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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish

Authors:
Matrone G, Jung SY, Choi JM, Jain A, Leung H-CE, Rajapakshe K, Coarfa C, Rodor J, Denvir MA, Baker AH, Cooke JP
Citation:
Nat Comm. 2021;12(1):6282. doi:10.1038/s41467-021-26621-0
Epub:
Not Epub
Abstract:
Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains...
Delivery Method:
microinjection, Vivo-Morpholino retro-orbital injection
Organism or Cell Type:
zebrafish
Citation Extract:
Matrone G, Jung SY, Choi JM, Jain A, Leung H-CE, Rajapakshe K, Coarfa C, Rodor J, Denvir MA, Baker AH, Cooke JP. Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nat Comm. 2021;12(1):6282. doi:10.1038/s41467-021-26621-0.

Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development

Authors:
Branigan GL, Olsen KS, Burda I, Haemmerle MW, Ho J, Venuto A, D’Antonio ND, Briggs IE, DiBenedetto AJ
Citation:
J Dev Biol. 2021;9(4):46. doi:10.3390/jdb9040046
Epub:
Not Epub
Abstract:
Brd2 belongs to the BET family of epigenetic transcriptional co-regulators that act as adaptor-scaffolds for the assembly of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Branigan GL, Olsen KS, Burda I, Haemmerle MW, Ho J, Venuto A, D’Antonio ND, Briggs IE, DiBenedetto AJ. Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development. J Dev Biol. 2021;9(4):46. doi:10.3390/jdb9040046.

The H3K27 demethylase controls the lateral line embryogenesis of zebrafish

Authors:
Tang D, Lu Y, Zuo N, Yan R, Wu C, Wu L, Liu S, He Y
Citation:
Cell Biol Toxicol. 2021 Oct 29. doi: 10.1007/s10565-021-09669-y. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Kdm6b, a specific histone 3 lysine 27 (H3K27) demethylase, has been reported to be implicated in a variety of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tang D, Lu Y, Zuo N, Yan R, Wu C, Wu L, Liu S, He Y. The H3K27 demethylase controls the lateral line embryogenesis of zebrafish. Cell Biol Toxicol. 2021 Oct 29. doi: 10.1007/s10565-021-09669-y. Online ahead of print.

Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis

Authors:
Müller-Deile J, Sopel N, Ohs A, Rose V, Gröner M, Wrede C, Hegermann J, Daniel C, Amann K, Zahner G, Schiffer M
Citation:
J Am Soc Nephrol. 2021 Nov;32(11):2777-2794. doi: 10.1681/ASN.2020121699
Epub:
Not Epub
Abstract:
Background: Autoantibodies binding to podocyte antigens cause idiopathic membranous glomerulonephritis (iMGN). However, it...
Organism or Cell Type:
zebrafish
Citation Extract:
Müller-Deile J, Sopel N, Ohs A, Rose V, Gröner M, Wrede C, Hegermann J, Daniel C, Amann K, Zahner G, Schiffer M. Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis. J Am Soc Nephrol. 2021 Nov;32(11):2777-2794. doi: 10.1681/ASN.2020121699.

Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation

Authors:
Zhu X, Wang P, Wei J, Li Y, Zhai J, Zheng T, Tao Q
Citation:
EMBO Rep. 2021 Oct 15:e53185. doi: 10.15252/embr.202153185. Online ahead of print
Epub:
Yes
Abstract:
The Spemann and Mangold Organizer (SMO) is of fundamental importance for dorsal ventral body axis formation during vertebrate...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Zhu X, Wang P, Wei J, Li Y, Zhai J, Zheng T, Tao Q. Lysosomal degradation of the maternal dorsal determinant Hwa safeguards dorsal body axis formation. EMBO Rep. 2021 Oct 15:e53185. doi: 10.15252/embr.202153185. Online ahead of print.

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period

Authors:
Ji WH, Li DD, Wei DP, Gu AQ, Yang Y, Peng JP
Citation:
Front Immunol. 2021 Oct 12;12:763067. doi: 10.3389/fimmu.2021.763067. eCollection 2021
Epub:
Not Epub
Abstract:
Uterine M1/M2 macrophages activation states undergo dynamic changes throughout pregnancy, and inappropriate macrophages...
Delivery Method:
intrauterine injection
Organism or Cell Type:
mice
Citation Extract:
Ji WH, Li DD, Wei DP, Gu AQ, Yang Y, Peng JP. Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period. Front Immunol. 2021 Oct 12;12:763067. doi: 10.3389/fimmu.2021.763067. eCollection 2021.

Antisense oligonucleotide repress telomerase activity via manipulating alternative splicing or translation

Authors:
Zhou J, Li T, Geng X, Sui L, Wang F
Citation:
Biochem Biophys Res Commun. 2021 Oct 21;582:118-124. doi: 10.1016/j.bbrc.2021.10.034. Online ahead of print
Epub:
Not Epub
Abstract:
Telomerase is a reverse transcriptase that catalyzes the addition of telomeric repeated DNA onto the 3' ends of linear...
Organism or Cell Type:
cell culture: HEK 293T, HeLa cells
Citation Extract:
Zhou J, Li T, Geng X, Sui L, Wang F. Antisense oligonucleotide repress telomerase activity via manipulating alternative splicing or translation. Biochem Biophys Res Commun. 2021 Oct 21;582:118-124. doi: 10.1016/j.bbrc.2021.10.034. Online ahead of print.

The development of shape. Modular control of growth in the lepidopteran forewing

Authors:
McKenna KZ, Nijhout HF
Citation:
J Exp Zool B Mol Dev Evol. 2021 Oct 28. doi:10.1002/jez.b.23101. Online ahead of print
Epub:
Yes
Abstract:
The mechanisms by which tissues and organs achieve their final size and shape during development are largely unknown. Although...
Organism or Cell Type:
Junonia coenia (butterfly)
Citation Extract:
McKenna KZ, Nijhout HF. The development of shape. Modular control of growth in the lepidopteran forewing. J Exp Zool B Mol Dev Evol. 2021 Oct 28. doi:10.1002/jez.b.23101. Online ahead of print.

Multifunctional Nanopolymers for Blood-Brain Barrier Delivery and Inhibition of Glioblastoma Growth through EGFR/EGFRvIII, c-Myc, and PD-1

Authors:
Patil R, Sun T, Rashid MH, Israel LL, Ramesh A, Davani S, Black KL, Ljubimov AV, Holler E, Ljubimova JY
Citation:
Nanomaterials. 2021;11(11):2892. doi:10.3390/nano11112892
Epub:
Not Epub
Abstract:
Glioblastoma (GBM) is the most prevalent primary brain cancer in the pediatric and adult population. It is known as an...
Delivery Method:
nanoparticle
Organism or Cell Type:
Xenograft GL261 (mouse glioblastoma) in mice
Citation Extract:
Patil R, Sun T, Rashid MH, Israel LL, Ramesh A, Davani S, Black KL, Ljubimov AV, Holler E, Ljubimova JY. Multifunctional Nanopolymers for Blood-Brain Barrier Delivery and Inhibition of Glioblastoma Growth through EGFR/EGFRvIII, c-Myc, and PD-1. Nanomaterials. 2021;11(11):2892. doi:10.3390/nano11112892.

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction

Authors:
Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A
Citation:
J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print
Epub:
Not Epub
Abstract:
Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Darrah K, Wesalo J, Lukasak B, Tsang M, Chen JK, Deiters A. Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. J Am Chem Soc. 2021 Oct 27. doi: 10.1021/jacs.1c08723. Online ahead of print.

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