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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
There are 12132 scientific papers returned from the database with the search filters currently being used below.
Paracrine regulation of neural crest EMT by placodal MMP28
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Citation:
bioRxiv. 2020;[preprint]. doi:10.1101/2020.11.19.389544 Epub:
Not Epub Abstract:
Epithelial-Mesenchymal Transition (EMT) is an early event in cell dissemination from epithelial tissues. EMT endows cells with... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Gouignard N, Bibonne A, Mata JF, Bajanca F, Berki B, Barriga EH, Saint-Jeannet J-P, Theveneau E. Paracrine regulation of neural crest EMT by placodal MMP28. bioRxiv. 2020;[preprint]. doi:10.1101/2020.11.19.389544 . |
Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target
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Citation:
Sci Rep. 2021 Jul 27;11(1):15238. doi: 10.1038/s41598-021-94715-2 Epub:
Not Epub Abstract:
Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade... Delivery Method:
Vivo-Morpholino piggyback hybrid Organism or Cell Type:
zebrafish Citation Extract: Raman R, Fallatah W, Al Qaryoute A, Dhinoja S, Jagadeeswaran P. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci Rep. 2021 Jul 27;11(1):15238. doi: 10.1038/s41598-021-94715-2. |
Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453496 Epub:
Not Epub Abstract:
Nascent vascular networks adapt to the increasing metabolic demands of growing tissues by expanding via angiogenesis. As... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen Y, Jiang Z, Fisher KH, Kim HR, Evans PC, Wilkinson RN. Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453496 . |
Systematic mapping of small nucleolar RNA targets in human cells
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.22.451324 Epub:
Not Epub Abstract:
Altered expression of box C/D small nucleolar RNAs (snoRNAs) is implicated in human diseases, including cancer. Box C/D snoRNAs... Organism or Cell Type:
cell culture: HEK Citation Extract: Dunn-Davies H, Dudnakova T, Langhendries J-L, Watkins N, Lafontaine DLJ, Tollervey D. Systematic mapping of small nucleolar RNA targets in human cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.22.451324. |
A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress
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Citation:
Nat Commun. 2021;12(1):4484. doi:10.1038/s41467-021-24831-0 Epub:
Not Epub Abstract:
Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is toxic for hematopoietic stem and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Cacialli P, Mahony CB, Petzold T, Bordignon P, Rougemont A-L, Bertrand JY. A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress. Nat Commun. 2021;12(1):4484. doi:10.1038/s41467-021-24831-0. |
An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier
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Citation:
Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118 Epub:
Not Epub Abstract:
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin) Citation Extract: Chang WW, Matt A-S, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier. Proc Nat Acad Sci USA. 2021;118(30):e2101378118. doi:10.1073/pnas.2101378118. |
MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes
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Citation:
Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2 Epub:
Not Epub Abstract:
The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane... Delivery Method:
intranasal Vivo-Morpholino Organism or Cell Type:
C57Bl/6 mice Citation Extract: Liu X, Xu F, Ren L, Zhao F, Huang Y, Wei L, Wang Y, Wang C, Fan Z, Mei S, Song J, Zhao Z, Cen S, Liang C, Wang J, Guo F. MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nat Commun. 2021;12:4427. doi:10.1038/s41467-021-24724-2. |
A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.19.452884 Epub:
Not Epub Abstract:
The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Naylor RWW, Lemarie E, Jackson-Crawford A, Davenport JB, Mironov A, Lowe M, Lennon R. A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.19.452884. |
Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
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Citation:
Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4 Epub:
Not Epub Abstract:
Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine... Delivery Method:
cell bathing Organism or Cell Type:
cell culture: Vero-E6 & SARS-CoV-2 Citation Extract: Li C, Callahan AJ, Simon MD, Totaro KA, Mijalis AJ, Phadke K-S, Zhang G, Hartrampf N, Schissel CK, Zhou M, Zong H, Hanson GJ, Loas A, Pohl NLB, Verhoeven DE, Pentelute BL. Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers. Nat Commun. 2021;12(1):4396. doi:10.1038/s41467-021-24598-4. |
Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations
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Citation:
Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281 Epub:
Not Epub Abstract:
Increased acrolein (ACR), a toxic metabolite derived from energy consumption, is associated with diabetes and its complications... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Qi H, Schmöhl F, Li X, Qian X, Tabler CT, Bennewitz K, Sticht C, Morgenstern J, Fleming T, Volk N, Hausser I, Heidenreich E, Hell R, Nawroth PP, Kroll J. Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Adv Sci. 2021;2101281 [Epub] doi:10.1002/advs.202101281. |