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Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27

Authors: 
Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin A, Sharma A, Oatley M, Yu T, Quigley K, Vest S, Cook JG, Bautch VL.
Citation: 
Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1265-1282. doi: 10.1161/ATVBAHA.124.320671. Epub 2024 Apr 11. PMID: 38602102.
Abstract: 
Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow-induced mechanotransduction. Laminar blood flow leads to quiescence, but how flow-mediated quiescence is established and maintained is poorly understood.
Epub: 
Not Epub
Link to Publication: 
https://www.ahajournals.org/doi/10.1161/ATVBAHA.124.320671
Organism or Cell Type: 
zebrafish
Delivery Method: 
microinjection