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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems

Authors:
Kolvenbach CM, Felger T, Schierbaum L, Thiffault I, Pastinen T, Szczepańska M, Zaniew M, Adamczyk P, Bayat A, Yilmaz Ö, Lindenberg TT, Thiele H, Hildebrandt F, Hinderhofer K, Moog U, Hilger AC, Sullivan B, Bartik L, Gnyś P, Grote P, Odermatt B, Reutter HM, Dworschak GC
Citation:
J Med Genet. 2022 Nov 15:jmedgenet-2022-108738. doi: 10.1136/jmg-2022-108738. Online ahead of print
Epub:
Yes
Abstract:
Background: SHROOM4 is thought to play an important role in cytoskeletal modification and development of the early nervous...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kolvenbach CM, Felger T, Schierbaum L, Thiffault I, Pastinen T, Szczepańska M, Zaniew M, Adamczyk P, Bayat A, Yilmaz Ö, Lindenberg TT, Thiele H, Hildebrandt F, Hinderhofer K, Moog U, Hilger AC, Sullivan B, Bartik L, Gnyś P, Grote P, Odermatt B, Reutter HM, Dworschak GC. X-linked variations in SHROOM4 are implicated in congenital anomalies of the urinary tract and the anorectal, cardiovascular and central nervous systems. J Med Genet. 2022 Nov 15:jmedgenet-2022-108738. doi: 10.1136/jmg-2022-108738. Online ahead of print.

Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction

Authors:
Pegge J, Tatsinkam AJ, Rider CC, Bell E
Citation:
Dev Biol. 2020 Apr 15;460(2):108-114. doi: 10.1016/j.ydbio.2019.12.015. Epub 2019 Dec 25
Epub:
Not Epub
Abstract:
Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pegge J, Tatsinkam AJ, Rider CC, Bell E. Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction. Dev Biol. 2020 Apr 15;460(2):108-114. doi: 10.1016/j.ydbio.2019.12.015. Epub 2019 Dec 25.

Zebrafish: A Tractable Model for Analysis of T Cell Development

Authors:
Sertori R, Zhang Y, Wiest DL
Citation:
In: Bosselut, R., Vacchio, M.S. (eds) T-Cell Development. Methods Mol Biol. 2023;vol 2580. Humana, New York, NY. doi:10.1007/978-1-0716-2740-2_22
Epub:
Not Epub
Abstract:
While the zebrafish has for some time been regarded as a powerful model organism with which to study early events in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sertori R, Zhang Y, Wiest DL. Zebrafish: A Tractable Model for Analysis of T Cell Development. In: Bosselut, R., Vacchio, M.S. (eds) T-Cell Development. Methods Mol Biol. 2023;vol 2580. Humana, New York, NY. doi:10.1007/978-1-0716-2740-2_22.

Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish

Authors:
Lei D, Zhang X, Rouf MA, Mahendra Y, Wen L, Li Y, Zhang X, Li L, Wang L, Zhang T, Wang G, Wang Y
Citation:
iScience. 2021 Oct 30;24(11):103386. doi: 10.1016/j.isci.2021.103386. eCollection 2021 Nov 19
Epub:
Not Epub
Abstract:
The differentiation of lymphatic progenitors is a crucial step in lymphangiogenesis. However, its underlying mechanism remains...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lei D, Zhang X, Rouf MA, Mahendra Y, Wen L, Li Y, Zhang X, Li L, Wang L, Zhang T, Wang G, Wang Y. Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 2021 Oct 30;24(11):103386. doi: 10.1016/j.isci.2021.103386. eCollection 2021 Nov 19.

Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish

Authors:
Fasano G, Muto V, Radio FC, Venditti M, Mosaddeghzadeh N, Coppola S, Paradisi G, Zara E, Bazgir F, Ziegler A, Chillemi G, Bertuccini L, Tinari A, Vetro A, Pantaleoni F, Pizzi S, Conti LA, Petrini S, Bruselles A, Prandi IG, Mancini C, Chandramouli B, Barth M, Bris C, Milani D, Selicorni A, Macchiaiolo M, Gonfiantini MV, Bartuli A, Mariani R, Curry CJ, Guerrini R, Slavotinek A, Iascone M, Dallapiccola B, Ahmadian MR, Lauri A, Tartaglia M
Citation:
Nat Commun. 2022 Nov 11;13(1):6841. doi: 10.1038/s41467-022-34354-x
Epub:
Not Epub
Abstract:
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fasano G, Muto V, Radio FC, Venditti M, Mosaddeghzadeh N, Coppola S, Paradisi G, Zara E, Bazgir F, Ziegler A, Chillemi G, Bertuccini L, Tinari A, Vetro A, Pantaleoni F, Pizzi S, Conti LA, Petrini S, Bruselles A, Prandi IG, Mancini C, Chandramouli B, Barth M, Bris C, Milani D, Selicorni A, Macchiaiolo M, Gonfiantini MV, Bartuli A, Mariani R, Curry CJ, Guerrini R, Slavotinek A, Iascone M, Dallapiccola B, Ahmadian MR, Lauri A, Tartaglia M. Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish. Nat Commun. 2022 Nov 11;13(1):6841. doi: 10.1038/s41467-022-34354-x.

The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway

Authors:
Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J
Citation:
Br J Nutr. 2022 Nov 14:1-31. doi: 10.1017/S0007114522003646. Online ahead of print
Epub:
Not Epub
Abstract:
As an internal time keeping mechanism, circadian rhythm plays crucial role in maintaining homeostasis when in response to...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Siniperca chuatsi (Chinese perch)
Citation Extract:
Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J. The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway. Br J Nutr. 2022 Nov 14:1-31. doi: 10.1017/S0007114522003646. Online ahead of print.

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Authors:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK
Citation:
Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y
Epub:
Not Epub
Abstract:
Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y.

Planar polarized force propagation integrates cell behavior and tissue morphogenesis during convergent extension

Authors:
Weng S, Huebner R, Devitt C, Nyaoga B, Alvarado J, Wallingford J
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.08.515701
Epub:
Not Epub
Abstract:
Convergent extension (CE) is an evolutionarily conserved developmental process whereby polarized collective cell movements...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Weng S, Huebner R, Devitt C, Nyaoga B, Alvarado J, Wallingford J. Planar polarized force propagation integrates cell behavior and tissue morphogenesis during convergent extension. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.08.515701 .

Syntaxin 4 is essential for hearing in human and zebrafish

Authors:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM
Citation:
Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print
Epub:
Not Epub
Abstract:
Congenital hearing impairment is a genetically highly heterogenous disorder in which prompt recognition and intervention are...
Organism or Cell Type:
zebrafish
Citation Extract:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM. Syntaxin 4 is essential for hearing in human and zebrafish. Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print.

The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network

Authors:
Chatzifrangkeskou M, Skourides PA
Citation:
Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0
Epub:
Not Epub
Abstract:
The Ciliary Adhesion (CA) complex forms in close association with the basal bodies of cilia during the early stages of...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chatzifrangkeskou M, Skourides PA. The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network. Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0.

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