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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
There are 12245 scientific papers returned from the database with the search filters currently being used below.
Cell-Penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model
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Citation:
Molec Ther. 2021 Nov 19;S1525-0016(21)00583-9. doi: 10.1016/j.ymthe.2021.11.012 Epub:
Yes Abstract:
Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of infant mortality. Recently approved... Link:
Delivery Method:
protein-linked Citation Extract: Bersani M, Rizzuti M, Pagliari E, Garbellini M, Saccomanno D, Moulton HM, Bresolin N, Comi GP, Corti S, Nizzardo M. Cell-Penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model. Molec Ther. 2021 Nov 19;S1525-0016(21)00583-9. doi: 10.1016/j.ymthe.2021.11.012. |
Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial
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Citation:
Nucleic Acid Ther. 2021 Nov 17. doi: 10.1089/nat.2021.0043. Online ahead of print Epub:
Yes Abstract:
The aim of this Phase 1/2, 2-part, multicenter trial was to report clinical safety and efficacy of long-term golodirsen... Delivery Method:
i.v. infusion Organism or Cell Type:
human Citation Extract: Servais L, Mercuri E, Straub V, Guglieri M, Seferian AM, Scoto M, Leone D, Koenig E, Khan N, Dugar A, Wang X, Han B, Wang D, Muntoni F; SKIP-NMD Study Group
. Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial. Nucleic Acid Ther. 2021 Nov 17. doi: 10.1089/nat.2021.0043. Online ahead of print. |
The Scf/Kit pathway implements self-organized epithelial patterning
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Citation:
Dev Cell. 2021 Mar 22;56(6):795-810.e7. doi: 10.1016/j.devcel.2021.02.026 Epub:
Not Epub Abstract:
How global patterns emerge from individual cell behaviors is poorly understood. In the Xenopus embryonic epidermis,... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Chuyen A, Rulquin C, Daian F, Thomé V, Clément R, Kodjabachian L, Pasini A. The Scf/Kit pathway implements self-organized epithelial patterning. Dev Cell. 2021 Mar 22;56(6):795-810.e7. doi: 10.1016/j.devcel.2021.02.026. |
A live-imaging protocol to track cell movement in the Xenopus embryo
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Citation:
STAR Protoc. 2021 Nov 2;2(4):100928. doi: 10.1016/j.xpro.2021.100928. eCollection 2021 Dec 17 Epub:
Not Epub Abstract:
Tracking individual cell movement during development is challenging, particularly in tissues subjected to major remodeling.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Chuyen A, Daian F, Pasini A, Kodjabachian L. A live-imaging protocol to track cell movement in the Xenopus embryo. STAR Protoc. 2021 Nov 2;2(4):100928. doi: 10.1016/j.xpro.2021.100928. eCollection 2021 Dec 17. |
Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death
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Citation:
mBio. 2021 Nov 16:e0271221. doi: 10.1128/mBio.02712-21. Online ahead of print Epub:
Yes Abstract:
Poliomyelitis-like illness is a common clinical manifestation of neurotropic viral infections. Functional loss and death of... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice BALB/c Citation Extract: Bhaskar M, Mukherjee S, Basu A. Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death. mBio. 2021 Nov 16:e0271221. doi: 10.1128/mBio.02712-21. Online ahead of print. |
Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis
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Citation:
Dev Neurobiol. 2021 Nov 14. doi: 10.1002/dneu.22860. Online ahead of print Epub:
Yes Abstract:
Interferon regulatory factor-7 (IRF7) is an essential regulator of both innate and adaptive immunity. It is also expressed in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hu SQ, Xu HM, Qian F, Chen CS, Wang X, Liu D, Cheng L. Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Dev Neurobiol. 2021 Nov 14. doi: 10.1002/dneu.22860. Online ahead of print. |
Identification of ACTA2 as a Key Contributor to Venous Malformation
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Citation:
Front Cell Dev Biol. 2021;9 [Epub]. doi:10.3389/fcell.2021.755409 Epub:
Not Epub Abstract:
Objectives: Proteomics and high connotation functional gene screening (HCS) were used to screen key functional genes that play... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang S, Zhou Z, Li J, Wang Y, Li H, Lv R, Xu G, Zhang J, Bi J, Huo R. Identification of ACTA2 as a Key Contributor to Venous Malformation. Front Cell Dev Biol. 2021;9 [Epub]. doi:10.3389/fcell.2021.755409. |
Modulation of CD22 protein expression in childhood leukemia by pervasive splicing aberrations: implications for CD22-directed immunotherapies
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Citation:
Blood Cancer Discov. 2022:3(2):103–15. doi:10.1158/2643-3230.BCD-21-0087 Epub:
Not Epub Abstract:
Downregulation of surface epitopes causes post-immunotherapy relapses in B-lymphoblastic leukemia (B-ALL). Here we demonstrate... Organism or Cell Type:
cell culture Citation Extract: Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallieres M, Hottman DA, Bagashev A, Chukinas J, Schmidt C, Asnani M, Shraim R, Taylor DM, Rheingold SR, O'Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A. Modulation of CD22 protein expression in childhood leukemia by pervasive splicing aberrations: implications for CD22-directed immunotherapies. Blood Cancer Discov. 2022:3(2):103–15. doi:10.1158/2643-3230.BCD-21-0087. |
Distinct Frizzled receptors independently mediate endomesoderm specification and primary archenteron invagination during gastrulation in Nematostella
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Citation:
Dev Biol. 2021 Nov 9:S0012-1606(21)00234-7. doi: 10.1016/j.ydbio.2021.11.002. Online ahead of print Epub:
Yes Abstract:
Endomesodermal cell fate specification and archenteron formation during gastrulation are tightly linked developmental processes... Delivery Method:
microinjection Organism or Cell Type:
Nematostella vectensis (sea anemone) Citation Extract: Wijesena N, Sun H, Kumburegama S, Wikramanayake AH. Distinct Frizzled receptors independently mediate endomesoderm specification and primary archenteron invagination during gastrulation in Nematostella. Dev Biol. 2021 Nov 9:S0012-1606(21)00234-7. doi: 10.1016/j.ydbio.2021.11.002. Online ahead of print. |
Nanog regulates primordial germ cell migration through Cxcr4b
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Citation:
Stem Cells. 2010 Sep;28(9):1457-64. doi: 10.1002/stem.469. PMID: 20578184 Epub:
Not Epub Abstract:
Gonadal development in vertebrates depends on the early determination of primordial germ cells (PGCs) and their correct... Organism or Cell Type:
Oryzias latipes (medaka) Citation Extract: Sánchez-Sánchez AV, Camp E, Leal-Tassias A, Atkinson SP, Armstrong L, Díaz-Llopis M, Mullor JL. Nanog regulates primordial germ cell migration through Cxcr4b. Stem Cells. 2010 Sep;28(9):1457-64. doi: 10.1002/stem.469. PMID: 20578184. |