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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Generation of a Triadin KnockOut Syndrome Zebrafish Model

Authors:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C
Citation:
Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720
Epub:
Not Epub
Abstract:
Different forms of sudden cardiac death have been described, including a recently identified form of genetic arrhythmogenic...
Link:
https://www.mdpi.com/1422-0067/22/18/9720
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C. Generation of a Triadin KnockOut Syndrome Zebrafish Model. Int J Mol Sci. 2021;22(18):9720. doi:10.3390/ijms22189720 .

Claudin-5a knockdown attenuates blood-neural barrier in zebrafish

Authors:
Ahn JC, Hwang SJ, Lee HJ, Kim KW
Citation:
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print
Epub:
Yes
Abstract:
Mammalian claudin-5 (cldn5), a zebrafish cldn5a homolog, is essential to blood-brain barrier (BBB) integrity. Previously, the...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1532045621002039
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahn JC, Hwang SJ, Lee HJ, Kim KW. Claudin-5a knockdown attenuates blood-neural barrier in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2021 Sep 6:109176. doi: 10.1016/j.cbpc.2021.109176. Online ahead of print.

Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development

Authors:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA
Citation:
Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6
Epub:
Not Epub
Abstract:
Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and craniofacial and/or renal defects. Variants...
Link:
https://journals.biologists.com/dev/article-abstract/148/17/dev199684/272053/Sobp-modulates-the-transcriptional-activation-of
Organism or Cell Type:
Xenopus
Citation Extract:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA. Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development. Development. 2021 Sep 1;148(17):dev199684. doi: 10.1242/dev.199684. Epub 2021 Sep 6.

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Authors:
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
Citation:
Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z
Epub:
Not Epub
Abstract:
Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and myelodysplastic syndrome. Binding of...
Link:
https://www.nature.com/articles/s41467-021-25634-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nat Commun. 2021 Sep 6;12(1):5263. doi: 10.1038/s41467-021-25634-z.

The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development

Authors:
Roffers-Agarwal J, Lidberg KA, Gammill LS
Citation:
Genesis. 2021 Sep 9:e23448. doi: 10.1002/dvg.23448. Online ahead of print
Epub:
Not Epub
Abstract:
SETD2 is a histone H3 lysine 36 (H3K36) tri-methylase that is upregulated in response to neural crest induction. Because the...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/dvg.23448
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Roffers-Agarwal J, Lidberg KA, Gammill LS. The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development. Genesis. 2021 Sep 9:e23448. doi: 10.1002/dvg.23448. Online ahead of print.

Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis

Authors:
Chung HY, Lin BA, Lin YX, Chang CW, Tzou WS, Pei TW, Hu CH
Citation:
FASEB J. 2021 Oct;35(10):e21915. doi: 10.1096/fj.202001044RRR
Epub:
Not Epub
Abstract:
During development, erythroid cells are generated by two waves of hematopoiesis. In zebrafish, primitive erythropoiesis takes...
Link:
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001044RRR
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chung HY, Lin BA, Lin YX, Chang CW, Tzou WS, Pei TW, Hu CH. Meis1, Hi1α, and GATA1 are integrated into a hierarchical regulatory network to mediate primitive erythropoiesis. FASEB J. 2021 Oct;35(10):e21915. doi: 10.1096/fj.202001044RRR.

Estrogen-related receptor γ2 controls NaCl uptake to maintain ionic homeostasis

Authors:
Shih SW, Yan JJ, Wang YH, Tsou YL, Chiu L, Tseng YC, Chou MY, Hwang PP
Citation:
J Endocrinol. 2021 Sep 1:JOE-21-0112.R2. doi: 10.1530/JOE-21-0112. Online ahead of print. PMID: 34494970
Epub:
Yes
Abstract:
Estrogen-related receptors (ERRs) are known to function in mammalian kidney as key regulators of ion transport-related genes;...
Link:
https://joe.bioscientifica.com/view/journals/joe/aop/joe-21-0112/joe-21-0112.xml
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Shih SW, Yan JJ, Wang YH, Tsou YL, Chiu L, Tseng YC, Chou MY, Hwang PP. Estrogen-related receptor γ2 controls NaCl uptake to maintain ionic homeostasis. J Endocrinol. 2021 Sep 1:JOE-21-0112.R2. doi: 10.1530/JOE-21-0112. Online ahead of print. PMID: 34494970.

Numb is required for optimal contraction of skeletal muscle

Authors:
De Gasperi R, Mo C, Azulai D, Wang Z, Harlow LM, Du Y, Graham Z, Pan J, Liu X-H, Guo L, Zhang B, Ko F, Raczkowski AM, Bauman WA, Goulbourne CN, Zhao W, Brotto M, Cardozo CP
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.03.453960
Epub:
Not Epub
Abstract:
Background: The role of Numb, a protein that is important for cell fate and development was investigated in adult skeletal...
Link:
https://www.biorxiv.org/content/10.1101/2021.09.03.453960v1
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: mouse primary myotubes
Citation Extract:
De Gasperi R, Mo C, Azulai D, Wang Z, Harlow LM, Du Y, Graham Z, Pan J, Liu X-H, Guo L, Zhang B, Ko F, Raczkowski AM, Bauman WA, Goulbourne CN, Zhao W, Brotto M, Cardozo CP. Numb is required for optimal contraction of skeletal muscle. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.03.453960.

Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l

Authors:
Kim H-S, Green YS, Xie Y, Christian JL
Citation:
Proc Nat Acad Sci USA. 2021:118(36)e2104661118. doi:10.1073/pnas.2104661118
Epub:
Yes
Abstract:
Toll-like receptor 4 (Tlr) interactor with leucine-rich repeats (Tril) functions as a Tlr coreceptor to mediate innate immunity...
Link:
https://www.pnas.org/content/118/36/e2104661118.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim H-S, Green YS, Xie Y, Christian JL. Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l. Proc Nat Acad Sci USA. 2021:118(36)e2104661118. doi:10.1073/pnas.2104661118.

Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase

Authors:
Li B, Chen K, Liu F, Zhang J, Chen X, Chen T, Chen Q, Yao Y, Hu W, Wang L, Wu Y
Citation:
Front Cardiovasc Med. 2021;8:1000. doi:10.3389/fcvm.2021.724846
Epub:
Not Epub
Abstract:
Background: Mitochondrial aminoacyl-tRNA synthetases (mtARSs) catalyze the binding of specific amino acids to their cognate...
Link:
https://www.frontiersin.org/articles/10.3389/fcvm.2021.724846/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li B, Chen K, Liu F, Zhang J, Chen X, Chen T, Chen Q, Yao Y, Hu W, Wang L, Wu Y. Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase. Front Cardiovasc Med. 2021;8:1000. doi:10.3389/fcvm.2021.724846.

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