Gagescu R, Sayer JA, Drummond IA. Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases. J Cell Sci. 2021 Jun 22:jcs.258568. doi: 10.1242/jcs.258568. Online ahead of print.

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