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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12152 scientific papers returned from the database with the search filters currently being used below.
There are 12152 scientific papers returned from the database with the search filters currently being used below.
The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells
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Citation:
Cancer Commun (Lond). 2022 Mar 2. doi: 10.1002/cac2.12274. Online ahead of print Epub:
Yes Abstract:
Background: Chemotherapy resistance is a primary reason of ovarian cancer therapy failure; hence it is important to investigate... Organism or Cell Type:
zebrafish Citation Extract: Wang Z, Chen W, Zuo L, Xu M, Wu Y, Huang J, Zhang X, Li Y, Wang J, Chen J, Wang H, Sun H. The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells. Cancer Commun (Lond). 2022 Mar 2. doi: 10.1002/cac2.12274. Online ahead of print. |
The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies
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Citation:
Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print Epub:
Not Epub Abstract:
Mutations in genes that lead to dysfunctional cilia can cause a broad spectrum of human disease phenotypes referred to as... Organism or Cell Type:
zebrafish Citation Extract: Epting D, Decker E, Ott E, Eisenberger T, Bader I, Bachmann N, Bergmann C. The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print. |
Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis
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Citation:
eLife. 2022;11:e74821. doi:10.7554/eLife.74821 Epub:
Not Epub Abstract:
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Paulissen E, Palmisano NJ, Waxman JS, Martin BL. Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLife. 2022;11:e74821. doi:10.7554/eLife.74821. |
Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model
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Citation:
Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003 Epub:
Yes Abstract:
Myotonic dystrophy type 1 is a debilitating neuromuscular disease causing muscle weakness, myotonia, and cardiac dysfunction.... Delivery Method:
Pip9b2 peptide-linked; intravenous (i.v.) Organism or Cell Type:
DM1 cells; HSALR mice Citation Extract: Overby SJ, Cerro-Herreros E, González-Martínez I, Varela MA, Seoane-Miraz D, Jad Y, Raz R, Møller T, Pérez-Alonso M, Wood MJ, Llamusí B, Artero R. Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model. Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003. |
Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
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Citation:
ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648 Epub:
Yes Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648. |
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
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Citation:
Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print Epub:
Yes Abstract:
RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors show... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
xenograft in mice Citation Extract: Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA. Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print. |
Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish
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Citation:
Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print Epub:
Yes Abstract:
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print. |
The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1
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Citation:
Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print Epub:
Yes Abstract:
Background: Spermatogonial stem cells (SSCs) are unique stem cells that account for the whole reproductive life of males and... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
murine explants Citation Extract: Zhou H, Shen C, Guo Y, Huang X, Zheng B, Wu Y. The plasminogen receptor directs maintenance of spermatogonial stem cells by targeting BMI1. Mol Biol Rep. 2022 Feb 27. doi: 10.1007/s11033-022-07289-1. Online ahead of print. |
Zebrafish her3 knockout impacts developmental and cancer-related gene signatures
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Citation:
Dev Biol. 2023 Apr;496:1-14. doi: 10.1016/j.ydbio.2023.01.003. Epub 2023 Jan 23. PMID: 36696714; PMCID: PMC10054701 Epub:
Not Epub Abstract:
HES3 is a basic helix-loop-helix transcription factor that regulates neural stem cell renewal during development. HES3... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Kent MR, Calderon D, Silvius KM, Kucinski JP, LaVigne CA, Cannon MV, Kendall GC. Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. Dev Biol. 2023 Apr;496:1-14. doi: 10.1016/j.ydbio.2023.01.003. Epub 2023 Jan 23. PMID: 36696714; PMCID: PMC10054701. |
Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells
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Citation:
RNA. 2022 Aug;28(8):1058-1073. doi: 10.1261/rna.079137.122. Epub 2022 May 25. PMID: 35613883; PMCID: PMC9297843 Epub:
Not Epub Abstract:
The interleukin 7 receptor (IL7R) is strongly associated with increased risk to develop multiple sclerosis (MS), an autoimmune... Delivery Method:
Endo-Porter PEG (HeLa), electroporation (primary CD4+ T) Organism or Cell Type:
cell culture: HeLa, human primary CD4+ T cells Citation Extract: Galarza-Muñoz G, Kennedy-Boone D, Schott G, Bradrick SS, Garcia-Blanco MA. Antisense modulation of IL7R splicing to control sIL7R expression in human CD4+ T cells. RNA. 2022 Aug;28(8):1058-1073. doi: 10.1261/rna.079137.122. Epub 2022 May 25. PMID: 35613883; PMCID: PMC9297843. |