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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss
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Citation:
Hum Genet. 2021 Oct 13. doi: 10.1007/s00439-021-02380-2. Online ahead of print Epub:
Yes Abstract:
Mitochondrial disorders are collectively common, genetically heterogeneous disorders in both pediatric and adult populations.... Organism or Cell Type:
zebrafish Citation Extract: Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE. A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss. Hum Genet. 2021 Oct 13. doi: 10.1007/s00439-021-02380-2. Online ahead of print. |
Antisense-Mediated Down-Regulation of Factor V-Short Splicing in a Liver Cell Line Model
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Citation:
Appl Sci. 2021;11(20):9621. doi:0.3390/app11209621 Epub:
Not Epub Abstract:
Coagulation factor V (FV) is a liver-derived protein encoded by the F5 gene. Alternative splicing of F5 exon 13 produces a low-... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: HepG2 Citation Extract: Todaro AM, Hackeng TM, Castoldi E. Antisense-Mediated Down-Regulation of Factor V-Short Splicing in a Liver Cell Line Model. Appl Sci. 2021;11(20):9621. doi:0.3390/app11209621 . |
Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders
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Citation:
Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w Epub:
Not Epub Abstract:
Recent advances in the genetics of neurodevelopmental disorders (NDDs) have identified the transcription factor FOXP2 as one of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lüffe TM, D’Orazio A, Bauer M, Gioga Z, Schoeffler V, Lesch K-P, Romanos Ml, Drepper C, Lillesaar C. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders. Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w. |
Antisense oligonucleotides: absorption, distribution, metabolism, and excretion
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Citation:
Expert Opin Drug Metab Toxicol. 2021 Oct 13. doi: 10.1080/17425255.2021.1992382. Online ahead of print Epub:
Yes Abstract:
Introduction: Antisense oligonucleotides (ASOs) have emerged as a promising novel drug modality that aims to address unmet... Citation Extract: Shadid M, Badawi M, Abulrob A. Antisense oligonucleotides: absorption, distribution, metabolism, and excretion. Expert Opin Drug Metab Toxicol. 2021 Oct 13. doi: 10.1080/17425255.2021.1992382. Online ahead of print. |
CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production
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Citation:
Int J Mol Sci. 2021 Oct 6;22(19):10806. doi: 10.3390/ijms221910806 Epub:
Not Epub Abstract:
Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Tan KS, Wang D, Lu Z, Zhang Y, Li S, Lin Y, Tan W. CNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production. Int J Mol Sci. 2021 Oct 6;22(19):10806. doi: 10.3390/ijms221910806. |
Stretch-induced endogenous electric fields drive neural crest directed collective cell migration in vivo
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.11.463916 Epub:
Not Epub Abstract:
Directed collective cell migration (dCCM) is essential for morphogenesis. Cell clusters migrate in inherently complex in vivo... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Ferreira F, Moreira S, Barriga EH. Stretch-induced endogenous electric fields drive neural crest directed collective cell migration in vivo. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.11.463916. |
Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals
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Citation:
Mol Psychiatry. 2021;[Epub]. doi:10.1038/s41380-021-01333-5 Epub:
Not Epub Abstract:
GABAergic projections from the nucleus accumbens core to the dorsolateral ventral pallidum are necessary for drug-conditioned... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Rat Citation Extract: Kruyer A, Dixon D, Angelis A, Amato D, Kalivas PW. Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals. Mol Psychiatry. 2021;[Epub]. doi:10.1038/s41380-021-01333-5. |
RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues
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Citation:
Bioorg Med Chem. 2009 Mar 15;17(6):2441-6. doi: 10.1016/j.bmc.2009.02.001. Epub 2009 Feb 8 Epub:
Not Epub Abstract:
siRNAs modified with morpholino nucleoside analogues were synthesized and their biological properties were examined in details... Organism or Cell Type:
cell culture Citation Extract: Zhang N, Tan C, Cai P, Zhang P, Zhao Y, Jiang Y. RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues. Bioorg Med Chem. 2009 Mar 15;17(6):2441-6. doi: 10.1016/j.bmc.2009.02.001. Epub 2009 Feb 8. |
Regulation of Nav1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developing Xenopus laevis tadpole
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463558 Epub:
Not Epub Abstract:
For individual neurons to function appropriately within a network that is undergoing synaptic reorganization and refinement due... Delivery Method:
injection then electroporation Organism or Cell Type:
Xenopus laevis Citation Extract: Thompson AC, Aizenman CD. Regulation of Nav1.6-mediated sodium currents underlie the homeostatic control of neuronal intrinsic excitability in the optic tectum of the developing Xenopus laevis tadpole. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463558 . |
Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes
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PLoS One. 2021 Oct 8;16(10):e0257774. doi: 10.1371/journal.pone.0257774. eCollection 2021 Epub:
Not Epub Abstract:
Previously we have shown that trypsin, a protein typically involved in digestion, is released from gills of both fresh and... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
zebrafish Citation Extract: Alsrhani A, Raman R, Jagadeeswaran P. Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes. PLoS One. 2021 Oct 8;16(10):e0257774. doi: 10.1371/journal.pone.0257774. eCollection 2021. |