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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12132 scientific papers returned from the database with the search filters currently being used below.

Homologous gene regulatory networks control development of apical organs and brains in Bilateria

Authors:
Feuda R, Peter IS
Citation:
Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2
Epub:
Not Epub
Abstract:
Apical organs are relatively simple larval nervous systems. The extent to which apical organs are evolutionarily related to the...
Link:
https://www.science.org/doi/10.1126/sciadv.abo2416
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Feuda R, Peter IS. Homologous gene regulatory networks control development of apical organs and brains in Bilateria. Sci Adv. 2022 Nov 4;8(44):eabo2416. doi: 10.1126/sciadv.abo2416. Epub 2022 Nov 2.

Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands

Authors:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW
Citation:
Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print
Epub:
Not Epub
Abstract:
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160622002020
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Dev Biol. 2022 Nov 2:S0012-1606(22)00202-0. doi: 10.1016/j.ydbio.2022.10.013. Online ahead of print.

Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development

Authors:
Kolas V, Mathieu G, Wu YT, Chung BC
Citation:
Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print
Epub:
Not Epub
Abstract:
Pregnenolone (P5) is a steroid that functions in the brain and in zebrafish embryogenesis. It is synthesized from cholesterol...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22014693
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kolas V, Mathieu G, Wu YT, Chung BC. Evaluation of two gene ablation methods for the analysis of pregnenolone function in zebrafish embryonic development. Biochem Biophys Res Commun. 2022 Oct 21;636(Pt 1):84-88. doi:10.1016/j.bbrc.2022.10.067. Online ahead of print.

Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro

Authors:
Catasús N, Rosas I, Bonache S, Negro A, Torres-Martin M, Plana-Pla A, Salvador H, Serra E, Blanco I, Castellanos E, on behalf of the NF2-related SWN Spanish National Reference Centre HUGTP-ICO-IGTP
Citation:
Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13.
Epub:
Not Epub
Abstract:
NF2-related schwannomatosis (NF2-related SWN) is an autosomal dominant condition caused by loss of function variants in the NF2...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(22)00293-1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human patient-derived fibroblasts
Citation Extract:
Catasús N, Rosas I, Bonache S, Negro A, Torres-Martin M, Plana-Pla A, Salvador H, Serra E, Blanco I, Castellanos E, on behalf of the NF2-related SWN Spanish National Reference Centre HUGTP-ICO-IGTP. Antisense oligonucleotides targeting exon 11 are able to partially rescue the NF2-related schwannomatosis phenotype in vitro. Mol Ther Nucleic Acids. 2022 Nov 4;30:493-505. doi: 10.1016/j.omtn.2022.10.026. eCollection 2022 Dec 13..

Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy

Authors:
Gushchina LV, Vetter TA, Frair EC, Bradley AJ, Grounds KM, Lay JW, Huang N, Suhaiba A, Schnell FJ, Hanson G, Simmons TR, Wein N, Flanigan KM
Citation:
Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13.
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(22)00291-8.pdf
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Gushchina LV, Vetter TA, Frair EC, Bradley AJ, Grounds KM, Lay JW, Huang N, Suhaiba A, Schnell FJ, Hanson G, Simmons TR, Wein N, Flanigan KM. Systemic PPMO-mediated dystrophin expression in the Dup2 mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2022 Nov 9;30:479-492. doi: 10.1016/j.omtn.2022.10.025. eCollection 2022 Dec 13..

Expression patterns and biological function of BCL2L10 during mouse preimplantation development

Authors:
Liu Y, Xin J, Zhang S, Li Q, Wang W, Chen J, Ming X, Wu X, Cao X, Cui W, Wang H, Li W
Citation:
Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285
Epub:
Not Epub
Abstract:
BCL2-like 10 (BCL2L10) is abundantly expressed in mammalian oocytes and plays a crucial role in the completion of oocyte...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1567133X22000552
Delivery Method:
microinjection
Organism or Cell Type:
mouse pronuclear embryo
Citation Extract:
Liu Y, Xin J, Zhang S, Li Q, Wang W, Chen J, Ming X, Wu X, Cao X, Cui W, Wang H, Li W. Expression patterns and biological function of BCL2L10 during mouse preimplantation development. Gene Expr Patterns. 2022;46:119285. doi:10.1016/j.gep.2022.119285.

Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

Authors:
Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J
Citation:
Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0
Epub:
Not Epub
Abstract:
During embryonic development, regeneration, and homeostasis, cells have to migrate and physically integrate into the target...
Link:
https://www.nature.com/articles/s41467-022-34165-0
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J. Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo. Nat Commun. 2022 Oct 28;13(1):6423. doi: 10.1038/s41467-022-34165-0.

DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon

Authors:
Goossens R, Verwey N, Ariyurek Y, Schnell F, Aartsma-Rus A
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237
Epub:
Not Epub
Abstract:
Mutations in the DMD gene are causative for Duchenne muscular dystrophy (DMD). Antisense oligonucleotide (AON) mediated exon...
Link:
https://www.biorxiv.org/content/10.1101/2022.10.28.514237v1
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: human myotubes, DMD and healthy sources
Citation Extract:
Goossens R, Verwey N, Ariyurek Y, Schnell F, Aartsma-Rus A. DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon. bioRxiv. 2022;[preprint] doi:10.1101/2022.10.28.514237.

Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin

Authors:
Ha J, Kim BS, Min B, Nam J, Lee JG, Lee M, Yoon BH, Choi YH, Im I, Park JS, Choi H, Baek A, Cho SM, Lee MO, Nam KH, Mun JY, Kim M, Kim SY, Son MY, Kang YK, Lee JS, Kim JK, Kim J
Citation:
Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28
Epub:
Not Epub
Abstract:
Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In...
Link:
https://www.science.org/doi/10.1126/sciadv.abk1239
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ha J, Kim BS, Min B, Nam J, Lee JG, Lee M, Yoon BH, Choi YH, Im I, Park JS, Choi H, Baek A, Cho SM, Lee MO, Nam KH, Mun JY, Kim M, Kim SY, Son MY, Kang YK, Lee JS, Kim JK, Kim J. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Sci Adv. 2022 Oct 28;8(43):eabk1239. doi: 10.1126/sciadv.abk1239. Epub 2022 Oct 28.

Embryonic microRNAs are essential for bovine preimplantation embryo development

Authors:
Paulson EE, Fishman EL, Schultz RM, Ross PJ
Citation:
Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2
Epub:
Not Epub
Abstract:
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression after transcription. miRNAs are present in...
Link:
https://www.pnas.org/doi/10.1073/pnas.2212942119
Delivery Method:
microinjection
Organism or Cell Type:
Bos taurus (cattle) embryo
Citation Extract:
Paulson EE, Fishman EL, Schultz RM, Ross PJ. Embryonic microRNAs are essential for bovine preimplantation embryo development. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212942119. doi: 10.1073/pnas.2212942119. Epub 2022 Nov 2.

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