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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12245 scientific papers returned from the database with the search filters currently being used below.

Pharmacological Profile of Viltolarsen for the Treatment of Duchenne Muscular Dystrophy: A Japanese Experience

Authors:
Roshmi RR, Yokota T
Citation:
Clin. Pharmacol. 2021;13:235-42. doi:10.2147/CPAA.S288842
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a fatal, X-linked recessive disorder characterized by progressive muscle loss and...
Link:
https://www.dovepress.com/pharmacological-profile-of-viltolarsen-for-the-treatment-of-duchenne-m-peer-reviewed-fulltext-article-CPAA
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Roshmi RR, Yokota T. Pharmacological Profile of Viltolarsen for the Treatment of Duchenne Muscular Dystrophy: A Japanese Experience. Clin. Pharmacol. 2021;13:235-42. doi:10.2147/CPAA.S288842.

Casimersen for Duchenne muscular dystrophy

Authors:
Wilton-Clark H, Yokota T
Citation:
Drugs Today (Barc). 2021 Dec;57(12):707-717. doi: 10.1358/dot.2021.57.12.3352740
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a genetic disorder affecting 1 in 5,000 males which causes progressive muscle...
Link:
https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=4&p_RefId=3352740&p_IsPs=N
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Wilton-Clark H, Yokota T. Casimersen for Duchenne muscular dystrophy. Drugs Today (Barc). 2021 Dec;57(12):707-717. doi: 10.1358/dot.2021.57.12.3352740.

Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice

Authors:
Wang X, Wang L, Dou J, Yu T, Cao P, Fan N, Borjigin U, Nashun B
Citation:
Epigenetics Chromatin. 2021 Dec 14;14(1):55. doi: 10.1186/s13072-021-00430-7
Epub:
Not Epub
Abstract:
Background: Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two...
Link:
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-021-00430-7
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Wang X, Wang L, Dou J, Yu T, Cao P, Fan N, Borjigin U, Nashun B. Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. Epigenetics Chromatin. 2021 Dec 14;14(1):55. doi: 10.1186/s13072-021-00430-7.

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Authors:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B
Citation:
Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print
Epub:
Yes
Abstract:
The vertebrate left-right axis is specified during embryogenesis by a transient organ: the left-right organizer (LRO). Species...
Link:
https://www.nature.com/articles/s41588-021-00970-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nat Genet. 2021 Dec 13. doi: 10.1038/s41588-021-00970-4. Online ahead of print.

FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish

Authors:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J
Citation:
Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print
Epub:
Yes
Abstract:
Fibroblast growth factor binding protein 3 (Fgfbp3) have been known to be crucial for the process of neural proliferation,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0014488621003526
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu G, Huang Z, Sheng J, Gao X, Xin W, Garcia JQ, Wei G, Liu D, Gong J. FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol. 2021 Dec 8:113944. doi: 10.1016/j.expneurol.2021.113944. Online ahead of print.

miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development

Authors:
Konrad KD, Song JL
Citation:
bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989
Epub:
Not Epub
Abstract:
MicroRNAs (miRNAs) regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The...
Link:
https://www.biorxiv.org/content/10.1101/2021.12.10.471989v1
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Konrad KD, Song JL. miR-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development. bioRxiv. 2021;[preprint]. doi:10.1101/2021.12.10.471989.

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

Authors:
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo W-T, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E
Citation:
Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410
Epub:
Not Epub
Abstract:
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting...
Link:
https://www.science.org/doi/epdf/10.1126/science.abk0410
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo W-T, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. Science. 2021;374(6573):eabk0410. doi:10.1126/science.abk0410.

KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Authors:
Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J
Citation:
Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z
Epub:
Not Epub
Abstract:
Metastasis is the main cause of carcinoma-related death, yet we know little about how it initiates due to our inability to...
Link:
https://www.nature.com/articles/s41467-021-27513-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fadul J, Zulueta-Coarasa T, Slattum GM, Redd NM, Jin MF, Redd MJ, Daetwyler S, Hedeen D, Huisken J, Rosenblatt J. KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion. Nat Commun. 2021;12:7180. doi:10.1038/s41467-021-27513-z.

PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans

Authors:
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M
Citation:
Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7
Epub:
Yes
Abstract:
Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe...
Link:
https://www.nature.com/articles/s41591-021-01572-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021:[Epub ahead of print]. doi:10.1038/s41591-021-01572-7.

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy

Authors:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J
Citation:
Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8
Epub:
Not Epub
Abstract:
The heterozygous Phospholamban p.Arg14del mutation is found in patients with dilated or arrhythmogenic cardiomyopathy. This...
Link:
https://www.nature.com/articles/s41467-021-27461-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J. Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nat Commun. 2021;12(1):7151. doi:10.1038/s41467-021-27461-8.

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