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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Mutated VWA8 Is Associated With Developmental Delay, Microcephaly, and Scoliosis and Plays a Novel Role in Early Development and Skeletal Morphogenesis in Zebrafish

Authors:
Umair M, Farooq Khan M, Aldrees M, Nashabat M, Alhamoudi KM, Bilal M, Alyafee Y, Al Tuwaijri A, Aldarwish M, Al-Rumayyan A, Alkhalaf H, Wadaan MAM, Alfadhel M
Citation:
Front Cell Dev Biol. 2021 Oct 1;9:736960. doi: 10.3389/fcell.2021.736960. eCollection 2021
Epub:
Not Epub
Abstract:
Von Willebrand A domain-containing protein 8 (VWA8), also named KIAA0564, is a poorly characterized, mitochondrial matrix-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Umair M, Farooq Khan M, Aldrees M, Nashabat M, Alhamoudi KM, Bilal M, Alyafee Y, Al Tuwaijri A, Aldarwish M, Al-Rumayyan A, Alkhalaf H, Wadaan MAM, Alfadhel M. Mutated VWA8 Is Associated With Developmental Delay, Microcephaly, and Scoliosis and Plays a Novel Role in Early Development and Skeletal Morphogenesis in Zebrafish. Front Cell Dev Biol. 2021 Oct 1;9:736960. doi: 10.3389/fcell.2021.736960. eCollection 2021.

Nucleolin loss-of-function leads to aberrant FGF signaling and craniofacial anomalies

Authors:
Dash S, Trainor PA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.14.460382
Epub:
Not Epub
Abstract:
rRNA transcription and ribosome biogenesis are global processes required for growth and proliferation of all cells, yet...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dash S, Trainor PA. Nucleolin loss-of-function leads to aberrant FGF signaling and craniofacial anomalies. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.14.460382.

The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling

Authors:
Ding Y, Li Y, Zhang CQ, Liu F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.08.459391
Epub:
Not Epub
Abstract:
Although thrombosis has been extensively studied using various animal models, however, our understanding of the underlying...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding Y, Li Y, Zhang CQ, Liu F. The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.08.459391.

Lmo7 recruits myosin II heavy chain to induce apical constriction in Xenopus ectoderm

Authors:
Matsuda M, Chu C-W, Sokol SY
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.05.12.443820
Epub:
Not Epub
Abstract:
Apical constriction, or reduction of the apical domain, underlies many morphogenetic events during development, such as furrow...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Matsuda M, Chu C-W, Sokol SY. Lmo7 recruits myosin II heavy chain to induce apical constriction in Xenopus ectoderm. bioRxiv. 2021;[preprint] doi:10.1101/2021.05.12.443820.

Admp regulates tail bending by controlling the intercalation of the ventral epidermis through myosin phosphorylation

Authors:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Heisenberg CP, Oka K, Hotta K
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.21.461063
Epub:
Not Epub
Abstract:
Chordate tailbud embryos have similar morphological features, including a bending tail. A recent study revealed that the...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian)
Citation Extract:
Kogure YS, Muraoka H, Koizumi WC, Gelin-alessi R, Godard B, Heisenberg CP, Oka K, Hotta K. Admp regulates tail bending by controlling the intercalation of the ventral epidermis through myosin phosphorylation. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.21.461063.

Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development

Authors:
Lee H, Lee NY, Kim Y, Choi H-S, Ismail T, Ryu H-Y, Cho D-H, Ryoo ZY, Lee D-S, Kwon TK, Park TJ, Kwon T, Lee H-S
Citation:
Antioxidants (Basel). 2021;10(10):1636. doi:10.3390/antiox10101636
Epub:
Not Epub
Abstract:
Glutathione peroxidase 1 (Gpx1) and peroxiredoxin 2 (Prdx2) belong to the thiol peroxidase family of antioxidants, and have...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Lee NY, Kim Y, Choi H-S, Ismail T, Ryu H-Y, Cho D-H, Ryoo ZY, Lee D-S, Kwon TK, Park TJ, Kwon T, Lee H-S. Physiological Functions of Thiol Peroxidases (Gpx1 and Prdx2) during Xenopus laevis Embryonic Development. Antioxidants (Basel). 2021;10(10):1636. doi:10.3390/antiox10101636.

Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish

Authors:
Chiang K-Y, Li Y-W, Li Y-H, Huang S-J, Wu C-L, Gong H-Y, Wu J-L
Citation:
Int J Mol Sci. 2021;22(20):11217. doi:10.3390/ijms222011217
Epub:
Not Epub
Abstract:
Compensatory hepatocyte proliferation and other liver regenerative processes are activated to sustain normal physiological...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Chiang K-Y, Li Y-W, Li Y-H, Huang S-J, Wu C-L, Gong H-Y, Wu J-L. Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. Int J Mol Sci. 2021;22(20):11217. doi:10.3390/ijms222011217.

A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss

Authors:
Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE
Citation:
Hum Genet. 2021 Oct 13. doi: 10.1007/s00439-021-02380-2. Online ahead of print
Epub:
Yes
Abstract:
Mitochondrial disorders are collectively common, genetically heterogeneous disorders in both pediatric and adult populations....
Organism or Cell Type:
zebrafish
Citation Extract:
Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE. A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss. Hum Genet. 2021 Oct 13. doi: 10.1007/s00439-021-02380-2. Online ahead of print.

Antisense-Mediated Down-Regulation of Factor V-Short Splicing in a Liver Cell Line Model

Authors:
Todaro AM, Hackeng TM, Castoldi E
Citation:
Appl Sci. 2021;11(20):9621. doi:0.3390/app11209621
Epub:
Not Epub
Abstract:
Coagulation factor V (FV) is a liver-derived protein encoded by the F5 gene. Alternative splicing of F5 exon 13 produces a low-...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HepG2
Citation Extract:
Todaro AM, Hackeng TM, Castoldi E. Antisense-Mediated Down-Regulation of Factor V-Short Splicing in a Liver Cell Line Model. Appl Sci. 2021;11(20):9621. doi:0.3390/app11209621 .

Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders

Authors:
Lüffe TM, D’Orazio A, Bauer M, Gioga Z, Schoeffler V, Lesch K-P, Romanos Ml, Drepper C, Lillesaar C
Citation:
Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w
Epub:
Not Epub
Abstract:
Recent advances in the genetics of neurodevelopmental disorders (NDDs) have identified the transcription factor FOXP2 as one of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lüffe TM, D’Orazio A, Bauer M, Gioga Z, Schoeffler V, Lesch K-P, Romanos Ml, Drepper C, Lillesaar C. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish -- implications for neurodevelopmental disorders. Transl Psychiatry. 2021;11:529. doi:10.1038/s41398-021-01651-w.

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