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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Authors:
Koltowska K, Okuda KS, Gloger M, Rondon-Galeano M, Mason E, Xuan J, Dudczig S, Chen H, Arnold H, Skoczylas R, Bower NI, Paterson S, Lagendijk AK, Baillie GJ,Leshchiner I, Simons C, Smith KA, Goessling W, Heath JK, Pearson RB, Sanij E, Schulte-Merker S, Hogan BM
Citation:
Nat Cell Biol. 2021;23(11):1136-47. doi:10.1038/s41556-021-00784-w
Epub:
Not Epub
Abstract:
The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network...
Link:
https://www.nature.com/articles/s41556-021-00784-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Koltowska K, Okuda KS, Gloger M, Rondon-Galeano M, Mason E, Xuan J, Dudczig S, Chen H, Arnold H, Skoczylas R, Bower NI, Paterson S, Lagendijk AK, Baillie GJ,Leshchiner I, Simons C, Smith KA, Goessling W, Heath JK, Pearson RB, Sanij E, Schulte-Merker S, Hogan BM. The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function. Nat Cell Biol. 2021;23(11):1136-47. doi:10.1038/s41556-021-00784-w.

MT1 but not MT2 melatonin receptor knockout decreases biliary damage and liver fibrosis during cholestatic liver injury

Authors:
Wu N, Carpino G, Ceci L, Baiocchi L, Francis H, Kennedy L, Zhou T, Chen L, Sato K, Kyritsi K, Meadows V, Ekser B, Franchitto A, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G
Citation:
Hepatology. 2021 Nov 7. doi: 10.1002/hep.32233. Online ahead of print
Epub:
Yes
Abstract:
Background & aims: Melatonin reduces biliary damage and liver fibrosis in cholestatic models by interaction with melatonin...
Link:
https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32233
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Wu N, Carpino G, Ceci L, Baiocchi L, Francis H, Kennedy L, Zhou T, Chen L, Sato K, Kyritsi K, Meadows V, Ekser B, Franchitto A, Mancinelli R, Onori P, Gaudio E, Glaser S, Alpini G. MT1 but not MT2 melatonin receptor knockout decreases biliary damage and liver fibrosis during cholestatic liver injury. Hepatology. 2021 Nov 7. doi: 10.1002/hep.32233. Online ahead of print.

Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish

Authors:
Mo C, Li W, Jia K, Liu W, Yi M
Citation:
Int J Mol Sci. 2021;22(21):11962. doi:10.3390/ijms222111962
Epub:
Not Epub
Abstract:
MicroRNAs (miRNAs) play important roles in post−transcriptional repression in nearly every biological process including germ...
Link:
https://www.mdpi.com/1422-0067/22/21/11962
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mo C, Li W, Jia K, Liu W, Yi M. Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish. Int J Mol Sci. 2021;22(21):11962. doi:10.3390/ijms222111962.

Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes

Authors:
Swartz SZ, Tan TH, Perillo M, Fakhri N, Wessel GM, Wikramanayake AH, Cheeseman IM
Citation:
Curr Biol. 2021;[Epub] doi:10.1016/j.cub.2021.10.022
Epub:
Yes
Abstract:
The organismal body axes that are formed during embryogenesis are intimately linked to intrinsic asymmetries established at the...
Link:
https://www.cell.com/current-biology/fulltext/S0960-9822(21)01411-1
Organism or Cell Type:
Patiria miniata (sea star)
Citation Extract:
Swartz SZ, Tan TH, Perillo M, Fakhri N, Wessel GM, Wikramanayake AH, Cheeseman IM. Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes. Curr Biol. 2021;[Epub] doi:10.1016/j.cub.2021.10.022.

Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin

Authors:
Honglin L, Yongde Z, Yanfei D, Lequn L, Zhaoan S, Yanling Y, Yong L, Xiaohan C, Pengfei F
Citation:
Front Cell Dev Biol. 2021;9:2716. doi:10.3389/fcell.2021.728821
Epub:
Not Epub
Abstract:
Precise regulation of angiogenesis is required for organ development, wound repair, and tumor progression. Here, we identified...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2021.728821/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Honglin L, Yongde Z, Yanfei D, Lequn L, Zhaoan S, Yanling Y, Yong L, Xiaohan C, Pengfei F. Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Front Cell Dev Biol. 2021;9:2716. doi:10.3389/fcell.2021.728821.

Clonal gametogenesis is triggered by intrinsic stimuli in the hybrid’s germ cells but is dependent on sex differentiation

Authors:
Tichopád T, Franěk R, Doležálková-Kaštánková M, Dedukh D, Marta A, Halačka K, Steinbach C, Janko K, Pšenička M.
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.27.466081
Epub:
Not Epub
Abstract:
Interspecific hybridization may trigger the transition from sexual reproduction to asexuality, but mechanistic reasons for such...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.27.466081v1
Delivery Method:
microinjection
Organism or Cell Type:
Cobitis taenia, Cobitis elongatoides (spined loach)
Citation Extract:
Tichopád T, Franěk R, Doležálková-Kaštánková M, Dedukh D, Marta A, Halačka K, Steinbach C, Janko K, Pšenička M.. Clonal gametogenesis is triggered by intrinsic stimuli in the hybrid’s germ cells but is dependent on sex differentiation. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.27.466081.

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs

Authors:
Wu X, Zhang H, Zhang B, Zhang Y, Wang Q, Shen W, Wu X, Lijia Li, Xia W, Nakamura Y, Liu B, Liu F, Takeda H, Meng A, Xie W
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.10.463758
Epub:
Not Epub
Abstract:
Drastic epigenetic reprogramming is essential to convert terminally-differentiated gametes to totipotent embryos. However, it...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.10.463758v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu X, Zhang H, Zhang B, Zhang Y, Wang Q, Shen W, Wu X, Lijia Li, Xia W, Nakamura Y, Liu B, Liu F, Takeda H, Meng A, Xie W. Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.10.463758 .

Amoeboid-like neuronal migration ensures correct horizontal cell layer formation in the developing vertebrate retina

Authors:
Amini R, Schlüßler R, Möllmert S, Bhatnagar A, Guck J, Norden C
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.15.464510
Epub:
Not Epub
Abstract:
As neurons are often born at positions different than where they ultimately function, neuronal migration is key to ensure...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.15.464510v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Amini R, Schlüßler R, Möllmert S, Bhatnagar A, Guck J, Norden C. Amoeboid-like neuronal migration ensures correct horizontal cell layer formation in the developing vertebrate retina. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.15.464510.

Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling

Authors:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.25.465818
Epub:
Not Epub
Abstract:
During neural development, progenitor cells generate different types of neurons in specific time windows. Despite the...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.25.465818v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacobs CT, Kejriwal A, Kocha KM, Jin KY, Huang P. Temporal cell fate determination in the spinal cord is mediated by the duration of Notch signalling. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.25.465818.

Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

Authors:
Ahmed M, Kojima Y, Masai I
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.18.464758
Epub:
Not Epub
Abstract:
In the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine and bipolar cells establishes a synaptic...
Link:
https://www.biorxiv.org/content/10.1101/2021.10.18.464758v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahmed M, Kojima Y, Masai I. Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.18.464758.

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